β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities

C. H. Li; D. Yamashiro; L. F. Tseng; W. C. Chang; P. Ferrara

doi:10.1073/pnas.76.7.3276

β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities

C. H. Li, D. Yamashiro, L. F. Tseng, W. C. Chang, P. Ferrara

研究成果: 雜誌貢獻 › 文章 › 同行評審

10 引文斯高帕斯（Scopus）

摘要

Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.

原文	英語
頁（從 - 到）	3276-3278
頁數	3
期刊	Proceedings of the National Academy of Sciences of the United States of America
卷	76
發行號	7
DOIs	https://doi.org/10.1073/pnas.76.7.3276
出版狀態	已發佈 - 十二月 1 1979
對外發佈	是

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多學科

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10.1073/pnas.76.7.3276

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title = "β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities",

abstract = "Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.",

author = "Li, {C. H.} and D. Yamashiro and Tseng, {L. F.} and Chang, {W. C.} and P. Ferrara",

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T2 - Synthesis of analogs modified at the carboxyl terminus with increased activities

AU - Li, C. H.

AU - Yamashiro, D.

AU - Tseng, L. F.

AU - Chang, W. C.

AU - Ferrara, P.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.

AB - Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.

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β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities

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