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研究成果

  • 1198 引文
  • 20 h-指數
  • 94 文章
  • 32 專利
篩選
文章
2020
1 引文 斯高帕斯(Scopus)

CC12 induces apoptotic cell death and cell cycle arrest in human glioblastoma cell lines and mouse xenograft model

Fann, L. Y., Shih, J. H., Tseng, J. H., Huang, H. S. & Hsiao, S. H., 四月 2020, 於 : Molecules. 25, 8, 25081793.

研究成果: 雜誌貢獻文章

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TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain

Dai, S. P., Hsieh, W. S., Chen, C. H., Lu, Y. H., Huang, H. S., Chang, D. M., Huang, S. L. & Sun, W. H., 五月 29 2020, 於 : Journal of Neuroinflammation. 17, 1, 170.

研究成果: 雜誌貢獻文章

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Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression

Kung, C. C., Dai, S. P., Chiang, H., Huang, H. S. & Sun, W. H., 一月 1 2020, (接受/付印) 於 : Molecular Biology Reports.

研究成果: 雜誌貢獻文章

2019
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2 引文 斯高帕斯(Scopus)

Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02

Ho, Y. J., Lu, J. W., Ho, L. J., Lai, J. H., Huang, H. S., Lee, C. C., Lin, T. Y., Lien, S. B., Lin, L. C., Chen, L. W., Gong, Z., Shen, M. C. & Liu, F. C., 九月 10 2019, 於 : Biochemical and Biophysical Research Communications. 517, 1, p. 155-163 9 p.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H-S., 十月 4 2019, 於 : Bioconjugate Chemistry.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

Chen, T. C., Guh, J. H., Hsu, H. W., Chen, C. L., Lee, C. C., Wu, C. L., Lee, Y. R., Lin, J. J., Yu, D. S. & Huang, H. S., 十二月 2019, 於 : Arabian Journal of Chemistry. 12, 8

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Chen, C. L., Chen, T. C., Lee, C. C., Shih, L. C., Lin, C. Y., Hsieh, Y. Y., Ali, A. A. A. & Huang, H. S., 十二月 2019, 於 : Arabian Journal of Chemistry. 12, 8

研究成果: 雜誌貢獻文章

2018

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., 六月 28 2018, 於 : Cancer Medicine.

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

Arthroprotective effects of Cf-02 sharing structural similarity with quercetin

Liu, F. C., Lu, J. W., Chien, C. Y., Huang, H. S., Lee, C. C., Lien, S. B., Lin, L. C., Chen, L. W., Ho, Y. J., Shen, M. C., Ho, L. J. & Lai, J. H., 五月 14 2018, 於 : International Journal of Molecular Sciences. 19, 5, 1453.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)
13 引文 斯高帕斯(Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., 一月 1 2018, 於 : Oncotarget. 9, 15, p. 11922-11937 16 p.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Novel technique for repairing posterior medial meniscus root tears using porcine knees and biomechanical study

Wu, J. L., Lee, C. H., Yang, C. T., Chang, C. M., Li, G., Cheng, C. K., Chen, C. H., Huang, H. S. & Lai, Y. S., 二月 2018, 於 : PLoS ONE. 13, 2, e0192027.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)
2017

The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation

Liu, F. L., Chen, C. L., Lee, C. C., Wu, C. C., Hsu, T. H., Tsai, C. Y., Huang, H. S. & Chang, D. M., 2017, 於 : International Journal of Medical Sciences. 14, 9, p. 840-852 13 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)
2016

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., 三月 1 2016, 於 : PLoS One. 11, 3, e0149317.

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

Chen, T. C., Yu, D-S., Chen, S-J., Chen, C-L., Lee, C-C., Hsieh, Y-Y., Chang, L-C., Guh, J-H., Lin, J-J. & Huang, H-S., 2016, 於 : Arabian Journal of Chemistry.

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 七月 19 2016, 於 : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis

Lee, C. C., Chen, C. L., Liu, F. L., Chiou, C. Y., Chen, T. C., Wu, C. C., Sun, W. H., Chang, D. M. & Huang, H. S., 五月 1 2016, 於 : Archiv der Pharmazie. 349, 5, p. 342-355 14 p.

