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研究成果

  • 1010 引文
  • 18 h-指數
  • 62 文章
  • 1 章節
2019
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E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness

Cheng, F. H. C., Lin, H. Y., Hwang, T. W., Chen, Y. C., Huang, R. L., Chang, C. B., Yang, W., Lin, R. I., Lin, C. W., Chen, G. C. W., Mai, S. Y., Lin, J. M. J., Chuang, Y. M., Chou, J. L., Kuo, L. W., Li, C., Cheng, A. S. L., Lai, H. C., Wu, S. F., Tsai, J. C. 及其他1, Chan, M. W. Y., 一月 1 2019, (接受/付印) 於 : Cancer Science.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

Ovarian cancer detection by DNA methylation in cervical scrapings

Wu, T. I., Huang, R. L., Su, P. H., Mao, S. P., Wu, C. H. & Lai, H. C., 十一月 27 2019, 於 : Clinical Epigenetics. 11, 1, 166.

研究成果: 雜誌貢獻文章

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Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer

Su, P. H., Lai, H. C., Huang, R. L., Chen, L. Y., Wang, Y. C., Wu, T. I., Chan, M. W. Y., Liao, C. C., Chen, C. W., Lin, W. Y. & Chang, C. C., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 9195.

研究成果: 雜誌貢獻文章

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3 引文 斯高帕斯(Scopus)

TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions

Su, P. H., Hsu, Y. W., Huang, R. L., Chen, L. Y., Chao, T. K., Liao, C. C., Chen, C. W., Wu, T. I., Mao, S. P., Balch, C. & Lai, H. C., 五月 28 2019, 於 : Cancer Letters. 450, p. 53-62 10 p.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target

Chen, L. Y., Huang, R. L., Chan, M. W. Y., Yan, P. S., Huang, T. S., Wu, R. C., Suryo Rahmanto, Y., Su, P. H., Weng, Y. C., Chou, J. L., Chao, T. K., Wang, Y. C., Shih, I. M. & Lai, H. C., 七月 2019, 於 : Journal of Pathology. 248, 3, p. 363-376 14 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells

Chung, V. Y., Tan, T. Z., Ye, J., Huang, R. L., Lai, H. C., Kappei, D., Wollmann, H., Guccione, E. & Huang, R. Y. J., 十二月 1 2019, 於 : Communications Biology. 2, 1, 272.

研究成果: 雜誌貢獻文章

開啟存取
6 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)
2018

Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors

Liew, P. L., Huang, R. L., Weng, Y. C., Fang, C. L., Hui-Ming Huang, T. & Lai, H. C., 七月 15 2018, 於 : International Journal of Cancer. 143, 2, p. 355-367 13 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Epigenetic loss of heparan sulfate 3-O-sulfation sensitizes ovarian carcinoma to oncogenic signals and predicts prognosis

Huang, R. L., Chen, H. J., Chen, L. Y., Chao, T. K., Lin, W. Y., Liew, P. L., Su, P. H., Weng, Y. C., Wang, Y. C., Liao, C. C., Hsu, Y. W., Wang, H. C. & Lai, H. C., 十月 15 2018, 於 : International Journal of Cancer. 143, 8, p. 1943-1953 11 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells

Chen, H. J., Huang, R. L., Liew, P. L., Su, P. H., Chen, L. Y., Weng, Y. C., Chang, C. C., Wang, Y. C., Chan, M. W. Y. & Lai, H. C., 一月 1 2018, (接受/付印) 於 : International Journal of Cancer.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

Tang, M. K. S., Yue, P. Y. K., Ip, P. P., Huang, R. L., Lai, H. C., Cheung, A. N. Y., Tse, K. Y., Ngan, H. Y. S. & Wong, A. S. T., 十二月 1 2018, 於 : Nature Communications. 9, 1, 2270.

研究成果: 雜誌貢獻文章

39 引文 斯高帕斯(Scopus)
2017

An epigenetic signature of adhesion molecules predicts poor prognosis of ovarian cancer patients

Chang, P-Y., Liao, Y-P., Wang, H-C., Chen, Y-C., Huang, R-L., Wang, Y-C., Yuan, C-C. & Lai, H-C., 八月 8 2017, 於 : Oncotarget. 8, 32, p. 53432-53449 18 p.

