15-Hydroxyprostaglandin dehydrogenase activity in the lower genitourinary tract. A preliminary report

C. C. Chang, S. N. Lin, F. S. Chen, W. C. Chang

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. In this study, we analysed 15-OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15-OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15-OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.

原文英語
頁(從 - 到)579-581
頁數3
期刊British Journal of Urology
68
發行號6
出版狀態已發佈 - 1991
對外發佈Yes

ASJC Scopus subject areas

  • Urology

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