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., 十一月 11 2016, 於 : Scientific Reports. 6, 36650.

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Chang, L. C., Chen, T. C., Chen, S. J., Chen, C. L., Lee, C. C., Wu, S. H., Yen, Y., Huang, H. S. & Lin, J. J., 十月 18 2016, 於 : Oncotarget. 7, 42, p. 67986-68001 16 p.

研究成果: 雜誌貢獻文章

Novel anthra[1,2-c][1,2,5]thiadiazole-6,11-diones as promising anticancer lead compounds: Biological evaluation, characterization & molecular targets determination

Ali, A. A. A., Lee, Y. R., Chen, T. C., Chen, C. L., Lee, C. C., Shiau, C. Y., Chiang, C. H. & Huang, H. S., 四月 1 2016, 於 : PLoS One. 11, 4, e0154278.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

Lin, Y. H., Chuang, S. M., Wu, P. C., Chen, C. L., Jeyachandran, S., Lo, S. C., Huang, H. S. & Hou, M. H., 八月 11 2016, 於 : Scientific Reports. 6, 31019.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells

Wu, D. W., Chen, T. C., Huang, H. S. & Lee, H., 六月 30 2016, 於 : Cell death & disease. 7, 6, p. e2290

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)
2015

Discovery of 5-(2′,4′-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κ°B ligand (RANKL)-induced osteoclastogenesis

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Chang, D. M. & Huang, H. S., 五月 25 2015, 於 : European Journal of Medicinal Chemistry. 98, p. 115-126 12 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Liu, F. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4522-4532 11 p.

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c[[1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents

Lee, Y. R., Chen, T. C., Lee, C. C., Chen, C. L., Ahmed Ali, A. A., Tikhomirov, A., Guh, J. H., Yu, D. S. & Huang, H. S., 九月 18 2015, 於 : European Journal of Medicinal Chemistry. 102, p. 661-676 16 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents

Chen, T. C., Wu, C. L., Lee, C. C., Chen, C. L., Yu, D. S. & Huang, H. S., 十月 20 2015, 於 : European Journal of Medicinal Chemistry. 103, p. 615-627 13 p.

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)
2014

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., 八月 15 2014, 於 : PLoS One. 9, 8, e104703.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells

Liou, J. T., Huang, H. S., Chiang, M. L., Lin, C. S., Yang, S. P., Ho, L. J. & Lai, J. H., 三月 5 2014, 於 : European Journal of Pharmacology. 726, 1, p. 124-132 9 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)
11 引文 斯高帕斯(Scopus)

Modified salicylanilide and 3-phenyl-2 H -benzo[ e ][1,3]oxazine-2,4(3 H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Ahmed Ali, A. A., Sytwu, H. K., Chang, D. M. & Huang, H. S., 十月 9 2014, 於 : Journal of Medicinal Chemistry. 57, 19, p. 8072-8085 14 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)
10 引文 斯高帕斯(Scopus)

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

Tang, S. H., Huang, H. S., Wu, H. U., Tsai, Y. T., Chuang, M. J., Yu, C. P., Huang, S. M., Sun, G. H., Chang, S. Y., Hsiao, P. W., Yu, D. S. & Cha, T. L., 2014, 於 : Oncotarget. 5, 21, p. 10342-10355 14 p.

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

Ring fusion strategy for the synthesis of anthra[2,3-d ]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Chang, W. W., Guh, J. H., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 十一月 24 2014, 於 : European Journal of Medicinal Chemistry. 87, p. 30-38 9 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)
2013

Ascorbigen induces dermal papilla cell proliferation in vitro, but fails to modulate chemotherapy-induced alopecia in vivo

Wang, C. H., Huang, H. S., Dai, N. T., Sheu, M. J. & Chang, D. M., 十二月 2013, 於 : Phytotherapy Research. 27, 12, p. 1863-1867 5 p.

