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研究成果

  • 3060 引文
  • 30 h-指數
  • 131 文章
  • 7 回顧型文獻
  • 4 評論/辯論
2020

Anaplastic lymphoma kinase inhibitors: an updated patent review (2014–2018)

Liu, Y. M., Kuo, C. N. & Liou, J. P., 一月 1 2020, (接受/付印) 於 : Expert Opinion on Therapeutic Patents.

研究成果: 雜誌貢獻回顧型文獻

CK1δ as a potential therapeutic target to treat bladder cancer

Lin, Y. C., Chen, M. C., Hsieh, T. H., Liou, J. P. & Chen, C. H., 四月 15 2020, 於 : Aging. 12, 7, p. 5764-5780 17 p.

研究成果: 雜誌貢獻文章

開啟存取
1 引文 斯高帕斯(Scopus)

Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells

Wu, W. C., Liu, Y. M., Liao, Y. H., Hsu, K. C., Lien, S. T., Chen, I. C., Lai, M. J., Li, Y. H., Pan, S. L., Chen, M. C. & Liou, J. P., 十月 1 2020, 於 : European Journal of Medicinal Chemistry. 203, 112540.

研究成果: 雜誌貢獻文章

Histone lysine specific demethylase 1 inhibitors

Mehndiratta, S. & Liou, J. P., 九月 2020, 於 : RSC Medicinal Chemistry. 11, 9, p. 969-981 13 p.

研究成果: 雜誌貢獻回顧型文獻

Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma

Yang, W-B., Hsu, C-C., Hsu, T-I., Liou, J-P., Chang, K-Y., Chen, P-Y., Liu, J-J., Yang, S-T., Wang, J-Y., Yeh, S-H., Chen, R-M., Chang, W-C. & Chuang, J-Y., 四月 24 2020, 於 : Neuro-Oncology.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 一月 1 2020, 於 : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)
2 引文 斯高帕斯(Scopus)
1 引文 斯高帕斯(Scopus)

Recent Update of HDAC Inhibitors in Lymphoma

Chen, I. C., Sethy, B. & Liou, J. P., 九月 3 2020, 於 : Frontiers in Cell and Developmental Biology. 8, 576391.

研究成果: 雜誌貢獻回顧型文獻

開啟存取

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 二月 1 2020, 於 : Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

研究成果: 雜誌貢獻文章

2019
7 引文 斯高帕斯(Scopus)
2 引文 斯高帕斯(Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., 六月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Chao, M. W., Chang, L. H., Tu, H. J., Chang, C. D., Lai, M. J., Chen, Y. Y., Liou, J. P., Teng, C. M. & Pan, S. L., 五月 29 2019, 於 : Clinical Epigenetics. 11, 1, 85.

研究成果: 雜誌貢獻文章

開啟存取
5 引文 斯高帕斯(Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., 一月 1 2019, 於 : Frontiers in Oncology. 9, APR, p. 249 249.

研究成果: 雜誌貢獻文章

開啟存取
7 引文 斯高帕斯(Scopus)
開啟存取
5 引文 斯高帕斯(Scopus)

Nitro-Group-Containing Drugs

Nepali, K., Lee, H. Y. & Liou, J. P., 三月 28 2019, 於 : Journal of Medicinal Chemistry. 62, 6, p. 2851-2893 43 p.

研究成果: 雜誌貢獻回顧型文獻

66 引文 斯高帕斯(Scopus)
4 引文 斯高帕斯(Scopus)
開啟存取
2 引文 斯高帕斯(Scopus)
開啟存取
2018

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 一月 1 2018, 於 : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

研究成果: 雜誌貢獻文章

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., 十二月 29 2018, 於 : Clinical Epigenetics. 10, 1, 162.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
19 引文 斯高帕斯(Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., 十月 1 2018, 於 : Redox Biology. 19, p. 74-80 7 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)
2017
5 引文 斯高帕斯(Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., 七月 7 2017, 於 : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., 二月 9 2017, 於 : Scientific Reports. 7, 42291.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huan, H. M., 八月 18 2017, (接受/付印) 於 : Apoptosis. p. 1 1 p.

研究成果: 雜誌貢獻文章

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 八月 15 2017, 於 : Cancer Research. 77, 16, p. 4305-4316 12 p.

研究成果: 雜誌貢獻文章

32 引文 斯高帕斯(Scopus)
7 引文 斯高帕斯(Scopus)

Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets

Liu, Y. M., Nepali, K. & Liou, J. P., 一月 26 2017, 於 : Journal of Medicinal Chemistry. 60, 2, p. 527-553 27 p.

研究成果: 雜誌貢獻回顧型文獻

38 引文 斯高帕斯(Scopus)
5 引文 斯高帕斯(Scopus)

Pharmacokinetics and protein binding of MPT0B292

Tien, Y. E., Li, C. J., Liou, J. P., Chang, J. Y. & Huang, J. D., 2017, (接受/付印) 於 : Biopharmaceutics and Drug Disposition.

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)