• 34347 引文
  • 88 h-指數
1975 …2018

每年研究成果

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研究成果

1996

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

Makhey, D., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 六月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 6, p. 781-791 11 p.

研究成果: 雜誌貢獻文章

84 引文 斯高帕斯(Scopus)

DNA rearrangement mediated by inverted repeats

Bi, X. & Liu, L-F., 一月 23 1996, 於 : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 819-823 5 p.

研究成果: 雜誌貢獻文章

77 引文 斯高帕斯(Scopus)

Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne

Gatto, B., Sanders, M. M., Yu, C., Wu, H. Y., Makhey, D., LaVoie, E. J. & Liu, L-F., 六月 15 1996, 於 : Cancer Research. 56, 12, p. 2795-2800 6 p.

研究成果: 雜誌貢獻文章

145 引文 斯高帕斯(Scopus)

Mechanism of action of camptothecin

Liu, L-F., Duann, P., Lin, C. T., D'Arpa, P. & Wu, J., 1996, 於 : Annals of the New York Academy of Sciences. 803, p. 44-49 6 p.

研究成果: 雜誌貢獻文章

63 引文 斯高帕斯(Scopus)
12 引文 斯高帕斯(Scopus)

Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons

Kim, J. S., Sun, Q., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 四月 1996, 於 : Bioorganic and Medicinal Chemistry. 4, 4, p. 621-630 10 p.

研究成果: 雜誌貢獻文章

98 引文 斯高帕斯(Scopus)

Substituted 2,5′-Bi-1H-benzimidazoles: Topoisoraerase I inhibition and cytotoxicity

Kim, J. S., Gatto, B., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 二月 16 1996, 於 : Journal of Medicinal Chemistry. 39, 4, p. 992-998 7 p.

研究成果: 雜誌貢獻文章

246 引文 斯高帕斯(Scopus)
1997

A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats

Lin, C. T., Lyu, Y. L. & Liu, L-F., 八月 1 1997, 於 : Nucleic Acids Research. 25, 15, p. 3009-3016 8 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)
41 引文 斯高帕斯(Scopus)

Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles

Goldman, G. H., Yu, C., Wu, H. Y., Sanders, M. M., La Voie, E. J. & Liu, L-F., 五月 27 1997, 於 : Biochemistry. 36, 21, p. 6488-6494 7 p.

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar

Sim, S. P., Gatto, B., Yu, C., Liu, A. A., Li, T. K., Pilch, D. S., LaVoie, E. J. & Liu, L-F., 十月 28 1997, 於 : Biochemistry. 36, 43, p. 13285-13291 7 p.

研究成果: 雜誌貢獻文章

38 引文 斯高帕斯(Scopus)

Incompatibility of Escherichia coli rho mutants with plasmids is mediated by plasmid-specific transcription

Li, T. K., Panchenko, Y. A., Drolet, M. & Liu, L-F., 九月 1997, 於 : Journal of Bacteriology. 179, 18, p. 5789-5794 6 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Induction of DNA topoisomerase II-mediated DNA cleavage by β-lapacphone and related naphthoquinones

Frydman, B., Marton, L. J., Sun, J. S., Neder, K., Witiak, D. T., Liu, A. A., Wang, H. M., Mao, Y., Wu, H. Y., Sanders, M. M. & Liu, L-F., 1997, 於 : Cancer Research. 57, 4, p. 620-627 8 p.

研究成果: 雜誌貢獻文章

171 引文 斯高帕斯(Scopus)

Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis

Li, X. G., Haluska, P., Hsiang, Y. H., Bharti, A. K., Kufe, D. W., Liu, L-F. & Rubin, E. H., 四月 4 1997, 於 : Biochemical Pharmacology. 53, 7, p. 1019-1027 9 p.

研究成果: 雜誌貢獻文章

37 引文 斯高帕斯(Scopus)

Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

Pilch, D. S., Yu, C., Makhey, D., LaVoie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Breslauer, K. J., Geacintov, N. E. & Liu, L. F., 十月 14 1997, 於 : Biochemistry. 36, 41, p. 12542-12553 12 p.

研究成果: 雜誌貢獻文章

109 引文 斯高帕斯(Scopus)

Processing of topoisomerase I cleavable complexes into DNA damage by transcription

Wu, J. & Liu, L-F., 十一月 1 1997, 於 : Nucleic Acids Research. 25, 21, p. 4181-4186 6 p.

研究成果: 雜誌貢獻文章

123 引文 斯高帕斯(Scopus)

Terbenzimidazoles: Influence of 2''-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons

Kim, J. S., Yu, C., Liu, A., Liu, L-F. & LaVoie, E. J., 八月 29 1997, 於 : Journal of Medicinal Chemistry. 40, 18, p. 2818-2824 7 p.

