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研究成果 1994 2019

篩選
文章
2007
24 引文 (Scopus)

Phase I trial of intraperitoneal gemcitabine in the treatment of advanced malignancies primarily confined to the peritoneal cavity

Morgan, R. J., Synold, T. W., Xi, B., Lim, D., Shibata, S., Margolin, K., Schwarz, R. E., Leong, L., Somlo, G., Twardowski, P., Yen, Y., Chow, W., Tetef, M., Lin, P., Paz, B., Koczywas, M., Wagman, L., Chu, D., Frankel, P., Stalter, S. 及其他1, Doroshow, J. H., 二月 15 2007, 於 : Clinical Cancer Research. 13, 4, p. 1232-1237 6 p.

研究成果: 雜誌貢獻文章

gemcitabine
Peritoneal Cavity
Area Under Curve
Neoplasms
Therapeutics
111 引文 (Scopus)

Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation In vitro and In vivo

Heidel, J. D., Liu, J. Y. C., Yen, Y., Zhou, B., Heale, B. S. E., Rossi, J. J., Bartlett, D. W. & Davis, M. E., 四月 1 2007, 於 : Clinical Cancer Research. 13, 7, p. 2207-2215 9 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Small Interfering RNA
Cell Proliferation
Luciferases
Cultured Cells
34 引文 (Scopus)

Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation

Xue, L., Zhou, B., Liu, X., Heung, Y., Chau, J., Chu, E., Li, S., Jiang, C., Un, F. & Yen, Y., 一月 1 2007, 於 : Cancer Research. 67, 1, p. 16-21 6 p.

研究成果: 雜誌貢獻文章

Cyclin-Dependent Kinase 2
Ribonucleotide Reductases
DNA Repair
DNA Damage
Amino Acids
44 引文 (Scopus)

Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer

Liu, X., Zhou, B., Xue, L., Yen, F., Chu, P., Un, F. & Yen, Y., 一月 1 2007, 於 : Clinical Colorectal Cancer. 6, 5, p. 374-381 8 p.

研究成果: 雜誌貢獻文章

Colonic Neoplasms
Biomarkers
Neoplasm Metastasis
Ribonucleotide Reductases
Diphosphates
119 引文 (Scopus)

Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression

Li, X., Lee, Y. K., Jeng, J. C., Yen, Y., Schultz, D. C., Shih, H. M. & Ann, D. K., 十二月 14 2007, 於 : Journal of Biological Chemistry. 282, 50, p. 36177-36189 13 p.

研究成果: 雜誌貢獻文章

Sumoylation
Phosphorylation
Serine
Switches
Proteins
285 引文 (Scopus)

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D. & Huang, W., 二月 1 2007, 於 : Cancer Research. 67, 3, p. 863-867 5 p.

研究成果: 雜誌貢獻文章

Bile Acids and Salts
Liver
Neoplasms
Homeostasis
Liver Cell Adenoma
17 引文 (Scopus)

The induction of growth arrest DNA damage-inducible gene 45 β in human hepatoma cell lines by S-adenosylmethionine

Qiu, W., Zhou, B., Chu, P. G., Luh, F. & Yen, Y., 一月 1 2007, 於 : American Journal of Pathology. 171, 1, p. 287-296 10 p.

研究成果: 雜誌貢獻文章

S-Adenosylmethionine
DNA Damage
Hepatocellular Carcinoma
Binding Sites
Cell Line
2 引文 (Scopus)

Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice

Lin, H. H., Xiong, Y., Ho, Y. S., Zhou, B., Nguyen, H. V., Deng, H., Lee, R., Yen, Y., Borok, Z. & Ann, D. K., 二月 1 2007, 於 : European Journal of Oral Sciences. 115, 1, p. 30-39 10 p.

研究成果: 雜誌貢獻文章

Salivary Glands
varespladib methyl
Transgenic Mice
Transcription Factors
Aquaporin 5
2006
104 引文 (Scopus)

A ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase

Shao, J., Zhou, B., Di Bilio, A. J., Zhu, L., Wang, T., Qi, C., Shih, J. & Yen, Y., 三月 1 2006, 於 : Molecular Cancer Therapeutics. 5, 3, p. 586-592 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Reactive Oxygen Species
Catalase
Superoxide Dismutase
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
24 引文 (Scopus)

Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI-2040 antisense drug treatment

Juhasz, A., Vassilakos, A., Chew, H. K., Gandara, D. & Yen, Y., 五月 1 2006, 於 : Oncology Reports. 15, 5, p. 1299-1304 6 p.

