• 33458 引文
  • 87 h-指數
1975 …2018
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研究成果 1975 2018

文章
48 引文 (Scopus)

11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X., Yang, J. M., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 15 2004, 於 : Bioorganic and Medicinal Chemistry. 12, 4, p. 795-806 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Cytotoxicity
Nude Mice
Antineoplastic Agents
Tumors
10 引文 (Scopus)

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., 九月 15 2008, 於 : Bioorganic and Medicinal Chemistry. 16, 18, p. 8598-8606 9 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Cytotoxicity
Derivatives
Tumor Cell Line
16 引文 (Scopus)

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., 四月 1 2009, 於 : Bioorganic and Medicinal Chemistry. 17, 7, p. 2877-2885 9 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cell growth
Growth
12 引文 (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, 於 : Mediators of Inflammation. 2016, 6953459.

研究成果: 雜誌貢獻文章

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
48 引文 (Scopus)

2,3-Dimethoxybenzo[i]phenanthridines: Topoisomerase I-targeting anticancer agents

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 2002, 於 : Bioorganic and Medicinal Chemistry. 11, 4, p. 521-528 8 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cytotoxicity
Tumor Cell Line
124 引文 (Scopus)

26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes

Mao, Y., Desai, S. D., Ting, C. Y., Hwang, J. & Liu, L-F., 十一月 2 2001, 於 : Journal of Biological Chemistry. 276, 44, p. 40652-40658 7 p.

研究成果: 雜誌貢獻文章

Teniposide
Type II DNA Topoisomerase
Proteasome Endopeptidase Complex
Isoenzymes
Dichlororibofuranosylbenzimidazole
14 引文 (Scopus)

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, M., Kim, J. S., Jin, S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 六月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 6, p. 1371-1382 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Cells
Cell Line
Derivatives
82 引文 (Scopus)

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 10 2005, 於 : Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

研究成果: 雜誌貢獻文章

Multiple Drug Resistance
Cytotoxicity
Cells
Metabolites
Cell Line
11 引文 (Scopus)

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 十月 20 2003, 於 : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Crystal structure
Topotecan
DNA Cleavage
X-Rays
88 引文 (Scopus)

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

研究成果: 雜誌貢獻文章

Naphthyridines
Type I DNA Topoisomerase
Antineoplastic Agents
Tumors
Nude Mice
22 引文 (Scopus)

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2006, 於 : Bioorganic and Medicinal Chemistry. 14, 9, p. 3131-3143 13 p.

研究成果: 雜誌貢獻文章

Lactams
Type I DNA Topoisomerase
Cytotoxicity
Topotecan
Tumor Cell Line
32 引文 (Scopus)

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 八月 15 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 17, p. 3795-3805 11 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Cytotoxicity
Cell proliferation
Assays
50 引文 (Scopus)

Acidic pH induces topoisomerase II-mediated DNA damage

Xiao, H., Li, T. K., Yang, J. M. & Liu, L-F., 四月 29 2003, 於 : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5205-5210 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
DNA Damage
Ataxia Telangiectasia
Poisons
Carcinogenesis
22 引文 (Scopus)

A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats

Lin, C. T., Lyu, Y. L. & Liu, L-F., 八月 1 1997, 於 : Nucleic Acids Research. 25, 15, p. 3009-3016 8 p.

研究成果: 雜誌貢獻文章

DNA
Escherichia coli
DNA Replication
Cruciform DNA
Replication Origin
16 引文 (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, 於 : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

研究成果: 雜誌貢獻文章

RNA Polymerase II
Proteasome Endopeptidase Complex
Ubiquitin
Adenosine Triphosphatases
Type II DNA Topoisomerase
135 引文 (Scopus)

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Li, T. K., Chen, A. Y., Yu, C., Mao, Y., Wang, H. & Liu, L-F., 六月 15 1999, 於 : Genes and Development. 13, 12, p. 1553-1560 8 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
U937 Cells
Hydrogen Peroxide
Reactive Oxygen Species
Oxidative Stress
1157 引文 (Scopus)

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L-F., 1984, 於 : Science. 226, 4673, p. 466-468 3 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Doxorubicin
DNA Damage
Antineoplastic Agents
Teniposide
40 引文 (Scopus)

A G-quadruplex stabilizer induces M-phase cell cycle arrest

Tsai, Y. C., Qi, H., Lin, C. P., Lin, R. K., Kerrigan, J. E., Rzuczek, S. G., LaVoie, E. J., Rice, J. E., Pilch, D. S., Lyu, Y. L. & Liu, L. F., 八月 21 2009, 於 : Journal of Biological Chemistry. 284, 34, p. 22535-22543 9 p.

