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研究成果 1994 2019

篩選
文章
2002
9 引文 (Scopus)

Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine: A California cancer consortium trial

Yen, Y., Chow, W., Leong, L., Margolin, K., Morgan, R., Raschko, J., Shibata, S., Somlo, G., Twardowski, P., Frankel, P., Longmate, J., Synold, T., Newman, E. M., Lenz, H. J., Gandara, D. & Doroshow, J. H., 十二月 21 2002, 於 : Cancer Chemotherapy and Pharmacology. 50, 5, p. 353-359 7 p.

研究成果: 雜誌貢獻文章

gemcitabine
Pharmacodynamics
Hydroxyurea
Neoplasms
Pharmacokinetics
23 引文 (Scopus)

Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells

Zhou, B., Mi, S., Mo, X., Shih, J., Tsai, J., Hu, E., Hsu, M., Kay, K. & Yen, Y., 八月 14 2002, 於 : Anticancer Research. 22, 3, p. 1369-1378 10 p.

研究成果: 雜誌貢獻文章

gemcitabine
KB Cells
Hydroxyurea
S Phase
Ribonucleotide Reductases
2001
31 引文 (Scopus)
Drug Resistance
Exons
Genes
Ribonucleotide Reductases
5' Flanking Region
27 引文 (Scopus)

High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma: Toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome

Somlo, G., Doroshow, J. H., Synold, T., Longmate, J., Reardon, D., Chow, W., Forman, S. J., Leong, L. A., Margolin, K. A., Morgan, J. J., Raschko, J. W., Shibata, S. I., Tetef, M. L., Yen, Y., Kogut, N., Schriber, J. & Alvarnas, J., 六月 15 2001, 於 : British Journal of Cancer. 84, 12, p. 1591-1598 8 p.

研究成果: 雜誌貢獻文章

Paclitaxel
Doxorubicin
Cyclophosphamide
Blood Cells
Stem Cells
32 引文 (Scopus)
Gene Amplification
Drug Resistance
Clone Cells
Chromosomes
Staining and Labeling
10 引文 (Scopus)

Inhibition of tumor cell growth by Schiff bases of hydroxysemicarbazide

Ren, S., Tokes, Z. A., Csipke, C., Zhou, B., Yen, Y. & Lien, E. J., 十二月 1 2001, 於 : Anticancer Research. 21, 5, p. 3445-3451 7 p.

研究成果: 雜誌貢獻文章

Hydroxyurea
Schiff Bases
gemcitabine
Tumor Cell Line
KB Cells
9 引文 (Scopus)

Phase II trial of high-dose intravenous doxorubicin, etoposide, and cyclophosphamide with autologous stem cell support in patients with residual or responding recurrent ovarian cancer

Morgan, R. J., Doroshow, J. H., Leong, L., Schriber, J., Shibata, S., Forman, S., Hamasaki, V., Margolin, K., Somlo, G., Alvarnas, J., McNamara, M., Longmate, J., Raschko, J., Chow, W., Vasilev, S., McGonigle, K. & Yen, Y., 十二月 13 2001, 於 : Bone Marrow Transplantation. 28, 9, p. 859-863 5 p.

研究成果: 雜誌貢獻文章

Etoposide
Ovarian Neoplasms
Doxorubicin
Cyclophosphamide
Stem Cells
25 引文 (Scopus)

Phase I trial of 96-hour continuous infusion of dexrazoxane in patients with advanced malignancies

Tetef, M. L., Synold, T. W., Chow, W., Leong, L., Margolin, K., Morgan, R., Raschko, J., Shibata, S., Somlo, G., Yen, Y., Doroshow, J. H., Groshen, S., Johnson, K., Lenz, H. J. & Gandara, D., 一月 1 2001, 於 : Clinical Cancer Research. 7, 6, p. 1569-1576 8 p.

研究成果: 雜誌貢獻文章

Dexrazoxane
Neoplasms
Doxorubicin
Divalent Cations
Granulocyte Colony-Stimulating Factor

Prognostic indicators of relapse-free and overall survival in patients with high-risk primary breast cancer following high-dose chemotherapy

Somlo, G., Chu, P., Frankel, P., Chow, W., Forman, S., Leong, L., Margolin, K., Morgan, R., Shibata, S., Yen, Y. & Doroshow, J., 2001, 於 : Breast Cancer Research and Treatment. 69, 3, p. 243 1 p.

