臺北醫學大學新藥開發研究中心

2022

Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy

Cheng, W. J., Chuang, K. H., Lo, Y. J., Chen, M., Chen, Y. J., Roffler, S. R., Ho, H. O., Lin, S. Y. & Sheu, M. T., 4月 2022, 於: Journal of Controlled Release. 344, p. 235-248 14 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

Lin, T. E., Yang, C. R., Chou, C. H., Hsu, J. Y., Chao, M. W., Sung, T. Y., Hsieh, J. H., Huang, W. J. & Hsu, K. C., 2月 2022, 於: Biomedicine and Pharmacotherapy. 146, 112459.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Identification and analysis of a selective DYRK1A inhibitor

Lin, T. E., Chao, M. W., HuangFu, W. C., Tu, H. J., Peng, Z. X., Su, C. J., Sung, T. Y., Hsieh, J. H., Lee, C. C., Yang, C. R., Pan, S. L. & Hsu, K. C., 2月 2022, 於: Biomedicine and Pharmacotherapy. 146, 112580.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach

Yen, S. C., Chen, L. C., Huang, H. L., HuangFu, W. C., Chen, Y. Y., Eight Lin, T., Lien, S. T., Tseng, H. J., Sung, T. Y., Hsieh, J. H., Huang, W. J., Pan, S. L. & Hsu, K. C., 4月 2022, 於: Bioorganic Chemistry. 121, 105675.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction

Lu, C. H., Chung, W. M., Tsai, C. H., Cheng, J. C., Hsu, K. C. & Tzeng, H. E., 12月 2022, 於: Scientific Reports. 12, 1, 303.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment

Mehndiratta, S., Qian, B., Chuang, J. Y., Liou, J. P. & Shih, J. C., 2月 2022, 於: Journal of Medicinal Chemistry. 65, 3, p. 2208-2224 17 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

Oleic Acid-Based Self Micro-Emulsifying Delivery System for Enhancing Antifungal Activities of Clotrimazole

Yang, T. L., Hsieh, C. M., Meng, L. J., Tsai, T. & Chen, C. T., 3月 2022, 於: Pharmaceutics. 14, 3, 478.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia

Yen, S. C., Wu, Y. W., Huang, C. C., Chao, M. W., Tu, H. J., Chen, L. C., Lin, T. E., Sung, T. Y., Tseng, H. J., Chu, J. C., Huang, W. J., Yang, C. R., HuangFu, W. C., Pan, S. L. & Hsu, K. C., 6月 2022, 於: Phytomedicine. 100, 154061.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Protein energy wasting–based nutritional assessment predicts outcomes of acute ischemic stroke and solves the epidemiologic paradox

Taiwan Stroke Registry Investigators, 1月 2022, 於: Nutrition. 93, 111431.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation

Tsai, Y. T., Lo, W. L., Chen, P. Y., Ko, C. Y., Chuang, J. Y., Kao, T. J., Yang, W. B., Chang, K. Y., Hung, C. Y., Kikkawa, U., Chang, W. C. & Hsu, T. I., 12月 2022, 於: Journal of Biomedical Science. 29, 1, 21.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Lin, T. E., Sung, L. C., Chao, M. W., Li, M., Zheng, J. H., Sung, T. Y., Hsieh, J. H., Yang, C. R., Lee, H. Y., Cho, E. C. & Hsu, K. C., 2022, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 37, 1, p. 226-235 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

2021

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

Wu, Y. W., Chao, M. W., Tu, H. J., Chen, L. C., Hsu, K. C., Liou, J. P., Yang, C. R., Yen, S. C., HuangFu, W. C. & Pan, S. L., 5月 2021, 於: Oncogenesis. 10, 5, 39.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

2 引文斯高帕斯（Scopus）

A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling

Chang, T. Y., Nepali, K., Chen, Y. Y., Yang, Y. C. S. H., Hsu, K. C., Yen, Y., Pan, S. L., Liou, J. P. & Lee, S. B., 6月 2021, 於: Biomedicine and Pharmacotherapy. 138, 111485.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab

Chang, T. K., Yin, T. C., Su, W. C., Tsai, H. L., Huang, C. W., Chen, Y. C., Li, C. C., Chen, P. J., Ma, C. J., Chuang, K. H., Cheng, T. L. & Wang, J. Y., 9月 2021, 於: Oncology Research. 28, 7, p. 801-809 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Butyrate modulates adipose-derived stem cells isolated from polygenic obese and diabetic mice to drive enhanced immunosuppression

Hsu, W. T., Huang, W. J., Chiang, B. L. & Tseng, P. H., 7月 2021, 於: Cytotherapy. 23, 7, p. 567-581 15 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

1 引文斯高帕斯（Scopus）

CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition

Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., 4月 5 2021, 於: European Journal of Medicinal Chemistry. 215, 113169.