研究成果: 雜誌貢獻文章

Genotype-specific methylation of HPV in cervical intraepithelial neoplasia

Hsu, Y. W., Huang, R. L., Su, P. H., Chen, Y. C., Wang, H. C., Liao, C. C. & Lai, H. C., 2017, 於 : Journal of Gynecologic Oncology. 28, 4, e56.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

Integrated epigenomics analysis reveals a DNA methylation panel for endometrial cancer detection using cervical scrapings

Huang, R. L., Su, P. H., Liao, Y. P., Wu, T. I., Hsu, Y. T., Lin, W. Y., Wang, H. C., Weng, Y. C., Ou, Y. C., Huang, T. H. M. & Lai, H. C., 一月 1 2017, 於 : Clinical Cancer Research. 23, 1, p. 263-272 10 p.

研究成果: 雜誌貢獻文章

24 引文 斯高帕斯(Scopus)

Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer

Chung, V. Y., Tan, T. Z., Huang, R. L., Lai, H. C. & Huang, R. Y. J., 十一月 30 2017, 於 : Gene. 635, p. 9-15 7 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Methylomics of nitroxidative stress on precancerous cells reveals DNA methylation alteration at the transition from in situ to invasive cervical cancer

Su, P. H., Hsu, Y. W., Huang, R. L., Weng, Y. C., Wang, H. C., Chen, Y. C., Tsai, Y. J., Yuan, C. C. & Lai, H. C., 2017, 於 : Oncotarget. 8, 39, p. 65281-65291 11 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer

Chao, T. K., Huang, T. S., Liao, Y. P., Huang, R. L., Su, P. H., Shen, H. Y., Lai, H. C. & Wang, Y. C., 七月 1 2017, 於 : PLoS One. 12, 7, e0182166.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)
2016

Paired boxed gene 1 expression: A single potential biomarker for differentiating endometrial lesions associated with favorable outcomes in patients with endometrial carcinoma

Liu, L. C., Lai, H. C., Chou, Y. C., Huang, R. L., Yu, M. H., Lin, C. P., Tsai, W. C., Chiang, K. J., Wang, Y. C. & Chao, T. K., 九月 1 2016, 於 : Journal of Obstetrics and Gynaecology Research. 42, 9, p. 1159-1167 9 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Platelet-derived growth factor in the ovarian follicle attracts the stromal cells of the fallopian tube fimbriae

Yeh, C. H., Chen, P. C., Chen, C. H., Hsu, C. F., Huang, R-L., Ding, D. C. & Chu, T. Y., 七月 1 2016, 於 : PLoS One. 11, 7, e0158266.

研究成果: 雜誌貢獻文章

Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer

Lin, C. K., Bai, M. Y., Hu, T. M., Wang, Y. C., Chao, T. K., Weng, S. J., Huang, R. L., Su, P. H. & Lai, H. C., 2016, 於 : Oncotarget. 7, 8, p. 8993-9006 14 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, 於 : Oncotarget. 7, 38, p. 61930-61944 15 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)
2015

Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Chang, C. C., Huang, R. L., Liao, Y. P., Su, P. H., Hsu, Y. W., Wang, H. C., Tien, C. Y., Yu, M. H., Lin, Y. W. & Lai, H. C., 五月 19 2015, 於 : BMC Cancer. 15, 1, 418.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Genome-wide dna methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer

Jadhav, R. R., Ye, Z., Huang, R-L., Liu, J., Hsu, P. Y., Huang, Y. W., Rangel, L. B., Lai, H. C., Roa, J. C., Kirma, N. B., Huang, T. H. M. & Jin, V. X., 二月 24 2015, 於 : Clinical Epigenetics. 7, 1

研究成果: 雜誌貢獻文章

31 引文 斯高帕斯(Scopus)

Global methylation silencing of clustered proto-cadherin genes in cervical cancer: Serving as diagnostic markers comparable to HPV

Wang, K. H., Lin, C. J., Liu, C. J., Liu, D. W., Huang, R. L., Ding, D. C., Weng, C. F. & Chu, T. Y., 一月 1 2015, 於 : Cancer Medicine. 4, 1, p. 43-55 13 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

Hypermethylation of the tgf-β target, abca1 is associated with poor prognosis in ovarian cancer patients

Chou, J. L., Huang, R-L., Shay, J., Chen, L. Y., Lin, S. J., Yan, P. S., Chao, W. T., Lai, Y. H., Lai, Y. L., Chao, T. K., Lee, C. I., Tai, C. K., Wu, S. F., Nephew, K. P., Huang, T. H. M., Lai, H. C. & Chan, M. W. Y., 一月 14 2015, 於 : Clinical Epigenetics. 7, 1

