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研究成果 2009 2019

  • 569 引文
  • 15 h-指數
  • 39 文章
篩選
文章
2019

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., 三月 1 2019, 於 : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

研究成果: 雜誌貢獻文章

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics
2018

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., 十一月 14 2018, 於 : Journal of Clinical Medicine. 7, 11

研究成果: 雜誌貢獻文章

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis
2 引文 (Scopus)

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Lu, W. J., Wu, G. J., Chen, R. J., Chang, C. C., Lien, L. M., Chiu, C. C., Tseng, M. F., Huang, L. T. & Lin, K. H., 八月 1 2018, 於 : Food and Function. 9, 8, p. 4500-4507 8 p.

研究成果: 雜誌貢獻文章

Cell Cycle Checkpoints
Glioma
cell growth
licorice
neoplasms
2 引文 (Scopus)
norcantharidin
Integrins
Fibrinogen
Blood Platelets
Clot Retraction
2017
3 引文 (Scopus)

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Hsia, C. H., Velusamy, M., Sheu, J. R., Khamrang, T., Jayakumar, T., Lu, W. J., Lin, K. H. & Chang, C. C., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 9556.

研究成果: 雜誌貢獻文章

Organometallic Compounds
Ruthenium
Fluorescein-5-isothiocyanate
Platelet Aggregation
Blood Platelets
1 引文 (Scopus)

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., 一月 1 2017, 於 : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

研究成果: 雜誌貢獻文章

Thrombin
Blood Platelets
Platelet Aggregation
Pharmaceutical Preparations
Epinephrine
6 引文 (Scopus)

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies

Lee, T. Y., Chang, C. C., Lu, W-J., Yen, T. L., Lin, K. H., Geraldine, P., Li, J. Y. & Sheu, J-R., 一月 5 2017, 於 : Scientific Reports. 7, 40002.

研究成果: 雜誌貢獻文章

Collagen Receptors
Glycoproteins
Blood Platelets
Collagen
Platelet Activation
8 引文 (Scopus)
Platelet Activation
Platelets
platelets
Thrombosis
Chemical activation
4 引文 (Scopus)

Nobiletin, a citrus flavonoid, activates Vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms

Jayakumar, T., Lin, K. C., Lu, W-J., Lin, C. Y., Pitchairaj, G., Li, J. Y. & Sheu, J-R., 一月 1 2017, 於 : International Journal of Molecular Medicine. 39, 1, p. 174-182 9 p.

研究成果: 雜誌貢獻文章

Citrus
Flavonoids
Blood Platelets
Nucleotides
Phosphorylation

Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation

Chang, Y., Hsu, W. H., Yang, W. B., Jayakumar, T., Lee, T. Y., Sheu, J. R., Lu, W. J. & Li, J. Y., 十一月 1 2017, 於 : International Journal of Molecular Medicine. 40, 5, p. 1520-1528 9 p.

研究成果: 雜誌貢獻文章

Platelet Activation
Structure-Activity Relationship
Oligosaccharides
Collagen
p38 Mitogen-Activated Protein Kinases
2016
23 引文 (Scopus)
Heme Oxygenase-1
Cytoprotection
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Rats
24 引文 (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., 二月 1 2016, 於 : Phytotherapy Research. 30, 2, p. 214-221 8 p.

研究成果: 雜誌貢獻文章

flavone
Glioma
Cell Movement
Cell Cycle
Growth
3 引文 (Scopus)

Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism

Yen, T. L., Wu, M. P., Chung, C. L., Yang, W. B., Jayakumar, T., Geraldine, P., Chou, C. M., Chang, C. Y., Lu, W-J. & Sheu, J. R., 二月 17 2016, 於 : Journal of Biomedical Science. 23, 1, 26.

研究成果: 雜誌貢獻文章

Thromboembolism
Platelets
Oligosaccharides
Platelet Aggregation
Collagen
15 引文 (Scopus)

Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies

Lu, W-J., Lin, K. C., Liu, C. P., Lin, C. Y., Wu, H. C., Chou, D. S., Geraldine, P., Huang, S. Y., Hsieh, C. Y. & Sheu, J. R., 二月 1 2016, 於 : Journal of Nutritional Biochemistry. 28, p. 1-8 8 p.

