• 34266 引文
  • 88 h-指數
1975 …2018

每年研究成果

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研究成果

文章

11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X., Yang, J. M., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 15 2004, 於 : Bioorganic and Medicinal Chemistry. 12, 4, p. 795-806 12 p.

研究成果: 雜誌貢獻文章

50 引文 斯高帕斯(Scopus)

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., 九月 15 2008, 於 : Bioorganic and Medicinal Chemistry. 16, 18, p. 8598-8606 9 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., 四月 1 2009, 於 : Bioorganic and Medicinal Chemistry. 17, 7, p. 2877-2885 9 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, 於 : Mediators of Inflammation. 2016, 6953459.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

2,3-Dimethoxybenzo[i]phenanthridines: Topoisomerase I-targeting anticancer agents

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 2002, 於 : Bioorganic and Medicinal Chemistry. 11, 4, p. 521-528 8 p.

研究成果: 雜誌貢獻文章

49 引文 斯高帕斯(Scopus)

26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes

Mao, Y., Desai, S. D., Ting, C. Y., Hwang, J. & Liu, L-F., 十一月 2 2001, 於 : Journal of Biological Chemistry. 276, 44, p. 40652-40658 7 p.

研究成果: 雜誌貢獻文章

139 引文 斯高帕斯(Scopus)

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, M., Kim, J. S., Jin, S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 六月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 6, p. 1371-1382 12 p.

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14 引文 斯高帕斯(Scopus)

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 10 2005, 於 : Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

研究成果: 雜誌貢獻文章

84 引文 斯高帕斯(Scopus)

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 十月 20 2003, 於 : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

研究成果: 雜誌貢獻文章

88 引文 斯高帕斯(Scopus)

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., 五月 1 2006, 於 : Bioorganic and Medicinal Chemistry. 14, 9, p. 3131-3143 13 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 八月 15 2003, 於 : Bioorganic and Medicinal Chemistry. 11, 17, p. 3795-3805 11 p.

研究成果: 雜誌貢獻文章

32 引文 斯高帕斯(Scopus)

Acidic pH induces topoisomerase II-mediated DNA damage

Xiao, H., Li, T. K., Yang, J. M. & Liu, L-F., 四月 29 2003, 於 : Proceedings of the National Academy of Sciences of the United States of America. 100, 9, p. 5205-5210 6 p.

研究成果: 雜誌貢獻文章

53 引文 斯高帕斯(Scopus)

A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats

Lin, C. T., Lyu, Y. L. & Liu, L-F., 八月 1 1997, 於 : Nucleic Acids Research. 25, 15, p. 3009-3016 8 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L. F., 2013, 於 : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Li, T. K., Chen, A. Y., Yu, C., Mao, Y., Wang, H. & Liu, L-F., 六月 15 1999, 於 : Genes and Development. 13, 12, p. 1553-1560 8 p.

研究成果: 雜誌貢獻文章

137 引文 斯高帕斯(Scopus)

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L-F., 1984, 於 : Science. 226, 4673, p. 466-468 3 p.

研究成果: 雜誌貢獻文章

1189 引文 斯高帕斯(Scopus)

A G-quadruplex stabilizer induces M-phase cell cycle arrest

Tsai, Y. C., Qi, H., Lin, C. P., Lin, R. K., Kerrigan, J. E., Rzuczek, S. G., LaVoie, E. J., Rice, J. E., Pilch, D. S., Lyu, Y. L. & Liu, L. F., 八月 21 2009, 於 : Journal of Biological Chemistry. 284, 34, p. 22535-22543 9 p.

研究成果: 雜誌貢獻文章

41 引文 斯高帕斯(Scopus)

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

Miller, K. G., Liu, L-F. & Englund, P. T., 九月 10 1981, 於 : Journal of Biological Chemistry. 256, 17, p. 9334-9339 6 p.

研究成果: 雜誌貢獻文章

272 引文 斯高帕斯(Scopus)

A model for tumor cell killing by topoisomerase poisons

Zhang, H., D'Arpa, P. & Liu, L-F., 1990, 於 : Cancer Cells. 2, 1, p. 23-26 4 p.