研究成果: 雜誌貢獻文章

Real-Time Polymerase Chain Reaction
Messenger RNA
Leukocytes
Pharmaceutical Preparations
Down-Regulation
13 引文 (Scopus)
Ribonucleotide Reductases
Holoenzymes
Assays
Diphosphates
In Vitro Techniques
5 引文 (Scopus)

Enzymatic property analysis of p53R2 subunit of human ribonucleotide reductase

Yen, Y., Chu, B., Yen, C., Shih, J. & Zhou, B., 九月 4 2006, 於 : Advances in Enzyme Regulation. 46, 1, p. 235-247 13 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Iron
Cytidine Diphosphate
Deferoxamine
Hydroxyurea
24 引文 (Scopus)

Esophageal cancer: Clinical Practice Guidelines in oncology™

Ajani, J., Bekaii-Saab, T., D'Amico, T. A., Fuchs, C., Gibson, M. K., Goldberg, M., Hayman, J. A., Ilson, D. H., Javle, M., Kelley, S., Kurtz, R. C., Locker, G. Y., Meropol, N. J., Minsky, B. D., Orringer, M. B., Osarogiagbon, R. U., Posey, J. A., Roth, J., Sasson, A. R., Swisher, S. G. 及其他2, Wood, D. E. & Yen, Y., 四月 2006, 於 : JNCCN Journal of the National Comprehensive Cancer Network. 4, 4, p. 328-347 20 p.

研究成果: 雜誌貢獻文章

Esophageal Neoplasms
Practice Guidelines
Carcinoma
Active Immunotherapy
Hiatal Hernia
2 引文 (Scopus)

Fibroblast growth factor Receptor 3 up-regulates vascular endothelial growth factor expression in L6 cells

Zhu, L., Yen, Y., Shao, J., Qi, C. H., Yen, C., Luo, J. & Zhou, B., 五月 1 2006, 於 : International Journal of Pharmacology. 2, 3, p. 324-330 7 p.

研究成果: 雜誌貢獻文章

Receptor, Fibroblast Growth Factor, Type 3
Vascular Endothelial Growth Factor A
Up-Regulation
Multiple Myeloma
Cell Proliferation
24 引文 (Scopus)

Gastric cancer: Clinical Practice Guidelines in oncology™

Ajani, J., Bekaii-Saab, T., D'Amico, T. A., Fuchs, C., Gibson, M. K., Goldberg, M., Hayman, J. A., Ilson, D. H., Javle, M., Kelley, S., Kurtz, R. C., Locker, G. Y., Meropol, N. J., Minsky, B. D., Orringer, M. B., Osarogiagbon, R. U., Posey, J. A., Roth, J., Sasson, A. R., Swisher, S. G. 及其他2, Wood, D. E. & Yen, Y., 四月 2006, 於 : JNCCN Journal of the National Comprehensive Cancer Network. 4, 4, p. 350-366 17 p.

研究成果: 雜誌貢獻文章

Practice Guidelines
Stomach Neoplasms
Stomach
Histology
Carcinoma

MAb against the small subunit of human ribonucleotide reductase (hRRM2)

Yen, Y., 十月 2006, 於 : Hybridoma. 25, 5, p. 313 1 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
43 引文 (Scopus)

Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells

Liu, X., Zhou, B., Xue, L., Shih, J., Tye, K., Lin, W., Qi, C., Chu, P., Un, F., Wen, W. & Yen, Y., 十一月 1 2006, 於 : Clinical Cancer Research. 12, 21, p. 6337-6344 8 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Neoplasm Metastasis
Neoplasms
Transfection
Colon
10 引文 (Scopus)

Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity

Un, F., Qi, C., Prosser, M., Wang, N., Zhou, B., Bronner, C. & Yen, Y., 七月 1 2006, 於 : Anticancer Research. 26, 4 B, p. 2761-2767 7 p.

