Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.
|頁（從 - 到）||3276-3278|
|期刊||Proceedings of the National Academy of Sciences of the United States of America|
|出版狀態||已發佈 - 十二月 1 1979|
ASJC Scopus subject areas
Li, C. H., Yamashiro, D., Tseng, L. F., Chang, W. C., & Ferrara, P. (1979). β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities. Proceedings of the National Academy of Sciences of the United States of America, 76(7), 3276-3278. https://doi.org/10.1073/pnas.76.7.3276