9-cis retinoic acid induces neurorepair in stroke brain

Seong Jin Yu, Mikko Airavaara, Kuo Jen Wu, Brandon K. Harvey, H. S. Liu, Yihong Yang, Alex Zacharek, Jieli Chen, Yun Wang

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.

原文英語
文章編號4512
期刊Scientific Reports
7
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2017
對外發佈Yes

ASJC Scopus subject areas

  • General

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