4- And 5-aroylindoles as novel classes of potent antitubulin agents

Jing Ping Liou, Chang Ying Wu, Hsing Pang Hsieh, Chi Yen Chang, Chi Ming Chen, Ching Chuan Kuo, Jang Yang Chang

研究成果: 雜誌貢獻文章

57 引文 斯高帕斯(Scopus)

摘要

A novel series of 4- and 5-aroylindole derivatives was prepared and evaluated for antitumor activity. Several compounds showed excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 13,14,15, and 18, with IC50 values of 1.9, 1.1, 1.2, and 1.8 μM, respectively, exhibited more potent inhibition of tubulin polymerization than colchicine. They also displayed antiproliferative activity, with IC50 values ranging from 10 to 43 nM in a variety of human cell lines from different organs.

原文英語
頁(從 - 到)4548-4552
頁數5
期刊Journal of Medicinal Chemistry
50
發行號18
DOIs
出版狀態已發佈 - 九月 6 2007

ASJC Scopus subject areas

  • Organic Chemistry

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    Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C., & Chang, J. Y. (2007). 4- And 5-aroylindoles as novel classes of potent antitubulin agents. Journal of Medicinal Chemistry, 50(18), 4548-4552. https://doi.org/10.1021/jm070557q