研究成果: 雜誌貢獻文章

Hydroxyurea
Ribonucleotide Reductases
Small Interfering RNA
DNA Damage
S Phase Cell Cycle Checkpoints
8 引文 (Scopus)

Production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues

Zhou, B., Phan, V., Liu, X., Juhasz, A., Chu, P. G. & Yen, Y., 一月 1 2006, 於 : Hybridoma. 25, 5, p. 264-270 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Immunohistochemistry
Monoclonal Antibodies
Neoplasms
Paraffin
208 引文 (Scopus)

Ribonucleotide reductase inhibitors and future drug design

Shao, J., Zhou, B., Chu, B. & Yen, Y., 2006, 於 : Current Cancer Drug Targets. 6, 5, p. 409-431 23 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Drug Design
Clinical Trials
gemcitabine
Neoplasms
30 引文 (Scopus)

Structurally dependent redox property of ribonucleotide reductase subunit p53R2

Xue, L., Zhou, B., Liu, X., Wang, T., Shih, J., Qi, C., Heung, Y. & Yen, Y., 二月 15 2006, 於 : Cancer Research. 66, 4, p. 1900-1905 6 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Oxidation-Reduction
Reactive Oxygen Species
Mitochondrial Membrane Potential
Oxidative Stress
5 引文 (Scopus)

SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone

Chung, V., Zhou, B., Liu, X., Zhu, L., Boo, L. M., Nguyen, H. V., Ann, D. K., Song, J., Chen, Y. & Yen, Y., 三月 1 2006, 於 : Molecular Cancer Therapeutics. 5, 3, p. 533-540 8 p.

研究成果: 雜誌貢獻文章

gemcitabine
Sumoylation
Clone Cells
Carcinoma
KB Cells
2005
12 引文 (Scopus)

A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases

Zhou, B., Shao, J., Su, L., Yuan, Y. C., Qi, C., Shih, J., Xi, B., Chu, B. & Yen, Y., 十二月 1 2005, 於 : Molecular Cancer Therapeutics. 4, 12, p. 1830-1836 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Tyrosine
Enzymes
Deoxyribonucleotides
Ribonucleotides
6 引文 (Scopus)

Clinicopathologic significance of synchronous and metachronous adenomas in colorectal cancer

Mattar, M., Frankel, P., David, D., Clarke, K. O., Chu, D. Z. J., Jiang, C. & Yen, Y., 一月 1 2005, 於 : Clinical Colorectal Cancer. 5, 4, p. 274-278 5 p.

研究成果: 雜誌貢獻文章

Adenoma
Colorectal Neoplasms
Survival
Colonoscopy
Disease-Free Survival
31 引文 (Scopus)

Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay

Shao, J., Zhou, B., Zhu, L., Bilio, A. J. D., Su, L., Yuan, Y. C., Ren, S., Lien, E. J., Shih, J. & Yen, Y., 二月 15 2005, 於 : Biochemical Pharmacology. 69, 4, p. 627-634 8 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Holoenzymes
Schiff Bases
Assays
Hydroxyurea
15 引文 (Scopus)

EGFR mutations in malignant pleural effusion of non-small cell lung cancer: A case report

Huang, M. J., Lim, K. H., Tzen, C. Y., Hsu, H. S., Yen, Y. & Huang, B. S., 九月 1 2005, 於 : Lung Cancer. 49, 3, p. 413-415 3 p.

研究成果: 雜誌貢獻文章

Malignant Pleural Effusion
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Mutation
47 引文 (Scopus)

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma

Zhu, L., Somlo, G., Zhou, B., Shao, J., Bedell, V., Slovak, M. L., Liu, X., Luo, J. & Yen, Y., 五月 1 2005, 於 : Molecular Cancer Therapeutics. 4, 5, p. 787-798 12 p.

研究成果: 雜誌貢獻文章

Receptor, Fibroblast Growth Factor, Type 3
Multiple Myeloma
Small Interfering RNA
Apoptosis
B-Cell Chronic Lymphocytic Leukemia
48 引文 (Scopus)

High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation

Boo, L. M., Lin, H. H., Chung, V., Zhou, B., Louie, S. G., O'Reilly, M. A., Yen, Y. & Ann, D. K., 八月 1 2005, 於 : Cancer Research. 65, 15, p. 6622-6630 9 p.