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

MeDIP-on-chip for methylation profiling

Hsu, Y. W., Huang, R-L. & Lai, H. C., 2015, 於 : Methods in molecular biology (Clifton, N.J.). 1249, p. 281-290 10 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

TET1-mediated epigenetic reprogramming switches metabolism and promotes malignant phenotypes of ovarian cancer

Huang, R-L., Chen, L. Y., Yan, P., Huang, T. S., Liao, Y. P., Chou, J. L., Lin, J. M. J., Chao, T. K., Chan, M. W. Y., Chang, W. S. W. & Lai, H-C., 八月 2015, 於 : Cancer Research. p. 1128 1 p.

研究成果: 雜誌貢獻文章

Triage of high-risk human papillomavirus-positive women by methylated POU4F3

Pun, P. B., Liao, Y. P., Su, P. H., Wang, H. C., Chen, Y. C., Hsu, Y. W., Huang, R. L., Chang, C. C. & Lai, H. C., 八月 21 2015, 於 : Clinical Epigenetics. 7, 1, 85.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Triple screening of gynecology cancers using cervical DNA methylation

Laio, Y-P., Su, P. H., Huang, R-L., Wang, H. C., Chen, Y. C. & Lai, H-C., 2015, 於 : International Journal of Gynecological Cancer.

研究成果: 雜誌貢獻文章

檔案
60 下載 (Pure)
2014

Disruption of TGF-β signaling induces demethylation of E-cadherin promoter and reverses mesenchymal phenotype in ovarian cancer

Chen, L. Y., Huang, R-L., Chou, H. L., Chou, J. L., Deng, W-T., Yang, H. W., Lin, R. I., Li, C. Y., Lin, H-J., Huang, T. H. M., Chiu, C. C., Lai, H-C. & Chan, M. W. Y., 十一月 13 2014, 於 : Cancer Research. 71, 8 Supplement, p. 3433 1 p.

研究成果: 雜誌貢獻文章

DNA methylation as a biomarker for the detection of hidden carcinoma in endometrial atypical hyperplasia

Lai, H. C., Wang, Y. C., Yu, M. H., Huang, R. L., Yuan, C-C., Chen, K. J., Wu, C. C., Chiang, K. J. & Chao, T. K., 十二月 1 2014, 於 : Gynecologic Oncology. 135, 3, p. 552-559 8 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

Effect of miR-29 on cisplatin sensitivity of ovarian cancer cells

Yu, P. N., Lin, W-C., Kuo, C. C., Huang, R-L., Yan, M. D., Shih, Y. L., Chou, Y. C., Lai, H-C. & Lin, Y. W., 十一月 21 2014, 於 : Cancer Research. 72, 8 Supplement, p. 1110 1 p.

研究成果: 雜誌貢獻文章

EpCAM-mediated hypomethylation of BMP and cell adhesion genes is associated with advanced endometrial cancer

Hsu, Y. T., Gu, F., Huang, Y. W., Liu, J., Ruan, J., Huang, R-L., Wang, C. M., Chen, C. L., Jadhav, R. R., Wang, Y. M., Jin, V. X., Lai, H-C., Mutch, D. G., Goodfellow, P. J., Thompson, I. M., Kirma, N. B. & Huang, T. H. M., 九月 30 2014, 於 : Cancer Research. 74, 19 Supplement, p. 1376 1 p.

研究成果: 雜誌貢獻文章

Epigenomic analysis of DNMT3B-mediated cervical cancer invasion by methylated DNA immunoprecipitation identifies PTPRR as a metastasis suppressor gene

Su, P. H., Huang, R-L., Liu, C. Y., Wang, H. C., Su, H. Y., Chung, M. T., Lin, Y. W. & Lai, H-C., 十月 8 2014, 於 : Cancer Research. 69, 9 Supplement, p. 5192 1 p.

研究成果: 雜誌貢獻文章

High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma

Chang, C. C., Huang, R. L., Wang, H. C., Liao, Y. P., Yu, M. H. & Lai, H. C., 一月 2014, 於 : International Journal of Gynecological Cancer. 24, 2, p. 201-209 9 p.

