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研究成果 2009 2019

  • 553 引文
  • 15 h-指數
  • 41 文章
  • 2 回顧型文獻
篩選
文章
2019
3 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., 一月 1 2019, 於 : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Hydrazones
Neoplasms
Pancreatic Neoplasms
Catalytic Domain
2018
13 引文 (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
9 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 一月 1 2018, 於 : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Emotions
2017
9 引文 (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
3 引文 (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
6 引文 (Scopus)
Carbolines
Histone Deacetylases
Cytotoxicity
Hydroxamic Acids
Indoles
2 引文 (Scopus)
Stilbenes
Rhizome
Glycosides
Metabolites
Oxidation
2016
4 引文 (Scopus)

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 十月 21 2016, 於 : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Antineoplastic Agents
Acetylation
Acrylamide
Structure-Activity Relationship
7 引文 (Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., 四月 22 2016, 於 : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

研究成果: 雜誌貢獻文章

Stilbenes
Decarboxylation
Cyclization
phenanthrene
denbinobin
2015
13 引文 (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
6 引文 (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
14 引文 (Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
KB Cells
Colchicine
Tubulin
Polymerization
6 引文 (Scopus)
Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
15 引文 (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
7 引文 (Scopus)
HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
2014
7 引文 (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於 : Oncotarget. 5, 20, p. 9838-9850 13 p.

研究成果: 雜誌貢獻文章

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
7 引文 (Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 四月 22 2014, 於 : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

研究成果: 雜誌貢獻文章

Benzophenones
Antimitotic Agents
KB Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
32 引文 (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 五月 22 2014, 於 : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

研究成果: 雜誌貢獻文章

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
5 引文 (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 九月 1 2014, 於 : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase
15 引文 (Scopus)

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., 十月 22 2014, 於 : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

研究成果: 雜誌貢獻文章

Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
MicroRNAs
Interleukin-1
Osteoarthritis
4 引文 (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., 十一月 28 2014, 於 : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tumors
Substitution reactions
selectivity
substitutes
16 引文 (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., 十月 6 2014, 於 : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Cell Survival
Anti-Inflammatory Agents
Cells
19 引文 (Scopus)

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Hsieh, I-N., Liou, J. P., Lee, H. Y., Lai, M-J., Li, Y-H. & Yang, C-R., 2014, 於 : Cell Death and Disease. 5, 4, e1166.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Arthritis
Pharmacokinetics
Histone Deacetylases
Oral Administration
45 引文 (Scopus)

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., 一月 2014, 於 : Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Microtubules
Spindle Apparatus
Tubulin
Neoplasms
2013
12 引文 (Scopus)

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 七月 2013, 於 : ChemBioChem. 14, 10, p. 1248-1254 7 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Cytokines
Anti-Inflammatory Agents
Inflammation
30 引文 (Scopus)

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, 於 : Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

研究成果: 雜誌貢獻文章

Tubulin
Antineoplastic Agents
Body Weight Changes
G2 Phase
Colchicine

Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 七月 2013, 於 : ChemBioChem. 14, 10, p. 1150 1 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Carrageenan
Lipopolysaccharides
Rats
Cytokines
2012
23 引文 (Scopus)

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Huang, H-L., Lee, H. Y., Tsai, A-C., Peng, C-Y., Lai, M-J., Wang, J-C., Pan, S. L., Teng, C-M. & Liou, J. P., 八月 22 2012, 於 : PLoS One. 7, 8, e43645.

研究成果: 雜誌貢獻文章

HCT116 Cells
histone deacetylase
Histone Deacetylase Inhibitors
colorectal neoplasms
Colorectal Neoplasms
4 引文 (Scopus)
colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
45 引文 (Scopus)

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

Lai, M. J., Huang, H. L., Pan, S. L., Liu, Y. M., Peng, C. Y., Lee, H. Y., Yeh, T. K., Huang, P. H., Teng, C. M., Chen, C. S., Chuang, H. Y. & Liou, J. P., 四月 26 2012, 於 : Journal of Medicinal Chemistry. 55, 8, p. 3777-3791 15 p.

研究成果: 雜誌貢獻文章

Indoles
Histone Deacetylase Inhibitors
Heterografts
Isoenzymes
Cell Line
2011
12 引文 (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H-Y., Chang, J-Y., Lai, M-J., Kuo, C-C., Lee, H. Y., Hsieh, H-P., Chen, Y-J., Chen, L-T., Pan, W-Y. & Liou, J. P., 三月 7 2011, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
40 引文 (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 十二月 22 2011, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
17 引文 (Scopus)

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

Lee, H. Y., Chang, J-Y., Chang, L-Y., Lai, W-Y., Lai, M-J., Shih, K-H., Kuo, C-C., Chang, C-Y. & Liou, J. P., 五月 7 2011, 於 : Organic and Biomolecular Chemistry. 9, 9, p. 3154-3157 4 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Antimitotic Agents
disrupting
Stilbenes
stilbene
24 引文 (Scopus)

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Lai, M-J., Chang, J-Y., Lee, H. Y., Kuo, C-C., Lin, M. H., Hsieh, H-P., Chang, C-Y., Wu, J-S., Wu, S-Y., Shey, K-S. & Liou, J. P., 九月 2011, 於 : European Journal of Medicinal Chemistry. 46, 9, p. 3623-3629 7 p.

研究成果: 雜誌貢獻文章

Indoles
Colchicine
Antineoplastic Agents
Multiple Drug Resistance
Tubulin
2 引文 (Scopus)

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Hsieh, C. C., Lee, H. Y., Nien, C. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 三月 2011, 於 : Molecules. 16, 3, p. 2274-2284 11 p.

研究成果: 雜誌貢獻文章

cultured cells
Antineoplastic Agents
cancer
Cells
Cell Line
2010
18 引文 (Scopus)
ellipticine
Acetals
Microwaves
Microwave irradiation
Cyclization
18 引文 (Scopus)

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Chang, J-Y., Lai, M-J., Chang, Y-T., Lee, H. Y., Cheng, Y-C., Kuo, C-C., Su, M-C., Chang, C-Y. & Liou, J. P., 八月 2010, 於 : MedChemComm. 1, 2, p. 152-155 4 p.

研究成果: 雜誌貢獻文章

Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
Colchicine
Binding Sites
2009
7 引文 (Scopus)

An improved screening model to identify inhibitors targeting zinc-enhanced amyloid aggregation

Chang, P. T., Kung, F. L., Talekar, R. S., Chen, C. S., Lai, S. Y., Lee, H. Y. & Chern, J. W., 八月 15 2009, 於 : Analytical Chemistry. 81, 16, p. 6944-6951 8 p.

研究成果: 雜誌貢獻文章

Amyloid
Zinc
Screening
Agglomeration
Chelating Agents