如果您對這些純文本內容做了任何改變,很快就會看到。

研究成果

  • 550 引文
  • 13 h-指數
  • 44 文章
  • 4 回顧型文獻
  • 3 會議貢獻
2020

Evaluation of machine learning methods to stroke outcome prediction using a nationwide disease registry

Lin, C. H., Hsu, K. C., Johnson, K. R., Fann, Y. C., Tsai, C. H., Sun, Y., Lien, L. M., Chang, W. L., Chen, P. L., Lin, C. L. & Hsu, C. Y., 七月 2020, 於 : Computer Methods and Programs in Biomedicine. 190, 105381.

研究成果: 雜誌貢獻文章

2019
5 引文 斯高帕斯(Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., 一月 1 2019, 於 : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

研究成果: 雜誌貢獻文章

開啟存取
1 引文 斯高帕斯(Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., 五月 1 2019, 於 : IUBMB Life. 71, 5, p. 539-548 10 p.

研究成果: 雜誌貢獻回顧型文獻

2 引文 斯高帕斯(Scopus)
開啟存取
5 引文 斯高帕斯(Scopus)

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., 五月 27 2019, 於 : Journal of Biomedical Science. 26, 1, 42.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
1 引文 斯高帕斯(Scopus)
2018

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, 於 : Frontiers in Pharmacology. 9, p. 1379

研究成果: 雜誌貢獻文章

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., 七月 3 2018, 於 : Frontiers in Pharmacology. 9, JUL, 708.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., 一月 1 2018, 於 : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation

Chang, C. C., Lin, C. C., Wang, C. H., Huang, C. C., Ke, T. W., Wei, P. L., Yeh, K. T., Hsu, K. C., Hsu, N. Y. & Cheng, Y. W., 五月 1 2018, 於 : Oncology Letters. 15, 5, p. 8107-8117 11 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
2017

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 12336.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 3228.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Structural Insights into the Cytotoxic Mechanism of Vibrio parahaemolyticus PirAvp and PirBvp Toxins

Lin, S-J., Hsu, K-C. & Wang, H-C., 十二月 1 2017, 於 : Marine Drugs. 15, 12

研究成果: 雜誌貢獻回顧型文獻

13 引文 斯高帕斯(Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., 十二月 1 2017, 於 : PLoS One. 12, 12, e0189461.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., 十一月 1 2017, 於 : Molecules. 22, 11, 1897.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)
2016

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., 十一月 10 2016, 於 : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Huang, K. W., Hsu, K. C., Chu, L. Y., Yang, J. M., Yuan, H. S. & Hsiao, Y. Y., 九月 8 2016, 於 : Journal of Medicinal Chemistry. 59, 17, p. 8019-8029 11 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., 六月 24 2016, 於 : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., 四月 1 2016, 於 : CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., 五月 19 2016, 於 : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
2015

Anchor-based classification and type-C inhibitors for tyrosine kinases

Hsu, K. C., Sung, T. Y., Lin, C. T., Chiu, Y. Y., Hsu, J. T. A., Hung, H. C., Sun, C. M., Barve, I., Chen, W. L., Huang, W. C., Huang, C. T., Chen, C. H. & Yang, J. M., 六月 16 2015, 於 : Scientific Reports. 5, 10938.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 五月 1 2015, 於 : NeuroToxicology. 48, p. 120-130 11 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
2014

5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Ma, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., Chen, C. Y., Chung, T. S., Li, S., Ho, C. T. & Pan, M. H., 2014, 於 : Journal of Functional Foods. 11, C, p. 528-537 10 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

Crowning proteins: Modulating the protein surface properties using crown ethers

Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W. Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., 十一月 24 2014, 於 : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.

研究成果: 雜誌貢獻文章

31 引文 斯高帕斯(Scopus)

DNA mimic proteins: Functions, structures, and bioinformatic analysis

Wang, H. C., Ho, C. H., Hsu, K. C., Yang, J. M. & Wang, A. H. J., 五月 13 2014, 於 : Biochemistry. 53, 18, p. 2865-2874 10 p.

研究成果: 雜誌貢獻回顧型文獻

19 引文 斯高帕斯(Scopus)

Homopharma: A new concept for exploring the molecular binding mechanisms and drug repurposing

Chiu, Y. Y., Tseng, J. H., Liu, K. H., Lin, C. T., Hsu, K. C. & Yang, J. M., 十二月 8 2014, 於 : BMC Genomics. 15, S8.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

KDM4B as a target for prostate cancer: Structural analysis and selective inhibition by a novel inhibitor

Chu, C. H., Wang, L. Y., Hsu, K. C., Chen, C. C., Cheng, H. H., Wang, S. M., Wu, C. M., Chen, T. J., Li, L. T., Liu, R., Hung, C. L., Yang, J. M., Kung, H. J. & Wang, W. C., 七月 24 2014, 於 : Journal of Medicinal Chemistry. 57, 14, p. 5975-5985 11 p.

研究成果: 雜誌貢獻文章

49 引文 斯高帕斯(Scopus)

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor

Wang, H. C., Hsu, K. C., Yang, J. M., Wu, M. L., Ko, T. P., Lin, S. R. & Wang, A. H. J., 2014, 於 : Nucleic Acids Research. 42, 2, p. 1354-1364 11 p.

