• 34260 引文
  • 88 h-指數
1975 …2018

每年研究成果

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研究成果

1975

On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy

Liu, L-F. & Wang, J. C., 七月 23 1975, 於 : BBA Section Nucleic Acids And Protein Synthesis. 395, 4, p. 405-412 8 p.

研究成果: 雜誌貢獻文章

56 引文 斯高帕斯(Scopus)
1976
138 引文 斯高帕斯(Scopus)
1978

DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme

Liu, L-F. & Wang, J. C., 1978, 於 : Cell. 15, 3, p. 979-984 6 p.

研究成果: 雜誌貢獻文章

131 引文 斯高帕斯(Scopus)
101 引文 斯高帕斯(Scopus)
148 引文 斯高帕斯(Scopus)

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

Javaherian, K., Liu, L-F. & Wang, J. C., 1978, 於 : Science. 199, 4335, p. 1345-1346 2 p.

研究成果: 雜誌貢獻文章

175 引文 斯高帕斯(Scopus)

Nonhistone proteins HMG1 and HMG2 unwind DNA double helix

Javaherian, K., Sadeghi, M. & Liu, L-F., 八月 10 1979, 於 : Nucleic Acids Research. 6, 11, p. 3569-3580 12 p.

研究成果: 雜誌貢獻文章

77 引文 斯高帕斯(Scopus)

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Liu, L-F., Liu, C. C. & Alberts, B. M., 1979, 於 : Nature. 281, 5731, p. 456-461 6 p.

研究成果: 雜誌貢獻文章

156 引文 斯高帕斯(Scopus)
1980

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

Liu, L-F., Liu, C. C. & Alberts, B. M., 1980, 於 : Cell. 19, 3, p. 697-707 11 p.

研究成果: 雜誌貢獻文章

370 引文 斯高帕斯(Scopus)
1981

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

Miller, K. G., Liu, L-F. & Englund, P. T., 九月 10 1981, 於 : Journal of Biological Chemistry. 256, 17, p. 9334-9339 6 p.

研究成果: 雜誌貢獻文章

272 引文 斯高帕斯(Scopus)
328 引文 斯高帕斯(Scopus)

Knotted DNA from bacteriophage capsids

Liu, L-F., Perkocha, L., Calendar, R. & Wang, J. C., 1981, 於 : Proceedings of the National Academy of Sciences of the United States of America. 78, 9 II, p. 5498-5502 5 p.

研究成果: 雜誌貢獻文章

73 引文 斯高帕斯(Scopus)

Novel topologically knotted DNA from bacteriophage P4 capsids: Studies with DNA topoisomerases

Liu, L-F., Davis, J. L. & Calender, R., 1981, 於 : Nucleic Acids Research. 9, 16, p. 3979-3989 11 p.

研究成果: 雜誌貢獻文章

174 引文 斯高帕斯(Scopus)
1982

Intra- and intermolecular strand transfer by HeLa DNA topoisomerase I.

Halligan, B. D., Davis, J. L., Edwards, K. A. & Liu, L-F., 四月 10 1982, 於 : Journal of Biological Chemistry. 257, 7, p. 3995-4000 6 p.

研究成果: 雜誌貢獻文章

86 引文 斯高帕斯(Scopus)

Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA

Edwards, K. A., Halligan, B. D., Davis, J. L., Nivera, N. L. & Liu, L-F., 四月 24 1982, 於 : Nucleic Acids Research. 10, 8, p. 2565-2576 12 p.

研究成果: 雜誌貢獻文章

93 引文 斯高帕斯(Scopus)
1983

Association of eukaryotic DNA topoisomerase I with nucleosomes and chromosomal proteins

Javaherian, K. & Liu, L-F., 一月 25 1983, 於 : Nucleic Acids Research. 11, 2, p. 461-472 12 p.

研究成果: 雜誌貢獻文章

50 引文 斯高帕斯(Scopus)

Cleavage of DNA by mammalian DNA topoisomerase II.

Liu, L-F., Rowe, T. C., Yang, L., Tewey, K. M. & Chen, G. L., 十二月 25 1983, 於 : Journal of Biological Chemistry. 258, 24, p. 15365-15370 6 p.

研究成果: 雜誌貢獻文章

471 引文 斯高帕斯(Scopus)
166 引文 斯高帕斯(Scopus)

HeLa topoisomerase I

Liu, L-F., 1983, 於 : Methods in Enzymology. Vol. 100, p. 133-137 5 p.

