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研究成果 2002 2019

  • 1342 引文
  • 21 h-指數
  • 81 文章
篩選
文章
2019
Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation
開啟存取
Phototoxic Dermatitis
Retinal Pigments
luminance
pigments
Cell culture
2018
1 引文 (Scopus)

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., 三月 1 2018, 於 : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

研究成果: 雜誌貢獻文章

p38 Mitogen-Activated Protein Kinases
Cell Death
Microtubules
Liver
Phosphorylation
5 引文 (Scopus)

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, 於 : British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

研究成果: 雜誌貢獻文章

GABA-A Receptors
Methamphetamine
Sensory Gating
Furosemide
Startle Reflex

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., 七月 3 2018, 於 : Frontiers in Pharmacology. 9, JUL, 708.

研究成果: 雜誌貢獻文章

Diarylheptanoids
Histone Deacetylases
Amyloid
Alzheimer Disease
Pyrogallol
7 引文 (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., 一月 1 2018, 於 : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Derivatives
Carbon
Molecular Docking Simulation
Cutaneous T-Cell Lymphoma
2017
9 引文 (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 五月 15 2017, 於 : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

研究成果: 雜誌貢獻文章

decitabine
Wnt Signaling Pathway
Histone Deacetylase Inhibitors
Histone Deacetylases
Non-Small Cell Lung Carcinoma
5 引文 (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 八月 1 2017, 於 : Cancer Letters. 400, p. 79-88 10 p.

研究成果: 雜誌貢獻文章

DNA-Activated Protein Kinase
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Etoposide
DNA Repair
13 引文 (Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 3228.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Computer Simulation
Protein Isoforms
Enzymes
3 引文 (Scopus)
Matrix Metalloproteinase 9
inhibitors
Lipopolysaccharides
interleukins
necrosis
1 引文 (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., 十一月 1 2017, 於 : Molecules. 22, 11, 1897.

研究成果: 雜誌貢獻文章

Derivatives
central nervous system
synthesis
liver
flavone
5 引文 (Scopus)
Histone Deacetylase Inhibitors
Cell Death
Breast Neoplasms
Heterografts
Genetic Promoter Regions
2016
13 引文 (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., 四月 15 2016, 於 : Life Sciences. 151, p. 7-14 8 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Cell Movement
Breast Neoplasms
Atlases
Assays
13 引文 (Scopus)
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Autophagy
Down-Regulation
Ionizing Radiation
8 引文 (Scopus)

Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum

Liao, Y. H., Lee, H. J., Huang, W. J., Fan, P. C. & Chiou, L. C., 九月 1 2016, 於 : Psychopharmacology. 233, 17, p. 3187-3199 13 p.

研究成果: 雜誌貢獻文章

Methamphetamine
GABA-A Receptors
Cerebellum
Transferases
Benzodiazepines
21 引文 (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 三月 31 2016, 於 : Frontiers in Pharmacology. 7, MAR, 81.

研究成果: 雜誌貢獻文章

Autophagy
Breast Neoplasms
Protein Stability
Acetylation
Protein Isoforms
2 引文 (Scopus)
Lovastatin
Reactive Oxygen Species
Cytotoxicity
Cells
Cell death
2015
7 引文 (Scopus)

Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan

Chen, C. Y., Chiu, F. Y., Lin, Y., Huang, W. J., Hsieh, P. S. & Hsu, F-L., 一月 22 2015, 於 : International Journal of Molecular Sciences. 16, 2, p. 2497-2516 20 p.

研究成果: 雜誌貢獻文章

Ferns
Taiwan
chemical analysis
Hypoglycemic Agents
Glucose
23 引文 (Scopus)

DUSP1 expression induced by HDAC1 inhibition mediates gefitinib sensitivity in non-small cell lung cancers

Lin, Y. C., Lin, Y. C., Shih, J. Y., Huang, W. J., Chao, S. W., Chang, Y. L. & Chen, C. C., 一月 15 2015, 於 : Clinical Cancer Research. 21, 2, p. 428-438 11 p.

研究成果: 雜誌貢獻文章

Non-Small Cell Lung Carcinoma
Phosphoprotein Phosphatases
gefitinib
Up-Regulation
Apoptosis
34 引文 (Scopus)

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Qi, J., Singh, S., Hua, W. K., Cai, Q., Chao, S. W., Li, L., Liu, H., Ho, Y., McDonald, T., Lin, A., Marcucci, G., Bhatia, R., Huang, W. J., Chang, C. I. & Kuo, Y. H., 十一月 5 2015, 於 : Cell Stem Cell. 17, 5, p. 597-610 14 p.

