• 33480 引文
  • 87 h-指數
1975 …2018
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研究成果 1975 2018

2007
181 引文 (Scopus)

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies

Azarova, A. M., Lyu, Y. L., Lin, C. P., Tsai, Y. C., Lau, J. Y. N., Wang, J. C. & Liu, L. F., 六月 26 2007, 於 : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 11014-11019 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Etoposide
Isoenzymes
Drug Therapy
Neoplasms
312 引文 (Scopus)

Targeting mammalian target of rapamycin (mTOR) for health and diseases

Tsang, C. K., Qi, H., Liu, L-F. & Zheng, X. F. S., 二月 2007, 於 : Drug Discovery Today. 12, 3-4, p. 112-124 13 p.

研究成果: 雜誌貢獻文章

Sirolimus
Health
Macrolides
Graft Rejection
Growth
159 引文 (Scopus)

The role of autophagy in mitochondria maintenance: Characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains

Zhang, Y., Qi, H., Taylor, R., Xu, W., Liu, L-F. & Jin, S., 七月 2007, 於 : Autophagy. 3, 4, p. 337-346 10 p.

研究成果: 雜誌貢獻文章

Autophagy
Saccharomyces cerevisiae
Mitochondria
Maintenance
Mitochondrial Membrane Potential
315 引文 (Scopus)

Topoisomerase IIβ-mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

Yi, L. L., Kerrigan, J. E., Lin, C. P., Azarova, A. M., Tsai, Y. C., Ban, Y. & Liu, L. F., 九月 15 2007, 於 : Cancer Research. 67, 18, p. 8839-8846 8 p.

研究成果: 雜誌貢獻文章

Dexrazoxane
Type II DNA Topoisomerase
Double-Stranded DNA Breaks
Doxorubicin
DNA Damage
2006
22 引文 (Scopus)

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2006, 於 : Bioorganic and Medicinal Chemistry. 14, 9, p. 3131-3143 13 p.

研究成果: 雜誌貢獻文章

Lactams
Type I DNA Topoisomerase
Cytotoxicity
Topotecan
Tumor Cell Line
90 引文 (Scopus)

A protease pathway for the repair of topoisomerase II-DNA covalent complexes

Zhang, A., Lyu, Y. L., Lin, C. P., Zhou, N., Azarova, A. M., Wood, L. M. & Liu, L-F., 十一月 24 2006, 於 : Journal of Biological Chemistry. 281, 47, p. 35997-36003 7 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Repair
Peptide Hydrolases
Proteasome Endopeptidase Complex
Etoposide
52 引文 (Scopus)

Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro

Yang, M., Hsu, C. T., Ting, C. Y., Liu, L-F. & Hwang, J., 三月 24 2006, 於 : Journal of Biological Chemistry. 281, 12, p. 8264-8274 11 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Camptothecin
Peptides
Lysine
DNA Damage
107 引文 (Scopus)

Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway

Desai, S. D., Haas, A. L., Wood, L. M., Tsai, Y. C., Pestka, S., Rubin, E. H., Saleem, A., Nur-E-Kamal, A. & Liu, L-F., 一月 15 2006, 於 : Cancer Research. 66, 2, p. 921-928 8 p.

研究成果: 雜誌貢獻文章

Ubiquitin
Genes
Neoplasms
Proteins
Small Interfering RNA
55 引文 (Scopus)

G-quadruplexes induce apoptosis in tumor cells

Qi, H., Lin, C. P., Fu, X., Wood, L. M., Liu, A. A., Tsai, Y. C., Chen, Y., Barbieri, C. M., Pilch, D. S. & Liu, L. F., 十二月 15 2006, 於 : Cancer Research. 66, 24, p. 11808-11816 9 p.

研究成果: 雜誌貢獻文章

G-Quadruplexes
Oligodeoxyribonucleotides
Apoptosis
Tail
JNK Mitogen-Activated Protein Kinases
49 引文 (Scopus)

Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: Synthesis and biological activity

Su, T. L., Lin, Y. W., Chou, T. C., Zhang, X., Bacherikov, V. A., Chen, C. H., Liu, L-F. & Tsai, T. J., 六月 15 2006, 於 : Journal of Medicinal Chemistry. 49, 12, p. 3710-3718 9 p.

研究成果: 雜誌貢獻文章

Bearings (structural)
Acridines
Mustard Plant
Chromophores
Bioactivity
27 引文 (Scopus)

Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia

Hars, E. S., Lyu, Y. L., Lin, C. P. & Liu, L-F., 九月 15 2006, 於 : Cancer Research. 66, 18, p. 8975-8979 5 p.

