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1975 …2018
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研究成果 1975 2018

1994

Preface

Liu, L-F., 1994, 於 : Advances in pharmacology (San Diego, Calif.). 29, PART B

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

Preface

Liu, L-F., 1994, 於 : Advances in pharmacology (San Diego, Calif.). 29, PART A

研究成果: 雜誌貢獻文章

88 引文 (Scopus)
Genetic Recombination
Plasmids
Base Pairing
Escherichia coli
24 引文 (Scopus)

Roles of DNA topoisomerases in transcription.

Drolet, M., Wu, H. Y. & Liu, L-F., 1994, 於 : Advances in pharmacology (San Diego, Calif.). 29 A, p. 135-146 12 p.

研究成果: 雜誌貢獻文章

DNA Topoisomerases
Genetic Transcription
Type I DNA Topoisomerase
DNA Replication
DNA
54 引文 (Scopus)

Structure activity of topoisomerase i poisons related to hoechst 33342

Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 十二月 22 1994, 於 : Bioorganic and Medicinal Chemistry Letters. 4, 24, p. 2871-2876 6 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Cytotoxicity
HOE 33342
37 引文 (Scopus)

Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin

Meegalla, S. K., Stevens, G. J., McQueen, C. A., Chen, A. Y., Yu, C., Liu, L. F., Liu, L-F. & LaVoie, E. J., 1994, 於 : Journal of Medicinal Chemistry. 37, 20, p. 3434-3439 6 p.

研究成果: 雜誌貢獻文章

batracylin
Quinazolinones
Antineoplastic Agents
Pharmacology
Derivatives
1993
149 引文 (Scopus)

A new mammalian DNA topoisomerase I poison Hoechst 33342: Cytotoxicity and drug resistance in human cell cultures

Chen, A. Y., Yu, C., Bodley, A., Peng, L. F. & Liu, L-F., 1993, 於 : Cancer Research. 53, 6, p. 1332-1337 6 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Drug Resistance
Coloring Agents
Cell Culture Techniques
26 引文 (Scopus)

A Structured–Activity Relationship Study of Batracylin Analogues

Luo, Y., Ren, Y. F., Chou, T. C., Chen, A. Y., Yu, C., Liu, L-F. & Cheng, C. C., 1993, 於 : Pharmaceutical Research. 10, 6, p. 918-923 6 p.

研究成果: 雜誌貢獻文章

batracylin
Quinazolines
DNA Cleavage
HL-60 Cells
Type II DNA Topoisomerase
53 引文 (Scopus)

Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. synthesis and biological activity studies of benzo[b]naphtho[2,3-d]furan-6,11-dione derivatives

Cheng, C. C., Dong, Q., Liu, D. F., Luo, Y. L., Liu, L-F., Chen, A. Y., Yu, C., Savaraj, N. & Chou, T. C., 1993, 於 : Journal of Medicinal Chemistry. 36, 25, p. 4108-4112 5 p.

研究成果: 雜誌貢獻文章

Small Cell Lung Carcinoma
Bioactivity
Antineoplastic Agents
Type II DNA Topoisomerase
Cells
293 引文 (Scopus)
Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Ligands
DNA
Camptothecin
38 引文 (Scopus)

Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide)

Bodley, A. L., Huang, H. C., Yu, C. & Liu, L-F., 1993, 於 : Molecular and Cellular Biology. 13, 10, p. 6190-6200 11 p.

研究成果: 雜誌貢獻文章

Teniposide
Type II DNA Topoisomerase
Simian virus 40
DNA
Molecular Weight
203 引文 (Scopus)

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: Studies in a cell-free SV40 DNA replication system

Tsao, Y. P., Liu, L-F., Nyamuswa, G., Silber, R. & Liu, L. F., 十二月 15 1993, 於 : Cancer Research. 53, 24, p. 5908-5914 7 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
DNA Replication
S Phase
G2 Phase Cell Cycle Checkpoints
1992
6 引文 (Scopus)

Identification of a DNA supercoiling activity in Saccharomyces cerevisiae

Koo, H. S., Lau, K., Wu, H. Y. & Liu, L-F., 十月 11 1992, 於 : Nucleic Acids Research. 20, 19, p. 5067-5072 6 p.

