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研究成果 1970 2019

2019
temozolomide
Dehydroepiandrosterone
Glioblastoma
Acetylation
Phosphorylation
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., 八月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

研究成果: 雜誌貢獻文章

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation

Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Lin, H. C., Ching, Y. H., Huang, C. C., Pao, P. C., Lee, Y. H., Chang, W. C., Kao, T. J. & Lee, Y. C., 四月 26 2019, 於 : Journal of Biomedical Science. 26, 1, 30.

研究成果: 雜誌貢獻文章

開啟存取
Zinc Fingers
Neurons
Zinc
Leukemia
Brain

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., 一月 1 2019, 於 : Molecular Neurobiology.

研究成果: 雜誌貢獻文章

Astrocytes
Synapses
Hippocampus
Neurons
Toll-Like Receptor 2

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., 五月 27 2019, 於 : Journal of Biomedical Science. 26, 1, 42.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
Ubiquitin
Peptide Hydrolases
Ubiquitination
Neoplasms
Proteins
4 引文 (Scopus)
glycolysis
adipose tissues
diets
Gallic Acid
Fructose
5 引文 (Scopus)
Ubiquitination
Glioma
Glioblastoma
Stem Cells
temozolomide
1 引文 (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., 十月 1 2018, 於 : Redox Biology. 19, p. 74-80 7 p.

研究成果: 雜誌貢獻文章

Acetylation
Oxidative stress
Zinc Fingers
Zinc
Oxidative Stress
3 引文 (Scopus)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Lee, Y-C., Huang, W-C., Lin, J-H., Kao, T-J., Lin, H-C., Lee, K-H., Lin, H-C., Shen, C-K. J., Chang, W-C. & Huang, C-C., 十一月 8 2018, 於 : Journal of Biomedical Science. 25, 1, p. 76 1 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Pathology
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Proteins
2017
6 引文 (Scopus)

EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis

Wang, S. A., Wang, Y. C., Chuang, Y. P., Huang, Y. H., Su, W. C., Chang, W. C. & Hung, J. J., 五月 25 2017, 於 : Oncogene. 36, 21, p. 2930-2945 16 p.

研究成果: 雜誌貢獻文章

開啟存取
Neoplastic Gene Expression Regulation
E1A-Associated p300 Protein
E2F4 Transcription Factor
Ubiquitin Thiolesterase
Securin
1 引文 (Scopus)

Epidermal growth factor–induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin

Hsu, J. Y., Chang, J. Y., Chang, K. Y., Chang, W. C. & Chen, B. K., 十月 1 2017, 於 : FASEB Journal. 31, 10, p. 4265-4276 12 p.

研究成果: 雜誌貢獻文章

Fibronectins
Matrix Metalloproteinases
Up-Regulation
Neoplasm Metastasis
Epidermal Growth Factor
6 引文 (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, 於 : Molecular Neurobiology. p. 1-15 15 p.

研究成果: 雜誌貢獻文章

Fingers
Embryonic Development
Blood Vessels
Brain
Proteins
9 引文 (Scopus)

Inhibition of the EGFR/STAT3/CEBPD Axis reverses cisplatin cross-resistance with paclitaxel in the urothelial carcinoma of the urinary bladder

Wang, W. J., Li, C. F., Chu, Y. Y., Wang, Y. H., Hour, T. C., Yen, C. J., Chang, W. C. & Wang, J. M., 一月 15 2017, 於 : Clinical Cancer Research. 23, 2, p. 503-513 11 p.

研究成果: 雜誌貢獻文章

CCAAT-Enhancer-Binding Protein-delta
Paclitaxel
Cisplatin
Urinary Bladder
NSC 74859
1 引文 (Scopus)

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Hung, C. Y., Wang, Y. C., Chuang, J. Y., Young, M. J., Liaw, H., Chang, W. C. & Hung, J. J., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 9166.

研究成果: 雜誌貢獻文章

Protein Biosynthesis
Lung Neoplasms
Proteins
Messenger RNA
Protein Stability
5 引文 (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., 十月 1 2017, 於 : Redox Biology. 13, p. 655-664 10 p.

研究成果: 雜誌貢獻文章

temozolomide
Methyltransferases
Glioblastoma
DNA
Proteins
13 引文 (Scopus)

Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury

Chuang, J-Y., Kao, T-J., Lin, S. H., Wu, A. C., Lee, P. T., Su, T. P., Yeh, S. H., Lee, Y-C., Wu, C-C. & Chang, W-C., 四月 1 2017, 於 : Redox Biology. 11, p. 135-143 9 p.

