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研究成果 1992 2019

  • 1286 引文
  • 22 h-指數
  • 67 文章
篩選
文章
2019

Characterizing tyrosinase modulators from the roots of angelica keiskei using tyrosinase inhibition assay and UPLC-MS/MS as the combinatorial novel approach

Lee, J. H., Mei, H. C., Kuo, I. C., Lee, T. H., Chen, Y. H. & Lee, C. K., 九月 10 2019, 於 : Molecules. 24, 18, 3297.

研究成果: 雜誌貢獻文章

開啟存取
Angelica
Monophenol Monooxygenase
Modulators
modulators
Assays

Efficient identification of fungal antimicrobial principles by tandem MS and NMR database

Lee, M. S., Yang, Y. L., Wu, C. Y., Chen, Y. L., Lee, C. K., Tzean, S. S. & Lee, T. H., 一月 1 2019, 於 : Journal of Food and Drug Analysis.

研究成果: 雜誌貢獻文章

開啟存取
nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
anti-infective agents
High Pressure Liquid Chromatography
Databases
2 引文 (Scopus)

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Ting, L. L., Lu, H. T., Yen, S. F., Ngo, T. H., Tu, F. Y., Tsai, I. S., Tsai, Y. H., Chang, F. Y., Li, X. J., Li, S., Lee, C. K., Kao, S. H., Kuo, Y. M. & Lin, Y. F., 十一月 1 2019, 於 : Molecular Neurobiology. 56, 11, p. 7572-7582 11 p.

研究成果: 雜誌貢獻文章

Amyloid beta-Protein Precursor
Alzheimer Disease
Pathology
Amyloid
Protein C
2 引文 (Scopus)

Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer's Disease Model Cells

Tsai, Y. F., Yang, D. J., Ngo, T. H., Shih, C. H., Wu, Y. F., Lee, C. K., Phraekanjanavichid, V., Yen, S. F., Kao, S. H., Lee, H. M., Huang, V. S., Shieh, J. C. C. & Lin, Y. F., 一月 16 2019, 於 : ACS Chemical Neuroscience. 10, 1, p. 528-536 9 p.

研究成果: 雜誌貢獻文章

Gangliosides
Amyloid beta-Protein Precursor
Toxicity
Alzheimer Disease
Cells
3 引文 (Scopus)
開啟存取
antioxidants
lungs
Lipid Peroxidation
Mitochondria
mitochondria

New abietane-type diterpenoids from the bark of cryptomeria japonica

Chang, C. I., Chen, J. J., Hsu, C., Chen, C. C., Cheng, W. Y., Wang, S. Y., Lee, C. K., Cheng, M. J. & Kuo, Y. H., 一月 1 2019, 於 : Natural Product Communications. 14, 1, p. 97-100 4 p.

研究成果: 雜誌貢獻文章

Abietane Diterpenes
Cryptomeria
xanthine oxidase
Cryptomeria japonica
Xanthine Oxidase
1 引文 (Scopus)

Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer's disease

Sheu, J. J., Yang, L. Y., Sanotra, M. R., Wang, S. T., Lu, H. T., Kam, R. S. Y., Hsu, I. U., Kao, S. H., Lee, C. K., Shieh, J. C. C. & Lin, Y. F., 一月 1 2019, (接受/付印) 於 : Clinical Biochemistry.

研究成果: 雜誌貢獻文章

Alzheimer Disease
Serum
Amyloid beta-Protein Precursor
Amyloid
Area Under Curve
1 引文 (Scopus)
Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
Protein Kinases
Lipase
2018
6 引文 (Scopus)
Apolipoproteins
Lysine
Immunoglobulin M
Alzheimer Disease
Peptides
2 引文 (Scopus)

Melanogenesis inhibitors from the rhizoma of ligusticum sinense in B16-f10 melanoma cells in vitro and zebrafish in vivo

Cheng, M. C., Lee, T. H., Chu, Y. T., Syu, L. L., Hsu, S. J., Cheng, C. H., Wu, J. & Lee, C. K., 十二月 1 2018, 於 : International Journal of Molecular Sciences. 19, 12, 3994.

研究成果: 雜誌貢獻文章

Ligusticum
Experimental Melanomas
ferulic acid
Cosmetics
Zebrafish

New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9

Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., 三月 7 2018, 於 : Molecules. 23, 3, 604.

