β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities

C. H. Li, D. Yamashiro, L. F. Tseng, W. C. Chang, P. Ferrara

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.
原文英語
頁(從 - 到)3276-3278
頁數3
期刊Proceedings of the National Academy of Sciences of the United States of America
76
發行號7
DOIs
出版狀態已發佈 - 十二月 1 1979
對外發佈Yes

ASJC Scopus subject areas

  • General

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