研究成果: 雜誌貢獻文章

Oxidative stress
Zinc Fingers
Brain Injuries
Zinc
Brain
2 引文 (Scopus)

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma

Chang, K. Y., Huang, C. T., Hsu, T. I., Hsu, C. C., Liu, J. J., Chuang, C. K., Hung, J. J., Chang, W. C., Tsai, K. K. & Chuang, J. Y., 十一月 4 2017, 於 : Biochemical and Biophysical Research Communications. 493, 1, p. 14-19 6 p.

研究成果: 雜誌貢獻文章

Neoplasm Genes
Glioblastoma
Gene expression
Chemical activation
temozolomide
4 引文 (Scopus)

Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer

Lai, C. H., Huang, Y. C., Lee, J. C., Tseng, J. T. C., Chang, K. C., Chen, Y. J., Ding, N. J., Huang, P. H., Chang, W. C., Lin, B. W., Chen, R. Y., Wang, Y. C., Lai, Y. C. & Hung, L. Y., 一月 12 2017, 於 : Cell death & disease. 8, 1, p. e2555

研究成果: 雜誌貢獻文章

Heterogeneous-Nuclear Ribonucleoproteins
Colorectal Neoplasms
Carcinogenesis
Up-Regulation
Cell Proliferation
temozolomide
Dehydroepiandrosterone
Glioma
Cytochrome P-450 Enzyme System
Up-Regulation
Esterification
Wine
Methanol
Polygalacturonase
Alcohols
2 引文 (Scopus)

V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients

Chang, W. C., Wong, H. S. C., Chang, C. M., Kao, C. C., Hsu, Y. W., Liu, X., Chang, W. C. & Wu, M. S., 七月 11 2017, 於 : Journal of Biomedical Science. 24, 1, 43.

研究成果: 雜誌貢獻文章

Erythropoietin
T-Cell Antigen Receptor
Chronic Kidney Failure
Anemia
Erythrocyte Count
3 引文 (Scopus)
Glioblastoma
Glioma
Cell Cycle
Growth
Survival Rate
2016
12 引文 (Scopus)

Cathodic-controlled and near-infrared organic upconverter for local blood vessels mapping

Yuan, C. H., Lee, C. C., Liu, C. F., Lin, Y. H., Su, W. C., Lin, S. Y., Chen, K. T., Li, Y. D., Chang, W. C., Li, Y. Z., Su, T. H., Liu, Y. H. & Liu, S. W., 八月 31 2016, 於 : Scientific Reports. 6, 32324.

研究成果: 雜誌貢獻文章

near infrared
vessel
blood
temperature
material
2 引文 (Scopus)

Continuous epidermal growth factor receptor-tyrosine kinase inhibitor administration in primary lung adenocarcinoma patients harboring favorable mutations with controlled target lung tumors dose not hinder survival benefit despite small new lesions

Hsu, P. C., Chiu, L. C., Li, S. H., Chen, C. H., Wang, C. L., Kao, K. C., Chang, J. W. C., Wang, C. W., Yu, C. T., Chung, F. T., Yang, C. T. & Liu, C. Y., 四月 1 2016, 於 : Biomedical Journal. 39, 2, p. 121-129 9 p.

研究成果: 雜誌貢獻文章

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Lung
Mutation
Survival
3 引文 (Scopus)
Open circuit voltage
Deposition rates
open circuit voltage
Charge transfer
volatile organic compounds
4 引文 (Scopus)
Open circuit voltage
open circuit voltage
Volatile organic compounds
Charge transfer
volatile organic compounds
19 引文 (Scopus)

Gallic acid ameliorates hyperglycemia and improves hepatic carbohydrate metabolism in rats fed a high-fructose diet

Huang, D. W., Chang, W. C., Wu, J. S. B., Shih, R. W. & Shen, S. C., 二月 1 2016, 於 : Nutrition Research. 36, 2, p. 150-160 11 p.

研究成果: 雜誌貢獻文章

Gallic Acid
Carbohydrate Metabolism
Fructose
Hyperglycemia
Diet
13 引文 (Scopus)

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability

Huang, C. L., Chao, C. C., Lee, Y. C., Lu, M. K., Cheng, J. J., Yang, Y. C., Wang, V. C., Chang, W. C. & Huang, N. K., 2016, 於 : Molecular Neurobiology.

