• 708 引文
  • 17 h-指數
20092020

每年研究成果

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研究成果

  • 708 引文
  • 17 h-指數
  • 44 文章
  • 2 回顧型文獻
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文章

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 七月 2013, 於 : ChemBioChem. 14, 10, p. 1248-1254 7 p.

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)
16 引文 斯高帕斯(Scopus)
6 引文 斯高帕斯(Scopus)

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 十月 21 2016, 於 : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H-Y., Chang, J-Y., Lai, M-J., Kuo, C-C., Lee, H. Y., Hsieh, H-P., Chen, Y-J., Chen, L-T., Pan, W-Y. & Liou, J. P., 三月 7 2011, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 十二月 22 2011, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: 雜誌貢獻文章

42 引文 斯高帕斯(Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

An improved screening model to identify inhibitors targeting zinc-enhanced amyloid aggregation

Chang, P. T., Kung, F. L., Talekar, R. S., Chen, C. S., Lai, S. Y., Lee, H. Y. & Chern, J. W., 八月 15 2009, 於 : Analytical Chemistry. 81, 16, p. 6944-6951 8 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於 : Oncotarget. 5, 20, p. 9838-9850 13 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)
27 引文 斯高帕斯(Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 四月 22 2014, 於 : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
5 引文 斯高帕斯(Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 五月 22 2014, 於 : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

研究成果: 雜誌貢獻文章

38 引文 斯高帕斯(Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 九月 1 2014, 於 : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J-Y., Chang, L-Y., Lai, W-Y., Lai, M-J., Shih, K-H., Kuo, C-C., Chang, C-Y. & Liou, J. P., 五月 7 2011, 於 : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 一月 1 2018, 於 : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

研究成果: 雜誌貢獻文章

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., 十月 22 2014, 於 : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., 十一月 28 2014, 於 : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)
18 引文 斯高帕斯(Scopus)

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, 於 : Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

研究成果: 雜誌貢獻文章

37 引文 斯高帕斯(Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., 十月 6 2014, 於 : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 七月 2013, 於 : ChemBioChem. 14, 10, p. 1150 1 p.

研究成果: 雜誌貢獻文章

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10 引文 斯高帕斯(Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

17 引文 斯高帕斯(Scopus)
21 引文 斯高帕斯(Scopus)
9 引文 斯高帕斯(Scopus)
13 引文 斯高帕斯(Scopus)

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., 一月 1 2019, 於 : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M-J., Chang, J-Y., Lee, H. Y., Kuo, C-C., Lin, M. H., Hsieh, H-P., Chang, C-Y., Wu, J-S., Wu, S-Y., Shey, K-S. & Liou, J. P., 九月 2011, 於 : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

研究成果: 雜誌貢獻文章

28 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

Lai, M. J., Huang, H. L., Pan, S. L., Liu, Y. M., Peng, C. Y., Lee, H. Y., Yeh, T. K., Huang, P. H., Teng, C. M., Chen, C. S., Chuang, H. Y. & Liou, J. P., 四月 26 2012, 於 : Journal of Medicinal Chemistry. 55, 8, p. 3777-3791 15 p.

研究成果: 雜誌貢獻文章

48 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 二月 1 2020, 於 : Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

研究成果: 雜誌貢獻文章

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 三月 2011, 於 : Molecules. 16, 3, p. 2274-2284 11 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J-Y., Lai, M-J., Chang, Y-T., Lee, H. Y., Cheng, Y-C., Kuo, C-C., Su, M-C., Chang, C-Y. & Liou, J. P., 八月 2010, 於 : MedChemComm. 1, 2, p. 152-155 4 p.

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., 四月 22 2016, 於 : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
3 引文 斯高帕斯(Scopus)

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., 一月 2014, 於 : Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

研究成果: 雜誌貢獻文章

55 引文 斯高帕斯(Scopus)