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研究成果 2003 2018

  • 460 引文
  • 11 h-指數
  • 28 文章
  • 1 快報
  • 1 回顧型文獻
2018
4 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., 一月 1 2018, 於 : PeerJ. 2018, 10, e5739.

研究成果: 雜誌貢獻文章

chondrocytes
Cartilage
Zebrafish
Chondrocytes
Danio rerio
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, 於 : Frontiers in Pharmacology. 9, p. 1379

研究成果: 雜誌貢獻文章

Janus Kinases
Phosphotransferases
Binding Sites
Pharmacology
Cytokine Receptors
4 引文 (Scopus)

Anti-TNF-α restricts dengue virus-induced neuropathy

Jhan, M. K., Huangfu, W. C., Chen, Y. F., Kao, J. C., Tsai, T. T., Ho, M. R., Shen, T. J., Tseng, P. C., Wang, Y. T. & Lin, C. F., 一月 1 2018, (接受/付印) 於 : Journal of Leukocyte Biology.

研究成果: 雜誌貢獻文章

Dengue Virus
Encephalitis
Virus Diseases
Dengue
Neurons

Distributed and side-pumped fiber laser using a laser diode bar stack

Lee, Y. W., Huangfu, W. C., Li, Y. Y., Wu, I. C., Huang, S. L., Peter Liaw, S. K. & Dubinskii, M., 一月 1 2018, 於 : IEEE Access. 6, p. 70456-70462 7 p., 8533341.

研究成果: 雜誌貢獻文章

Fiber lasers
Semiconductor lasers
Pumps
Fibers
Fused silica
7 引文 (Scopus)

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

Kao, J. C., HuangFu, W. C., Tsai, T. T., Ho, M. R., Jhan, M. K., Shen, T. J., Tseng, P. C., Wang, Y. T. & Lin, C. F., 八月 1 2018, 於 : PLoS Neglected Tropical Diseases. 12, 8, e0006715.

研究成果: 雜誌貢獻文章

Niclosamide
Antiparasitic Agents
Dengue Virus
Virus Diseases
Sirolimus
2017
2 引文 (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., 十一月 10 2017, 於 : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
9 引文 (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
3 引文 (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
2 引文 (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., 二月 9 2017, 於 : Scientific Reports. 7, 42291.

研究成果: 雜誌貢獻文章

Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy
4 引文 (Scopus)

Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells

Lee, M. K., Lin, S. P., HuangFu, W. C., Yang, D. S. & Liu, I. H., 八月 1 2017, 於 : PLoS One. 12, 8, e0184111.

研究成果: 雜誌貢獻文章

Stem cells
Mesenchymal Stromal Cells
extracellular matrix
bone marrow
Extracellular Matrix
3 引文 (Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 12336.

研究成果: 雜誌貢獻文章

Neuraminidase
Saliva
Binding Sites
Pharmaceutical Preparations
Human Influenza
10 引文 (Scopus)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., 四月 7 2017, 於 : Scientific Reports. 7, 46134.

研究成果: 雜誌貢獻文章

Cardiac Glycosides
Protein Kinase C
Hepatocellular Carcinoma
Apoptosis
Digitalis
2016
4 引文 (Scopus)

Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis

Chang, N. Y., Chan, Y. J., Ding, S. T., Lee, Y. H., Huangfu, W. C. & Liu, I. H., 十二月 1 2016, 於 : PLoS One. 11, 12, e0167644.

研究成果: 雜誌貢獻文章

cholesterol acyltransferase
Zebrafish
Danio rerio
Embryonic Development
embryogenesis
2015
21 引文 (Scopus)

Mechanisms of dihydrotestosterone action on resveratrolinduced anti-proliferation in breast cancer cells with different ER status

Chin, Y. T., Yang, S. H., Chang, T. C., Changou, C. A., Lai, H. Y., Fu, E., HuangFu, W. C., Davis, P. J., Lin, H. Y. & Liu, L. F., 2015, 於 : Oncotarget. 6, 34, p. 35866-35879 14 p.

研究成果: 雜誌貢獻文章

Dihydrotestosterone
Breast Neoplasms
Apoptosis
p53 Genes
Integrins
2014
39 引文 (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, 於 : Oncotarget. 5, 24, p. 12891-12907 17 p.

研究成果: 雜誌貢獻文章

Breast Neoplasms
Gene Expression
Stilbenes
Cell Proliferation
Perfusion
4 引文 (Scopus)

Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Cheng, C. C., Lee, Y. H., Lin, S. P., Huangfu, W. C. & Liu, I. H., 三月 13 2014, 於 : Journal of Biomedical Science. 21, 1, 21.

研究成果: 雜誌貢獻文章

Stem cells
Mesenchymal Stromal Cells
Bone
Bone Marrow
Heparitin Sulfate
2013
37 引文 (Scopus)

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

Bhattacharya, S., Huangfu, W. C., Dong, G., Qian, J., Baker, D. P., Karar, J., Koumenis, C., Diehl, J. A. & Fuchs, S. Y., 九月 2013, 於 : Oncogene. 32, 36, p. 4214-4221 8 p.