研究成果: 雜誌貢獻文章

Phosphatidylinositol 3-Kinase
varespladib methyl
Protein Kinases
DNA Damage
Doxorubicin
138 引文 (Scopus)

Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: Application of CDX2, CK17, MUC1, and MUC2

Chu, P. G., Schwarz, R. E., Lau, S. K., Yen, Y. & Weiss, L. M., 三月 1 2005, 於 : American Journal of Surgical Pathology. 29, 3, p. 359-367 9 p.

研究成果: 雜誌貢獻文章

Mucin-2
Keratin-17
Ampulla of Vater
Mucin-1
Pancreatic Ductal Carcinoma
34 引文 (Scopus)

Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma

Qiu, W. H., Zhou, B. S., Chu, P. G., Chen, W. G., Chung, C., Shih, J., Hwu, P., Yeh, C., Lopez, R. & Yen, Y., 九月 14 2005, 於 : World Journal of Gastroenterology. 11, 34, p. 5266-5272 7 p.

研究成果: 雜誌貢獻文章

Receptor, Fibroblast Growth Factor, Type 3
Hepatocellular Carcinoma
Liver
Oligonucleotide Array Sequence Analysis
Northern Blotting
23 引文 (Scopus)

Paclitaxel-based high-dose chemotherapy with autologous stem cell rescue for relapsed germ cell cancer

Margolin, K. A., Doroshow, J. H., Frankel, P., Chow, W., Leong, L. A., Lim, D., McNamara, M., Morgan, R. J., Shibata, S., Somlo, G., Twardowski, P., Yen, Y., Kogut, N., Schriber, J., Alvarnas, J. & Stalter, S., 十一月 1 2005, 於 : Biology of Blood and Marrow Transplantation. 11, 11, p. 903-911 9 p.

研究成果: 雜誌貢獻文章

Germ Cell and Embryonal Neoplasms
Paclitaxel
Stem Cells
Drug Therapy
Peripheral Blood Stem Cell Transplantation
11 引文 (Scopus)

Ribozyme cleavage leads to decreased expression of fibroblast growth factor receptor 3 in human multiple myeloma cells, which is associated with apoptosis and downregulation of vascular endothelial growth factor

Qian, S., Somlo, G., Zhou, B., Zhu, L., Mi, S., Mo, X., Cheung, E. M., Qiu, W., Lin, R. J., Rossi, J., Holtz, M., Chu, P. & Yen, Y., 四月 7 2005, 於 : Oligonucleotides. 15, 1, p. 1-11 11 p.

研究成果: 雜誌貢獻文章

Receptor, Fibroblast Growth Factor, Type 3
Catalytic RNA
Multiple Myeloma
Vascular Endothelial Growth Factor A
Down-Regulation
25 引文 (Scopus)

The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells

Liu, X., Zhou, B., Xue, L., Shih, J., Tye, K., Qi, C. & Yen, Y., 十一月 1 2005, 於 : Biochemical Pharmacology. 70, 9, p. 1288-1297 10 p.

研究成果: 雜誌貢獻文章

KB Cells
Ribonucleotide Reductases
DNA Replication
DNA
Phase Transition
76 引文 (Scopus)

The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells

Wang, T., Tamae, D., LeBon, T., Shively, J. E., Yen, Y. & Li, J. J., 十一月 15 2005, 於 : Cancer Research. 65, 22, p. 10338-10346 9 p.

研究成果: 雜誌貢獻文章

Peroxiredoxins
Ionizing Radiation
Radiation
Breast Neoplasms
Reactive Oxygen Species
2004
82 引文 (Scopus)

A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer

Yen, Y., Margolin, K., Doroshow, J., Fishman, M., Johnson, B., Clairmont, C., Sullivan, D. & Sznol, M., 十月 1 2004, 於 : Cancer Chemotherapy and Pharmacology. 54, 4, p. 331-342 12 p.

研究成果: 雜誌貢獻文章

gemcitabine
Neoplasms
Methemoglobinemia
Cytotoxicity
Toxicity
2 引文 (Scopus)

A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies

Shibata, S. I., Pezner, R., Chu, D., Doroshow, J. H., Chow, W. A., Leong, L. A., Margolin, K. A., McNamara, M. V., Morgan, R. J., Raschko, J. W., Somlo, G., Tetef, M. L., Yen, Y., Synold, T. W., Wagman, L., Vora, N., Carroll, M., Lin, S. & Longmate, J., 八月 1 2004, 於 : European Journal of Surgical Oncology. 30, 6, p. 650-657 8 p.