研究成果: 雜誌貢獻文章

31 引文 斯高帕斯(Scopus)
1984

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L-F., 1984, 於 : Science. 226, 4673, p. 466-468 3 p.

研究成果: 雜誌貢獻文章

1189 引文 斯高帕斯(Scopus)

Identification of the breakage-reunion subunit of T4 DNA topoisomerase

Rowe, T. C., Tewey, K. M. & Liu, L-F., 1984, 於 : Journal of Biological Chemistry. 259, 14, p. 9177-9181 5 p.

研究成果: 雜誌貢獻文章

67 引文 斯高帕斯(Scopus)

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Tewey, K. M., Chen, G. L., Nelson, E. M. & Liu, L-F., 1984, 於 : Journal of Biological Chemistry. 259, 14, p. 9182-9187 6 p.

研究成果: 雜誌貢獻文章

513 引文 斯高帕斯(Scopus)

Mechanism of antitumor drug action: Poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

Nelson, E. M., Tewey, K. M. & Liu, L-F., 1984, ISOTOPENPRAXIS. 1 編輯 卷 20. p. 1361-1365 5 p.

研究成果: 書貢獻/報告類型章節

578 引文 斯高帕斯(Scopus)

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Chen, G. L., Yang, L., Rowe, T. C., Halligan, B. D., Tewey, K. M. & Liu, L-F., 1984, 於 : Journal of Biological Chemistry. 259, 21, p. 13560-13566 7 p.

研究成果: 雜誌貢獻文章

620 引文 斯高帕斯(Scopus)

Role of Topoisomerase II in Mediating Epipodophyllotoxin-induced DNA Cleavage

Ross, W., Glisson, B., Yalowich, J., Rowe, T. & Liu, L-F., 十二月 1 1984, 於 : Cancer Research. 44, p. 5857-5860 4 p.

研究成果: 雜誌貢獻文章

439 引文 斯高帕斯(Scopus)
1985

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

Hsiang, Y. H., Hertzberg, R., Hecht, S. & Liu, L-F., 1985, 於 : Journal of Biological Chemistry. 260, 27, p. 14873-14878 6 p.

研究成果: 雜誌貢獻文章

2061 引文 斯高帕斯(Scopus)

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin

Yang, L., Rowe, T. C., Nelson, E. M. & Liu, L-F., 1985, 於 : Cell. 41, 1, p. 127-132 6 p.

研究成果: 雜誌貢獻文章

112 引文 斯高帕斯(Scopus)

Purification and characterization of a type II DNA topoisomerase from bovine calf thymus

Halligan, B. D., Edwards, K. A. & Liu, L-F., 1985, 於 : Journal of Biological Chemistry. 260, 4, p. 2475-2482 8 p.

研究成果: 雜誌貢獻文章

196 引文 斯高帕斯(Scopus)

Topoisomerase II is a structural component of mitotic chromosome scaffolds

Earnshaw, W. C., Halligan, B., Cooke, C. A., Heck, M. M. S. & Liu, L-F., 五月 1 1985, 於 : Journal of Cell Biology. 100, 5, p. 1706-1715 10 p.

研究成果: 雜誌貢獻文章

573 引文 斯高帕斯(Scopus)
1986

Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy

Chen, G. L. & Liu, L-F., 1986, 於 : Annual Reports in Medicinal Chemistry. 21, C, p. 257-262 6 p.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II

Rowe, T. C., Chen, G. L., Hsiang, Y. H. & Liu, L-F., 1986, 於 : Cancer Research. 46, 4 II, p. 2021-2026 6 p.

研究成果: 雜誌貢獻文章

236 引文 斯高帕斯(Scopus)

Induction of sister chromatid exchanges by inhibitors of topoisomerases

Lim, M., Liu, L-F., Jacobson-Kram, D. & Williams, J. R., 十二月 1986, 於 : Cell Biology and Toxicology. 2, 4, p. 485-494 10 p.

研究成果: 雜誌貢獻文章

37 引文 斯高帕斯(Scopus)

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin

Rowe, T. C., Wang, J. C. & Liu, L-F., 1986, 於 : Molecular and Cellular Biology. 6, 4, p. 985-992 8 p.

