• 33470 引文
  • 87 h-指數
1975 …2018
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研究成果 1975 2018

2000
3 引文 (Scopus)

Rapid chromatin reorganization induced by topoisomerase I-mediated DNA damage

Sun, M. E. I., Duann, P. U., Chin-Tai, L. I. N., Zhang, H. U. I. & Liu, L-F., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 340-342 3 p.

研究成果: 雜誌貢獻文章

Damage
Reorganization
13 引文 (Scopus)

Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: A potential role of ligand-induced DNA bending at a distal site

Sim, S. P., Pilch, D. S. & Liu, L-F., 八月 15 2000, 於 : Biochemistry. 39, 32, p. 9928-9934 7 p.

研究成果: 雜誌貢獻文章

Nogalamycin
Type I DNA Topoisomerase
DNA Cleavage
Ligands
DNA
38 引文 (Scopus)

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Makhey, D., Yu, C., Liu, A., Liu, L-F. & Lavoie, E. J., 五月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 5, p. 1171-1182 12 p.

研究成果: 雜誌貢獻文章

coralyne
Poisons
Derivatives
Acridines
DNA Cleavage
106 引文 (Scopus)

SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y., Desai, S. D. & Liu, L-F., 八月 25 2000, 於 : Journal of Biological Chemistry. 275, 34, p. 26066-26073 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Ubiquitin
Isoenzymes
DNA Damage
Teniposide
166 引文 (Scopus)
Sumoylation
Type I DNA Topoisomerase
Camptothecin
DNA Damage
Yeasts
1 引文 (Scopus)

The camptothecins: Unfolding their anticancer potential: Introduction

Liu, L-F., Desai, S. D., Tsai-Kun, L. I., Yong, M. A. O., Sun, M. E. I. & Sai-Peng, S. I. M., 2000, 於 : Annals of the New York Academy of Sciences. 922

研究成果: 雜誌貢獻文章

Camptothecin
32 引文 (Scopus)

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Rangarajan, M., Kim, J. S., Sim, S. P., Liu, A., Liu, L-F. & LaVoie, E. J., 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 11, p. 2591-2600 10 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cytotoxicity
Poisoning
Derivatives
Poisons
22 引文 (Scopus)

Ubiquitin, SUMO-1, and UCRP in camptothesin sensitivity and resistance

Desai, S. D., Yong, M. A. O., Sun, M. E. I., Tsai-Kun, L. I., Jiaxi, W. U., Liu, L-F. & New Jersey, J., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 306-308 3 p.

研究成果: 雜誌貢獻文章

Ubiquitin
1999
135 引文 (Scopus)

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Li, T. K., Chen, A. Y., Yu, C., Mao, Y., Wang, H. & Liu, L-F., 六月 15 1999, 於 : Genes and Development. 13, 12, p. 1553-1560 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
U937 Cells
Hydrogen Peroxide
Reactive Oxygen Species
Oxidative Stress
40 引文 (Scopus)
Bioactivity
Antineoplastic Agents
Hydroxyl Radical
Derivatives
naphthazarin
68 引文 (Scopus)

Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

Haluska, P., Saleem, A., Rasheed, Z., Ahmed, F., Su, E. W., Liu, L-F. & Rubin, E. H., 六月 15 1999, 於 : Nucleic Acids Research. 27, 12, p. 2538-2544 7 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Serine
Arginine
RING Finger Domains
Proteins
22 引文 (Scopus)

Inversion/Dimerization of plasmids mediated by inverted repeats

Lyu, Y. L., Lin, C. T. & Liu, L-F., 一月 29 1999, 於 : Journal of Molecular Biology. 285, 4, p. 1485-1501 17 p.

研究成果: 雜誌貢獻文章

Dimerization
Genetic Recombination
Plasmids
Cruciform DNA
Inverted Repeat Sequences
46 引文 (Scopus)

Mutations of human topoisomerase IIα affecting multidrug resistance and sensitivity

Mao, Y., Yu, C., Hsieh, T. S., Nitiss, J. L., Liu, A. A., Wang, H. & Liu, L-F., 八月 17 1999, 於 : Biochemistry. 38, 33, p. 10793-10800 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Multiple Drug Resistance
Adenosine Triphosphate
Mutation
Enzymes
11 引文 (Scopus)

Plasmid linking number change induced by topoisomerase I-mediated DNA damage

Duann, P., Sun, M., Lin, C. T., Zhang, H. & Liu, L-F., 七月 15 1999, 於 : Nucleic Acids Research. 27, 14, p. 2905-2911 7 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
DNA Damage
Plasmids
Camptothecin
DNA
1998
39 引文 (Scopus)

DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles

Xu, Z., Li, T. K., Kim, J. S., LaVoie, E. J., Breslauer, K. J., Liu, L-F. & Pilch, D. S., 三月 10 1998, 於 : Biochemistry. 37, 10, p. 3558-3566 9 p.