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)
2013

KIDFamMap: A database of kinase-inhibitor-disease family maps for kinase inhibitor selectivity and binding mechanisms

Chiu, Y. Y., Lin, C. T., Huang, J. W., Hsu, K. C., Tseng, J. H., You, S. R. & Yang, J. M., 一月 1 2013, 於 : Nucleic Acids Research. 41, D1

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Parallel Screening of Wild-Type and Drug-Resistant Targets for Anti-Resistance Neuraminidase Inhibitors

Hsu, K. C., Hung, H. C., Horng, J. T., Fang, M. Y., Chang, C. Y., Li, L. T., Chen, I. J., Chen, Y. C., Chou, D. L., Chang, C. W., Hsieh, H. P., Yang, J. M. & Hsu, J. T. A., 二月 20 2013, 於 : PLoS One. 8, 2, e56704.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways

Hsu, K. C., Cheng, W. C., Chen, Y. F., Wang, W. C. & Yang, J. M., 七月 2013, 於 : PLoS Computational Biology. 9, 7, e1003127.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Rank-based interolog mapping for predicting proteinprotein interactions between genomes

Lo, Y. S., Chen, C. C., Hsu, K-C. & Yang, J. M., 2013, International Conference on Systems Biology, ISB. IEEE Computer Society, p. 55-62 8 p. 6623794

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

Lin, C. H., Chang, T. C., Das, A., Fang, M. Y., Hung, H. C., Hsu, K. C., Yang, J. M., Von Itzstein, M., Mong, K. K. T., Hsu, T. A. & Lin, C. C., 六月 28 2013, 於 : Organic and Biomolecular Chemistry. 11, 24, p. 3943-3948 6 p.

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)
2012

Core site-moiety maps reveal inhibitors and binding mechanisms of orthologous proteins by screening compound libraries

Hsu, K. C., Cheng, W. C., Chen, Y. F., Wang, H. J., Li, L. T., Wang, W. C. & Yang, J. M., 二月 29 2012, 於 : PLoS One. 7, 2, e32142.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

GemAffinity: A scoring function for predicting binding affinity and Virtual Screening

Hsu, K. C., Chen, Y. F. & Yang, J. M., 二月 2012, 於 : International Journal of Data Mining and Bioinformatics. 6, 1, p. 27-41 15 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets.

Chiu, Y. Y., Lin, C. Y., Lin, C. T., Hsu, K. C., Chang, L. Z. & Yang, J. M., 2012, 於 : BMC Genomics. 13 Suppl 7, S21.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism

Cheng, W. C., Chen, Y. F., Wang, H. J., Hsu, K. C., Lin, S. C., Chen, T. J., Yang, J. M. & Wang, W. C., 三月 16 2012, 於 : PLoS One. 7, 3, e33481.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)
2011

7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration

Tsai, C. C., Liu, H. F., Hsu, K. C., Yang, J. M., Chen, C., Liu, K. K., Hsu, T. S. & Chao, J. I., 四月 1 2011, 於 : Biochemical Pharmacology. 81, 7, p. 856-865 10 p.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

Igemdock: A graphical environment of enhancing gemdock using pharmacological interactions and post-screening analysis

Hsu, K. C., Chen, Y. F., Lin, S. R. & Yang, J. M., 二月 15 2011, 於 : BMC Bioinformatics. 12, SUPPL. 1, S33.

研究成果: 雜誌貢獻文章

121 引文 斯高帕斯(Scopus)

LigSeeSVM: Ligand-based virtual Screening using Support Vector Machines and data fusion

Chen, Y. F., Hsu, K. C., Lin, P. T., Frank Hsu, D., Kristal, B. S. & Yang, J. M., 七月 2011, 於 : International Journal of Computational Biology and Drug Design. 4, 3, p. 274-289 16 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

The relevance of protein-ligand interaction profiles in computer-aided novel compound design and applications

Clinciu, D. L., Yang, J. M., Hsu, K. C., Lo, C. C., Wallace, S. & Yu, H. C., 九月 2011, 於 : Current Bioinformatics. 6, 3, p. 383-388 6 p.

研究成果: 雜誌貢獻文章

2010

ATRIPPI: An atom-residue preference scoring function for protein-protein interactions

Liu, K. P., Hsu, K. C., Huang, J. W., Chang, L. S. & Yang, J. M., 六月 2010, 於 : International Journal on Artificial Intelligence Tools. 19, 3, p. 251-266 16 p.

研究成果: 雜誌貢獻文章

SiMMap: A web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties

Chen, Y. F., Hsu, K. C., Lin, S. R., Wang, W. C., Huang, Y. C. & Yang, J. M., 六月 2 2010, 於 : Nucleic Acids Research. 38, SUPPL. 2, gkq480.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)
2009

GemAffinity: A scoring function for predicting binding affinity and virtual screening

Hsu, K. C., Chen, Y. F. & Yang, J. M., 2009, 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009. p. 309-314 6 p. 5341774

研究成果: 書貢獻/報告類型會議貢獻