研究成果: 雜誌貢獻文章

42 引文 斯高帕斯(Scopus)

Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients

Liao, Y. P., Chen, L. Y., Huang, R-L., Su, P. H., Chan, M. W. Y., Chang, C. C., Yu, M. H., Wang, P. H., Yen, M. S., Nephew, K. P. & Lai, H. C., 四月 1 2014, 於 : Human Molecular Genetics. 23, 7, p. 1894-1906 13 p.

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

MeDIP-on-chip for methylation profiling

Hsu, Y. W., Huang, R. L. & Lai, H. C., 十月 27 2014, Cervical Cancer: Methods and Protocols. Springer New York, p. 281-290 10 p.

研究成果: 書貢獻/報告類型章節

2 引文 斯高帕斯(Scopus)

Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer

Chen, Y. C., Huang, R. L., Huang, Y. K., Liao, Y. P., Su, P. H., Wang, H. C., Chang, C. C., Lin, Y. W., Yu, M. H., Chu, T. Y. & Lai, H. C., 七月 1 2014, 於 : International Journal of Cancer. 135, 1, p. 117-127 11 p.

研究成果: 雜誌貢獻文章

43 引文 斯高帕斯(Scopus)

Serum cytokeratin-19 fragment (Cyfra 21-1) is a prognostic indicator for epithelial ovarian cancer

Wu, H. H., Wang, P. H., Yeh, J. Y., Chen, Y. J., Yen, M. S., Huang, R. L., Tsai, Y. J. & Yuan, C. C., 2014, 於 : Taiwanese Journal of Obstetrics and Gynecology. 53, 1, p. 30-34 5 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)
2013

Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers

Huang, R. L., Gu, F., Kirma, N. B., Ruan, J., Chen, C. L., Wang, H. C., Liao, Y. P., Chang, C. C., Yu, M. H., Pilrose, J. M., Thompson, I. M., Huang, H. C., Huang, T. H. M., Lai, H. C. & Nephew, K. P., 一月 1 2013, 於 : Epigenetics. 8, 6

研究成果: 雜誌貢獻文章

CpG island shore methylation regulates caveolin-1 expression in breast cancer

Rao, X., Evans, J., Chae, H., Pilrose, J., Kim, S., Yan, P., Huang, R. L., Lai, H. C., Lin, H., Liu, Y., Miller, D., Rhee, J. K., Huang, Y. W., Gu, F., Gray, J. W., Huang, T. M. & Nephew, K. P., 九月 19 2013, 於 : Oncogene. 32, 38, p. 4519-4528 10 p.

研究成果: 雜誌貢獻文章

82 引文 斯高帕斯(Scopus)

Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells

Yu, P. N., Yan, M. D., Lai, H-C., Huang, R. L., Chou, Y. C., Lin, W. C., Yeh, L. T. & Lin, Y. W., 2013, 於 : International Journal of Cancer. 134, 3, p. 542-551 10 p.

研究成果: 雜誌貢獻文章

Drug screening identifies growth inhibition of ovarian tumor-initiating cells by niclosamide

Lai, H., Yo, Y. W., Wang, Y., Balch, C., Huang, R., Chang, C., Nephew, K. P. & Huang, T., 七月 2013, 於 : Gynecologic Oncology. 130, 1, p. e132

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer

Su, P. H., Lin, Y. W., Huang, R. L., Liao, Y. P., Lee, H. Y., Wang, H. C., Chao, T. K., Chen, C. K., Chan, M. W. Y., Chu, T. Y., Yu, M. H. & Lai, H. C., 一月 3 2013, 於 : Oncogene. 32, 1, p. 15-26 12 p.

研究成果: 雜誌貢獻文章

45 引文 斯高帕斯(Scopus)

Methylomic profiling of ovarian cancer-initiating cells identifies DNA methylation as a prognostic biomarker

Lai, H., Liao, Y. & Huang, R., 七月 2013, 於 : Gynecologic Oncology. 130, 1, p. e133-e134

研究成果: 雜誌貢獻文章

Ovarian cancer stem-like cells with induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor

Liu, K. C., Yo, Y. T., Huang, R. L., Wang, Y. C., Liao, Y. P., Huang, T. S., Chao, T. K., Lin, C. K., Weng, S. J., Ma, K. H., Chang, C. C., Yu, M. H. & Lai, H-C., 十二月 2013, 於 : Oncotarget. 4, 12, p. 2366-2382 17 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)