• 322 引文
  • 11 h-指數
20022020

Research output per year

如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果

  • 322 引文
  • 11 h-指數
  • 34 文章
  • 2 評論/辯論
  • 2 回顧型文獻
2020
開啟存取
2019
1 引文 斯高帕斯(Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., 一月 31 2019, 於 : ACS Omega. 4, 1, p. 2387-2397 11 p.

研究成果: 雜誌貢獻文章

開啟存取
1 引文 斯高帕斯(Scopus)

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., 十二月 5 2019, 於 : Journal of Biomedical Science. 26, 1, 96.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
4 引文 斯高帕斯(Scopus)

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Lang, Y. D., Chen, H. Y., Ho, C. M., Shih, J. H., Hsu, E. C., Shen, R., Lee, Y. C., Chen, J. W., Wu, C. Y., Yeh, H. W., Chen, R. H. & Jou, Y. S., 十二月 1 2019, 於 : Nature Communications. 10, 1, 5716.

研究成果: 雜誌貢獻文章

開啟存取
1 引文 斯高帕斯(Scopus)
2018

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., 十月 1 2018, 於 : Toxins. 10, 10, 383.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., 一月 1 2018, (接受/付印) 於 : Animal Biotechnology.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., 九月 1 2018, 於 : Viral Immunology. 31, 7, p. 492-499 8 p.

研究成果: 雜誌貢獻文章

2017

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., 二月 9 2017, 於 : Scientific Reports. 7, 42291.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., 四月 7 2017, 於 : Scientific Reports. 7, 46134.

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

Single chain antibody fragment against venom from the snake Daboia russelii formosensis

Lee, C. H., Lee, Y. C., Lee, Y. L., Leu, S. J., Lin, L. T., Chen, C. C., Chiang, J. R., Fellow, P., Tsai, B. Y., Hung, C. S. & Yang, Y. Y., 十一月 1 2017, 於 : Toxins. 9, 11, 347.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
2016

A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies

Wong, Y. H., Chiu, C. C., Lin, C. L., Chen, T. S., Jheng, B. R., Lee, Y. C., Chen, J. & Chen, B. S., 十一月 1 2016, 於 : Current Pharmaceutical Biotechnology. 17, 14, p. 1246-1267 22 p.

研究成果: 雜誌貢獻回顧型文獻

3 引文 斯高帕斯(Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., 十二月 9 2016, 於 : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., 一月 1 2016, 於 : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., 一月 1 2016, 於 : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., 十一月 3 2016, 於 : BMC Complementary and Alternative Medicine. 16, 1, 432.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
2015

Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Tung, C. P., Chen, I. C., Yu, C. M., Peng, H. P., Jian, J. W., Ma, S. H., Lee, Y. C., Jan, J. T. & Yang, A. S., 十月 12 2015, 於 : Scientific Reports. 5, 15053.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling

Chen, W-C., Tseng, T-S., Hsiao, N-W., Lin, Y-L., Wen, Z-H., Tsai, C-C., Lee, Y-C., Lin, H-H. & Tsai, K-C., 2015, 於 : Scientific Reports. 5

研究成果: 雜誌貢獻文章

69 引文 斯高帕斯(Scopus)

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, T-S., Tsai, K-C., Chen, W-C., Wang, Y-T., Lee, Y-C., Lu, C-K., Don, M-J., Chang, C-Y., Lee, C-H., Lin, H-H., Hsu, H-J. & Hsiao, N-W., 2015, 於 : Journal of Agricultural and Food Chemistry. 63, 27, p. 6181-6188 8 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens

Chen, H. S., Hou, S. C., Jian, J. W., Goh, K. S., Shen, S. T., Lee, Y. C., You, J. J., Peng, H. P., Kuo, W. C., Chen, S. T., Peng, M. C., Wang, A. H. J., Yu, C. M., Chen, I. C., Tung, C. P., Chen, T. H., Ping Chiu, K., Ma, C., Yuan Wu, C., Lin, S. W. 及其他1, Yang, A. S., 七月 23 2015, 於 : Scientific Reports. 5, 12411.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)
2014

Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments

Hsu, H. J., Lee, K. H., Jian, J. W., Chang, H. J., Yu, C. M., Lee, Y. C., Chen, I. C., Peng, H. P., Wu, C. Y., Huang, Y. F., Shao, C. Y., Chiu, K. P. & Yang, A. S., 一月 7 2014, 於 : Structure. 22, 1, p. 22-34 13 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments

Chang, H. J., Jian, J. W., Hsu, H. J., Lee, Y. C., Chen, H. S., You, J. J., Hou, S. C., Shao, C. Y., Chen, Y. J., Chiu, K. P., Peng, H. P., Lee, K. H. & Yang, A. S., 一月 7 2014, 於 : Structure. 22, 1, p. 9-21 13 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors

Hsiao, N-W., Tseng, T-S., Lee, Y-C., Chen, W-C., Lin, H-H., Chen, Y-R., Wang, Y-T., Hsu, H-J. & Tsai, K-C., 2014, 於 : Journal of Chemical Information and Modeling. 54, 11, p. 3099-3111 13 p.

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)
2012

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface

Yu, C. M., Peng, H. P., Chen, I. C., Lee, Y. C., Chen, J. B., Tsai, K. C., Chen, C. T., Chang, J. Y., Yang, E. W., Hsu, P. C., Jian, J. W., Hsu, H. J., Chang, H. J., Hsu, W. L., Huang, K. F., Ma, A. C. & Yang, A. S., 三月 22 2012, 於 : PLoS One. 7, 3, e33340.

研究成果: 雜誌貢獻文章

28 引文 斯高帕斯(Scopus)
2011

Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries

Lee, Y. C., Chen, I. C., Yu, C. M., Huang, Y. J., Hsu, H. J. & Yang, A. S., 七月 29 2011, 於 : Biochemical and Biophysical Research Communications. 411, 2, p. 348-353 6 p.

研究成果: 雜誌貢獻文章

2010

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Tsai, K. C., Chen, Y. C., Hsiao, N. W., Wang, C. L., Lin, C. L., Lee, Y. C., Li, M. & Wang, B., 四月 1 2010, 於 : European Journal of Medicinal Chemistry. 45, 4, p. 1544-1551 8 p.

研究成果: 雜誌貢獻文章

35 引文 斯高帕斯(Scopus)

Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries

Huang, Y. J., Chen, I. C., Yu, C. M., Lee, Y. C., Hsu, H. J., Ching, A. T. C., Chang, H. J. & Yang, A. S., 三月 12 2010, 於 : Journal of Biological Chemistry. 285, 11, p. 7880-7891 12 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF

Chen, I. C., Yu, C. M., Lee, Y. C., Huang, Y. J., Hsu, H. J. & Yang, A. S., 六月 21 2010, 於 : Molecular BioSystems. 6, 7, p. 1307-1315 9 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)
2009

The first pharmacophore model for potent NF-κB inhibitors

Tsai, K-C., Teng, L-W., Shao, Y-M., Chen, Y-C., Lee, Y-C., Li, M-Y. & Hsiao, N-W., 2009, 於 : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5665-5669 5 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
2007

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., 五月 15 2007, 於 : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

Chicken single-chain variable fragments against the SARS-CoV spike protein

Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., 十二月 2007, 於 : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)