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個人檔案

學歷

  • 1969 臺灣大學理學院化學系學士
  • 1975 美國加州理工學院化學系博士

經歷

  • 現職
  • 2018.01- 臺北醫學大學癌症生物學與藥物研發博士學位學程講座教授
  • 2008- 藥物研發博士學位學程加州大學戴維斯分校生化與分子醫學系特聘教授
  • 經歷
  • 2012.12-2017.12 國家衛生研究院分子與基因醫學研究所特聘研究員
  • 2017.02-2017.09 國家衛生研究院分子與基因醫學研究所代理所長
  • 2012.12-2015.12 國家衛生研究院院長
  • 1998-2012 美國加州大學戴維斯分校癌症中心副主任兼基礎研究主任
  • 1998-2008 美國加州大學戴維斯分校生化與分子醫學系教授
  • 1997-1998 國家衛生研究院分子與基因醫學研究組主任
  • 1990-1998 美國凱斯西儲大學癌症中心基礎醫學研究副主任
  • 1989-1998 美國凱斯西儲大學醫學系教授
  • 1984-1988 美國凱斯西儲大學分子生物與微生物學系副教授/教授
  • 1987-1988 中央研究院分子生物研究所客座教授
  • 1978-1984 密西根州立大學生物化學助理教授/副教授
  • 1976-1978 美國加州大學舊金山分校博士後研究員

獎項

  • 交通大學生命科學系講座教授 (2013.5迄今)
  • NIH Norman Salzman Lectureship (2012)
  • 臺北醫學大學轉譯醫學綜合實驗室特聘講座教授 (2010.8迄今)
  • 清華大學生命科學院特聘講座教授 (2009.8迄今)
  • Auburn Community Cancer Endowed Chair in Basic Science (2007)
  • Joan Oettinger Memorial Award in Lung and Cancer Research (2006)
  • Society of American Asian Scientists in Cancer Research (SAASCR), recipient of annual award (2006)
  • UC Davis School of Medicine Faculty Research Award (2005)
  • CaP CURE Research Award (1999)
  • 中央研究院院士 (1998終身職)
  • 國家衛生研究院榮譽研究員 (1998迄今)
  • Goodman-Blum Professor in Cancer Research, Case Western Reserve University (1997)
  • NCI MERIT Award, CA46613 (1993-2002)
  • NCI MERIT Award, CA39207 (1991-2000)
  • American Cancer Society Faculty Research Development Award (1983-1988)
  • Faculty Research Award, American Cancer Society (1983-1987)
  • Fellow of Leukemia Society of America (1976-1977)

研究興趣

  • Cancer Virology
  • Genetics
  • Epigenetics
  • Therapeutics

Dr.Kung’s lab has a long standing interest in tyrosine kinases, histone demethylases and androgen receptor regulation. His lab was credited for the original discovery of erbB/EGFR as a target gene for retroviral insertion, establishing this locus as a protooncogene, initial cloning of human c-src gene and demonstrating oncogenecity of v-src DNA. In the area of prostate cancer, his lab was the first to establish: a tyrosine kinase profile, IL-6 induced neuroendocrine differentiation, the involvement of Src/Etk/FAK trio-kinase complex in androgen-independent growth. More recently, his lab contributed to the identification of the origin of the newest human retrovirus, XMRV and dispelled its direct relationship to prostate cancer and chronic fatigue syndrome.

His current research specifically focuses on the identification of genetic and epigenetic factors contributing to the development of human malignancies including prostate cancer and Kaposi's sarcoma. Kaposi’s sarcoma is caused by Kaposi’s sarcoma associated herpesviruses (KSHV). The lab discovered that KSHV encodes a SUMO-E3 ligase and a SUMO-targeting Ubiquitin ligase (STUbL).  Under investigations are posttranslational modifiers of signal molecules and chromatins, which include kinases, E3 SUMO ligases and histone demethylases. In collaborative studies, the lab is also involved in developing inhibitors or therapeutic agents which target these oncogenes, resulting in specific and enhanced killing of tumor cells. More recent work has been directed toward the understanding of autophagy (self-eating) as a modulator of apoptosis (self-killing). Efforts are being made to develop effective means to measure autophagy and to modulate this process.

指紋 查看啟用 Hsing-Jien Kung 的研究主題。這些主題標籤來自此人的作品。共同形成了獨特的指紋。

  • 2 類似的檔案
Prostatic Neoplasms Medicine & Life Sciences
Marek Disease Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Viruses Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
Herpesviridae Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

網絡 國家層面的近期外部合作。點選圓點深入探索詳細資料。

研究成果 1974 2019

KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis

Wu, M. C., Cheng, H. H., Yeh, T. S., Li, Y. C., Chen, T. J., Sit, W. Y., Chuu, C. P., Kung, H. J., Chien, S. & Wang, W. C., 二月 1 2019, 於 : Cell Death and Disease. 10, 2, 68.

研究成果: 雜誌貢獻文章

Interleukin-8
Stomach
Carcinogenesis
Epigenomics
Helicobacter pylori
3 引文 (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. 及其他3, Wang, W. C., Chen, H. W. & Kung, H. J., 一月 3 2019, 於 : Oncogene. 38, 1, p. 17-32

研究成果: 雜誌貢獻文章

Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms
1 引文 (Scopus)

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

Chen, T. J., Wang, H. J., Liu, J. S., Cheng, H. H., Hsu, S. C., Wu, M. C., Lu, C. H., Wu, Y. F., Wu, J. W., Liu, Y. Y., Kung, H. J. & Wang, W. C., 十二月 1 2019, 於 : Communications Biology. 2, 1, 105.

研究成果: 雜誌貢獻文章

開啟存取
exons
Exons
mutation
Mutation
Allosteric Regulation
3 引文 (Scopus)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. 及其他4, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., 十二月 1 2018, 於 : Communications Biology. 1, 1, 178.

研究成果: 雜誌貢獻文章

開啟存取
aspartic acid
Starvation
Aspartic Acid
arginine
starvation
4 引文 (Scopus)

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis

Lin, H. H., Chung, Y., Cheng, C. T., Ouyang, C., Fu, Y., Kuo, C. Y., Chi, K. K., Sadeghi, M., Chu, P., Kung, H. J., Li, C. F., Limesand, K. H. & Ann, D. K., 九月 2 2018, 於 : Autophagy. 14, 9, p. 1481-1498 18 p.

研究成果: 雜誌貢獻文章

Autophagy
Carcinogenesis
Aspartate-Ammonia Ligase
Asparagine
Neoplasms