6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

Chun Mao Lin, Sheng Tung Huang, Fu Wei Lee, Hsien Saw Kuo, Mei Hsiang Lin

研究成果: 雜誌貢獻文章同行評審

62 引文 斯高帕斯(Scopus)

摘要

A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in LPS-induced RAW 264.7 cells with an IC 50 value of 7.6 μM, and it effectively reduced the hydroxyl radical production by 50% at 100 μM in the electron spin resonance study.

原文英語
頁(從 - 到)4402-4409
頁數8
期刊Bioorganic and Medicinal Chemistry
14
發行號13
DOIs
出版狀態已發佈 - 七月 1 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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