9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription

Yung Wei Lin, Li Ming Lien, Tien Shun Yeh, Hsiao Mei Wu, Yi Li Liu, Rong Hong Hsieh

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

We previously reported that 9-cis retinoic acid (RA) treatment induced an increase in mitochondrial (mt)DNA transcription. In order to extend these results, we tested various concentrations of 9-cis RA were used to treat 143B cells. Cells with low membrane potential treated with 9-cis RA showed significantly lower amounts of RXRα in mitochondria. We also found lower RXRα levels in mtDNA-depleted cells. Treating cells with 9-cis RA significantly increased expression of ND1, ND6, and COX I RNA. However, 9-cis RA-treatment did not appear to induce any significant changes in mtDNA copy number or mitochondrial mass. This study represents that 9-cis RA increases mtDNA transcription but not mtDNA replication, and it suggests that the effects of 9-cis RA on mitochondria are mediated by RXR localization to mitochondria. In addition, this is the first report that 9-cis RA regulation of RXR mitochondrial translocation depends on mitochondrial membrane potential and ATP.
原文英語
頁(從 - 到)351-354
頁數4
期刊Biochemical and Biophysical Research Communications
377
發行號2
DOIs
出版狀態已發佈 - 十二月 12 2008

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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