研究成果: 雜誌貢獻文章

Breast Neoplasms
Recurrence
Drug Therapy
Survival
Neoplasms
4 引文 (Scopus)

Tandem-cycle high-dose melphalan and cisplatin with peripheral blood progenitor cell support in patients with breast cancer and other malignancies

Somlo, G., Chow, W., Hamasaki, V., Leong, L., Margolin, K., Morgan, R., Sniecinski, I., Frankel, P., Reardon, D., Longmate, J., Raschko, J., Shibata, S., O'Donnell, M., Smith, E., Tetef, M., Forman, S., Yen, Y., Molina, A. & Doroshow, J. H., 一月 1 2001, 於 : Biology of Blood and Marrow Transplantation. 7, 5, p. 284-293 10 p.

研究成果: 雜誌貢獻文章

Melphalan
Cisplatin
Blood Cells
Stem Cells
Confidence Intervals
2000
7 引文 (Scopus)

A phase I study of carboplatin and etoposide administered in conjunction with dipyridamole, prochlorperazine and cyclosporine A

Raschko, J. W., Synold, T. W., Chow, W., Coluzzi, P., Hamasaki, V., Leong, L. A., Margolin, K. A., Morgan, R. J., Shibata, S. I., Somlo, G., Tetef, M. L., Yen, Y., Ter Veer, A. & Doroshow, J. H., 十一月 27 2000, 於 : Cancer Chemotherapy and Pharmacology. 46, 5, p. 403-410 8 p.

研究成果: 雜誌貢獻文章

Prochlorperazine
Dipyridamole
Carboplatin
Etoposide
Cyclosporine
24 引文 (Scopus)

Inhibition of human cancer cell growth by inducible expression of human ribonucleotide reductase antisense cDNA

Chen, S., Zhou, B., He, F. & Yen, Y., 一月 1 2000, 於 : Antisense and Nucleic Acid Drug Development. 10, 2, p. 111-116 6 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Cell growth
Complementary DNA
Clone Cells
Messenger RNA
1999
20 引文 (Scopus)

Electrochemical treatment of human KB cells in vitro

Yen, Y., Li, J. R., Zhou, B. S., Rojas, F., Yu, J. & Chou, C. K., 十二月 1 1999, 於 : Bioelectromagnetics. 20, 1, p. 34-41 8 p.

研究成果: 雜誌貢獻文章

KB Cells
Neoplasms
Thymidine
Cell Survival
Electrodes
36 引文 (Scopus)

Ethnic differences in the behavior of hepatocellular carcinoma

Chin, P. L., Chu, D. Z. J., Clarke, K. G., Odom-Maryon, T., Yen, Y. & Wagman, L. D., 五月 1 1999, 於 : Cancer. 85, 9, p. 1931-1936 6 p.

研究成果: 雜誌貢獻文章

Hepatocellular Carcinoma
Survival
Fetal Proteins
Hepatitis B
Ethnic Groups
193 引文 (Scopus)

Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line

Goan, Y. G., Zhou, B., Hu, E., Mi, S. & Yen, Y., 九月 1 1999, 於 : Cancer Research. 59, 17, p. 4204-4207 4 p.

研究成果: 雜誌貢獻文章

KB Cells
Ribonucleotide Reductases
Clone Cells
Deoxycytidine Kinase
Cell Line
76 引文 (Scopus)

Recombinant human thrombopoietin in combination with granulocyte colony- stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy

Somlo, G., Sniecinski, I., Ter Veer, A., Longmate, J., Knutson, G., Vuk-Pavlovic, S., Bhatia, R., Chow, W., Leong, L., Morgan, R., Margolin, K., Raschko, J., Shibata, S., Tetef, M., Yen, Y., Forman, S., Jones, D., Ashby, M., Fyfe, G., Hellmann, S. 及其他1, Doroshow, J. H., 五月 1 1999, 於 : Blood. 93, 9, p. 2798-2806 9 p.

研究成果: 雜誌貢獻文章

Thrombopoietin
Chemotherapy
Granulocyte Colony-Stimulating Factor
Platelets
Blood Cells
1998
17 引文 (Scopus)

A simple and sensitive ribonucleotide reductase assay

Jong, A. Y., Yu, K., Zhou, B., Frgala, T., Reynolds, P. & Yen, Y., 一月 1 1998, 於 : Journal of Biomedical Science. 5, 1, p. 62-68 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Assays
Hydroxyurea
Ribonucleases
Adenosine Triphosphate
21 引文 (Scopus)

Determination of deoxyribonucleoside triphosphate pool sizes in ribonucleotide reductase cDNA transfected human KB cells

Zhou, B. S., Ker, R., Ho, R., Yu, J., Zhao, Y. R., Shih, J. & Yen, Y., 五月 15 1998, 於 : Biochemical Pharmacology. 55, 10, p. 1657-1665 9 p.