研究成果: 雜誌貢獻 › 文章 › 同行評審

7 引文斯高帕斯（Scopus）

Comprehensive Deep Mutational Scanning Reveals the Immune-Escaping Hotspots of SARS-CoV-2 Receptor-Binding Domain Targeting Neutralizing Antibodies

Tsai, K. C., Lee, Y. C. & Tseng, T. S., 7月 15 2021, 於: Frontiers in Microbiology. 12, 698365.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

4 引文斯高帕斯（Scopus）

Correlation between the expression of cancer stem cell marker BMI1 and glioma prognosis

Tsai, Y. T., Wu, C. C., Ko, C. Y., Hsu, T. I., Chang, W. C., Lo, W. L. & Chuang, J. Y., 4月 2021, 於: Biochemical and Biophysical Research Communications. 550, p. 113-119 7 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

Development of a simple fluorescence sensing system for carbonyl stress in urine

Huang, W. J., Sun, Y. T., Lee, W. H., Lin, P. Y. & Chen, C. M., 2021, 於: Sensors and Materials. 33, 10, p. 3489-3497 9 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Differential co-occurring patterns between depressive symptomatology and sleep-wake-related disturbances in mood disorders

Chen, S. Y., Chen, C. H., Lo, C., Lu, M. L., Hsu, C. D., Chiu, Y. H., Chen, C. H., Lin, S. K., Huang, M. C., Chen, H. C. & Kuo, P. H., 2021, 於: Nature and Science of Sleep. 13, p. 503-514 12 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

Drug Repurposing for Atopic Dermatitis by Integration of Gene Networking and Genomic Information

Adikusuma, W., Irham, L. M., Chou, W. H., Wong, H. S. C., Mugiyanto, E., Ting, J., Perwitasari, D. A., Chang, W. P. & Chang, W. C., 10月 2021, 於: Frontiers in Immunology. 12, 724277.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., 12月 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Efficacy and safety of mineralocorticoid receptor antagonists in kidney failure patients treated with dialysis: A systematic review and meta-analysis

Chen, K. T., Kang, Y. N., Lin, Y. C., Tsai, I. L., Chang, W. C., Fang, T. C., Wu, M. S. & Kao, C. C., 6月 2021, 於: Clinical Journal of the American Society of Nephrology. 16, 6, p. 916-925 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

EGFL6 promotes colorectal cancer cell growth and mobility and the anti‐cancer property of anti-EGFL6 antibody

Sung, T. Y., Huang, H. L., Cheng, C. C., Chang, F. L., Wei, P. L., Cheng, Y. W., Huang, C. C., Lee, Y. C., HuangFu, W. C. & Pan, S. L., 12月 2021, 於: Cell and Bioscience. 11, 1, p. 53 53.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection

Huang, Y. L., Huang, M. T., Sung, P. S., Chou, T. Y., Yang, R. B., Yang, A. S., Yu, C. M., Hsu, Y. W., Chang, W. C. & Hsieh, S. L., 12月 2021, 於: Communications Biology. 4, 1, 229.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

Expression profiles and prognostic value of FABPs in colorectal adenocarcinomas

Prayugo, F. B., Kao, T. J., Anuraga, G., Ta, H. D. K., Chuang, J. Y., Lin, L. C., Wu, Y. F., Wang, C. Y. & Lee, K. H., 10月 2021, 於: Biomedicines. 9, 10, 1460.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease

Hsu, Y. W., Lu, H. F., Chou, W. H., Kuo, H. C. & Chang, W. C., 2月 2021, 於: Pediatric Allergy and Immunology. 32, 2, p. 363-370 8 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

Generation of avian-derived anti-B7-H4 antibodies exerts a blockade effect on the immunosuppressive response

Lin, T. Y., Tsai, T. H., Chen, C. T., Yang, T. W., Chang, F. L., Lo, Y. N., Chung, T. S., Cheng, M. H., Chen, W. C., Tsai, K. C. & Lee, Y. C., 2021, 於: Experimental Animals. 70, 3, p. 333-343 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Genetic association of the functional wdr4 gene in male fertility

Wang, Y. J., Mugiyanto, E., Peng, Y. T., Huang, W. C., Chou, W. H., Lee, C. C., Wang, Y. S., Irham, L. M., Perwitasari, D. A., Hsu, M. I. & Chang, W. C., 8月 2021, 於: Journal of Personalized Medicine. 11, 8, 760.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Genotypic diversity of ciprofloxacin nonsusceptibility and its relationship with minimum inhibitory concentrations in nontyphoidal salmonella clinical isolates in taiwan