研究成果: 雜誌貢獻文章

Interferon Type I
Phosphotransferases
Prokaryotic Initiation Factor-2
Eukaryotic Initiation Factor-2
eIF-2 Kinase
2012
33 引文 (Scopus)

Inflammatory signaling compromises cell responses to interferon alpha

Huangfu, W. C., Qian, J., Liu, C., Liu, J., Lokshin, A. E., Baker, D. P., Rui, H. & Fuchs, S. Y., 一月 12 2012, 於 : Oncogene. 31, 2, p. 161-172 12 p.

研究成果: 雜誌貢獻文章

Interferon-alpha
Interferon alpha-beta Receptor
Melanoma
p38 Mitogen-Activated Protein Kinases
Cytokines
2011
29 引文 (Scopus)

Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1

Qian, J., Zheng, H., HuangFu, W. C., Liu, J., Carbone, C. J., Leu, N. A., Baker, D. P. & Fuchs, S. Y., 六月 2011, 於 : PLoS Pathogens. 7, 6, e1002065.

研究成果: 雜誌貢獻文章

Interferon Type I
Interferon alpha-beta Receptor
Phosphorylation
Innate Immunity
Dendritic Cells
2010
35 引文 (Scopus)

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of Type I interferon receptor

Bhattacharya, S., HuangFu, W. C., Liu, J., Veeranki, S., Baker, D. P., Koumenis, C., Diehl, J. A. & Fuchs, S. Y., 一月 22 2010, 於 : Journal of Biological Chemistry. 285, 4, p. 2318-2325 8 p.

研究成果: 雜誌貢獻文章

Interferon alpha-beta Receptor
Phosphorylation
Casein Kinase I
Unfolded Protein Response
Ubiquitination
8 引文 (Scopus)
25 引文 (Scopus)

Ubiquitination-dependent regulation of signaling receptors in cancer

HuangFu, W. C. & Fuchs, S. Y., 2010, 於 : Genes and Cancer. 1, 7, p. 725-734 10 p.

研究成果: 雜誌貢獻回顧型文獻

Ubiquitination
Neoplasms
Cell Surface Receptors
Cell Survival
Cell Proliferation
2009
82 引文 (Scopus)

Virus-Induced Unfolded Protein Response Attenuates Antiviral Defenses via Phosphorylation-Dependent Degradation of the Type I Interferon Receptor

Liu, J., HuangFu, W. C., Kumar, K. G. S., Qian, J., Casey, J. P., Hamanaka, R. B., Grigoriadou, C., Aldabe, R., Diehl, J. A. & Fuchs, S. Y., 一月 22 2009, 於 : Cell Host and Microbe. 5, 1, p. 72-83 12 p.

研究成果: 雜誌貢獻文章

Interferon alpha-beta Receptor
Unfolded Protein Response
Virus Diseases
Antiviral Agents
Interferon Type I
2008
20 引文 (Scopus)

Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor

HuangFu, W. C., Liu, J., Harty, R. N. & Fuchs, S. Y., 九月 22 2008, 於 : FEBS Letters. 582, 21-22, p. 3206-3210 5 p.

研究成果: 雜誌貢獻文章

Interferon Type I
Phosphorylation
Interferon alpha-beta Receptor
Tobacco Products
Down-Regulation
2007
3 引文 (Scopus)

Osmotic stress blocks NF-κB-dependent inflammatory responses by inhibiting ubiquitination of IκB

HuangFu, W. C., Matsumoto, K. & Ninomiya-Tsuji, J., 十二月 11 2007, 於 : FEBS Letters. 581, 29, p. 5549-5554 6 p.

研究成果: 雜誌貢獻文章

Ubiquitination
Osmotic Pressure
Inflammation
Interleukin-1
Chemokines
2006
39 引文 (Scopus)

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-κB activation: TAO2 regulates TAK1 pathways

HuangFu, W. C., Omori, E., Akira, S., Matsumoto, K. & Ninomiya-Tsuji, J., 九月 29 2006, 於 : Journal of Biological Chemistry. 281, 39, p. 28802-28810 9 p.

研究成果: 雜誌貢獻文章

MAP Kinase Signaling System
Osmotic Pressure
Chemical activation
Phosphotransferases
Mitogen-Activated Protein Kinase Kinases
2005
Cobalt
RNA
Molecules
Electrophoretic mobility
Substrates
2003
30 引文 (Scopus)

Mechanistic aspects of CoII(HAPP)(TFA)2 in DNA bulge-specific recognition

Cheng, C. C., Huang-Fu, W. C., Hung, K. C., Chen, P. J., Wang, W. J. & Chen, Y. J., 四月 15 2003, 於 : Nucleic Acids Research. 31, 8, p. 2227-2233 7 p.

研究成果: 雜誌貢獻文章

Trifluoroacetic Acid
DNA Cleavage
DNA
Deoxyribose
Single-Stranded DNA