研究成果: 雜誌貢獻文章

Saccharomyces Cerevisiae
Yeast
Saccharomyces cerevisiae
DNA
Adenosine Triphosphate
4 引文 (Scopus)

Interlocking of plasmid DNAs due to lac repressor-operator interaction

Wu, H. Y., Lau, K. & Liu, L-F., 十二月 20 1992, 於 : Journal of Molecular Biology. 228, 4, p. 1104-1114 11 p.

研究成果: 雜誌貢獻文章

Lac Repressors
Plasmids
DNA
Escherichia coli
Proteins
227 引文 (Scopus)

The involvement of active DNA synthesis in camptothecin-induced G2 arrest: Altered regulation of p34(cdc2)/cyclin B

Tsao, Y. P., D'Arpa, P. & Liu, L-F., 1992, 於 : Cancer Research. 52, 7, p. 1823-1829 7 p.

研究成果: 雜誌貢獻文章

Cyclin B
Camptothecin
G2 Phase
DNA
Cell Cycle Checkpoints
44 引文 (Scopus)
Neoplasm DNA
Cultured Tumor Cells
Superhelical DNA
Camptothecin
Type II DNA Topoisomerase
3 引文 (Scopus)

Topological approaches to studies of protein-mediated looping of DNA in vivo

Wu, H. Y. & Liu, L-F., 1992, 於 : Methods in Enzymology. 212, p. 346-351 6 p.

研究成果: 雜誌貢獻文章

Lac Repressors
DNA
Proteins
Plasmids
Binding Sites
1991
62 引文 (Scopus)
Adenosine Triphosphate
Escherichia coli
Type I DNA Topoisomerase
DNA
Mutant Proteins
171 引文 (Scopus)

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

Chen, A. Y., Yu, C., Liu, L-F., Wall, M. E., Wani, M. C. & Liu, L. F., 十一月 15 1991, 於 : Cancer Research. 51, 22, p. 6039-6044 6 p.

研究成果: 雜誌貢獻文章

KB Cells
Camptothecin
Carcinoma
Topotecan
irinotecan
41 引文 (Scopus)

DNA looping alters local DNA conformation during transcription

Wu, H. Y. & Liu, L-F., 六月 20 1991, 於 : Journal of Molecular Biology. 219, 4, p. 615-622 8 p.

研究成果: 雜誌貢獻文章

Nucleic Acid Conformation
Lac Repressors
DNA
Plasmids
Type I DNA Topoisomerase
1990
172 引文 (Scopus)

A model for tumor cell killing by topoisomerase poisons

Zhang, H., D'Arpa, P. & Liu, L-F., 1990, 於 : Cancer Cells. 2, 1, p. 23-26 4 p.

研究成果: 雜誌貢獻文章

Poisons
Double-Stranded DNA Breaks
DNA
Pharmaceutical Preparations
Antineoplastic Agents
11 引文 (Scopus)
Xenopus Proteins
Type I DNA Topoisomerase
Simian virus 40
Neoplasm Antigens
Oocytes
220 引文 (Scopus)

DNA topoisomerases as anticancer drug targets.

Schneider, E., Hsiang, Y. H. & Liu, L-F., 1990, 於 : Advances in pharmacology (San Diego, Calif.). 21, p. 149-183 35 p.

研究成果: 雜誌貢獻文章

DNA Topoisomerases
Type I DNA Topoisomerase
Drug Resistance
Antineoplastic Agents
Cell Survival
14 引文 (Scopus)

Effects of transcription and translation on gyrase-mediated DNA cleavage in Escherichia coli

Koo, H. S., Wu, H. Y. & Liu, L-F., 七月 25 1990, 於 : Journal of Biological Chemistry. 265, 21, p. 12300-12305 6 p.

研究成果: 雜誌貢獻文章

DNA Cleavage
Transcription
Escherichia coli
DNA
Oxolinic Acid
124 引文 (Scopus)

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines

Sugimoto, Y., Tsukahara, S., Oh-hara, T., Liu, L. F. & Liu, L-F., 十二月 15 1990, 於 : Cancer Research. 50, 24, p. 7962-7965 4 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type II DNA Topoisomerase
Tumor Cell Line
Type I DNA Topoisomerase
Durapatite
164 引文 (Scopus)

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

Kanzawa, F., Sugimoto, Y., Minato, K., Kasahara, K., Bungo, M., Nakagawa, K., Fujiwara, Y., Liu, L-F. & Saijo, N., 九月 15 1990, 於 : Cancer Research. 50, 18, p. 5919-5924 6 p.