研究成果: 雜誌貢獻文章

G-Quadruplexes
M Phase Cell Cycle Checkpoints
Telomerase
Cells
Cell Division
271 引文 (Scopus)

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

Miller, K. G., Liu, L-F. & Englund, P. T., 九月 10 1981, 於 : Journal of Biological Chemistry. 256, 17, p. 9334-9339 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Cell Nucleus
HeLa Cells
Cells
DNA
172 引文 (Scopus)

A model for tumor cell killing by topoisomerase poisons

Zhang, H., D'Arpa, P. & Liu, L-F., 1990, 於 : Cancer Cells. 2, 1, p. 23-26 4 p.

研究成果: 雜誌貢獻文章

Poisons
Double-Stranded DNA Breaks
DNA
Pharmaceutical Preparations
Antineoplastic Agents
149 引文 (Scopus)

A new mammalian DNA topoisomerase I poison Hoechst 33342: Cytotoxicity and drug resistance in human cell cultures

Chen, A. Y., Yu, C., Bodley, A., Peng, L. F. & Liu, L-F., 1993, 於 : Cancer Research. 53, 6, p. 1332-1337 6 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Poisons
Drug Resistance
Coloring Agents
Cell Culture Techniques
29 引文 (Scopus)

A novel role for ATM in regulating proteasome- mediated protein degradation through suppression of the ISG15 conjugation pathway

Wood, L. M., Sankar, S., Reed, R. E., Haas, A. L., Liu, L-F., McKinnon, P. & Desai, S. D., 2011, 於 : PLoS One. 6, 1, e16422.

研究成果: 雜誌貢獻文章

Ataxia Telangiectasia
proteasome endopeptidase complex
Automatic teller machines
Proteasome Endopeptidase Complex
protein degradation
6 引文 (Scopus)

A novel synthetic bipartite carrier protein for developing glycotope-based vaccines

Chiang, H. L., Lin, C. Y., Jan, F. D., Lin, Y. S., Hsu, C. T., Whang-Peng, J., Liu, L. F., Nieh, S., Lin, C. C. & Hwang, J., 十二月 14 2012, 於 : Vaccine. 30, 52, p. 7573-7581 9 p.

研究成果: 雜誌貢獻文章

transport proteins
Carrier Proteins
Vaccines
vaccines
antigens
38 引文 (Scopus)

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Weinkauf, R. L., Chen, A. Y., Yu, C., Liu, L-F., Barrows, L. & LaVoie, E. J., 1994, 於 : Bioorganic and Medicinal Chemistry. 2, 8, p. 781-786 6 p.

研究成果: 雜誌貢獻文章

ellipticine
Isoquinolines
Quinolines
Heterocyclic Compounds
Antineoplastic Agents
42 引文 (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, 於 : Oncotarget. 5, 24, p. 12891-12907 17 p.

研究成果: 雜誌貢獻文章

Breast Neoplasms
Gene Expression
Stilbenes
Cell Proliferation
Perfusion
90 引文 (Scopus)

A protease pathway for the repair of topoisomerase II-DNA covalent complexes

Zhang, A., Lyu, Y. L., Lin, C. P., Zhou, N., Azarova, A. M., Wood, L. M. & Liu, L-F., 十一月 24 2006, 於 : Journal of Biological Chemistry. 281, 47, p. 35997-36003 7 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Repair
Peptide Hydrolases
Proteasome Endopeptidase Complex
Etoposide
11 引文 (Scopus)
Xenopus Proteins
Type I DNA Topoisomerase
Simian virus 40
Neoplasm Antigens
Oocytes
47 引文 (Scopus)

A replicational model for DNA recombination between direct repeats

Bi, X. & Liu, L-F., 三月 15 1996, 於 : Journal of Molecular Biology. 256, 5, p. 849-858 10 p.