研究成果: 雜誌貢獻文章

Poisoning
DNA
Poisons
Ligands
human TOP1 protein
14 引文 (Scopus)

Modulation of gyrase-mediated DNA cleavage and cell killing by ATP

Li, T. K. & Liu, L-F., 五月 1998, 於 : Antimicrobial Agents and Chemotherapy. 42, 5, p. 1022-1027 6 p.

研究成果: 雜誌貢獻文章

DNA Cleavage
Poisons
Adenosine Triphosphate
Adenosine Diphosphate
DNA Gyrase
40 引文 (Scopus)

Quantitative structure-activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents

Kim, J. S., Sun, Q., Yu, C., Liu, A., Liu, L-F. & Lavoie, E. J., 二月 1 1998, 於 : Bioorganic and Medicinal Chemistry. 6, 2, p. 163-172 10 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Quantitative Structure-Activity Relationship
Poisons
Cytotoxicity
Antineoplastic Agents
39 引文 (Scopus)
Naphthoquinones
Quinones
Type II DNA Topoisomerase
Biomimetics
Mercaptoethanol
51 引文 (Scopus)

Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells

Sanders, M. M., Liu, A. A., Li, T. K., Wu, H. Y., Desai, S. D., Mao, Y., Rubin, E. H., LaVoie, E. J., Makhey, D. & Liu, L-F., 十一月 1 1998, 於 : Biochemical Pharmacology. 56, 9, p. 1157-1166 10 p.

研究成果: 雜誌貢獻文章

coralyne
Glioblastoma
Cytotoxicity
Biogenic Amines
Cells
5 引文 (Scopus)

Topoisomerase I-targeting drugs. New developments in cancer pharmacology

Gatto, B. & Liu, L-F., 1998, 於 : Advances in DNA Sequence-Specific Agents. 3, C, p. 39-66 28 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Drug Delivery Systems
Pharmacology
Neoplasms
1997
22 引文 (Scopus)

A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats

Lin, C. T., Lyu, Y. L. & Liu, L-F., 八月 1 1997, 於 : Nucleic Acids Research. 25, 15, p. 3009-3016 8 p.

研究成果: 雜誌貢獻文章

DNA
Escherichia coli
DNA Replication
Cruciform DNA
Replication Origin
41 引文 (Scopus)
Type I DNA Topoisomerase
Poisoning
Netropsin
Poisons
DNA
20 引文 (Scopus)

Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles

Goldman, G. H., Yu, C., Wu, H. Y., Sanders, M. M., La Voie, E. J. & Liu, L-F., 五月 27 1997, 於 : Biochemistry. 36, 21, p. 6488-6494 7 p.

研究成果: 雜誌貢獻文章

Aspergillus nidulans
Type I DNA Topoisomerase
Aspergillus
Poisoning
Yeast
38 引文 (Scopus)

Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar

Sim, S. P., Gatto, B., Yu, C., Liu, A. A., Li, T. K., Pilch, D. S., LaVoie, E. J. & Liu, L-F., 十月 28 1997, 於 : Biochemistry. 36, 43, p. 13285-13291 7 p.

研究成果: 雜誌貢獻文章

Menogaril
Nogalamycin
Sugars
Poisoning
Type I DNA Topoisomerase
3 引文 (Scopus)

Incompatibility of Escherichia coli rho mutants with plasmids is mediated by plasmid-specific transcription

Li, T. K., Panchenko, Y. A., Drolet, M. & Liu, L-F., 九月 1997, 於 : Journal of Bacteriology. 179, 18, p. 5789-5794 6 p.

研究成果: 雜誌貢獻文章

Plasmids
Escherichia coli
Thiogalactosides
Viverridae
Gene Silencing
170 引文 (Scopus)

Induction of DNA topoisomerase II-mediated DNA cleavage by β-lapacphone and related naphthoquinones

Frydman, B., Marton, L. J., Sun, J. S., Neder, K., Witiak, D. T., Liu, A. A., Wang, H. M., Mao, Y., Wu, H. Y., Sanders, M. M. & Liu, L-F., 1997, 於 : Cancer Research. 57, 4, p. 620-627 8 p.

