摘要
Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 3276-3278 |
| 頁數 | 3 |
| 期刊 | Proceedings of the National Academy of Sciences of the United States of America |
| 卷 | 76 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | 已發佈 - 十二月 1 1979 |
| 對外發佈 | Yes |
ASJC Scopus subject areas
- General
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引用此
Li, C. H., Yamashiro, D., Tseng, L. F., Chang, W. C., & Ferrara, P. (1979). β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities. Proceedings of the National Academy of Sciences of the United States of America, 76(7), 3276-3278. https://doi.org/10.1073/pnas.76.7.3276