研究成果: 雜誌貢獻文章

Platelets
Thrombosis
Platelet Aggregation
Platelet Activation
Blood Platelets
2015
16 引文 (Scopus)
carotenoids
secretions
Lymphocytes
lymphocytes
Carotenoids
3 引文 (Scopus)
Concanavalin A
Cell Cycle Checkpoints
Lymphocytes
T-Lymphocytes
Cell Cycle Resting Phase
11 引文 (Scopus)

Inhibitory mechanisms of cme-1, a novel polysaccharide from the mycelia of cordyceps sinensis, in platelet activation

Chang, Y., Hsu, W. H., Lu, W. J., Jayakumar, T., Liao, J. C., Lin, M. J., Wang, S. H., Geraldine, P., Lin, K. H. & Sheu, J. R., 2015, 於 : Current Pharmaceutical Biotechnology. 16, 5, p. 451-461 11 p.

研究成果: 雜誌貢獻文章

Cordyceps
Mycelium
Platelet Activation
Polysaccharides
Platelet Aggregation
3 引文 (Scopus)

N-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

Guo, Y. R., Hsu, Y. H., Liang, A., Lu, W. J., Wu, C. H., Lee, H. C. & Huang, S. Y., 十二月 1 2015, 於 : Journal of Functional Foods. 19, p. 522-536 15 p., 1300.

研究成果: 雜誌貢獻文章

Omega-3 Fatty Acids
omega-3 fatty acids
polyunsaturated fatty acids
rats
Oils
5 引文 (Scopus)

Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway

Lu, W-J., Chang, C. C., Lien, L. M., Yen, T. L., Chiu, H. C., Huang, S. Y., Sheu, J. R. & Lin, K. H., 十月 1 2015, 於 : Journal of Functional Foods. 18, p. 538-549 12 p., 1255.

研究成果: 雜誌貢獻文章

Humulus lupulus
Humulus
autophagy
Autophagy
Glioma
2014
8 引文 (Scopus)

Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2 -PKC and MAPK pathways

Yen, T. L., Lu, W-J., Lien, L. M., Thomas, P. A., Lee, T. Y., Chiu, H. C., Sheu, J. R. & Lin, K. H., 2014, 於 : BioMed Research International. 2014, 728019.

研究成果: 雜誌貢獻文章

Iridoid Glycosides
Platelet Activation
Type C Phospholipases
Platelets
Mitogen-Activated Protein Kinases
23 引文 (Scopus)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

Chen, Y. Y., Hsieh, C. Y., Jayakumar, T., Lin, K. H., Chou, D. S., Lu, W-J., Hsu, M. J. & Sheu, J. R., 七月 10 2014, 於 : Scientific Reports. 4, 5651.

研究成果: 雜誌貢獻文章

Non-Receptor Type 6 Protein Tyrosine Phosphatase
Protein Phosphatase 2
p38 Mitogen-Activated Protein Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
12 引文 (Scopus)
Aminobutyrates
gamma-Aminobutyric Acid
Glycoproteins
Collagen
Blood Platelets
4 引文 (Scopus)

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: The pivotal role of protein kinase C

Lu, W-J., Lin, S. C., Lan, C. C., Lee, T. Y., Hsia, C. H., Huang, Y. K., Lee, H. C. & Sheu, J. R., 2014, 於 : Scientific World Journal. 2014, 745802.

研究成果: 雜誌貢獻文章

Antrodia
Platelet Activation
Platelets
Protein Kinase C
Thrombosis
13 引文 (Scopus)
Cordyceps
Mycelium
Platelet Activation
Adenylyl Cyclases
Cyclic AMP
7 引文 (Scopus)

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Lu, W-J., Wu, M. P., Lin, K. H., Lin, Y. C., Chou, H. C. & Sheu, J. R., 十二月 1 2014, 於 : Platelets. 25, 8, p. 595-602 8 p.