研究成果: 雜誌貢獻文章

Paraquat
Mitochondrial Membranes
Permeability
Cell Death
Apoptosis
7 引文 (Scopus)

Positive feedback regulation between IL10 and EGFR promotes lung cancer formation

Hsu, T. I., Wang, Y. C., Hung, C. Y., Yu, C. H., Su, W. C., Chang, W. C. & Hung, J. J., 四月 12 2016, 於 : Oncotarget. 7, 15, p. 20840-20854 15 p.

研究成果: 雜誌貢獻文章

Interleukin-10
Lung Neoplasms
Neoplasms
Carcinogenesis
Lung

RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription

Yang, C. P., Kuo, Y. L., Lee, Y. C., Lee, K. H., Chiang, C. W., Wang, J. M., Hsu, C. C., Chang, W. C. & Lin, D. Y., 九月 16 2016, 於 : Biochemical and Biophysical Research Communications. 478, 2, p. 873-880 8 p.

研究成果: 雜誌貢獻文章

Transcription
Genes
Proteins
Ribosomal DNA
Ribosomes
7 引文 (Scopus)

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., 十一月 18 2016, 於 : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

研究成果: 雜誌貢獻文章

Glioma
Stem Cells
Glioblastoma
Cells
Histone Deacetylases
9 引文 (Scopus)

The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury

Su, T. C., Lin, S. H., Lee, P. T., Yeh, S. H., Hsieh, T. H., Chou, S. Y., Su, T. P., Hung, J. J., Chang, W. C., Lee, Y. C. & Chuang, J. Y., 六月 1 2016, 於 : Neuropharmacology. 105, p. 1-9 9 p.

研究成果: 雜誌貢獻文章

Zinc Fingers
Hydrogen Peroxide
Reactive Oxygen Species
Wounds and Injuries
Dehydroepiandrosterone Sulfate
5 引文 (Scopus)

Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy

Wang, Y. C., Wang, S. A., Chen, P. H., Hsu, T. I., Yang, W. B., Chuang, Y. P., Su, W. C., Liaw, H. J., Chang, W. C. & Hung, J. J., 七月 14 2016, 於 : Oncogene. 35, 28, p. 3669-3680 12 p.

研究成果: 雜誌貢獻文章

Ubiquitin
Lung Neoplasms
Peptide Hydrolases
Neoplasms
Single Nucleotide Polymorphism
5 引文 (Scopus)
Syzygium
Waxes
Malus
Nutrition
Fructose
2015
12 引文 (Scopus)

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2015, 於 : Oncotarget. 6, 15, p. 13671-13687 17 p.

研究成果: 雜誌貢獻文章

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
24 引文 (Scopus)

Biological roles of CCAAT/enhancer-binding protein delta during inflammation

Ko, C. Y., Chang, W. C. & Wang, J. M., 一月 16 2015, 於 : Journal of Biomedical Science. 22, 1, 6.

研究成果: 雜誌貢獻文章

CCAAT-Enhancer-Binding Protein-delta
Inflammation
Genes
CCAAT-Enhancer-Binding Proteins
Biological Phenomena
9 引文 (Scopus)
High Fat Diet
caffeic acid
high fat diet
Leptin
leptin
6 引文 (Scopus)

Decoupling the optical and electrical properties of subphthalocyanine/C70 bi-layer organic photovoltaic devices: Improved photocurrent while maintaining a high open-circuit voltage and fill factor

Lee, C. C., Su, W. C., Shu, Y. S., Chang, W. C., Huang, B. Y., Lee, Y. Z., Su, T. H., Chen, K. T. & Liu, S. W., 一月 1 2015, 於 : RSC Advances. 5, 8, p. 5617-5626 10 p.

研究成果: 雜誌貢獻文章

Open circuit voltage
Photocurrents
Energy dissipation
Electric properties
Optical properties
18 引文 (Scopus)

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

Huang, C. R., Lee, C. T., Chang, K. Y., Chang, W. C., Liu, Y. W., Lee, J. C. & Chen, B. K., 2015, 於 : Oncotarget. 6, 13, p. 11530-11546 17 p.

研究成果: 雜誌貢獻文章

Aryl Hydrocarbon Receptor Nuclear Translocator
Fibronectins
Integrins
Down-Regulation
Neoplasm Metastasis
5 引文 (Scopus)

Downscaling the sample thickness to sub-micrometers by employing organic photovoltaic materials as a charge-generation layer in the time-of-flight measurement

Liu, S. W., Lee, C. C., Su, W. C., Yuan, C. H., Lin, C. F., Chen, K. T., Shu, Y. S., Li, Y. Z., Su, T. H., Huang, B. Y., Chang, W. C. & Liu, Y. H., 五月 22 2015, 於 : Scientific Reports. 5, 10384.