研究成果: 雜誌貢獻文章

Myeloid Progenitor Cells
Histone Deacetylases
Acetylation
Leukemia
Acute Myeloid Leukemia
10 引文 (Scopus)

Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice

Huang, W. J., Lee, H. J., Chen, H. L., Fan, P. C., Ku, Y. L. & Chiou, L. C., 五月 26 2015, 於 : Journal of Ethnopharmacology. 166, p. 18-22 5 p.

研究成果: 雜誌貢獻文章

Clerodendrum
Tics
Methamphetamine
Tic Disorders
Ethanol
6 引文 (Scopus)

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

Wei, T. T., Lin, Y. C., Lin, P. H., Shih, J. Y., Chou, C. W., Huang, W. J., Yang, Y. C., Hsiao, P. W. & Chen, C. C., 2015, 於 : Oncotarget. 6, 14, p. 12481-12492 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Growth
Neoplasms
9 引文 (Scopus)
Monascus
Lovastatin
Oxidopamine
PC12 Cells
Nerve Growth Factor
7 引文 (Scopus)

N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK

Lee, W. H., Wu, H. H., Huang, W. J., Li, Y. N., Lin, R-J., Lin, S. Y. & Liang, Y. C., 三月 1 2015, 於 : Molecules. 20, 3, p. 4516-4529 14 p.

研究成果: 雜誌貢獻文章

hyperglycemia
AMP-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
glucose
Hyperglycemia
4 引文 (Scopus)

The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death

Huang, Y. H., Huang, S. W., Hsu, Y. F., Ou, G., Huang, W. J. & Hsu, M. J., 十月 29 2015, 於 : Scientific Reports. 5, 15900.

研究成果: 雜誌貢獻文章

Colorectal Neoplasms
Cell Death
AMP-Activated Protein Kinases
HCT116 Cells
Cyclin D1
9 引文 (Scopus)

Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1

Chao, S. W., Su, M. Y., Chiou, L. C., Chen, L. C., Chang, C. I. & Huang, W. J., 八月 28 2015, 於 : Journal of Natural Products. 78, 8, p. 1969-1976 8 p.

研究成果: 雜誌貢獻文章

Proto-Oncogene Proteins c-pim-1
flavone
Proto-Oncogenes
Quercetin
Hinges
9 引文 (Scopus)
Protein Phosphatase 1
Protein Tyrosine Phosphatases
Vascular Endothelial Growth Factor A
Phosphorylation
NSC-87877
14 引文 (Scopus)
Dual Specificity Phosphatase 1
Anti-Inflammatory Agents
CCAAT-Enhancer-Binding Proteins
Macrophages
Phosphorylation
2014
26 引文 (Scopus)

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., 二月 10 2014, 於 : PLoS One. 9, 2, e88644.

研究成果: 雜誌貢獻文章

neurotoxicity
Kainic Acid
glutamates
Rats
Glutamic Acid
14 引文 (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 四月 28 2014, 於 : Cancer Letters. 346, 1, p. 84-93 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Non-Small Cell Lung Carcinoma
Cisplatin
Lung Neoplasms
Neoplasms
16 引文 (Scopus)
Histone Deacetylases
Human Activities
Refractory materials
Prostatic Neoplasms
Display devices
20 引文 (Scopus)
Dioscorea
yams
Galactose
galactose
tubers
8 引文 (Scopus)

Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model

Chen, C. Y., Huang, C. C., Tsai, K. C., Huang, W. J., Huang, W. C., Hsu, Y. C. & Hsu, F-L., 2014, 於 : Evidence-based Complementary and Alternative Medicine. 2014, 873607.

研究成果: 雜誌貢獻文章

Gout Suppressants
Xanthine Oxidase
Enzyme Assays
Phytochemicals
Uric Acid
5 引文 (Scopus)

Identification of trans, trans-2,4-Decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry

Pan, K. L., Huang, W. J., Hsu, M. H., Lee, H. L., Liu, H. J., Cheng, C. W., Tsai, M. H., Shen, M. Y. & Lin, P., 十月 20 2014, 於 : Chemical Research in Toxicology. 27, 10, p. 1707-1719 13 p.