研究成果: 雜誌貢獻文章

36 引文 斯高帕斯(Scopus)

Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

Desai, S. D., Liu, L-F., Vazquez-Abad, D. & D'Arpa, P., 九月 26 1997, 於 : Journal of Biological Chemistry. 272, 39, p. 24159-24164 6 p.

研究成果: 雜誌貢獻文章

208 引文 斯高帕斯(Scopus)
1998

DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles

Xu, Z., Li, T. K., Kim, J. S., LaVoie, E. J., Breslauer, K. J., Liu, L-F. & Pilch, D. S., 三月 10 1998, 於 : Biochemistry. 37, 10, p. 3558-3566 9 p.

研究成果: 雜誌貢獻文章

39 引文 斯高帕斯(Scopus)

Modulation of gyrase-mediated DNA cleavage and cell killing by ATP

Li, T. K. & Liu, L-F., 五月 1998, 於 : Antimicrobial Agents and Chemotherapy. 42, 5, p. 1022-1027 6 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Quantitative structure-activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents

Kim, J. S., Sun, Q., Yu, C., Liu, A., Liu, L-F. & Lavoie, E. J., 二月 1 1998, 於 : Bioorganic and Medicinal Chemistry. 6, 2, p. 163-172 10 p.

研究成果: 雜誌貢獻文章

41 引文 斯高帕斯(Scopus)
39 引文 斯高帕斯(Scopus)

Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells

Sanders, M. M., Liu, A. A., Li, T. K., Wu, H. Y., Desai, S. D., Mao, Y., Rubin, E. H., LaVoie, E. J., Makhey, D. & Liu, L-F., 十一月 1 1998, 於 : Biochemical Pharmacology. 56, 9, p. 1157-1166 10 p.

研究成果: 雜誌貢獻文章

52 引文 斯高帕斯(Scopus)

Topoisomerase I-targeting drugs. New developments in cancer pharmacology

Gatto, B. & Liu, L-F., 1998, 於 : Advances in DNA Sequence-Specific Agents. 3, C, p. 39-66 28 p.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)
1999

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Li, T. K., Chen, A. Y., Yu, C., Mao, Y., Wang, H. & Liu, L-F., 六月 15 1999, 於 : Genes and Development. 13, 12, p. 1553-1560 8 p.

研究成果: 雜誌貢獻文章

137 引文 斯高帕斯(Scopus)
41 引文 斯高帕斯(Scopus)

Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

Haluska, P., Saleem, A., Rasheed, Z., Ahmed, F., Su, E. W., Liu, L-F. & Rubin, E. H., 六月 15 1999, 於 : Nucleic Acids Research. 27, 12, p. 2538-2544 7 p.

研究成果: 雜誌貢獻文章

70 引文 斯高帕斯(Scopus)

Inversion/Dimerization of plasmids mediated by inverted repeats

Lyu, Y. L., Lin, C. T. & Liu, L-F., 一月 29 1999, 於 : Journal of Molecular Biology. 285, 4, p. 1485-1501 17 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

Mutations of human topoisomerase IIα affecting multidrug resistance and sensitivity

Mao, Y., Yu, C., Hsieh, T. S., Nitiss, J. L., Liu, A. A., Wang, H. & Liu, L-F., 八月 17 1999, 於 : Biochemistry. 38, 33, p. 10793-10800 8 p.

研究成果: 雜誌貢獻文章

46 引文 斯高帕斯(Scopus)

Plasmid linking number change induced by topoisomerase I-mediated DNA damage

Duann, P., Sun, M., Lin, C. T., Zhang, H. & Liu, L-F., 七月 15 1999, 於 : Nucleic Acids Research. 27, 14, p. 2905-2911 7 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)
2000

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, M., Kim, J. S., Jin, S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 六月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 6, p. 1371-1382 12 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Jin, S., Kim, J. S., Sim, S. P., Liu, A., Pilch, D. S., Liu, L-F. & Lavoie, E. J., 四月 2000, 於 : Bioorganic and Medicinal Chemistry Letters. 10, 8, p. 719-723 5 p.

研究成果: 雜誌貢獻文章

44 引文 斯高帕斯(Scopus)

Human topoisomerase I poisoning by protoberberines: Potential roles for both drug-DNA and drug-enzyme interactions

Li, T. K., Bathory, E., LaVoie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Liu, L. F. & Pilch, D. S., 六月 20 2000, 於 : Biochemistry. 39, 24, p. 7107-7116 10 p.

研究成果: 雜誌貢獻文章

91 引文 斯高帕斯(Scopus)

Mechanism of action of camptothecin

Liu, L. F., Desai, S. D., Li, T. K., Mao, Y., Sun, M. & Sim, S. P., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 1-10 10 p.