研究成果: 雜誌貢獻文章

Chamaecyparis
Cupressaceae
Terpenes
Metalloproteases
leaves
2017
1 引文 (Scopus)

Chemical composition and antioxidant, bactericidal, and matrix metalloproteinase inhibition activity of food-related plant

Chen, C. H., Chang, T. C., Chen, S. Y., Hsu, S. J., Huang, H. W. & Lee, C. K., 九月 1 2017, 於 : LWT - Food Science and Technology. 82, p. 411-419 9 p.

研究成果: 雜誌貢獻文章

Edible Plants
gelatinase A
xanthine oxidase
metalloproteinases
Matrix Metalloproteinases
2016
18 引文 (Scopus)

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., 十二月 23 2016, 於 : Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

研究成果: 雜誌貢獻文章

Angiogenesis Inhibitors
Macrophages
Endothelial cells
Inhibitory Concentration 50
Lipopolysaccharides
3 引文 (Scopus)

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

Lee, T-H., Hsu, C. C., Hsiao, G., Fang, J. Y., Liu, W. M. & Lee, C. K., 五月 1 2016, 於 : Planta Medica. 82, 8, p. 698-704

研究成果: 雜誌貢獻文章

Rhodiola
Matrix Metalloproteinase 2
Matrix Metalloproteinases
Skin
Collagenases
1 引文 (Scopus)

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Wu, C. H., Pan, C. H., Lee, C. K., Sheu, M. J., Liu, F. C., Wang, G. J. & Wu, C. H., 六月 1 2016, 於 : Journal of Functional Foods. 24, p. 173-182 10 p.

研究成果: 雜誌貢獻文章

Hypolipidemic Agents
atherogenesis
hyperlipidemia
Hyperlipidemias
Atherosclerosis
2015
7 引文 (Scopus)
PPAR alpha
AMP-Activated Protein Kinases
Lipolysis
Adipocytes
Fatty Acids
2014
10 引文 (Scopus)

Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells

Wang, C. H., Hsiao, C. J., Lin, Y. N., Wu, J. W., Kuo, Y. C., Lee, C. K. & Hsiao, G., 十一月 1 2014, 於 : Pharmaceutical Biology. 52, 11, p. 1451-1459 9 p.

研究成果: 雜誌貢獻文章

Carbamazepine
Nitric Oxide Synthase Type II
Lipopolysaccharides
Cyclooxygenase 2
Reactive Oxygen Species
5 引文 (Scopus)

Two new acidic diterpenoids from the heartwood of pinus massoniana LAMB.

Mohamed, H. A., Hsieh, C. L., Hsu, C., Kuo, C. C., Chang, H. S., Lee, C. K., Lee, T. H., Wu, J. B., Chang, C. I. & Kuo, Y. H., 2014, 於 : Helvetica Chimica Acta. 97, 8, p. 1146-1151 6 p.

研究成果: 雜誌貢獻文章

Pinus
Diterpenes
Trientine
acids
Acids
2013
3 引文 (Scopus)

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Li, Z-H., Chen, Y. C., Lee, C. K., Chang, H. S., Kuo, C. C., Chao, C. Y., Lin, J. J., Lo, L. C. & Kuo, Y. H., 2013, 於 : Natural Product Communications. 8, 6, p. 827-828 2 p.

研究成果: 雜誌貢獻文章

Aconitum
telomerase
Far East
Telomerase
Chinese Traditional Medicine
9 引文 (Scopus)

Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography-tandem mass spectrometry

Wang, K. C., Cheng, M. C., Hsieh, C. L., Hsu, J. F., Wu, J. D. & Lee, C. K., 一月 10 2013, 於 : Forensic Science International. 224, 1-3, p. 84-89 6 p.

研究成果: 雜誌貢獻文章

nimetazepam
Nitrazepam
Tandem Mass Spectrometry
Liquid Chromatography
Urine
7 引文 (Scopus)

Extracts of Koelreuteria henryi Dummer induce apoptosis and autophagy by inhibiting dihydrodiol dehydrogenase, thus enhancing anticancer effects

Chiang, Y. Y., Wang, S. L., Yang, C. L., Yang, H. Y., Yang, H. C., Sudhakar, J. N., Lee, C. K., Huang, H. W., Chen, C. M., Chiou, S. H., Chiang, S. F., Fang, H. Y., Chen, C. Y., Shieh, S. H. & Chow, K. C., 九月 2013, 於 : International Journal of Molecular Medicine. 32, 3, p. 577-584 8 p.