研究成果: 雜誌貢獻文章

Etoposide
Acute Myeloid Leukemia
Leukemia
Fibroblasts
Plasmids
114 引文 (Scopus)

Role of topoisomerase IIβ in the expression of developmentally regulated genes

Lyu, Y. L., Lin, C. P., Azarova, A. M., Cai, L., Wang, J. C. & Liu, L-F., 十一月 2006, 於 : Molecular and Cellular Biology. 26, 21, p. 7929-7941 13 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Genes
Brain
Histone Deacetylase 2
Embryonic Structures
2005
82 引文 (Scopus)

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 10 2005, 於 : Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

研究成果: 雜誌貢獻文章

Multiple Drug Resistance
Cytotoxicity
Cells
Metabolites
Cell Line
44 引文 (Scopus)

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i] phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A. A., Liu, L-F. & LaVoie, E. J., 十二月 15 2005, 於 : Bioorganic and Medicinal Chemistry. 13, 24, p. 6782-6794 13 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Amides
Esters
Cytotoxicity
33 引文 (Scopus)

Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: Synthesis and biological activity

Bacherikov, V. A., Chou, T. C., Dong, H. J., Zhang, X., Chen, C. H., Lin, Y. W., Tsai, T. J., Lee, R. Z., Liu, L-F. & Su, T. L., 六月 2 2005, 於 : Bioorganic and Medicinal Chemistry. 13, 12, p. 3993-4006 14 p.

研究成果: 雜誌貢獻文章

Bearings (structural)
Mustard Plant
Bioactivity
Tumors
Paclitaxel
2004
48 引文 (Scopus)

11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X., Yang, J. M., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 15 2004, 於 : Bioorganic and Medicinal Chemistry. 12, 4, p. 795-806 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cytotoxicity
Nude Mice
Antineoplastic Agents
Tumors
16 引文 (Scopus)

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Zhu, S., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 十一月 15 2004, 於 : Bioorganic and Medicinal Chemistry Letters. 14, 22, p. 5585-5589 5 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cytotoxicity
Phenanthridines
Derivatives
Lactams
98 引文 (Scopus)

Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death

Daroui, P., Desai, S. D., Li, T. K., Liu, A. A. & Liu, L-F., 四月 9 2004, 於 : Journal of Biological Chemistry. 279, 15, p. 14587-14594 8 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cell death
Hydrogen Peroxide
DNA Damage
Cell Death
25 引文 (Scopus)

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Kerrigan, J. E., Li, T. K., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 七月 1 2004, 於 : Bioorganic and Medicinal Chemistry. 12, 13, p. 3731-3742 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cytotoxicity
Substitution reactions
Derivatives
84 引文 (Scopus)

Nuclear translocation of cytochrome c during apoptosis

Nur-E-Kamal, A., Gross, S. R., Pan, Z., Balklava, Z., Ma, J. & Liu, L-F., 六月 11 2004, 於 : Journal of Biological Chemistry. 279, 24, p. 24911-24914 4 p.

研究成果: 雜誌貢獻文章

Cytochromes c
Apoptosis
Mitochondria
Caspases
Histones
141 引文 (Scopus)

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

Rajendra, R., Malegaonkar, D., Pungaliya, P., Marshall, H., Rasheed, Z., Brownell, J., Liu, L-F., Lutzker, S., Saleem, A. & Rubin, E. H., 八月 27 2004, 於 : Journal of Biological Chemistry. 279, 35, p. 36440-36444 5 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Ubiquitination
Type I DNA Topoisomerase
Osteosarcoma
Proteasome Endopeptidase Complex
2003
11 引文 (Scopus)

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 十月 20 2003, 於 : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Crystal structure
Topotecan
DNA Cleavage
X-Rays
88 引文 (Scopus)

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

研究成果: 雜誌貢獻文章

Naphthyridines
Type I DNA Topoisomerase
Antineoplastic Agents
Tumors
Nude Mice
32 引文 (Scopus)

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 八月 15 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 17, p. 3795-3805 11 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Cytotoxicity
Cell proliferation
Assays
50 引文 (Scopus)

Acidic pH induces topoisomerase II-mediated DNA damage

Xiao, H., Li, T. K., Yang, J. M. & Liu, L-F., 四月 29 2003, 於 : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5205-5210 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
DNA Damage
Ataxia Telangiectasia
Poisons
Carcinogenesis
6 引文 (Scopus)

Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents

Singh, S. K., Ruchelman, A. L., Zhou, N., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 2003, 於 : Medicinal Chemistry Research. 12, 1, p. 1-12 12 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Structure-Activity Relationship
Cytotoxicity
Antineoplastic Agents
85 引文 (Scopus)

Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug

Li, T. K., Houghton, P. J., Desai, S. D., Daroui, P., Liu, A. A., Hars, E. S., Ruchelman, A. L., LaVoie, E. J. & Liu, L-F., 十二月 1 2003, 於 : Cancer Research. 63, 23, p. 8400-8407 8 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Drug Delivery Systems
Camptothecin
irinotecan
Antineoplastic Agents
119 引文 (Scopus)

DNA damage-mediated apoptosis induced by selenium compounds

Zhou, N., Xiao, H., Li, T. K., Nur-E-Kamal, A. & Liu, L-F., 八月 8 2003, 於 : Journal of Biological Chemistry. 278, 32, p. 29532-29537 6 p.

研究成果: 雜誌貢獻文章

Selenium Compounds
Selenious Acid
Type II DNA Topoisomerase
DNA Damage
Automatic teller machines
55 引文 (Scopus)

Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast

Qi, H., Li, T. K., Kuo, D., Nur-E-Kamal, A. & Liu, L-F., 四月 25 2003, 於 : Journal of Biological Chemistry. 278, 17, p. 15136-15141 6 p.

研究成果: 雜誌貢獻文章

Telomere
Yeast
Yeasts
Telomere-Binding Proteins
Chemical activation
48 引文 (Scopus)

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

Ting, C. Y., Hsu, C. T., Hsu, H. T., Su, J. S., Chen, T. Y., Tarn, W. Y., Kuo, Y. H., Whang-Peng, J., Liu, L. F. & Hwang, J., 十一月 15 2003, 於 : Biochemical Pharmacology. 66, 10, p. 1981-1991 11 p.

研究成果: 雜誌貢獻文章

Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Camptothecin
DNA
Diospyros
43 引文 (Scopus)

Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-ones: Effect on topoisomerase-I targeting activity and cytotoxicity

Singh, S. K., Ruchelman, A. L., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 22 2003, 於 : Journal of Medicinal Chemistry. 46, 11, p. 2254-2257 4 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Cytotoxicity
Substitution reactions
Derivatives
42 引文 (Scopus)

Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals

Nur-E-Kamal, A., Li, T. K., Zhang, A., Qi, H., Hars, E. S. & Liu, L-F., 四月 4 2003, 於 : Journal of Biological Chemistry. 278, 14, p. 12475-12481 7 p.

研究成果: 雜誌貢獻文章

Ataxia Telangiectasia
Single-Stranded DNA
DNA Damage
DNA
Apoptosis
40 引文 (Scopus)

Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents

Makhey, D., Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 四月 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 8, p. 1809-1820 12 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Alkaloids
Type I DNA Topoisomerase
DNA Topoisomerases
Derivatives
73 引文 (Scopus)

Substituted dibenzo[c,h]cinnolines: Topoisomerase I-targeting anticancer agents

Yu, Y., Singh, S. K., Liu, A., Li, T. K., Liu, L-F. & LaVoie, E. J., 四月 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 7, p. 1475-1491 17 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cytotoxicity
Camptothecin
61 引文 (Scopus)

The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway

Xiao, H., Mao, Y., Desai, S. D., Zhou, N., Ting, C. Y., Hwang, J. & Liu, L-F., 三月 18 2003, 於 : Proceedings of the National Academy of Sciences of the United States of America. 100, 6, p. 3239-3244 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
DNA Damage
3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
DNA
Poisons
107 引文 (Scopus)

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes

Desai, S. D., Zhang, H., Rodriguez-Bauman, A., Yang, J. M., Wu, X., Gounder, M. K., Rubin, E. H. & Liu, L-F., 四月 2003, 於 : Molecular and Cellular Biology. 23, 7, p. 2341-2350 10 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
RNA
RNA Polymerase II
DNA-Directed RNA Polymerases
DNA
2002
48 引文 (Scopus)

2,3-Dimethoxybenzo[i]phenanthridines: Topoisomerase I-targeting anticancer agents

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 2002, 於 : Bioorganic and Medicinal Chemistry. 11, 4, p. 521-528 8 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cytotoxicity
Tumor Cell Line
49 引文 (Scopus)

Diaza- and triazachrysenes: Potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

Ruchelman, A. L., Singh, S. K., Wu, X., Ray, A., Yang, J. M., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 十一月 18 2002, 於 : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3333-3336 4 p.

