β-Glucan, but not Lactobacillus plantarum P-8, inhibits lipid accumulation through selected lipid metabolic enzymes in obese rats

Hsiu Chuan Lee, Wei Ting Yu, Yu Ru Guo, Shih-Yi Huang

研究成果: 雜誌貢獻文章

摘要

We compared the effects of barley β-glucan and Lactobacillus plantarum P-8 on changes in body weight, white adipose tissue, and the activities of specific lipid metabolic enzymes in diet-induced obese rats. Obese rats were administered barley β-glucan (B), L. plantarum P-8 (P), or both for 8 weeks. The results showed that the dietary intervention reduced the body weight and white adipose tissue accumulation, and altered gut microbiota in the distal faeces of the B group. Furthermore, acetate and propionate levels considerably increased in the caecal digest and rectal feces of the B group. In addition, β-glucan, but not L. plantarum P-8, increased the activities of hepatic acetyl CoA carboxylase, fatty acid synthase, and carnitine palmitoyl transferase and reduced epididymal fat lipoprotein lipase activity, thus resulting in decreased white adipose tissue accumulation in the obese rats. However, β-glucan and L. plantarum P-8 showed no synergistic effects. Practical applications: β-Glucan ameliorates hyperlipidaemia, increases hepatic acetyl CoA carboxylase, fatty acid synthase, and carnitine palmitoyl transferase activities, and reduces epididymal fat lipoprotein lipase activity, thus resulting in reduced white adipose tissue accumulation in obese rats. β-Glucan reduces of reducing lipid levels and regulating specific lipid metabolic enzymes.
原文英語
文章編號e12336
期刊Journal of Food Biochemistry
41
發行號1
DOIs
出版狀態已發佈 - 二月 1 2017

指紋

Lactobacillus plantarum
Glucans
glucans
White Adipose Tissue
white adipose tissue
Lipids
rats
Enzymes
lipids
enzymes
carnitine palmitoyltransferase
Acetyl-CoA Carboxylase
Fatty Acid Synthases
acetyl-CoA carboxylase
fatty-acid synthase
lipoprotein lipase
Carnitine
Lipoprotein Lipase
Hordeum
Transferases

ASJC Scopus subject areas

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

引用此文

β-Glucan, but not Lactobacillus plantarum P-8, inhibits lipid accumulation through selected lipid metabolic enzymes in obese rats. / Lee, Hsiu Chuan; Yu, Wei Ting; Guo, Yu Ru; Huang, Shih-Yi.

於: Journal of Food Biochemistry, 卷 41, 編號 1, e12336, 01.02.2017.

研究成果: 雜誌貢獻文章

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