研究成果: 雜誌貢獻文章

Glycoproteins
Blood Platelets
Platelet Activation
Platelet Aggregation
Integrins
14 引文 (Scopus)

Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo

Lien, L. M., Chen, Z. C., Chung, C. L., Yen, T. L., Chiu, H. C., Chou, D. S., Huang, S. Y., Sheu, J. R., Lu, W-J. & Lin, K. H., 八月 15 2014, 於 : European Journal of Pharmacology. 737, p. 159-167 9 p.

研究成果: 雜誌貢獻文章

P-Glycoproteins
Thrombosis
Cyclic Nucleotides
Platelet Activation
Collagen
22 引文 (Scopus)

Role of a Janus kinase 2-dependent signaling pathway in platelet activation

Lu, W-J., Lin, K. C., Huang, S. Y., Thomas, P. A., Wu, Y. H., Wu, H. C., Lin, K. H. & Sheu, J. R., 2014, 於 : Thrombosis Research. 133, 6, p. 1088-1096 9 p.

研究成果: 雜誌貢獻文章

Janus Kinase 2
Platelet Activation
Collagen
Janus Kinases
Protein Kinase C
2013
24 引文 (Scopus)
Platelet Activation
Platelets
Adenylyl Cyclases
Chemical activation
Phosphorylation
11 引文 (Scopus)
Andrographis
Brain Ischemia
Brain Injuries
Reperfusion
Endothelial Cells
8 引文 (Scopus)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets

Chang, Y., Huang, S. K. H., Lu, W. J., Chung, C. L., Chen, W. L., Lu, S. H., Lin, K. H. & Sheu, J. R., 一月 25 2013, 於 : Journal of Biomedical Science. p. 4 1 p.

研究成果: 雜誌貢獻文章

Caesalpinia
Collagen Receptors
Platelets
Blood Platelets
Platelet Aggregation
27 引文 (Scopus)

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Lin, K. H., Kuo, J. R., Lu, W-J., Chung, C. L., Chou, D. S., Huang, S. Y., Lee, H. C. & Sheu, J. R., 五月 15 2013, 於 : Biochemical Pharmacology. 85, 10, p. 1478-1485 8 p.

研究成果: 雜誌貢獻文章

Platelet Activation
Platelets
Thrombosis
Chemical activation
Platelet Aggregation
23 引文 (Scopus)

Mechanisms of andrographolide-induced platelet apoptosis in human platelets: Regulatory roles of the extrinsic apoptotic pathway

Lien, L-M., Su, C. C., Hsu, W. H., Lu, W-J., Chung, C-L., Yen, T. L., Chiu, H. C., Sheu, J-R. & Lin, K. H., 2013, 於 : Phytotherapy Research. 27, 11, p. 1671-1677 7 p.

研究成果: 雜誌貢獻文章

Blood Platelets
Apoptosis
Caspase 8
Platelet Activation
Andrographis
2012
51 引文 (Scopus)
Humulus lupulus
Humulus
neuroprotective effect
hops
Neuroprotective Agents
44 引文 (Scopus)
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Platelets
Hydroxyl Radical
Blood Platelets
20 引文 (Scopus)
Humulus
Platelet Activation
Flavonoids
Blood Platelets
Platelet Aggregation
2011
55 引文 (Scopus)
NF-kappa B
Nitric Oxide Synthase Type III
Cyclic GMP
Platelet Activation
p38 Mitogen-Activated Protein Kinases
28 引文 (Scopus)

A novel role of sesamol in inhibiting NF-B-mediated signaling in platelet activation

Chang, C. C., Lu, W-J., Ong, E. T., Chiang, C-W., Lin, S-C., Huang, S. Y. & Sheu, J. R., 2011, 於 : Journal of Biomedical Science. 18, 1, 93.

研究成果: 雜誌貢獻文章

Platelet Activation
Platelets
Chemical activation
Platelet Aggregation
Phosphorylation
2010
25 引文 (Scopus)
p38 Mitogen-Activated Protein Kinases
Cyclic AMP
Platelets
Phosphorylation
Nitric Oxide Synthase Type III
2009
21 引文 (Scopus)
Blood Platelets
Apoptosis
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Calcimycin
Platelet Activation