15d-prostaglandin J2 protects brain from ischemia-reperfusion injury

Teng Nan Lin, Wai Mui Cheung, Jui Sheng Wu, Jean Ju Chen, Heng Lin, Jin Jer Chen, Jun Yang Liou, Song Kun Shyue, Kenneth K. Wu

研究成果: 雜誌貢獻文章

114 引文 斯高帕斯(Scopus)

摘要

Objective - Brain expresses abundant lipocalin-type prostaglandin (PG) D2 (PGD2) synthase but the role of PGD2 and its metabolite, 15-deoxy-Δ12,14 PGJ2 (15d-PGJ 2) in brain protection is unclear. The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection. Methods and Results - Adenoviral transfer of cyclooxygenase-1 (Adv-COX-1) was used to amplify the production of 15d-PGJ2 in ischemic cortex in a rat focal infarction model. Cortical 15d-PGJ2 in Adv-COX-1-treated rats was increased by 3-fold over control, which was correlated with reduced infarct volume and activated caspase 3, and increased peroxisome proliferator activated receptor-γ (PPARγ) and heme oxygenase-1 (HO-1). Intraventricular infusion of 15d-PGJ2 resulted in reduction of infarct volume, which was abrogated by a PPARγ inhibitor. Rosiglitazone infusion had a similar effect. 15d-PGJ2 and rosiglitazone at low concentrations suppressed H2O2-induced rat or human neuronal apoptosis and necrosis and induced PPARγ and HO-1 expression. The anti-apoptotic effect was abrogated by PPARγ inhibition. Conclusion - 15d-PGJ2 suppressed ischemic brain infarction and neuronal apoptosis and necrosis in a PPARγ dependent manner. 15d-PGJ2 may play a role in controlling acute brain damage induced by ischemia-reperfusion.

原文英語
頁(從 - 到)481-487
頁數7
期刊Arteriosclerosis, Thrombosis, and Vascular Biology
26
發行號3
DOIs
出版狀態已發佈 - 三月 2006
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此

Lin, T. N., Cheung, W. M., Wu, J. S., Chen, J. J., Lin, H., Chen, J. J., Liou, J. Y., Shyue, S. K., & Wu, K. K. (2006). 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(3), 481-487. https://doi.org/10.1161/01.ATV.0000201933.53964.5b