研究成果: 雜誌貢獻文章

173 引文 斯高帕斯(Scopus)

A new mammalian DNA topoisomerase I poison Hoechst 33342: Cytotoxicity and drug resistance in human cell cultures

Chen, A. Y., Yu, C., Bodley, A., Peng, L. F. & Liu, L-F., 1993, 於 : Cancer Research. 53, 6, p. 1332-1337 6 p.

研究成果: 雜誌貢獻文章

153 引文 斯高帕斯(Scopus)

A novel role for ATM in regulating proteasome- mediated protein degradation through suppression of the ISG15 conjugation pathway

Wood, L. M., Sankar, S., Reed, R. E., Haas, A. L., Liu, L-F., McKinnon, P. & Desai, S. D., 2011, 於 : PLoS One. 6, 1, e16422.

研究成果: 雜誌貢獻文章

32 引文 斯高帕斯(Scopus)

A novel synthetic bipartite carrier protein for developing glycotope-based vaccines

Chiang, H. L., Lin, C. Y., Jan, F. D., Lin, Y. S., Hsu, C. T., Whang-Peng, J., Liu, L. F., Nieh, S., Lin, C. C. & Hwang, J., 十二月 14 2012, 於 : Vaccine. 30, 52, p. 7573-7581 9 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Weinkauf, R. L., Chen, A. Y., Yu, C., Liu, L-F., Barrows, L. & LaVoie, E. J., 1994, 於 : Bioorganic and Medicinal Chemistry. 2, 8, p. 781-786 6 p.

研究成果: 雜誌貢獻文章

42 引文 斯高帕斯(Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, 於 : Oncotarget. 5, 24, p. 12891-12907 17 p.

研究成果: 雜誌貢獻文章

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46 引文 斯高帕斯(Scopus)

A protease pathway for the repair of topoisomerase II-DNA covalent complexes

Zhang, A., Lyu, Y. L., Lin, C. P., Zhou, N., Azarova, A. M., Wood, L. M. & Liu, L-F., 十一月 24 2006, 於 : Journal of Biological Chemistry. 281, 47, p. 35997-36003 7 p.

研究成果: 雜誌貢獻文章

95 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

A replicational model for DNA recombination between direct repeats

Bi, X. & Liu, L-F., 三月 15 1996, 於 : Journal of Molecular Biology. 256, 5, p. 849-858 10 p.

研究成果: 雜誌貢獻文章

51 引文 斯高帕斯(Scopus)

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

Hsiang, Y. H., Lihou, M. G. & Liu, L-F., 1989, 於 : Cancer Research. 49, 18, p. 5077-5082 6 p.

研究成果: 雜誌貢獻文章

978 引文 斯高帕斯(Scopus)

Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro

Yang, M., Hsu, C. T., Ting, C. Y., Liu, L-F. & Hwang, J., 三月 24 2006, 於 : Journal of Biological Chemistry. 281, 12, p. 8264-8274 11 p.

研究成果: 雜誌貢獻文章

53 引文 斯高帕斯(Scopus)

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins

Javaherian, K. & Liu, L-F., 一月 25 1983, 於 : Nucleic Acids Research. 11, 2, p. 461-472 12 p.

研究成果: 雜誌貢獻文章

50 引文 斯高帕斯(Scopus)

A Structured–Activity Relationship Study of Batracylin Analogues

Luo, Y., Ren, Y. F., Chou, T. C., Chen, A. Y., Yu, C., Liu, L-F. & Cheng, C. C., 1993, 於 : Pharmaceutical Research. 10, 6, p. 918-923 6 p.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)
41 引文 斯高帕斯(Scopus)

ATP-bound Topoisomerase II as a Target for Antitumor Drugs

Wang, H., Mao, Y., Zhou, N., Hu, T., Hsieh, T. S. & Liu, L-F., 五月 11 2001, 於 : Journal of Biological Chemistry. 276, 19, p. 15990-15995 6 p.

研究成果: 雜誌貢獻文章

48 引文 斯高帕斯(Scopus)
63 引文 斯高帕斯(Scopus)

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes

Lin, C. P., Ban, Y., Lyu, Y. L., Desai, S. D. & Liu, L-F., 七月 25 2008, 於 : Journal of Biological Chemistry. 283, 30, p. 21074-21083 10 p.