研究成果: 雜誌貢獻文章

Naphthoquinones
Type II DNA Topoisomerase
DNA Cleavage
Quinones
Poisoning
37 引文 (Scopus)

Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis

Li, X. G., Haluska, P., Hsiang, Y. H., Bharti, A. K., Kufe, D. W., Liu, L-F. & Rubin, E. H., 四月 4 1997, 於 : Biochemical Pharmacology. 53, 7, p. 1019-1027 9 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Catalysis
Amino Acids
Enzymes
109 引文 (Scopus)

Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

Pilch, D. S., Yu, C., Makhey, D., LaVoie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Breslauer, K. J., Geacintov, N. E. & Liu, L-F., 十月 14 1997, 於 : Biochemistry. 36, 41, p. 12542-12553 12 p.

研究成果: 雜誌貢獻文章

Poisoning
Type I DNA Topoisomerase
Ligands
DNA
human TOP1 protein
122 引文 (Scopus)

Processing of topoisomerase I cleavable complexes into DNA damage by transcription

Wu, J. & Liu, L-F., 十一月 1 1997, 於 : Nucleic Acids Research. 25, 21, p. 4181-4186 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
DNA-Directed RNA Polymerases
DNA Damage
DNA Repair
36 引文 (Scopus)

Terbenzimidazoles: Influence of 2''-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons

Kim, J. S., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 八月 29 1997, 於 : Journal of Medicinal Chemistry. 40, 18, p. 2818-2824 7 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Cytotoxicity
Pharmacology
Cytotoxins
199 引文 (Scopus)

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

Desai, S. D., Liu, L-F., Vazquez-Abad, D. & D'Arpa, P., 九月 26 1997, 於 : Journal of Biological Chemistry. 272, 39, p. 24159-24164 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Ubiquitin
Antineoplastic Agents
Ubiquitination
1996
47 引文 (Scopus)

A replicational model for DNA recombination between direct repeats

Bi, X. & Liu, L-F., 三月 15 1996, 於 : Journal of Molecular Biology. 256, 5, p. 849-858 10 p.

研究成果: 雜誌貢獻文章

Nucleic Acid Repetitive Sequences
Genetic Recombination
DNA
Gene Rearrangement
Genomic Instability
34 引文 (Scopus)

Cellular resistance to topoisomerase poisons.

Rubin, E. H., Li, T. K., Duann, P. & Liu, L-F., 1996, 於 : Cancer Treatment and Research. 87, p. 243-260 18 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Type I DNA Topoisomerase
Poisons
Drug Resistance
Antineoplastic Agents
23 引文 (Scopus)

Characterizing the DNA binding modes of a topoisomerasei-poisoning terbenzimidazole: Evidence for both intercalative and minor groove binding properties

Pilch, D. S., Xu, Z., Sun, Q., Lavoie, E. J., Liu, L-F., Geacintov, N. E. & Breslauer, K. J., 1996, 於 : Drug Design and Discovery. 13, 3-4, p. 115-133 19 p.

研究成果: 雜誌貢獻文章

Poisoning
DNA
Type I DNA Topoisomerase
Netropsin
Fluorescence
83 引文 (Scopus)

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

Makhey, D., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 六月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 6, p. 781-791 11 p.

研究成果: 雜誌貢獻文章

coralyne
Type II DNA Topoisomerase
Type I DNA Topoisomerase
Poisons
Camptothecin
75 引文 (Scopus)

DNA rearrangement mediated by inverted repeats

Bi, X. & Liu, L-F., 一月 23 1996, 於 : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 819-823 5 p.

研究成果: 雜誌貢獻文章

Gene Rearrangement
Genetic Recombination
Genome
DNA Replication
Cruciform DNA
143 引文 (Scopus)

Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne

Gatto, B., Sanders, M. M., Yu, C., Wu, H. Y., Makhey, D., LaVoie, E. J. & Liu, L-F., 六月 15 1996, 於 : Cancer Research. 56, 12, p. 2795-2800 6 p.

