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研究成果

2020

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., 一月 1 2020, 於 : BioMed Research International. 2020, 3415471.

研究成果: 雜誌貢獻文章

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3 引文 斯高帕斯(Scopus)
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Cybersecurity in Science and Medicine: Threats and Challenges

Luh, F. & Yen, Y., 2020, (接受/付印) 於 : Trends in Biotechnology.

研究成果: 雜誌貢獻簡短的問卷調查

Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., 十二月 1 2020, 於 : Scientific Reports. 10, 1, 866.

研究成果: 雜誌貢獻文章

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1 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. 及其他4, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., 三月 22 2020, 於 : Cancers. 12, 3, 752.

研究成果: 雜誌貢獻文章

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2019
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2 引文 斯高帕斯(Scopus)

Cancers in Taiwan: Practical insight from epidemiology, treatments, biomarkers, and cost

Kuo, C. N., Liao, Y. M., Kuo, L. N., Tsai, H. J., Chang, W. C. & Yen, Y., 一月 1 2019, (接受/付印) 於 : Journal of the Formosan Medical Association.

研究成果: 雜誌貢獻回顧型文獻

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5 引文 斯高帕斯(Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., 一月 31 2019, 於 : ACS Omega. 4, 1, p. 2387-2397 11 p.

研究成果: 雜誌貢獻文章

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1 引文 斯高帕斯(Scopus)
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Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H-S., 十月 4 2019, 於 : Bioconjugate Chemistry.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., 十二月 5 2019, 於 : Journal of Biomedical Science. 26, 1, 96.

研究成果: 雜誌貢獻回顧型文獻

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2 引文 斯高帕斯(Scopus)

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Chen, C. W., Li, Y., Hu, S., Zhou, W., Meng, Y., Li, Z., Zhang, Y., Sun, J., Bo, Z., DePamphilis, M. L., Yen, Y., Han, Z. & Zhu, W., 三月 2019, 於 : Oncogene. 38, 13, p. 2364-2379 16 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., 十月 1 2019, 於 : Medicine (United States). 98, 40, p. e17461 e17461.

研究成果: 雜誌貢獻文章

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2 引文 斯高帕斯(Scopus)

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., 十月 23 2019, 於 : Journal of Biomedical Science. 26, 1, 1 p., 85.

研究成果: 雜誌貢獻回顧型文獻

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3 引文 斯高帕斯(Scopus)

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Lu, H., Wang, C., Xue, L., Zhang, Q., Luh, F., Wang, J., Lin, T. G., Yen, Y. & Liu, X., 一月 1 2019, 於 : Journal of Oncology. 2019, 2316237.

研究成果: 雜誌貢獻文章

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2 引文 斯高帕斯(Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 9687.

研究成果: 雜誌貢獻文章

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7 引文 斯高帕斯(Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. 及其他30, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., 二月 1 2019, 於 : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Randomized trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer

Gupta, R., Cristea, M., Frankel, P., Ruel, C., Chen, C., Wang, Y., Morgan, R., Leong, L., Chow, W., Koczywas, M., Koehler, S., Lim, D., Luu, T., Martel, C., McNamara, M., Somlo, G., Twardowski, P., Yen, Y., Idorenyi, A., Raechelle, T. 及其他2, Carroll, M. & Chung, V., 一月 1 2019, 於 : Cancer Treatment and Research Communications. 21, 100155.

研究成果: 雜誌貢獻文章

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Chen, Y. F., Lin, I. H., Guo, Y. R., Chiu, W. J., Wu, M. S., Jia, W. & Yen, Y., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 1 p., 13238.