研究成果: 雜誌貢獻文章

69 引文 斯高帕斯(Scopus)

Autophagy regulates ageing in C. elegans

Hars, E. S., Qi, H., Ryazanov, A. G., Jin, S., Cai, L., Hu, C. & Liu, L-F., 三月 2007, 於 : Autophagy. 3, 2, p. 93-95 3 p.

研究成果: 雜誌貢獻文章

153 引文 斯高帕斯(Scopus)

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., 十二月 8 2014, 於 : PLoS ONE. 9, 12, e111529.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents

Singh, S. K., Ruchelman, A. L., Zhou, N., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., 2003, 於 : Medicinal Chemistry Research. 12, 1, p. 1-12 12 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

Hsiang, Y. H., Hertzberg, R., Hecht, S. & Liu, L-F., 1985, 於 : Journal of Biological Chemistry. 260, 27, p. 14873-14878 6 p.

研究成果: 雜誌貢獻文章

2061 引文 斯高帕斯(Scopus)

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells

Chen, A. Y., Yu, C., Liu, L-F., Wall, M. E., Wani, M. C. & Liu, L. F., 十一月 15 1991, 於 : Cancer Research. 51, 22, p. 6039-6044 6 p.

研究成果: 雜誌貢獻文章

173 引文 斯高帕斯(Scopus)

Cell cycle-specific and transcription-related phosphorylation of mammalian topoisomerase I

D'Arpa, P. & Liu, L-F., 1995, 於 : Experimental Cell Research. 217, 1, p. 125-131 7 p.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

Cellular resistance to topoisomerase poisons.

Rubin, E. H., Li, T. K., Duann, P. & Liu, L-F., 1996, 於 : Cancer Treatment and Research. 87, p. 243-260 18 p.

研究成果: 雜誌貢獻文章

34 引文 斯高帕斯(Scopus)

Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy

Chen, G. L. & Liu, L-F., 1986, 於 : Annual Reports in Medicinal Chemistry. 21, C, p. 257-262 6 p.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug

Li, T. K., Houghton, P. J., Desai, S. D., Daroui, P., Liu, A. A., Hars, E. S., Ruchelman, A. L., LaVoie, E. J. & Liu, L. F., 十二月 1 2003, 於 : Cancer Research. 63, 23, p. 8400-8407 8 p.

研究成果: 雜誌貢獻文章

86 引文 斯高帕斯(Scopus)

Characterizing the DNA binding modes of a topoisomerasei-poisoning terbenzimidazole: Evidence for both intercalative and minor groove binding properties

Pilch, D. S., Xu, Z., Sun, Q., Lavoie, E. J., Liu, L-F., Geacintov, N. E. & Breslauer, K. J., 1996, 於 : Drug Design and Discovery. 13, 3-4, p. 115-133 19 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

Chemotherapeutics and radiation stimulate MHC class i expression through elevated interferon-beta signaling in breast cancer cells

Wan, S., Pestka, S., Jubin, R. G., Lyu, Y. L., Tsai, Y. C. & Liu, L. F., 三月 1 2012, 於 : PLoS ONE. 7, 3, e32542.

研究成果: 雜誌貢獻文章

108 引文 斯高帕斯(Scopus)

Cleavage of DNA by mammalian DNA topoisomerase II.

Liu, L-F., Rowe, T. C., Yang, L., Tewey, K. M. & Chen, G. L., 十二月 25 1983, 於 : Journal of Biological Chemistry. 258, 24, p. 15365-15370 6 p.

研究成果: 雜誌貢獻文章

471 引文 斯高帕斯(Scopus)

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

Tsai-Pflugfelder, M., Liu, L. F., Liu, A. A., Tewey, K. M., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M. & Wang, J. C., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 19, p. 7177-7181 5 p.

研究成果: 雜誌貢獻文章

365 引文 斯高帕斯(Scopus)

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

Makhey, D., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 六月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 6, p. 781-791 11 p.

研究成果: 雜誌貢獻文章

84 引文 斯高帕斯(Scopus)