研究成果: 雜誌貢獻文章

Autophagy
Apoptosis
Medicinal Plants
Drug Resistance
DNA Repair
5 引文 (Scopus)

Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata

Chen, P. Y., Wu, J. D., Tang, K. Y., Yu, C. C., Kuo, Y. H., Zhong, W-B. & Lee, C. K., 七月 2013, 於 : Molecules. 18, 7, p. 7600-7608 9 p.

研究成果: 雜誌貢獻文章

Antrodia
activity (biology)
dioxides
cultured cells
isolation
11 引文 (Scopus)

Phyto-SERM constitutes from Flemingia macrophylla

Lai, W. C., Tsui, Y. T., Singab, A. N. B., El-Shazly, M., Du, Y. C., Hwang, T. L., Wu, C. C., Yen, M. H., Lee, C. K., Hou, M. F., Wu, Y. C. & Chang, F. R., 2013, 於 : International Journal of Molecular Sciences. 14, 8, p. 15578-15594 17 p.

研究成果: 雜誌貢獻文章

estrogens
Selective Estrogen Receptor Modulators
Phytoestrogens
Spectroscopic analysis
Genetically Modified Plants
2012
7 引文 (Scopus)

Heptadecanols from the leaves of Persea americana var. americana

Li, Z-H., Tsai, Y. F., Huang, T. T., Chen, P. Y., Liang, W. L. & Lee, C. K., 五月 15 2012, 於 : Food Chemistry. 132, 2, p. 921-924 4 p.

研究成果: 雜誌貢獻文章

Persea americana var. americana
Persea
Fruits
Fruit
chemical derivatives
10 引文 (Scopus)

Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana hayata

Yu, C. C., Hsieh, C. R., Hsiao, G., Chen, P. Y., Chang, M. L., Yin, H. W., Li, Z-H. & Lee, C. K., 二月 2012, 於 : Molecules. 17, 2, p. 2082-2090 9 p.

研究成果: 雜誌貢獻文章

Abietane Diterpenes
Euphorbia
Diterpenes
Fibrosarcoma
gelatins
2011
34 引文 (Scopus)

Antimutagenic constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with potential cancer chemopreventive activity

Chen, H. H., Chiang, W., Chang, J. Y., Chien, Y. L., Lee, C. K., Liu, K. J., Cheng, Y. T., Chen, T. F., Kuo, Y. H. & Kuo, C. C., 六月 22 2011, 於 : Journal of Agricultural and Food Chemistry. 59, 12, p. 6444-6452 9 p.

研究成果: 雜誌貢獻文章

Coix
Coix lacryma-jobi
antimutagenic activity
hulls
neoplasms
21 引文 (Scopus)

Cytotoxic steroidal saponins from Agave sisalana

Chen, P. Y., Chen, C. H., Kuo, C. C., Li, Z-H., Kuo, Y. H. & Lee, C. K., 2011, 於 : Planta Medica. 77, 9, p. 929-933 5 p.

研究成果: 雜誌貢獻文章

Agave
Saponins
Sapogenins
Sugars
Nuclear magnetic resonance spectroscopy
3 引文 (Scopus)

Ficuschlorins A-D, lactone chlorins from the leaves of ficus microcarpa

Lin, H. Y., Chiu, H. L., Lan, Y. H., Tzeng, C. Y., Li, Z-H., Lee, C. K., Shao, Y. Y., Chen, C. R., Chang, C. I. & Kuo, Y. H., 九月 2011, 於 : Chemistry and Biodiversity. 8, 9, p. 1701-1708 8 p.

研究成果: 雜誌貢獻文章

Pheophytins
Ficus
Lactones
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
5 引文 (Scopus)

Ficusmicrochlorin A - C, two new methoxy lactone chlorins and an anhydride chlorin from the leaves of Ficus microcarpa

Lin, H. Y., Chiu, H. L., Lu, T. L., Tzeng, C. Y., Li, Z-H., Lee, C. K., Shao, Y. Y., Chen, C. R., Chang, C. I. & Kuo, Y. H., 一月 2011, 於 : Chemical and Pharmaceutical Bulletin. 59, 1, p. 113-116 4 p.

研究成果: 雜誌貢獻文章

Pheophytins
Ficus
Anhydrides
Lactones
Nuclear magnetic resonance
2010
6 引文 (Scopus)

Rapid identification of the antioxidant constituent of Koelreuteria henryi

Chen, C. H., Chena, P. Y., Wang, K. C. & Lee, C. K., 2010, 於 : Journal of the Chinese Chemical Society. 57, 3 A, p. 404-410 7 p.