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

Brand name or generic? What are the health professionals prescribed for treating diabetes? A longitudinal analysis of the National Health Insurance reimbursement database

Liou, W. S., Hsieh, S. C., Chang, W. Y., Wu, G. H. M., Huang, H. S. & Lee, C., 七月 2013, 於 : Pharmacoepidemiology and Drug Safety. 22, 7, p. 752-759 8 p.

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase i inhibitory properties

Lee, C. C., Chang, D. M., Huang, K. F., Chen, C. L., Chen, T. C., Lo, Y., Guh, J. H. & Huang, H. S., 十一月 15 2013, 於 : Bioorganic and Medicinal Chemistry. 21, 22, p. 7125-7133 9 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules

Lee, Y. R., Yu, D. S., Liang, Y. C., Huang, K. F., Chou, S. J., Chen, T. C., Lee, C. C., Chen, C. L., Chiou, S. H. & Huang, H. S., 二月 25 2013, 於 : PLoS One. 8, 2, e56284.

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents

Chen, T. C., Yu, D. S., Huang, K. F., Fu, Y. C., Lee, C. C., Chen, C. L., Huang, F. C., Hsieh, H. H., Lin, J. J. & Huang, H. S., 2013, 於 : European Journal of Medicinal Chemistry. 69, p. 278-293 16 p.

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology

Chen, C. L., Chang, D. M., Chen, T. C., Lee, C. C., Hsieh, H. H., Huang, F. C., Huang, K. F., Guh, J. H., Lin, J. J. & Huang, H. S., 二月 2013, 於 : European Journal of Medicinal Chemistry. 60, p. 29-41 13 p.

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)
2012

A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: A potential osteoclastogenesis inhibitor for experimental arthritis

Cheng, C. P., Huang, H. S., Hsu, Y. C., Sheu, M. J. & Chang, D. M., 八月 2012, 於 : Journal of Clinical Immunology. 32, 4, p. 762-777 16 p.

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells

Cheng, M. H., Yang, Y. C., Wong, Y. H., Chen, T. R., Lee, C. Y., Yang, C. C., Chen, S. H., Yang, I. N., Yang, Y. S., Huang, H. S., Yang, C. Y., Huang, M. S. & Chiu, H. F., 二月 2012, 於 : Anti-Cancer Drugs. 23, 2, p. 191-199 9 p.

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones

Lee, C. C., Huang, K. F., Chang, D. M., Hsu, J. J., Huang, F. C., Shih, K. N., Chen, C. L., Chen, T. C., Chen, R. H., Lin, J. J. & Huang, H. S., 四月 2012, 於 : European Journal of Medicinal Chemistry. 50, p. 102-112 11 p.

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives

Lee, C. C., Huang, K. F., Lin, P. Y., Huang, F. C., Chen, C. L., Chen, T. C., Guh, J. H., Lin, J. J. & Huang, H. S., 一月 2012, 於 : European Journal of Medicinal Chemistry. 47, 1, p. 323-336 14 p.

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

Synthesis, telomerase evaluation and anti-proliferative studies on various series of diaminoanthraquinone-lkinked aminoacyl residue derivatives

Huang, F. C., Huang, K. F., Chen, R. H., Wu, J. E., Chen, T. C., Chen, C. L., Lee, C. C., Chen, J. Y., Lin, J. J. & Huang, H. S., 二月 2012, 於 : Archiv der Pharmazie. 345, 2, p. 101-111 11 p.

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)
2011

A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: A potential disease-modifying drug for osteoarthritis therapeutics

Liu, F. C., Huang, H. S., Huang, C. Y., Yang, R., Chang, D. M., Lai, J. H. & Ho, L. J., 十二月 2011, 於 : Journal of Clinical Immunology. 31, 6, p. 1131-1142 12 p.

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin

Chang, Y. L., Lee, H. J., Liu, S. T., Lin, Y. S., Chen, T. C., Hsieh, T. Y., Huang, H. S. & Huang, S. M., 十二月 2011, 於 : International Journal of Biochemistry and Cell Biology. 43, 12, p. 1720-1728 9 p.

研究成果: 雜誌貢獻文章

21 引文 斯高帕斯(Scopus)