研究成果: 雜誌貢獻文章

Nucleic Acid Repetitive Sequences
Genetic Recombination
DNA
Gene Rearrangement
Genomic Instability
966 引文 (Scopus)

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

Hsiang, Y. H., Lihou, M. G. & Liu, L-F., 1989, 於 : Cancer Research. 49, 18, p. 5077-5082 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
Type I DNA Topoisomerase
DNA Replication
Pharmaceutical Preparations
DNA
52 引文 (Scopus)

Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro

Yang, M., Hsu, C. T., Ting, C. Y., Liu, L-F. & Hwang, J., 三月 24 2006, 於 : Journal of Biological Chemistry. 281, 12, p. 8264-8274 11 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Camptothecin
Peptides
Lysine
DNA Damage
50 引文 (Scopus)

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins

Javaherian, K. & Liu, L-F., 一月 25 1983, 於 : Nucleic Acids Research. 11, 2, p. 461-472 12 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Nucleosomes
DNA
Proteins
Protein
26 引文 (Scopus)

A Structured–Activity Relationship Study of Batracylin Analogues

Luo, Y., Ren, Y. F., Chou, T. C., Chen, A. Y., Yu, C., Liu, L-F. & Cheng, C. C., 1993, 於 : Pharmaceutical Research. 10, 6, p. 918-923 6 p.

研究成果: 雜誌貢獻文章

batracylin
Quinazolines
DNA Cleavage
HL-60 Cells
Type II DNA Topoisomerase
41 引文 (Scopus)
Type I DNA Topoisomerase
Poisoning
Netropsin
Poisons
DNA
47 引文 (Scopus)

ATP-bound Topoisomerase II as a Target for Antitumor Drugs

Wang, H., Mao, Y., Zhou, N., Hu, T., Hsieh, T. S. & Liu, L-F., 五月 11 2001, 於 : Journal of Biological Chemistry. 276, 19, p. 15990-15995 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Antineoplastic Agents
Adenosine Triphosphate
Poisons
DNA Cleavage
61 引文 (Scopus)
Adenosine Triphosphate
Escherichia coli
Type I DNA Topoisomerase
DNA
Mutant Proteins
62 引文 (Scopus)

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes

Lin, C. P., Ban, Y., Lyu, Y. L., Desai, S. D. & Liu, L-F., 七月 25 2008, 於 : Journal of Biological Chemistry. 283, 30, p. 21074-21083 10 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Proteasome Endopeptidase Complex
Ubiquitin
Repair
Camptothecin
147 引文 (Scopus)

Autophagy regulates ageing in C. elegans

Hars, E. S., Qi, H., Ryazanov, A. G., Jin, S., Cai, L., Hu, C. & Liu, L-F., 三月 2007, 於 : Autophagy. 3, 2, p. 93-95 3 p.

研究成果: 雜誌貢獻文章

Autophagy
RNA Interference
Genes
Yeasts
Beclin-1
21 引文 (Scopus)

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., 十二月 8 2014, 於 : PLoS One. 9, 12, e111529.

研究成果: 雜誌貢獻文章

cholesteryl ester transfer protein
Cholesterol Ester Transfer Proteins
High Fat Diet
Fatty Liver
high fat diet
6 引文 (Scopus)

Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents

Singh, S. K., Ruchelman, A. L., Zhou, N., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 2003, 於 : Medicinal Chemistry Research. 12, 1, p. 1-12 12 p.

研究成果: 雜誌貢獻文章

Phenanthridines
Type I DNA Topoisomerase
Structure-Activity Relationship
Cytotoxicity
Antineoplastic Agents
2029 引文 (Scopus)

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

Hsiang, Y. H., Hertzberg, R., Hecht, S. & Liu, L-F., 1985, 於 : Journal of Biological Chemistry. 260, 27, p. 14873-14878 6 p.