研究成果: 雜誌貢獻文章

Antioxidants
Xanthine Oxidase
Assays
Scavenging
Quercetin
2009
10 引文 (Scopus)

A new flavonol galloylrhamnoside and a new lignan glucoside from the leaves of Koelreuteria henryi Dummer

Li, Z-H., Chiang, Y. H., Chen, C. H., Chen, P. Y. & Lee, C. K., 四月 2009, 於 : Journal of Natural Medicines. 63, 2, p. 209-214 6 p.

研究成果: 雜誌貢獻文章

Lignans
Glucosides
Glycosides
Aromatic compounds
Scavenging
58 引文 (Scopus)

Antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase

Chen, C. H., Chan, H. C., Chu, Y. T., Ho, H. Y., Chen, P. Y., Li, Z-H. & Lee, C. K., 八月 2009, 於 : Molecules. 14, 8, p. 2947-2958 12 p.

研究成果: 雜誌貢獻文章

xanthines
Lipoxygenase
Monophenol Monooxygenase
Xanthine Oxidase
oxidase
22 引文 (Scopus)

Constituents of Polyalthia longifolia var. pendula

Li, Z-H., Wang, M. J., Chen, P. Y., Wu, T. Y., Wen, W. C., Tsai, F. Y. & Lee, C. K., 十一月 30 2009, 於 : Journal of Natural Products. 72, 11, p. 1960-1963 4 p.

研究成果: 雜誌貢獻文章

Polyalthia
Acids
Clerodane Diterpenes
MCF-7 Cells
Cytotoxicity
1 引文 (Scopus)

Determination of antioxidative properties of Morinda citrifolia using near supercritical fluid extraction

Chen, C. H., Lin, T. P., Chung, Y. L., Lee, C. K., Yeh, D. B. & Chen, S. Y., 十月 2009, 於 : Journal of Food and Drug Analysis. 17, 5

研究成果: 雜誌貢獻文章

Morinda
Morinda citrifolia
Supercritical Fluid Chromatography
supercritical fluid extraction
Antioxidants
7 引文 (Scopus)

Four new lignans with a bicyclo[3.3.1]nonadienemethanol skeleton from Cunninghamia lanceolata

Lee, C. K., Yeh, M. H., Li, Z-H., Chiu, H. L. & Kuo, Y. H., 十月 2009, 於 : Helvetica Chimica Acta. 92, 10, p. 1983-1989 7 p.

研究成果: 雜誌貢獻文章

Cunninghamia
Lignans
musculoskeletal system
Skeleton
Nuclear magnetic resonance
32 引文 (Scopus)

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine Ex Engelm

Chen, P. Y., Kuo, Y. C., Chen, C. H., Kuo, Y. H. & Lee, C. K., 五月 2009, 於 : Molecules. 14, 5, p. 1789-1795 7 p.

研究成果: 雜誌貢獻文章

Agave
Flavones
thymidine
Isoflavones
Spectroscopic analysis
2008
40 引文 (Scopus)

Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum

Wang, G. J., Chen, Y. M., Li, Z-H., Lee, C. K., Chen, K. J. & Lee, T. H., 六月 19 2008, 於 : Journal of Ethnopharmacology. 118, 1, p. 71-78 8 p.

研究成果: 雜誌貢獻文章

Flavonoids
Nitric Oxide Synthase
Luteolin
Rutin
Traditional Medicine
52 引文 (Scopus)
glyphosate
Ion chromatography
Liquid chromatography
Herbicides
Diquat
8 引文 (Scopus)

Unexpected novel pheophytin peroxides from the leaves of Biden pilosa

Li, Z-H., Lu, C. K., Kuo, Y. H., Lo, J. M. & Lee, C. K., 2008, 於 : Helvetica Chimica Acta. 91, 1, p. 79-84 6 p.

研究成果: 雜誌貢獻文章

Bidens
Pheophytins
FORTRAN
Biosynthetic Pathways
Peroxides
2007
71 引文 (Scopus)

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Li, Z-H., Lee, C. K., Tsou, W. L., Liu, S. Y., Kuo, M. T. & Wen, W. C., 十月 2007, 於 : Planta Medica. 73, 13, p. 1412-1415 4 p.

