Among various ECM proteins, collagen type-I is a widely distributed extracellular matrix (ECM) protein expressed in different types of cancers and induces tumor growth and drug resistance. To prove this, in the present work we co-cultured colon cancer cells (HCT-8) and fibroblast cells (NIH3T3) in a PDMS based open welled micro 3D (μ-3D) cell culture chip. This co-culture model was employed to study the interaction of cancer cells and stromal cells and revealed that collagen treatment before chemotherapy can be a game-changer in a colon cancer treatment.
|名字||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|會議||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020|
|期間||10/4/20 → 10/9/20|
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