研究成果: 雜誌貢獻文章

irinotecan
Camptothecin
Non-Small Cell Lung Carcinoma
Cell Line
Type I DNA Topoisomerase
411 引文 (Scopus)

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

D'Arpa, P., Beardmore, C. & Liu, L-F., 十一月 1 1990, 於 : Cancer Research. 50, 21, p. 6919-6924 6 p.

研究成果: 雜誌貢獻文章

Poisons
Camptothecin
Nucleic Acids
Type II DNA Topoisomerase
Type I DNA Topoisomerase
1989
966 引文 (Scopus)

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

Hsiang, Y. H., Lihou, M. G. & Liu, L-F., 1989, 於 : Cancer Research. 49, 18, p. 5077-5082 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
DNA Replication
Pharmaceutical Preparations
DNA
199 引文 (Scopus)

DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA

Bodley, A., Liu, L-F., Israel, M., Seshadri, R., Koseki, Y., Giuliani, F. C., Kirschenbaum, S., Silber, R. & Potmesil, M., 1989, 於 : Cancer Research. 49, 21, p. 5969-5978 10 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Daunorubicin
Doxorubicin
Intercalating Agents
DNA
381 引文 (Scopus)

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

Hsiang, Y. H., Liu, L-F., Wall, M. E., Wani, M. C., Nicholas, A. W., Manikumar, G., Kirschenbaum, S., Silber, R. & Potmesil, M., 1989, 於 : Cancer Research. 49, 16, p. 4385-4389 5 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
DNA Cleavage
Leukemia L1210
Pharmaceutical Preparations
659 引文 (Scopus)

DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts

Giovanella, B. C., Stehlin, J. S., Wall, M. E., Wani, M. C., Nicholas, A. W., Liu, L-F., Silber, R. & Potmesil, M., 1989, 於 : Science. 246, 4933, p. 1046-1048 3 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Heterografts
Colonic Neoplasms
Drug Therapy

DNA topoisomerase poisons as antitumor drugs

Hsiang, Y. H. & Liu, L-F., 1989, Cancer chemotherapy: challenges for the future: proceedings of the Fourth Nagoya International Symposium on cancer treatment. ICS904. Kimura, K., Ota, K., Carter, S. K., Pinedo, H. M., Kimura, K., Ota, K., Carter, S. K. & Pinedo, H. M. (編輯). Elsevier Science Publishers B.V., p. 305-311 7 p.

研究成果: 書貢獻/報告類型會議貢獻

Type I DNA Topoisomerase
Poisons
Antineoplastic Agents
1857 引文 (Scopus)

DNA topoisomerase poisons as antitumor drugs

Liu, L-F., 1989, 於 : Annual Review of Biochemistry. 58, p. 351-375 25 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Antineoplastic Agents
80 引文 (Scopus)

Evidence for the reversibility of cellular DNA lesion induced by mammalian topoisomerase II poisons

Hsiang, Y. H. & Liu, L-F., 1989, 於 : Journal of Biological Chemistry. 264, 17, p. 9713-9715 3 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Poisons
Teniposide
DNA Breaks
Antineoplastic Agents
67 引文 (Scopus)

Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity

Kasid, U. N., Halligan, B., Liu, L-F., Dritschilo, A. & Smulson, M., 1989, 於 : Journal of Biological Chemistry. 264, 31, p. 18687-18692 6 p.

研究成果: 雜誌貢獻文章

Poly Adenosine Diphosphate Ribose
Type I DNA Topoisomerase
Post Translational Protein Processing
Adenosine Diphosphate
Chromatin
32 引文 (Scopus)
Type I DNA Topoisomerase
Simian virus 40
Neoplasm Antigens
Adenosine Triphosphate
DNA
87 引文 (Scopus)

Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs

Hsiang, W. H., Jiang, J. B. & Liu, L-F., 1989, 於 : Molecular Pharmacology. 36, 3, p. 371-376 6 p.