研究成果: 雜誌貢獻文章

Antrodia
Taiwanofungus camphoratus
Ubiquinone
Mycelium
Cytotoxins
21 引文 (Scopus)
Monophenol Monooxygenase
Melanocytes
Melanins
Biflavonoids
Messenger RNA
8 引文 (Scopus)

New lignans from the heartwood of Cunninghamia lanceolata

Li, Z-H., Yeh, M. H., Chang, C. I., Lee, C. K., Shao, Y. Y. & Kuo, Y. H., 2007, 於 : Bioscience, Biotechnology and Biochemistry. 71, 8, p. 2075-2078 4 p.

研究成果: 雜誌貢獻文章

Cunninghamia
Cunninghamia lanceolata
Lignans
heartwood
lignans
54 引文 (Scopus)

Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus

Wen, C. C., Kuo, Y. H., Jan, J. T., Liang, P. H., Wang, S. Y., Liu, H. G., Lee, C. K., Chang, S. T., Kuo, C. J., Lee, S. S., Hou, C. C., Hsiao, P. W., Chien, S. C., Shyur, L. F. & Yang, N. S., 八月 23 2007, 於 : Journal of Medicinal Chemistry. 50, 17, p. 4087-4095 9 p.

研究成果: 雜誌貢獻文章

Severe Acute Respiratory Syndrome
Coronavirus
Diterpenes
Terpenes
Antiviral Agents
2006
5 引文 (Scopus)

New constituents from the heartwood of Picea morrisonicola HAYATA

Li, Z-H., Yeh, M. H., Chang, C. I., Lee, C. K., Shao, Y. Y. & Kuo, Y. H., 2006, 於 : Chemical and Pharmaceutical Bulletin. 54, 5, p. 693-695 3 p.

研究成果: 雜誌貢獻文章

Picea
Lignans
Monoterpenes
Spectroscopic analysis
Derivatives
2005
29 引文 (Scopus)

Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima

Lu, C. K., Chou, H. N., Lee, C. K. & Li, Z-H., 九月 1 2005, 於 : Organic Letters. 7, 18, p. 3893-3896 4 p.

研究成果: 雜誌貢獻文章

trienes
Polyketides
Dinoflagellida
epoxidation
epoxy compounds
52 引文 (Scopus)

Separation and determination of chemical constituents in the roots of Rhus javanica L. var. roxburghiana

Li, Z-H., Chiou, J. L., Lee, C. K. & Kuo, Y. H., 2005, 於 : Journal of the Chinese Chemical Society. 52, 4, p. 833-841 9 p.

研究成果: 雜誌貢獻文章

Lignans
Cytotoxicity
Flavonoids
Spectrum analysis
Steroids
2004
43 引文 (Scopus)

New prenylated flavones from the roots of Ficus beecheyana

Lee, C. K., Lu, C. K., Kuo, Y. H., Chen, J. Z. & Sun, G. Z., 四月 2004, 於 : Journal of the Chinese Chemical Society. 51, 2, p. 437-441 5 p.

研究成果: 雜誌貢獻文章

Flavones
Flavanones
Vanillic Acid
Ficusin
Metabolites
2003
3 引文 (Scopus)

Chemical constituents from the roots of Cassia fistula L.

Lee, C. K., Chung, Y. Y., Hsu, F-L. & Kuo, Y. H., 八月 2003, 於 : Chinese Pharmaceutical Journal. 55, 4, p. 231-237 7 p.

研究成果: 雜誌貢獻文章

Emodin
Cassia
Catechin
Glycerol
Stigmasterol
2002
67 引文 (Scopus)

2,2′-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls

Kuo, C. C., Chiang, W., Liu, G. P., Chien, Y. L., Chang, J. Y., Lee, C. K., Lo, J. M., Huang, S. L., Shih, M. C. & Kuo, Y. H., 十月 9 2002, 於 : Journal of Agricultural and Food Chemistry. 50, 21, p. 5850-5855 6 p.

研究成果: 雜誌貢獻文章

Coix
Coix lacryma-jobi
1-Butanol
Scavenging
butanol
41 引文 (Scopus)

Five new phenolics from the roots of Ficus beecheyana

Li, Z-H., Kuo, Y. C., Wang, G. J., Kuo, Y. H., Chang, C. I., Lu, C. K. & Lee, C. K., 十月 1 2002, 於 : Journal of Natural Products. 65, 10, p. 1497-1500 4 p.

研究成果: 雜誌貢獻文章

Ficus
glycols
extracts
Ficus erecta