3D co-cultured multicellular spheroids on microfluidic chip for studying ecm-mediated drug resistance

Venkanagouda S. Goudar, Long Sheng Lu, Manohar Prasad Koduri, Fan Gang Tseng

研究成果: 書貢獻/報告類型會議貢獻

摘要

Among various ECM proteins, collagen type-I is a widely distributed extracellular matrix (ECM) protein expressed in different types of cancers and induces tumor growth and drug resistance. To prove this, in the present work we co-cultured colon cancer cells (HCT-8) and fibroblast cells (NIH3T3) in a PDMS based open welled micro 3D (μ-3D) cell culture chip. This co-culture model was employed to study the interaction of cancer cells and stromal cells and revealed that collagen treatment before chemotherapy can be a game-changer in a colon cancer treatment.
原文英語
主出版物標題MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
發行者Chemical and Biological Microsystems Society
頁面853-854
頁數2
ISBN(電子)9781733419017
出版狀態已發佈 - 2020
事件24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
持續時間: 十月 4 2020十月 9 2020

出版系列

名字MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

會議

會議24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
城市Virtual, Online
期間10/4/2010/9/20

ASJC Scopus subject areas

  • 化學工程(雜項)
  • 生物工程
  • 化學 (全部)
  • 控制與系統工程

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