研究成果: 雜誌貢獻文章

362 引文 斯高帕斯(Scopus)

Rapid chromatin reorganization induced by topoisomerase I-mediated DNA damage

Sun, M. E. I., Duann, P. U., Chin-Tai, L. I. N., Zhang, H. U. I. & Liu, L-F., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 340-342 3 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: A potential role of ligand-induced DNA bending at a distal site

Sim, S. P., Pilch, D. S. & Liu, L-F., 八月 15 2000, 於 : Biochemistry. 39, 32, p. 9928-9934 7 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Makhey, D., Yu, C., Liu, A., Liu, L-F. & Lavoie, E. J., 五月 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 5, p. 1171-1182 12 p.

研究成果: 雜誌貢獻文章

38 引文 斯高帕斯(Scopus)

SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y., Desai, S. D. & Liu, L. F., 八月 25 2000, 於 : Journal of Biological Chemistry. 275, 34, p. 26066-26073 8 p.

研究成果: 雜誌貢獻文章

109 引文 斯高帕斯(Scopus)
168 引文 斯高帕斯(Scopus)

The camptothecins: Unfolding their anticancer potential: Introduction

Liu, L-F., Desai, S. D., Tsai-Kun, L. I., Yong, M. A. O., Sun, M. E. I. & Sai-Peng, S. I. M., 2000, 於 : Annals of the New York Academy of Sciences. 922

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Rangarajan, M., Kim, J. S., Sim, S. P., Liu, A., Liu, L-F. & LaVoie, E. J., 2000, 於 : Bioorganic and Medicinal Chemistry. 8, 11, p. 2591-2600 10 p.

研究成果: 雜誌貢獻文章

35 引文 斯高帕斯(Scopus)

Ubiquitin, SUMO-1, and UCRP in camptothesin sensitivity and resistance

Desai, S. D., Yong, M. A. O., Sun, M. E. I., Tsai-Kun, L. I., Jiaxi, W. U., Liu, L-F. & New Jersey, J., 2000, 於 : Annals of the New York Academy of Sciences. 922, p. 306-308 3 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)
2001

26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes

Mao, Y., Desai, S. D., Ting, C. Y., Hwang, J. & Liu, L-F., 十一月 2 2001, 於 : Journal of Biological Chemistry. 276, 44, p. 40652-40658 7 p.

研究成果: 雜誌貢獻文章

139 引文 斯高帕斯(Scopus)

ATP-bound Topoisomerase II as a Target for Antitumor Drugs

Wang, H., Mao, Y., Zhou, N., Hu, T., Hsieh, T. S. & Liu, L. F., 五月 11 2001, 於 : Journal of Biological Chemistry. 276, 19, p. 15990-15995 6 p.

研究成果: 雜誌貢獻文章

49 引文 斯高帕斯(Scopus)

Effect of nutritional support on nutritional status and outcome in malnourished cardiac surgery patients

Liou, H. L., Chiou, Y. F., Liu, L. F. & Shih, C. C., 一月 1 2001, 於 : Tzu Chi Medical Journal. 13, 3, p. 177-185 9 p.

研究成果: 雜誌貢獻文章

Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis

Sim, S. P. & Liu, L-F., 八月 24 2001, 於 : Journal of Biological Chemistry. 276, 34, p. 31590-31595 6 p.

研究成果: 雜誌貢獻文章

46 引文 斯高帕斯(Scopus)

Sensitivity to camptothecin in Aspergillus nidulans identifies a novel gene, scaA+, related to the cellular DNA damage response

Bruschi, G. C. M., De Souza, C. C., Fagundes, M. R. V. Z. K., Dani, M. A. C., Goldman, M. H. S., Morris, N. R., Liu, L-F. & Goldman, G. H., 2001, 於 : Molecular and General Genetics. 265, 2, p. 264-275 12 p.

研究成果: 雜誌貢獻文章

17 引文 斯高帕斯(Scopus)

Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation

Wang, H., Mao, Y., Chen, A. Y., Zhou, N., Lavoie, E. J. & Liu, L-F., 三月 20 2001, 於 : Biochemistry. 40, 11, p. 3316-3323 8 p.

研究成果: 雜誌貢獻文章

130 引文 斯高帕斯(Scopus)

Tumor cell death induced by topoisomerase-targeting drugs

Li, T. K. & Liu, L. F., 2001, 於 : Annual Review of Pharmacology and Toxicology. 41, p. 53-77 25 p.

研究成果: 雜誌貢獻回顧型文獻

448 引文 斯高帕斯(Scopus)

Ubiquitin/26s proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells

Desai, S. D., Li, T. K., Rodriguez-Bauman, A., Liu, L-F. & Liu, L. F., 八月 1 2001, 於 : Cancer Research. 61, 15, p. 5926-5932 7 p.

研究成果: 雜誌貢獻文章

178 引文 斯高帕斯(Scopus)