研究成果: 雜誌貢獻文章

Camptothecin
Biological Models
Type II DNA Topoisomerase
Type I DNA Topoisomerase
DNA Breaks
171 引文 (Scopus)

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

Chen, A. Y., Yu, C., Liu, L-F., Wall, M. E., Wani, M. C. & Liu, L. F., 十一月 15 1991, 於 : Cancer Research. 51, 22, p. 6039-6044 6 p.

研究成果: 雜誌貢獻文章

KB Cells
Camptothecin
Carcinoma
Topotecan
irinotecan
26 引文 (Scopus)

Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I

D'Arpa, P. & Liu, L-F., 1995, 於 : Experimental Cell Research. 217, 1, p. 125-131 7 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Interphase
Cell Cycle
Phosphorylation
Mitosis
34 引文 (Scopus)

Cellular resistance to topoisomerase poisons.

Rubin, E. H., Li, T. K., Duann, P. & Liu, L-F., 1996, 於 : Cancer Treatment and Research. 87, p. 243-260 18 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Type I DNA Topoisomerase
Poisons
Drug Resistance
Antineoplastic Agents
27 引文 (Scopus)

Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy

Chen, G. L. & Liu, L-F., 1986, 於 : Annual Reports in Medicinal Chemistry. 21, C, p. 257-262 6 p.

研究成果: 雜誌貢獻文章

DNA Topoisomerases
Chemotherapy
DNA
Type II DNA Topoisomerase
Type I DNA Topoisomerase
85 引文 (Scopus)

Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug

Li, T. K., Houghton, P. J., Desai, S. D., Daroui, P., Liu, A. A., Hars, E. S., Ruchelman, A. L., LaVoie, E. J. & Liu, L-F., 十二月 1 2003, 於 : Cancer Research. 63, 23, p. 8400-8407 8 p.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Drug Delivery Systems
Camptothecin
irinotecan
Antineoplastic Agents
23 引文 (Scopus)

Characterizing the DNA binding modes of a topoisomerasei-poisoning terbenzimidazole: Evidence for both intercalative and minor groove binding properties

Pilch, D. S., Xu, Z., Sun, Q., Lavoie, E. J., Liu, L-F., Geacintov, N. E. & Breslauer, K. J., 1996, 於 : Drug Design and Discovery. 13, 3-4, p. 115-133 19 p.

研究成果: 雜誌貢獻文章

Poisoning
DNA
Type I DNA Topoisomerase
Netropsin
Fluorescence
87 引文 (Scopus)

Chemotherapeutics and radiation stimulate MHC class i expression through elevated interferon-beta signaling in breast cancer cells

Wan, S., Pestka, S., Jubin, R. G., Lyu, Y. L., Tsai, Y. C. & Liu, L-F., 三月 1 2012, 於 : PLoS One. 7, 3, e32542.

研究成果: 雜誌貢獻文章

interferon-beta
Topotecan
Interferon-beta
major histocompatibility complex
breast neoplasms
466 引文 (Scopus)

Cleavage of DNA by mammalian DNA topoisomerase II.

Liu, L-F., Rowe, T. C., Yang, L., Tewey, K. M. & Chen, G. L., 十二月 25 1983, 於 : Journal of Biological Chemistry. 258, 24, p. 15365-15370 6 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
DNA Cleavage
DNA
DNA Gyrase
Type I DNA Topoisomerase
363 引文 (Scopus)

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

Tsai-Pflugfelder, M., Liu, L. F., Liu, A. A., Tewey, K. M., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M. & Wang, J. C., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 19, p. 7177-7181 5 p.

研究成果: 雜誌貢獻文章

Type II DNA Topoisomerase
Organism Cloning
Complementary DNA
Chromosomes
Genes
83 引文 (Scopus)

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

Makhey, D., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 六月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 6, p. 781-791 11 p.

研究成果: 雜誌貢獻文章

coralyne
Type II DNA Topoisomerase
Type I DNA Topoisomerase
Poisons
Camptothecin