研究成果: 雜誌貢獻文章

Liquid chromatography
Metabolites
Liquid Chromatography
Mass spectrometry
Mass Spectrometry
11 引文 (Scopus)
Cell Movement
Transforming Growth Factors
Adenocarcinoma
Derivatives
Phosphorylation
2013
5 引文 (Scopus)
Endoplasmic Reticulum Stress
Histone Deacetylases
Human Activities
Histone Deacetylase Inhibitors
Prostatic Neoplasms
2 引文 (Scopus)
Propolis
Hepatocellular Carcinoma
Apoptosis
Activating Transcription Factor 3
Eukaryotic Initiation Factor-2
7 引文 (Scopus)

NBM-T-L-BMX-OS01, semisynthesized from osthole, is a novel inhibitor of histone deacetylase and enhances learning and memory in rats

Yang, Y. C., Chen, C. N., Wu, C. I., Huang, W. J., Kuo, T. Y., Kuan, M. C., Tsai, T. H., Huang, J. S. & Huang, C. Y., 2013, 於 : Evidence-based Complementary and Alternative Medicine. 2013, 514908.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Learning
Cnidium
Cyclic AMP Response Element-Binding Protein
Neuronal Plasticity
9 引文 (Scopus)
Cytotoxicity
Colon
Adenocarcinoma
Derivatives
Phosphorylation
7 引文 (Scopus)

Semisynthesis and myocardial activity of thaliporphine N-homologues

Chiou, C. M., Lin, C. T., Huang, W. J., Chang, Y. M., Ho, Y. J., Su, M. J. & Lee, S. S., 三月 22 2013, 於 : Journal of Natural Products. 76, 3, p. 405-412 8 p.

研究成果: 雜誌貢獻文章

Isomers
Saturn
Spectroscopic analysis
Hydrogenation
Rats
37 引文 (Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 十月 10 2013, 於 : PLoS One. 8, 10, e76340.

研究成果: 雜誌貢獻文章

hydroxamic acids
histone deacetylase
Histone Deacetylase Inhibitors
Radiation Tolerance
metastasis
2012
12 引文 (Scopus)

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C. & Huang, W. J., 一月 1 2012, 於 : Natural Product Research. 26, 2, p. 116-124 9 p.

研究成果: 雜誌貢獻文章

Flavanones
Propolis
propolis
flavanones
Chemical modification
10 引文 (Scopus)

Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia

Chen, H. L., Lee, H. J., Huang, W. J., Chou, J. F., Fan, P. C., Du, J. C., Ku, Y. L. & Chiou, L. C., 2012, 於 : Evidence-based Complementary and Alternative Medicine. 2012, 284301.

研究成果: 雜誌貢獻文章

Clerodendrum
Tourette Syndrome
Animal Behavior
Schizophrenia
Methamphetamine
19 引文 (Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., 六月 15 2012, 於 : Food Chemistry. 132, 4, p. 2074-2080 7 p.

研究成果: 雜誌貢獻文章

Monophenol Monooxygenase
Niacin
niacin
catechol oxidase
Antioxidants
16 引文 (Scopus)
Caesalpinia
Scavenging
scavenging
antioxidants
Antioxidants
17 引文 (Scopus)

Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors

Huang, C. Y., Chi, L. L., Huang, W. J., Chen, Y. W., Chen, W. J., Kuo, Y. C., Yuan, C. M. & Chen, C. N., 六月 20 2012, 於 : Journal of Agricultural and Food Chemistry. 60, 24, p. 6139-6149 11 p.

研究成果: 雜誌貢獻文章

royal jelly
histone deacetylase
Histone Deacetylase Inhibitors
Bees
queen insects
7 引文 (Scopus)

Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings

Lin, T. Y., Lu, C. W., Huang, W. J. & Wang, S. J., 三月 2012, 於 : Synapse. 66, 3, p. 232-239 8 p.

研究成果: 雜誌貢獻文章

Nerve Endings
Glutamic Acid
4-Aminopyridine
Cnidium
Phosphodiesterase 5 Inhibitors
16 引文 (Scopus)

NBM-HD-1: A novel histone deacetylase inhibitor with anticancer activity

Huang, W. J., Liang, Y. C., Chuang, S. E., Chi, L. L., Lee, C. Y., Lin, C. W., Chen, A. L., Huang, J. S., Chiu, C. J., Lee, C. F., Huang, C. Y. & Chen, C. N., 2012, 於 : Evidence-based Complementary and Alternative Medicine. 2012, 781417.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
bcl-1 Genes
Gelsolin
Propolis
Cyclin B1
34 引文 (Scopus)

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Huang, W. J., Wang, Y. C., Chao, S. W., Yang, C. Y., Chen, L. C., Lin, M. H., Hou, W. C., Chen, M. Y., Lee, T. L., Yang, P. & Chang, C. I., 十月 2012, 於 : ChemMedChem. 7, 10, p. 1815-1824 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Cytotoxicity
Biological Phenomena
Protein Isoforms
Cells
2011
44 引文 (Scopus)
Cornus officinalis
Cornus
Phosphoenolpyruvate
insulin-dependent diabetes mellitus
Medical problems