如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果 2011 2020

  • 320 引文
  • 11 h-指數
  • 31 文章
篩選
文章
2020
1 引文 (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 一月 1 2020, 於 : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

研究成果: 雜誌貢獻文章

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 二月 1 2020, 於 : Bioorganic and Medicinal Chemistry. 28, 3, 115250.

研究成果: 雜誌貢獻文章

2019
5 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 五月 1 2019, 於 : Oncotarget. 10, 36, 1 p.

研究成果: 雜誌貢獻文章

開啟存取
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid
1 引文 (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., 一月 1 2019, 於 : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

研究成果: 雜誌貢獻文章

開啟存取
Xylaria
Isoptera
termite mounds
Ethers
nitric oxide
開啟存取
Colorectal Neoplasms
Apoptosis
Ligands
Autophagy
Cell Death
2017
21 引文 (Scopus)

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, 於 : Oncotarget. 8, 17, p. 28342-28358 17 p.

研究成果: 雜誌貢獻文章

Non-Small Cell Lung Carcinoma
Reactive Oxygen Species
Apoptosis
Noxae
Protein Kinases
5 引文 (Scopus)
Autophagy
Colorectal Neoplasms
Cell Death
HCT116 Cells
Cyclin B1
2 引文 (Scopus)

Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea

Chen, M. C., Cho, T. Y., Kuo, Y. H. & Lee, T. H., 九月 22 2017, 於 : Journal of Natural Products. 80, 9, p. 2439-2446 8 p.

研究成果: 雜誌貢獻文章

Antrodia
Fungi
antroquinonol
Alcoholic Intoxication
Structure-Activity Relationship
9 引文 (Scopus)
Carbolines
Histone Deacetylases
Cytotoxicity
Hydroxamic Acids
Indoles

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., 四月 7 2017, 於 : Scientific Reports. 7, 46149.

研究成果: 雜誌貢獻文章

Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
G2 Phase
G1 Phase
2016
2 引文 (Scopus)

Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623

Cho, T. Y., Wang, G. J., Ju, Y. M., Chen, M. C. & Lee, T. H., 五月 1 2016, 於 : Journal of the Chinese Chemical Society. 63, 5, p. 404-409 6 p.

研究成果: 雜誌貢獻文章

Lipopolysaccharides
Benzofurans
Optical rotation
Macrophages
Natural resources
5 引文 (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., 六月 9 2016, 於 : Scientific Reports. 6, 27794.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Pancreatic Neoplasms
Polyploidy
Microtubules
Growth
5 引文 (Scopus)
Antineoplastic Agents
Ovarian Neoplasms
Cisplatin
Apoptosis
Pharmaceutical Preparations
14 引文 (Scopus)
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
2015
7 引文 (Scopus)

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., 十二月 2 2015, 於 : International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

研究成果: 雜誌貢獻文章

Pyracantha
Monophenol Monooxygenase
Cosmetics
Taiwan
inhibitors
16 引文 (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
7 引文 (Scopus)
HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
1 引文 (Scopus)
DNA Mutational Analysis
Hydroxymethylbilane Synthase
Acute Intermittent Porphyria
Rhabdomyolysis
Pedigree
11 引文 (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., 六月 1 2015, 於 : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
DNA Repair
DNA Damage
gemcitabine
Deoxyribonucleotides
2014
33 引文 (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 五月 22 2014, 於 : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

研究成果: 雜誌貢獻文章

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
6 引文 (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 九月 1 2014, 於 : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase
9 引文 (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., 十一月 5 2014, 於 : PLoS One. 9, 11, e112220.

研究成果: 雜誌貢獻文章

DNA topoisomerase (ATP-hydrolysing)
Type II DNA Topoisomerase
Poisons
Renal Cell Carcinoma
DNA damage
32 引文 (Scopus)

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, 於 : Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Liver Neoplasms
Heterografts
Cell Survival
Histone Code
2013
45 引文 (Scopus)

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Chen, M. C., Chen, C. H., Wang, J. C., Tsai, A. C., Liou, J. P., Pan, S. L. & Teng, C. M., 九月 2013, 於 : Cell Death and Disease. 4, 9, e810.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Epidermal Growth Factor Receptor
Cell Death
Protein-Tyrosine Kinases
erbB-1 Genes
12 引文 (Scopus)

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Chen, M. C., Chen, C. H., Liu, Y. N., Wang, H. P., Pan, S. L. & Teng, C. M., 八月 19 2013, 於 : Cancer Letters. 336, 2, p. 370-378 9 p.

研究成果: 雜誌貢獻文章

3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
Autophagy
Non-Small Cell Lung Carcinoma
G2 Phase
Cell Division
2012
21 引文 (Scopus)

Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo

Lai, C. Y., Tsai, A. C., Chen, M. C., Chang, L. H., Sun, H. L., Chang, Y. L., Chen, C. C., Teng, C. M. & Pan, S. L., 八月 13 2012, 於 : PLoS One. 7, 8, e42192.

研究成果: 雜誌貢獻文章

DNA damage
apoptosis
Cells
Apoptosis
Chrysopogon aciculatus
10 引文 (Scopus)

QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells

Chen, M. C., Pan, S. L., Shi, Q., Xiao, Z., Lee, K. H., Li, T. K. & Teng, C. M., 一月 2012, 於 : Cancer Science. 103, 1, p. 80-87 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Non-Small Cell Lung Carcinoma
Apoptosis
DNA Damage
DNA
2011
17 引文 (Scopus)

Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression

Chen, C-H., Huang, P. H., Chu, P. C., Chen, M. C., Chou, C. C., Wang, D., Kulp, S. K., Teng, C. M., Wang, Q. & Chen, C. S., 三月 25 2011, 於 : Journal of Biological Chemistry. 286, 12, p. 9968-9976 9 p.

研究成果: 雜誌貢獻文章

Kruppel-Like Transcription Factors
Tumor Suppressor Genes
Epigenomics
Gene expression
Histones
23 引文 (Scopus)

Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells

Chen, M. C., Chen, C-H., Chuang, H. C., Kulp, S. K., Teng, C. M. & Chen, C. S., 一月 2011, 於 : Hepatology. 53, 1, p. 148-159 12 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Phosphorylation
F-Box Proteins