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研究成果

  • 1509 引文
  • 23 h-指數
  • 86 文章
2020

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., 三月 2020, 於 : Food and Function. 11, 3, p. 2328-2338 11 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., 四月 15 2020, 於 : European Journal of Medicinal Chemistry. 192, p. 112193 112193.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)
2019
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1 引文 斯高帕斯(Scopus)

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., 十二月 4 2019, 於 : Biomolecules. 9, 12

研究成果: 雜誌貢獻文章

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1 引文 斯高帕斯(Scopus)
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2 引文 斯高帕斯(Scopus)
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2018

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., 三月 1 2018, 於 : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, 於 : British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., 七月 3 2018, 於 : Frontiers in Pharmacology. 9, JUL, 708.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., 一月 1 2018, 於 : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)
2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 五月 15 2017, 於 : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 八月 1 2017, 於 : Cancer Letters. 400, p. 79-88 10 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 3228.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., 十一月 1 2017, 於 : Molecules. 22, 11, 1897.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)
10 引文 斯高帕斯(Scopus)
2016

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., 四月 15 2016, 於 : Life Sciences. 151, p. 7-14 8 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)
21 引文 斯高帕斯(Scopus)

Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum

Liao, Y. H., Lee, H. J., Huang, W. J., Fan, P. C. & Chiou, L. C., 九月 1 2016, 於 : Psychopharmacology. 233, 17, p. 3187-3199 13 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 三月 31 2016, 於 : Frontiers in Pharmacology. 7, MAR, 81.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)
2 引文 斯高帕斯(Scopus)
2015

Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan

Chen, C. Y., Chiu, F. Y., Lin, Y., Huang, W. J., Hsieh, P. S. & Hsu, F-L., 一月 22 2015, 於 : International Journal of Molecular Sciences. 16, 2, p. 2497-2516 20 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

DUSP1 expression induced by HDAC1 inhibition mediates gefitinib sensitivity in non-small cell lung cancers

Lin, Y. C., Lin, Y. C., Shih, J. Y., Huang, W. J., Chao, S. W., Chang, Y. L. & Chen, C. C., 一月 15 2015, 於 : Clinical Cancer Research. 21, 2, p. 428-438 11 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

Qi, J., Singh, S., Hua, W. K., Cai, Q., Chao, S. W., Li, L., Liu, H., Ho, Y., McDonald, T., Lin, A., Marcucci, G., Bhatia, R., Huang, W. J., Chang, C. I. & Kuo, Y. H., 十一月 5 2015, 於 : Cell Stem Cell. 17, 5, p. 597-610 14 p.

研究成果: 雜誌貢獻文章

36 引文 斯高帕斯(Scopus)

Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice

Huang, W. J., Lee, H. J., Chen, H. L., Fan, P. C., Ku, Y. L. & Chiou, L. C., 五月 26 2015, 於 : Journal of Ethnopharmacology. 166, p. 18-22 5 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

Wei, T. T., Lin, Y. C., Lin, P. H., Shih, J. Y., Chou, C. W., Huang, W. J., Yang, Y. C., Hsiao, P. W. & Chen, C. C., 2015, 於 : Oncotarget. 6, 14, p. 12481-12492 12 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)
15 引文 斯高帕斯(Scopus)

N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK

Lee, W. H., Wu, H. H., Huang, W. J., Li, Y. N., Lin, R-J., Lin, S. Y. & Liang, Y. C., 三月 1 2015, 於 : Molecules. 20, 3, p. 4516-4529 14 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death

Huang, Y. H., Huang, S. W., Hsu, Y. F., Ou, G., Huang, W. J. & Hsu, M. J., 十月 29 2015, 於 : Scientific Reports. 5, 15900.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1

Chao, S. W., Su, M. Y., Chiou, L. C., Chen, L. C., Chang, C. I. & Huang, W. J., 八月 28 2015, 於 : Journal of Natural Products. 78, 8, p. 1969-1976 8 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)
10 引文 斯高帕斯(Scopus)
18 引文 斯高帕斯(Scopus)
2014

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., 二月 10 2014, 於 : PLoS One. 9, 2, e88644.

研究成果: 雜誌貢獻文章

31 引文 斯高帕斯(Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 四月 28 2014, 於 : Cancer Letters. 346, 1, p. 84-93 10 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)
18 引文 斯高帕斯(Scopus)
27 引文 斯高帕斯(Scopus)

Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model

Chen, C. Y., Huang, C. C., Tsai, K. C., Huang, W. J., Huang, W. C., Hsu, Y. C. & Hsu, F-L., 2014, 於 : Evidence-based Complementary and Alternative Medicine. 2014, 873607.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Identification of trans, trans-2,4-Decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry

Pan, K. L., Huang, W. J., Hsu, M. H., Lee, H. L., Liu, H. J., Cheng, C. W., Tsai, M. H., Shen, M. Y. & Lin, P., 十月 20 2014, 於 : Chemical Research in Toxicology. 27, 10, p. 1707-1719 13 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
12 引文 斯高帕斯(Scopus)
2013
5 引文 斯高帕斯(Scopus)
3 引文 斯高帕斯(Scopus)

NBM-T-L-BMX-OS01, semisynthesized from osthole, is a novel inhibitor of histone deacetylase and enhances learning and memory in rats

Yang, Y. C., Chen, C. N., Wu, C. I., Huang, W. J., Kuo, T. Y., Kuan, M. C., Tsai, T. H., Huang, J. S. & Huang, C. Y., 2013, 於 : Evidence-based Complementary and Alternative Medicine. 2013, 514908.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

Semisynthesis and myocardial activity of thaliporphine N-homologues

Chiou, C. M., Lin, C. T., Huang, W. J., Chang, Y. M., Ho, Y. J., Su, M. J. & Lee, S. S., 三月 22 2013, 於 : Journal of Natural Products. 76, 3, p. 405-412 8 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

Chiu, H. W., Yeh, Y. L., Wang, Y. C., Huang, W. J., Chen, Y. A., Chiou, Y. S., Ho, S. Y., Lin, P. & Wang, Y. J., 十月 10 2013, 於 : PLoS One. 8, 10, e76340.

研究成果: 雜誌貢獻文章

40 引文 斯高帕斯(Scopus)
2012

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chen, C. N., Hsiao, C. J., Lee, S. S., Guh, J. H., Chiang, P. C., Huang, C. C. & Huang, W. J., 一月 1 2012, 於 : Natural Product Research. 26, 2, p. 116-124 9 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia

Chen, H. L., Lee, H. J., Huang, W. J., Chou, J. F., Fan, P. C., Du, J. C., Ku, Y. L. & Chiou, L. C., 2012, 於 : Evidence-based Complementary and Alternative Medicine. 2012, 284301.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Y. S., Chen, S-H., Huang, W. J., Chen, C. H., Chien, M. Y., Lin, S. Y. & Hou, W. C., 六月 15 2012, 於 : Food Chemistry. 132, 4, p. 2074-2080 7 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)
20 引文 斯高帕斯(Scopus)