研究成果: 雜誌貢獻文章

Fluorouracil
Radiotherapy
Neoplasms
Radiation
Anus Neoplasms
13 引文 (Scopus)

Case 3. Parathyroid hormone-related hypercalcemia in cholangiocarcinoma

Yen, Y., Chu, P. G. & Feng, W., 十二月 1 2004, 於 : Journal of Clinical Oncology. 22, 11, p. 2244-2245 2 p.

研究成果: 雜誌貢獻文章

Paraneoplastic Endocrine Syndromes
Parathyroid Hormone-Related Protein
Cholangiocarcinoma
Hypercalcemia
Liver Neoplasms
7 引文 (Scopus)

Feasibility and pharmacokinetic study of infusional dexrazoxane and dose-intensive doxorubicin administered concurrently over 96 h for the treatment of advanced malignancies

Chow, W. A., Synold, T. W., Tetef, M. L., Longmate, J., Frankel, P., Lawrence, J., Al-Khadimi, Z., Leong, L., Lim, D., Margolin, K., Morgan, R. J., Raschko, J., Shibata, S., Somlo, G., Twardowski, P., Yen, Y. & Doroshow, J. H., 一月 1 2004, 於 : Cancer Chemotherapy and Pharmacology. 54, 3, p. 241-248 8 p.

研究成果: 雜誌貢獻文章

Dexrazoxane
Pharmacokinetics
Feasibility Studies
Doxorubicin
Neoplasms
54 引文 (Scopus)

Hypermethylation of growth arrest DNA damage-inducible gene 45 β promoter in human hepatocellular carcinoma

Qiu, W., Zhou, B., Zou, H., Liu, X., Chu, P. G., Lopez, R., Shih, J., Chung, C. & Yen, Y., 一月 1 2004, 於 : American Journal of Pathology. 165, 5, p. 1689-1699 11 p.

研究成果: 雜誌貢獻文章

DNA Damage
Hepatocellular Carcinoma
Liver Neoplasms
Growth
Genes
74 引文 (Scopus)

In Vitro Characterization of Enzymatic Properties and Inhibition of the p53R2 Subunit of Human Ribonucleotide Reductase

Shao, J., Zhou, B., Zhu, L., Qiu, W., Yuan, Y. C., Xi, B. & Yen, Y., 一月 1 2004, 於 : Cancer Research. 64, 1, p. 1-6 6 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Iron
In Vitro Techniques
Cytidine Diphosphate
Deferoxamine
20 引文 (Scopus)

Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone

Liu, X., Zhou, B., Xue, L., Qiu, W., Shih, J., Zheng, S. & Yen, Y., 四月 15 2004, 於 : Biochemical Pharmacology. 67, 8, p. 1499-1511 13 p.

研究成果: 雜誌貢獻文章

gemcitabine
Transcriptional Activation
Clone Cells
Genes
Histone Deacetylases
6 引文 (Scopus)

Phase II trial of carboplatin and infusional cyclosporine in platinum-resistant recurrent ovarian

Morgan, R. J., Synold, T. W., Gandara, D., Muggia, F., Scudder, S., Reed, E., Margolin, K., Raschko, J., Leong, L., Shibata, S., Tetef, M., Vasilev, S., McGonigle, K., Longmate, J., Yen, Y., Chow, W., Somlo, G., Carroll, M. & Doroshow, J. H., 十月 1 2004, 於 : Cancer Chemotherapy and Pharmacology. 54, 4, p. 283-289 7 p.

研究成果: 雜誌貢獻文章

Carboplatin
Platinum
Cyclosporine
Pharmacokinetics
Assays
54 引文 (Scopus)

Prognostic indicators and survival in patients with stage IIIB inflammatory breast carcinoma after dose-intense chemotherapy

Somlo, G., Frankel, P., Chow, W., Leong, L., Margolin, K., Morgan, R., Shibata, S., Chu, P., Forman, S., Lim, D., Twardowski, P., Weitzel, J., Alvarnas, J., Kogut, N., Schriber, J., Fermin, E., Yen, Y., Damon, L. & Doroshow, J. H., 十二月 1 2004, 於 : Journal of Clinical Oncology. 22, 10, p. 1839-1848 10 p.