研究成果: 雜誌貢獻文章

coralyne
Type I DNA Topoisomerase
Alkaloids
Camptothecin
Benzophenanthridines
61 引文 (Scopus)

Mechanism of action of camptothecin

Liu, L-F., Duann, P., Lin, C. T., D'Arpa, P. & Wu, J., 1996, 於 : Annals of the New York Academy of Sciences. 803, p. 44-49 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
12 引文 (Scopus)
Rec A Recombinases
Bacterial DNA
Sister Chromatid Exchange
DNA Transposable Elements
Nucleic Acid Repetitive Sequences
96 引文 (Scopus)

Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons

Kim, J. S., Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 四月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 4, p. 621-630 10 p.

研究成果: 雜誌貢獻文章

Benzimidazoles
Type I DNA Topoisomerase
Poisons
Structure-Activity Relationship
Topoisomerase I Inhibitors
240 引文 (Scopus)

Substituted 2,5′-Bi-1H-benzimidazoles: Topoisoraerase I inhibition and cytotoxicity

Kim, J. S., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 16 1996, 於 : Journal of Medicinal Chemistry. 39, 4, p. 992-998 7 p.

研究成果: 雜誌貢獻文章

Benzimidazoles
Type I DNA Topoisomerase
Cytotoxicity
Derivatives
Poisons
1995
26 引文 (Scopus)

Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I

D'Arpa, P. & Liu, L-F., 1995, 於 : Experimental Cell Research. 217, 1, p. 125-131 7 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Interphase
Cell Cycle
Phosphorylation
Mitosis
160 引文 (Scopus)
Ribonuclease H
Type I DNA Topoisomerase
Escherichia coli
Growth
DNA Gyrase
15 引文 (Scopus)

Specific stimulation of recA-independent plasmid recombination by a DNA sequence at a distance

Bi, X., Lyu, Y. L. & Liu, L-F., 1995, 於 : Journal of Molecular Biology. 247, 5, p. 890-902 13 p.

研究成果: 雜誌貢獻文章

Genetic Recombination
Plasmids
Tandem Repeat Sequences
Base Pairing
Sequence Analysis
77 引文 (Scopus)

Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors

Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 1995, 於 : Journal of Medicinal Chemistry. 38, 18, p. 3638-3644 7 p.

研究成果: 雜誌貢獻文章

Topoisomerase I Inhibitors
Camptothecin
Cytotoxicity
Type I DNA Topoisomerase
Tumors
1994
38 引文 (Scopus)

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Weinkauf, R. L., Chen, A. Y., Yu, C., Liu, L-F., Barrows, L. & LaVoie, E. J., 1994, 於 : Bioorganic and Medicinal Chemistry. 2, 8, p. 781-786 6 p.

研究成果: 雜誌貢獻文章

ellipticine
Isoquinolines
Quinolines
Heterocyclic Compounds
Antineoplastic Agents
13 引文 (Scopus)

Design of Topoisomerase Inhibitors to Overcome MDR1-Mediated Drug Resistance

Chen, A. Y. & Liu, L-F., 1994, 於 : Advances in pharmacology (San Diego, Calif.). 29, PART B, p. 245-256 12 p.

研究成果: 雜誌貢獻文章

Neoplasm Drug Resistance
Topoisomerase Inhibitors
MDR Genes
Camptothecin
Type II DNA Topoisomerase
746 引文 (Scopus)

DNA topoisomerases: Essential enzymes and lethal targets

Chen, A. Y. & Liu, L-F., 1994, 於 : Annual Review of Pharmacology and Toxicology. 34, p. 191-218 28 p.

研究成果: 雜誌貢獻文章

DNA Topoisomerases
Intercalating Agents
Type II DNA Topoisomerase
Type I DNA Topoisomerase
Drug Resistance
88 引文 (Scopus)

Hypernegative supercoiling of the DNA template during transcription elongation in vitro

Drolet, M., Bi, X. & Liu, L-F., 一月 21 1994, 於 : Journal of Biological Chemistry. 269, 3, p. 2068-2074 7 p.

研究成果: 雜誌貢獻文章

Superhelical DNA
Transcription
Elongation
Plasmids
DNA
26 引文 (Scopus)

Mechanisms of resistance to topoisomerase inhibitors.

Chen, A. Y. & Liu, L-F., 1994, 於 : Cancer Treatment and Research. 73, p. 263-281 19 p.

研究成果: 雜誌貢獻文章

Neoplasm Proteins
Topoisomerase Inhibitors
Cultured Tumor Cells
Camptothecin
Type II DNA Topoisomerase