研究成果: 雜誌貢獻文章

amonafide
Type II DNA Topoisomerase
DNA Cleavage
Antineoplastic Agents
DNA
506 引文 (Scopus)

Topoisomerase-targeting antitumor drugs

D'Arpa, P. & Liu, L-F., 十二月 17 1989, 於 : BBA - Reviews on Cancer. 989, 2, p. 163-177 15 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type II DNA Topoisomerase
Type I DNA Topoisomerase
Drug Design
Antineoplastic Agents
241 引文 (Scopus)

Transcription-driven supercoiling of DNA: Direct biochemical evidence from in vitro studies

Tsao, Y. P., Wu, H. Y. & Liu, L-F., 一月 13 1989, 於 : Cell. 56, 1, p. 111-118 8 p.

研究成果: 雜誌貢獻文章

Transcription
DNA
Elongation
Type I DNA Topoisomerase
Elastic waves
1988
363 引文 (Scopus)

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

Tsai-Pflugfelder, M., Liu, L. F., Liu, A. A., Tewey, K. M., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M. & Wang, J. C., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 19, p. 7177-7181 5 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Organism Cloning
Complementary DNA
Chromosomes
Genes
96 引文 (Scopus)

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2

Juan, C. C., Hwang, J., Liu, A. A., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M., Zhang, H., Wang, J. C. & Liu, L. F., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 23, p. 8910-8913 4 p.

研究成果: 雜誌貢獻文章

Chromosomes
Complementary DNA
Type I DNA Topoisomerase
Genes
Human Chromosomes
815 引文 (Scopus)

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

Hsiang, Y. H. & Liu, L-F., 1988, 於 : Cancer Research. 48, 7, p. 1722-1726 5 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Pharmaceutical Preparations
DNA Breaks
Nucleic Acid Synthesis Inhibitors
248 引文 (Scopus)
Camptothecin
Type I DNA Topoisomerase
rRNA Genes
DNA-Directed RNA Polymerases
HeLa Cells
246 引文 (Scopus)

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., 1988, 於 : Cancer Research. 48, 11, p. 3230-3235 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Cultured Cells
Fibroblasts
Skin
HeLa Cells
40 引文 (Scopus)

Topoisomerases: Novel therapeutic targets in cancer chemotherapy

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., 五月 1 1988, 於 : Biochemical Pharmacology. 37, 9, p. 1801-1802 2 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Antineoplastic Agents
DNA Damage
Cell Cycle
Drug Therapy
56 引文 (Scopus)

Topoisomerases as novel targets for cancer chemotherapy

Bodley, A. L. & Liu, L-F., 1988, 於 : Bio/Technology. 6, 11, p. 1315-1319 5 p.

研究成果: 雜誌貢獻文章

Antineoplastic Agents
Drug Therapy
DNA
Neoplasms
Camptothecin
489 引文 (Scopus)

Transcription generates positively and negatively supercoiled domains in the template

Wu, H. Y., Shyy, S., Wang, J. C. & Liu, L-F., 五月 6 1988, 於 : Cell. 53, 3, p. 433-440 8 p.

研究成果: 雜誌貢獻文章

Transcription
Superhelical DNA
Type I DNA Topoisomerase
Plasmids
DNA
1987
25 引文 (Scopus)

DNA topoisomerase II as a potential factor in drug resistance of human malignancies

Potmesil, M., Hsiang, Y. H., Liu, L-F., Wu, H. Y., Traganos, F., Bank, B. & Silber, R., 1987, 於 : NCI Monographs. 4, p. 105-109 5 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Drug Resistance
Antineoplastic Agents
Leukemia
Mutation
40 引文 (Scopus)

Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targeting antitumor drugs

Kupfer, G., Bodley, A. L. & Liu, L-F., 1987, NCI Monographs. 4 編輯 p. 37-40 4 p.

研究成果: 書貢獻/報告類型章節

Neoplastic Cell Transformation
Teniposide
Podophyllotoxin
Dinitrophenols
Camptothecin
15 引文 (Scopus)

Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II

Silber, R., Liu, L-F., Israel, M., Bodley, A. L., Hsiang, Y. H., Kirschenbaum, S., Sweatman, T. W., Seshadri, R. & Potmesil, M., 1987, 於 : NCI Monographs. 4, p. 111-115 5 p.

研究成果: 雜誌貢獻文章

Inbred Strains Rats
Type II DNA Topoisomerase
Preclinical Drug Evaluations
Inbred Strains Mice
Drug Evaluation