β-Endorphin: Deletion of a single amino acid residue abolishes immunoreactivity but retains opiate potency

Choh Hao Li, Wen Chang Chang, Donald Yamashiro, Liang Fu Tseng

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Two synthetic analogs of camel β-endorphin, one with omission of Leu-14 and the other with omission of Asn-20, have been assayed for immunoreactivity by radioimmunoassay, opiate activity in the guinea pig ileum preparation and analgesic potency in mice. It was found that the omission analogs had no immunoreactivity, but retained significant biological activities. As far as we are aware, this is the first instance in which deletion of a single amino acid residue in a biologically active peptide abolished immunoreactivity.
原文英語
頁(從 - 到)693-697
頁數5
期刊Biochemical and Biophysical Research Communications
87
發行號3
DOIs
出版狀態已發佈 - 四月 13 1979
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 生物化學
  • 分子生物學
  • 細胞生物學

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