研究成果: 雜誌貢獻文章

Deoxyribonucleosides
KB Cells
Ribonucleotide Reductases
Complementary DNA
Clone Cells
86 引文 (Scopus)

Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential

Zhou, B. S., Tsai, P., Ker, R., Tsai, J., Ho, R., Yu, J., Shih, J. & Yen, Y., 三月 31 1998, 於 : Clinical and Experimental Metastasis. 16, 1, p. 43-49 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Messenger RNA
Clone Cells
Neoplasms
Complementary DNA
6 引文 (Scopus)

Phase I trial of intraperitoneal iododeoxyuridine with and without intravenous high-dose folinic acid in the treatment of advanced malignancies primarily confined to the peritoneal cavity: Flow cytometric and pharmacokinetic analysis

Morgan, R. J., Newman, E. M., Doroshow, J. H., McGonigle, K., Margolin, K., Raschko, J., Chow, W., Somlo, G., Leong, L., Tetef, M., Shibata, S., Hamasaki, V., Carroll, M., Vasilev, S., Akman, S., Coluzzi, P., Wagman, L., Longmate, J., Paz, B., Yen, Y. 及其他1, Klevecz, R., 七月 1 1998, 於 : Cancer Research. 58, 13, p. 2793-2800 8 p.

研究成果: 雜誌貢獻文章

Idoxuridine
Leucovorin
Peritoneal Cavity
Pharmacokinetics
Neoplasms
18 引文 (Scopus)

Reversal of hydroquinone-mediated suppression of T cell proliferation by transfection of the M2 subunit of ribonucleotide reductase

Li, Q., Kasten-Jolly, J., Yen, Y. & Freed, B. M., 一月 1 1998, 於 : Toxicology and Applied Pharmacology. 150, 1, p. 154-157 4 p.

研究成果: 雜誌貢獻文章

T-cells
Cell proliferation
Transfection
Cell Proliferation
T-Lymphocytes
19 引文 (Scopus)

Role of the M2 subunit of ribonucleotide reductase in regulation by hydroxyurea of the activity of the anti-HIV-1 agent 2',3'-dideoxyinosine

Gao, W. Y., Zhou, B. S., Johns, D. G., Mitsuya, H. & Yen, Y., 七月 1 1998, 於 : Biochemical Pharmacology. 56, 1, p. 105-112 8 p.

研究成果: 雜誌貢獻文章

Didanosine
Anti-HIV Agents
Hydroxyurea
HIV-1
DNA
1997
73 引文 (Scopus)

High-dose chemotherapy and stem-cell rescue in the treatment of high- risk breast cancer: Prognostic indicators of progression-free and overall survival

Somlo, G., Doroshow, J. H., Forman, S. J., Odom-Maryon, T., Lee, J., Chow, W., Hamasaki, V., Leong, L., Morgan, R., Margolin, K., Raschko, J., Shibata, S., Tetef, M., Yen, Y., Simpson, J. & Molina, A., 一月 1 1997, 於 : Journal of Clinical Oncology. 15, 8, p. 2882-2893 12 p.

研究成果: 雜誌貢獻文章

Disease-Free Survival
Stem Cells
Confidence Intervals
Breast Neoplasms
Drug Therapy
15 引文 (Scopus)

Pharmacokinetics and toxicity of 120-hour continuous-infusion hydroxyurea in patients with advanced solid tumors

Newman, E. M., Carroll, M., Akman, S. A., Chow, W., Coluzzi, P., Hamasaki, V., Leong, L. A., Margolin, K. A., Morgan, R. J., Raschko, J. W., Shibata, S., Somlo, G., Tetef, M., Yen, Y., Ahn, C. W. & Doroshow, J. H., 一月 1 1997, 於 : Cancer Chemotherapy and Pharmacology. 39, 3, p. 254-258 5 p.

研究成果: 雜誌貢獻文章

Pharmacokinetics
Hydroxyurea
Toxicity
Tumors
Neoplasms
1995
57 引文 (Scopus)
KB Cells
Ribonucleotide Reductases
Hydroxyurea
Clone Cells
Messenger RNA
1994
56 引文 (Scopus)

Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine

Yen, Y., Grill, S. P., Dutschman, G. E., Chang, C. N., Zhou, B. S. & Cheng, Y. C., 七月 15 1994, 於 : Cancer Research. 54, 14, p. 3686-3691 6 p.

研究成果: 雜誌貢獻文章

Thioguanine
KB Cells
Hydroxyurea
Cell Line
Ribonucleotide Reductases