研究成果: 雜誌貢獻文章

micrometers
carrier mobility
hole mobility
diamines
optoelectronic devices
6 引文 (Scopus)

Early radiographic response to epidermal growth factor receptor-tyrosine kinase inhibitor in non-small cell lung cancer patients with epidermal growth factor receptor mutations: A prospective study

Chang, J. W. C., Hou, M. M., Hsieh, J. J., Cheung, Y. C., Wang, H. M., Chen, J. S., Wang, C. H., Chen, C. H., Yeh, K. Y., Ou, L. Y., Hsieh, C. H., Wu, H. D. I., Chen, Y. T., Chang, I. C. & Huang, S. F., 五月 1 2015, 於 : Biomedical Journal. 38, 3, p. 221-228 8 p.

研究成果: 雜誌貢獻文章

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Prospective Studies
Mutation
14 引文 (Scopus)

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Hsu, J. Y., Chang, K. Y., Chen, S. H., Lee, C. T., Chang, S. T., Cheng, H. C., Chang, W. C. & Chen, B. K., 2015, 於 : Oncotarget. 6, 3, p. 1723-1739 17 p.

研究成果: 雜誌貢獻文章

Cyclooxygenase 2
Fibronectins
Epidermal Growth Factor
Up-Regulation
Neoplasm Metastasis

Erratum: Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58) (Journal of Biomedical Science (2015) 22:60 )

Yang, C. P., Chiang, C. W., Chen, C. H., Lee, Y. C., Wu, M. H., Tsou, Y. H., Yang, Y. S., Chang, W. C. & Lin, D. Y., 七月 24 2015, 於 : Journal of Biomedical Science. 22, 1, 60.

研究成果: 雜誌貢獻文章

Nuclear Localization Signals
Proteins
9 引文 (Scopus)

Function of DNA methyltransferase 3a in lead (Pb2+)-Induced Cyclooxygenase-2 gene

Tsai, Y. T., Chang, C. M., Wang, J. Y., Hou, M. F., Wang, J. M., Shiurba, R., Chang, W. C. & Chang, W. C., 九月 1 2015, 於 : Environmental Toxicology. 30, 9, p. 1024-1032 9 p.

研究成果: 雜誌貢獻文章

Cyclooxygenase 2
Genes
DNA
Messenger RNA
ion
5 引文 (Scopus)

Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)

Yang, C. P., Chiang, C. W., Chen, C. H., Lee, Y. C., Wu, M. H., Tsou, Y. H., Yang, Y. S., Chang, W. C. & Lin, D. Y., 五月 16 2015, 於 : Journal of Biomedical Science. 22, 1, 33.

研究成果: 雜誌貢獻文章

Nuclear Localization Signals
Cell proliferation
Cell Proliferation
Karyopherins
Basic Amino Acids
3 引文 (Scopus)

Improving performance and lifetime of small-molecule organic photovoltaic devices by using bathocuproine-fullerene cathodic layer

Liu, S. W., Lee, C. C., Su, W. C., Yuan, C. H., Shu, Y. S., Chang, W. C., Guo, J. Y., Chiu, C. F., Li, Y. Z., Su, T. H., Chen, K. T., Chang, P. C., Yeh, T. H. & Liu, Y. H., 五月 6 2015, 於 : ACS Applied Materials and Interfaces. 7, 17, p. 9262-9273 12 p.

研究成果: 雜誌貢獻文章

Fullerenes
Buffer layers
Molecules
Electrodes
Electrons
20 引文 (Scopus)

MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy

Hsu, T. I., Lin, S. C., Lu, P. S., Chang, W-C., Hung, C. Y., Yeh, Y. M., Su, W. C., Liao, P. C. & Hung, J. J., 二月 12 2015, 於 : Oncogene. 34, 7, p. 826-837 12 p.

研究成果: 雜誌貢獻文章

Neoplasms
Lung Neoplasms
RNA Stability
nucleolin
Matrix Metalloproteinase 7
1 引文 (Scopus)

Origin of the open-circuit voltage in small-molecular organic photovoltaic devices: Effects of deposition rate control of donor material

Lee, C. C., Chang, W. C., Su, W. C., Huang, B. Y., Lin, C. F. & Liu, S. W., 三月 1 2015, 於 : Japanese Journal of Applied Physics. 54, 3, p. 03CD01

研究成果: 雜誌貢獻文章

donor materials
volatile organic compounds
Open circuit voltage
Deposition rates
open circuit voltage