研究成果: 雜誌貢獻文章

Heterografts
Nude Mice
Human Activities
Tumors
DNA
2001
126 引文 (Scopus)

26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes

Mao, Y., Desai, S. D., Ting, C. Y., Hwang, J. & Liu, L-F., 十一月 2 2001, 於 : Journal of Biological Chemistry. 276, 44, p. 40652-40658 7 p.

研究成果: 雜誌貢獻文章

Teniposide
Type II DNA Topoisomerase
Proteasome Endopeptidase Complex
Isoenzymes
Dichlororibofuranosylbenzimidazole
47 引文 (Scopus)

ATP-bound Topoisomerase II as a Target for Antitumor Drugs

Wang, H., Mao, Y., Zhou, N., Hu, T., Hsieh, T. S. & Liu, L-F., 五月 11 2001, 於 : Journal of Biological Chemistry. 276, 19, p. 15990-15995 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Antineoplastic Agents
Adenosine Triphosphate
Poisons
DNA Cleavage

Effect of nutritional support on nutritional status and outcome in malnourished cardiac surgery patients

Liou, H. L., Chiou, Y. F., Liu, L. F. & Shih, C. C., 一月 1 2001, 於 : Tzu Chi Medical Journal. 13, 3, p. 177-185 9 p.

研究成果: 雜誌貢獻文章

Nutritional Support
Nutritional Status
Thoracic Surgery
Hospitalization
Ideal Body Weight
45 引文 (Scopus)

Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis

Sim, S. P. & Liu, L-F., 八月 24 2001, 於 : Journal of Biological Chemistry. 276, 34, p. 31590-31595 6 p.

研究成果: 雜誌貢獻文章

Leukemia
Apoptosis
Pharmaceutical Preparations
Etoposide
DNA Cleavage
16 引文 (Scopus)

Sensitivity to camptothecin in Aspergillus nidulans identifies a novel gene, scaA+, related to the cellular DNA damage response

Bruschi, G. C. M., De Souza, C. C., Fagundes, M. R. V. Z. K., Dani, M. A. C., Goldman, M. H. S., Morris, N. R., Liu, L-F. & Goldman, G. H., 2001, 於 : Molecular and General Genetics. 265, 2, p. 264-275 12 p.

研究成果: 雜誌貢獻文章

Aspergillus nidulans
Camptothecin
DNA Damage
Type I DNA Topoisomerase
Genes
128 引文 (Scopus)

Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation

Wang, H., Mao, Y., Chen, A. Y., Zhou, N., Lavoie, E. J. & Liu, L-F., 三月 20 2001, 於 : Biochemistry. 40, 11, p. 3316-3323 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Sulfhydryl Compounds
DNA Damage
Quinones
DNA Cleavage
434 引文 (Scopus)

Tumor cell death induced by topoisomerase-targeting drugs

Li, T. K. & Liu, L-F., 2001, 於 : Annual Review of Pharmacology and Toxicology. 41, p. 53-77 25 p.

研究成果: 雜誌貢獻文章

Cell death
Drug Delivery Systems
DNA Topoisomerases
Tumors
Cell Death
171 引文 (Scopus)

Ubiquitin/26s proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells

Desai, S. D., Li, T. K., Rodriguez-Bauman, A., Liu, L-F. & Liu, L. F., 八月 1 2001, 於 : Cancer Research. 61, 15, p. 5926-5932 7 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
Ubiquitin
Down-Regulation
Neoplasms
2000
14 引文 (Scopus)

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, M., Kim, J. S., Jin, S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 六月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 6, p. 1371-1382 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Cells
Cell Line
Derivatives
43 引文 (Scopus)

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Jin, S., Kim, J. S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 四月 2000, 於 : Bioorganic and Medicinal Chemistry Letters. 10, 8, p. 719-723 5 p.

研究成果: 雜誌貢獻文章

Topoisomerase I Inhibitors
Hydrogen
Derivatives
Atoms
Type I DNA Topoisomerase
90 引文 (Scopus)

Human topoisomerase I poisoning by protoberberines: Potential roles for both drug-DNA and drug-enzyme interactions

Li, T. K., Bathory, E., LaVoie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Liu, L-F. & Pilch, D. S., 六月 20 2000, 於 : Biochemistry. 39, 24, p. 7107-7116 10 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Drug Interactions
Poisoning
DNA
Ligands
344 引文 (Scopus)

Mechanism of action of camptothecin

Liu, L-F., Desai, S. D., Li, T. K., Mao, Y., Sun, M. & Sim, S. P., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 1-10 10 p.

研究成果: 雜誌貢獻文章

Camptothecin
DNA Damage
Tumors
DNA
Repair