α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro

Ka Wai Tam, Chi Tang Ho, Shih Hsin Tu, Wen Jui Lee, Ching Shui Huang, Ching Shyang Chen, Chih Hsiung Wu, Chia Hwa Lee, Yuan Soon Ho

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Vitamin E (Vit. E) is considered an essential dietary nutrient for humans and animals. An enormous body of evidence indicates the biological and protective effects of Vit. E consumption. Tocopherol-associated protein (TAP) is a major tocopherolbinding protein affecting Vit. E stimulation and downstream signaling transduction. However, how Vit. E utilizes TAP as an anti-cancer mechanism remains unclear. Microarray analysis of signature gene profiles in breast cancer cells treated with α-tocopheryl succinate (α-TOS, a Vit. E isoform) resulted in cell cycle arrest and anticancer activity in breast cancer cells. Pterostilbene (PS), a natural dietary antioxidant found in blueberries, in combination with α-TOS synergistically maximized breast cancer cell growth inhibition by disrupting signal transduction, transcription factors and cell cycle proteins. In a xenograft mouse model, PS treatment with Vit. E inhibited breast tumor growth and cell invasion, which were evaluated using our recently developed circulating tumor cell (CTC) detection assay. Because dietary Vit. E and PS supplementation contributed to preventative and therapeutic effects in vitro and in vivo, this combination may benefit breast cancer therapy in the clinic.
原文英語
頁(從 - 到)4593-4606
頁數14
期刊Oncotarget
9
發行號4
DOIs
出版狀態已發佈 - 一月 1 2018

指紋

alpha-Tocopherol
Vitamin E
Human Activities
Breast Neoplasms
Neoplasms
Tocopherols
Blueberry Plants
Circulating Neoplastic Cells
Cell Cycle Proteins
Proteins
Succinic Acid
Therapeutic Uses
Microarray Analysis
Growth
Cell Cycle Checkpoints
pterostilbene
In Vitro Techniques
Heterografts
Signal Transduction
Protein Isoforms

ASJC Scopus subject areas

  • Oncology

引用此文

α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro. / Tam, Ka Wai; Ho, Chi Tang; Tu, Shih Hsin; Lee, Wen Jui; Huang, Ching Shui; Chen, Ching Shyang; Wu, Chih Hsiung; Lee, Chia Hwa; Ho, Yuan Soon.

於: Oncotarget, 卷 9, 編號 4, 01.01.2018, p. 4593-4606.

研究成果: 雜誌貢獻文章

Tam, Ka Wai ; Ho, Chi Tang ; Tu, Shih Hsin ; Lee, Wen Jui ; Huang, Ching Shui ; Chen, Ching Shyang ; Wu, Chih Hsiung ; Lee, Chia Hwa ; Ho, Yuan Soon. / α-Tocopherol succinate enhances pterostilbene anti-tumor activity in human breast cancer cells in vivo and in vitro. 於: Oncotarget. 2018 ; 卷 9, 編號 4. 頁 4593-4606.
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AU - Chen, Ching Shyang

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