研究成果: 雜誌貢獻文章

75 引文 斯高帕斯(Scopus)

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

Nelson, W. G., Liu, L-F. & Coffey, D. S., 1986, 於 : Nature. 322, 6075, p. 187-189 3 p.

研究成果: 雜誌貢獻文章

152 引文 斯高帕斯(Scopus)
1987

DNA topoisomerase II as a potential factor in drug resistance of human malignancies

Potmesil, M., Hsiang, Y. H., Liu, L-F., Wu, H. Y., Traganos, F., Bank, B. & Silber, R., 1987, 於 : NCI Monographs. 4, p. 105-109 5 p.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targeting antitumor drugs

Kupfer, G., Bodley, A. L. & Liu, L-F., 1987, NCI Monographs. 4 編輯 p. 37-40 4 p.

研究成果: 書貢獻/報告類型章節

40 引文 斯高帕斯(Scopus)

Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II

Silber, R., Liu, L-F., Israel, M., Bodley, A. L., Hsiang, Y. H., Kirschenbaum, S., Sweatman, T. W., Seshadri, R. & Potmesil, M., 1987, 於 : NCI Monographs. 4, p. 111-115 5 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Regulation of DNA topoisomerases during cellular differentiation

Bodley, A. L., Wu, H. Y. & Liu, L-F., 1987, NCI Monographs. 4 編輯 p. 31-35 5 p.

研究成果: 書貢獻/報告類型章節

29 引文 斯高帕斯(Scopus)

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro

Yang, L., Wold, M. S., Li, J. J., Kelly, T. J. & Liu, L-F., 1987, 於 : Proceedings of the National Academy of Sciences of the United States of America. 84, 4, p. 950-954 5 p.

研究成果: 雜誌貢獻文章

233 引文 斯高帕斯(Scopus)

Supercoiling of the DNA template during transcription.

Liu, L-F. & Wang, J. C., 十月 1987, 於 : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7024-7027 4 p.

研究成果: 雜誌貢獻文章

1361 引文 斯高帕斯(Scopus)
1988

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

Tsai-Pflugfelder, M., Liu, L. F., Liu, A. A., Tewey, K. M., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M. & Wang, J. C., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 19, p. 7177-7181 5 p.

研究成果: 雜誌貢獻文章

365 引文 斯高帕斯(Scopus)

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2

Juan, C. C., Hwang, J., Liu, A. A., Whang-Peng, J., Knutsen, T., Huebner, K., Croce, C. M., Zhang, H., Wang, J. C. & Liu, L. F., 1988, 於 : Proceedings of the National Academy of Sciences of the United States of America. 85, 23, p. 8910-8913 4 p.

研究成果: 雜誌貢獻文章

98 引文 斯高帕斯(Scopus)

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

Hsiang, Y. H. & Liu, L-F., 1988, 於 : Cancer Research. 48, 7, p. 1722-1726 5 p.

研究成果: 雜誌貢獻文章

825 引文 斯高帕斯(Scopus)
250 引文 斯高帕斯(Scopus)

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., 1988, 於 : Cancer Research. 48, 11, p. 3230-3235 6 p.

研究成果: 雜誌貢獻文章

249 引文 斯高帕斯(Scopus)

Topoisomerases: Novel therapeutic targets in cancer chemotherapy

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., 五月 1 1988, 於 : Biochemical Pharmacology. 37, 9, p. 1801-1802 2 p.

研究成果: 雜誌貢獻文章

40 引文 斯高帕斯(Scopus)

Topoisomerases as novel targets for cancer chemotherapy

Bodley, A. L. & Liu, L-F., 1988, 於 : Bio/Technology. 6, 11, p. 1315-1319 5 p.

研究成果: 雜誌貢獻文章

57 引文 斯高帕斯(Scopus)

Transcription generates positively and negatively supercoiled domains in the template

Wu, H. Y., Shyy, S., Wang, J. C. & Liu, L-F., 五月 6 1988, 於 : Cell. 53, 3, p. 433-440 8 p.

研究成果: 雜誌貢獻文章

503 引文 斯高帕斯(Scopus)
1989

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

Hsiang, Y. H., Lihou, M. G. & Liu, L-F., 1989, 於 : Cancer Research. 49, 18, p. 5077-5082 6 p.

研究成果: 雜誌貢獻文章

978 引文 斯高帕斯(Scopus)