研究成果: 雜誌貢獻文章

Inflammatory Breast Neoplasms
Drug Therapy
Survival
Progesterone Receptors
Estrogen Receptors
2003
63 引文 (Scopus)

Down-regulation of growth arrest DNA damage-inducible gene 45β expression is associated with human hepatocellular carcinoma

Qiu, W., David, D., Zhou, B., Chu, P. G., Zhang, B., Wu, M., Xiao, J., Han, T., Zhu, Z., Wang, T., Liu, X., Lopez, R., Frankel, P., Jong, A. & Yen, Y., 六月 1 2003, 於 : American Journal of Pathology. 162, 6, p. 1961-1974 14 p.

研究成果: 雜誌貢獻文章

DNA Damage
Hepatocellular Carcinoma
Down-Regulation
Gene Expression
Growth
15 引文 (Scopus)

Phase I study of cisdiamminedichloroplatinum in combination with azidothymidine in the treatment of patients with advanced malignancies

Morgan, R. J., Newman, E. M., Sowers, L., Scanlon, K., Harrison, J., Akman, S., Leong, L., Margolin, K., Niland, J., Raschko, J., Somlo, G., Carroll, M., Chow, W., Tetef, M., Hamasaki, V., Yen, Y. & Doroshow, J. H., 六月 1 2003, 於 : Cancer Chemotherapy and Pharmacology. 51, 6, p. 459-464 6 p.

研究成果: 雜誌貢獻文章

Maximum Tolerated Dose
Zidovudine
Toxicity
Pharmacokinetics
Cisplatin
60 引文 (Scopus)

Phase I Trial of Intraperitoneal Docetaxel in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity: Dose-Limiting Toxicity and Pharmacokinetics

Morgan, R. J., Doroshow, J. H., Synold, T., Lim, D., Shibata, S., Margolin, K., Schwarz, R., Leong, L., Somlo, G., Twardowski, P., Yen, Y., Chow, W., Lin, P., Paz, B., Chu, D., Frankel, P. & Stalter, S., 十二月 1 2003, 於 : Clinical Cancer Research. 9, 16 I, p. 5896-5901 6 p.

研究成果: 雜誌貢獻文章

docetaxel
Peritoneal Cavity
Pharmacokinetics
Neoplasms
Maximum Tolerated Dose
17 引文 (Scopus)

Quantification of chemotherapeutic target gene mRNA expression in human breast cancer biopsies: Comparison of real-time reverse transcription-PCR vs. Relative quantification reverse transcription-PCR utilizing DNA sequencer analysis of PCR products

Juhasz, A., Frankel, P., Cheng, C., Rivera, H., Vishwanath, R., Chiu, A., Margolin, K., Yen, Y., Newman, E. M., Synold, T., Wilczynski, S., Lenz, H. J., Gandara, D., Albain, K. S., Longmate, J. & Doroshow, J. H., 九月 26 2003, 於 : Journal of Clinical Laboratory Analysis. 17, 5, p. 184-194 11 p.

研究成果: 雜誌貢獻文章

Biopsy
Transcription
gemcitabine
Reverse Transcription
Tumors
13 引文 (Scopus)

Ribonucleotide reductase subunit one as gene therapy target

Yen, Y., 十月 1 2003, 於 : Clinical Cancer Research. 9, 12, p. 4304-4308 5 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Genetic Vectors
Adenoviridae
Genetic Therapy
Colonic Neoplasms
67 引文 (Scopus)

The Human Ribonucleotide Reductase Subunit hRRM2 Complements p53R2 in Response to UV-Induced DNA Repair in Cells with Mutant p53

Zhou, B., Liu, X., Mo, X., Xue, L., Darwish, D., Qiu, W., Shih, J., Hwu, E. B., Luh, F. & Yen, Y., 十月 15 2003, 於 : Cancer Research. 63, 20, p. 6583-6594 12 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
DNA Repair
KB Cells
Holoenzymes
Diphosphates
95 引文 (Scopus)

Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits

Xue, L., Zhou, B., Liu, X., Qiu, W., Jin, Z. & Yen, Y., 三月 1 2003, 於 : Cancer Research. 63, 5, p. 980-986 7 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
DNA Repair
Proteins
Deoxyribonucleotides
Ribonucleotides