研究成果: 雜誌貢獻文章

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2 引文 斯高帕斯(Scopus)

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., 四月 15 2019, 於 : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)
2018

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., 一月 1 2018, (接受/付印) 於 : European Journal of Medical Genetics.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma

El-Khoueiry, A. B., O’Donnell, R., Semrad, T. J., Mack, P., Blanchard, S., Bahary, N., Jiang, Y., Yen, Y., Wright, J., Chen, H., Lenz, H. J. & Gandara, D. R., 五月 1 2018, 於 : Cancer Chemotherapy and Pharmacology. 81, 5, p. 957-963 7 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43

Dai, Y., Wang, C., Chiu, L. Y., Abbasi, K., Tolbert, B. S., Sauvé, G., Yen, Y. & Liu, C. C., 十月 15 2018, 於 : Biosensors and Bioelectronics. 117, p. 60-67 8 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. 及其他4, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., 十二月 1 2018, 於 : Communications Biology. 1, 1, 178.

研究成果: 雜誌貢獻文章

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12 引文 斯高帕斯(Scopus)

Benefits and harms of the centers for medicare & medicaid services ruling on next-generation sequencing

Luh, F. & Yen, Y., 九月 1 2018, 於 : JAMA oncology. 4, 9, p. 1171-1172 2 p.

研究成果: 雜誌貢獻簡短的問卷調查

Differences in silencing of mismatched targets by sliced versus diced siRNAs

Sun, G., Wang, J., Huang, Y., Yuan, C. W. Y., Zhang, K., Hu, S., Chen, L., Lin, R. J., Yen, Y. & Riggs, A. D., 一月 1 2018, 於 : Nucleic Acids Research. 46, 13, p. 6806-6822 17 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)
8 引文 斯高帕斯(Scopus)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., 三月 27 2018, 於 : Neuro-Oncology. 20, 4, p. 519-530 12 p.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., 九月 15 2018, 於 : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

研究成果: 雜誌貢獻文章

51 引文 斯高帕斯(Scopus)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

Luu, T., Kim, K. P., Blanchard, S., Anyang, B., Hurria, A., Yang, L., Beumer, J. H., Somlo, G. & Yen, Y., 一月 1 2018, 於 : Breast Cancer Research and Treatment. 167, 2, p. 469-478 10 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., 一月 1 2018, 於 : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas

Liang, M. L., Hsieh, T. H., Liu, Y. R., Chen, Y. W., Lee, Y. Y., Chang, F. C., Lin, S. C., Huang, M. C., Ho, D. M. T., Wong, T-T., Yen, Y. & Yang, M. H., 一月 1 2018, 於 : Oncotarget. 9, 2, p. 2527-2542 16 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., 六月 1 2018, 於 : Experimental and Molecular Medicine. 50, 6, p. 70 70.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, 於 : Current Medical Research and Opinion. p. 1-9 9 p.

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

Web-based platform vs genetic counselors in educating patients about carrier results from exome sequencing

Yen, Y. & Luh, F., 七月 1 2018, 於 : JAMA Internal Medicine. 178, 7, p. 998-999 2 p.

研究成果: 雜誌貢獻快報

1 引文 斯高帕斯(Scopus)
2017
5 引文 斯高帕斯(Scopus)
2 引文 斯高帕斯(Scopus)

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., 二月 1 2017, 於 : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., 五月 1 2017, 於 : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

研究成果: 雜誌貢獻文章

28 引文 斯高帕斯(Scopus)
7 引文 斯高帕斯(Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., 六月 22 2017, 於 : Nature Communications. 8, 15874.

研究成果: 雜誌貢獻文章

66 引文 斯高帕斯(Scopus)

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, 於 : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

研究成果: 雜誌貢獻文章

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., 二月 28 2017, 於 : Journal of hematology & oncology. 10, 1, p. 60 1 p.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., 六月 1 2017, 於 : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., 十二月 1 2017, 於 : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
2016

A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Xie, Z., Yen, Y., Popplewell, L., Chen, R., Aljitawi, O., Tuscano, J. M., Chan, K. K. & Newman, E. M., 十月 2 2016, 於 : Leukemia and Lymphoma. 57, 10, p. 2307-2314 8 p.

研究成果: 雜誌貢獻文章

Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells

Chen, Y. R., Tsou, B., Hu, S., Ma, H., Liu, X., Yen, Y. & Ann, D. K., 一月 1 2016, 於 : Oncotarget. 7, 2, p. 1984-1999 16 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)