• 266 引文
  • 9 h-指數
20022020
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研究成果 2002 2019

  • 266 引文
  • 9 h-指數
  • 30 文章
  • 1 評論/辯論
  • 1 回顧型文獻
篩選
文章
2019
sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., 一月 31 2019, 於 : ACS Omega. 4, 1, p. 2387-2397 11 p.

研究成果: 雜誌貢獻文章

開啟存取
Receptor, Fibroblast Growth Factor, Type 2
Epitopes
Antibodies, Monoclonal, Humanized
Fibroblast Growth Factor Receptors
Fibroblasts
1 引文 (Scopus)
Endometriosis
Estrogen Receptors
Apoptosis
Mitochondria
Mitochondrial DNA
2018
1 引文 (Scopus)

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., 十月 1 2018, 於 : Toxins. 10, 10, 383.

研究成果: 雜誌貢獻文章

Cobra Venoms
Elapidae
Single-Chain Antibodies
Immunoglobulin Fragments
Venoms
6 引文 (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
1 引文 (Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., 一月 1 2018, (接受/付印) 於 : Animal Biotechnology.

研究成果: 雜誌貢獻文章

Complementarity Determining Regions
Single-Chain Antibodies
Immunoglobulin Fragments
Antibodies
Chickens

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., 九月 1 2018, 於 : Viral Immunology. 31, 7, p. 492-499 8 p.

研究成果: 雜誌貢獻文章

Hepatitis B virus
Epitopes
Single-Chain Antibodies
Virus Diseases
Surface Antigens
2016
4 引文 (Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., 十二月 9 2016, 於 : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

研究成果: 雜誌貢獻文章

Hepatitis delta Antigens
Hepatitis Delta Virus
Cell Nucleus Active Transport
Viruses
Virion
3 引文 (Scopus)
Quantitative Structure-Activity Relationship
Plasmodium falciparum
Malaria
Parasites
Parasitic Diseases
1 引文 (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., 一月 1 2016, 於 : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

研究成果: 雜誌貢獻文章

Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
1 引文 (Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., 一月 1 2016, 於 : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

研究成果: 雜誌貢獻文章

Paeonia
Therapeutic Uses
Hypoglycemic Agents
Ethanol
Polyphenols
9 引文 (Scopus)
Bungarus
venom
Single-Chain Antibodies
Snake Venoms
venoms
6 引文 (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., 十一月 3 2016, 於 : BMC Complementary and Alternative Medicine. 16, 1, 432.

研究成果: 雜誌貢獻文章

Silk
Insulin-Secreting Cells
Zea mays
Antioxidants
Insulin
2015
9 引文 (Scopus)

Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., 十月 12 2015, 於 : Scientific Reports. 5, 15053.

研究成果: 雜誌貢獻文章

Hemagglutinins
Neutralizing Antibodies
Bacteriophages
Human Influenza
Epitopes
62 引文 (Scopus)

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, 於 : Scientific Reports. 5

研究成果: 雜誌貢獻文章

Monophenol Monooxygenase
Melanins
Zebrafish
Gastrodia
Agaricales
7 引文 (Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, 於 : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

研究成果: 雜誌貢獻文章

dipeptides
Monophenol Monooxygenase
Dipeptides
Cysteine
cysteine
7 引文 (Scopus)

Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. 及其他1, Yang, A. S., 七月 23 2015, 於 : Scientific Reports. 5, 12411.

研究成果: 雜誌貢獻文章

Antibody Formation
Antigens
Antibodies
Proteins
Bacteriophages
2014
12 引文 (Scopus)

Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments

Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., 一月 7 2014, 於 : Structure. 22, 1, p. 22-34 13 p.

研究成果: 雜誌貢獻文章

Antigens
Antibodies
Protein Stability
Mutagenesis
Proteins
15 引文 (Scopus)

Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments

Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., 一月 7 2014, 於 : Structure. 22, 1, p. 9-21 13 p.

研究成果: 雜誌貢獻文章

Antibodies
Complementarity Determining Regions
Antigens
High-Throughput Nucleotide Sequencing
Single-Chain Antibodies
16 引文 (Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, 於 : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

研究成果: 雜誌貢獻文章

Neurodegenerative diseases
Melanin
Monophenol Monooxygenase
Cosmetics
Biological Products
2012
28 引文 (Scopus)

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface

Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., 三月 22 2012, 於 : PLoS One. 7, 3, e33340.

研究成果: 雜誌貢獻文章

Complementarity Determining Regions
antigens
Antigens
antibodies
Antibodies
2011

Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries

Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., 七月 29 2011, 於 : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.

研究成果: 雜誌貢獻文章

Single-Chain Antibodies
Bacteriophages
Protein Sorting Signals
Disulfides
Libraries
2010
33 引文 (Scopus)

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., 四月 1 2010, 於 : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

研究成果: 雜誌貢獻文章

Static Electricity
Electrostatics
Quantitative Structure-Activity Relationship
Computational chemistry
Atoms
14 引文 (Scopus)

Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries

Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., 三月 12 2010, 於 : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.

研究成果: 雜誌貢獻文章

Immunoglobulin Fragments
Bacteriophages
Disulfides
Vascular Endothelial Growth Factor A
Libraries
2 引文 (Scopus)

Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF

Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., 六月 21 2010, 於 : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.

研究成果: 雜誌貢獻文章

Single-Chain Antibodies
Protein Sorting Signals
Disulfides
Bacteriophages
Vascular Endothelial Growth Factor A
2009
5 引文 (Scopus)

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, 於 : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

研究成果: 雜誌貢獻文章

NF-kappa B
Molecules
Quantitative Structure-Activity Relationship
Bioactivity
Hydrogen
2007
13 引文 (Scopus)

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., 五月 15 2007, 於 : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

研究成果: 雜誌貢獻文章

Avian Proteins
Severe Acute Respiratory Syndrome
Single-Chain Antibodies
bacteriophages
Bacteriophages
8 引文 (Scopus)

Chicken single-chain variable fragments against the SARS-CoV spike protein

Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., 十二月 2007, 於 : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.

研究成果: 雜誌貢獻文章

Severe Acute Respiratory Syndrome
Single-Chain Antibodies
Chickens
Proteins
Bacteriophages