Fang, S. B., Lauderdale, T. L. Y., Huang, C. H., Chang, P. R., Wang, Y. H., Shigemura, K., Lin, Y. H., Chang, W. C., Wang, K. C., Huang, T. W. & Chang, Y. C., 11月 2021, 於: Antibiotics. 10, 11, 1383.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

Chao, M. W., Lin, T. E., HuangFu, W. C., Chang, C. D., Tu, H. J., Chen, L. C., Yen, S. C., Sung, T. Y., Huang, W. J., Yang, C. R., Pan, S. L. & Hsu, K. C., 12月 2021, 於: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 98-108 11 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Increased short- and long-term risk of sleep disorders in people with traumatic brain injury

Wang, Y. J., Chang, W. C., Wu, C. C., Chiang, Y. H., Chiu, W. T., Chen, K. Y. & Chang, W. P., 2021, 於: Neuropsychological Rehabilitation. 31, 2, p. 211-230 20 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent

Ojha, R., Chen, I. C., Hsieh, C. M., Nepali, K., Lai, R. W., Hsu, K. C., Lin, T. E., Pan, S. L., Chen, M. C. & Liou, J. P., 2021, (接受/付印) 於: Journal of Medicinal Chemistry. 64, 24, p. 17824-17845 22 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

Investigation of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease

Kao, C. C., Wu, M. S., Chuang, M. T., Lin, Y. C., Huang, C. Y., Chang, W. C., Chen, C. W. & Chang, T. H., 8月 2021, 於: PLoS ONE. 16, 8 August, e0255645.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia

Yen, S. C., Chen, L. C., Huang, H. L., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., 1月 22 2021, 於: Journal of Natural Products. 84, 1, p. 1-10 10 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

4 引文斯高帕斯（Scopus）

Long Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells

Chang, Y. S., Lee, Y. T., Yen, J. C., Chang, Y. C., Lin, L. L., Chan, W. L., Chang, W. C., Lin, S. Y. & Chang, J. G., 9月 2021, 於: Frontiers in Oncology. 11, 592045.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

1 引文斯高帕斯（Scopus）

Modeling-based estimate of the vaccination rate, lockdown rules and covid-19

Guo, C. & Chang, W. C., 10月 2021, 於: Healthcare (Switzerland). 9, 10, 1245.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

One-pot fabrication of sacchachitin for production of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) utilized as scaffolds to enhance bone regeneration

Wu, M. H., Wang, W., Chao, F. C., Hsieh, C. M., Chen, L. C., Lin, H. L., Ho, H. O., Huang, T. J. & Sheu, M. T., 2月 2021, 於: Carbohydrate Polymers. 254, 117270.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

Paxillin is required for proper spinal motor axon growth into the limb

Tsai, W-L., Chang, C-J., Wang, C-Y., Hsu, T-I., Chang, M-Y., Wu, Y-H., Chang, P-S., Lin, K-L., Chuang, J-Y., Kania, A. & Kao, T-J., 3月 16 2021, (打印前電子出版) 於: Journal of Neuroscience.

研究成果: 雜誌貢獻 › 文章 › 同行評審

2 引文斯高帕斯（Scopus）

Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma

Nepali, K., Hsu, T. I., Hsieh, C. M., Lo, W. L., Lai, M. J., Hsu, K. C., Lin, T. E., Chuang, J. Y. & Liou, J. P., 5月 5 2021, 於: European Journal of Medicinal Chemistry. 217, 113338.

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

Profiling of T Cell Repertoire in SARS-CoV-2-Infected COVID-19 Patients Between Mild Disease and Pneumonia

Chang, C. M., Feng, P. H., Wu, T. H., Alachkar, H., Lee, K. Y. & Chang, W. C., 2021, (接受/付印) 於: Journal of Clinical Immunology. 41, 6, p. 1131-1145 15 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

8 引文斯高帕斯（Scopus）

Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer

Kao, T. J., Wu, C. C., Phan, N. N., Liu, Y. H., Ta, H. D. K., Anuraga, G., Wu, Y. F., Lee, K. H., Chuang, J. Y. & Wang, C. Y., 7月 31 2021, 於: Aging. 13, 14, p. 18946-18977 32 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

9 引文斯高帕斯（Scopus）

Prognostic and genomic analysis of proteasome 20s subunit alpha (PSMA) family members in breast cancer

Chiao, C. C., Liu, Y. H., Phan, N. N., Ton, N. T. A., Ta, H. D. K., Anuraga, G., Xuan, D. T. M., Fitriani, F., Hermanto, E. M. P., Athoillah, M., Andriani, V., Ajiningrum, P. S., Wu, Y. F., Lee, K. H., Chuang, J. Y., Wang, C. Y. & Kao, T. J., 12月 2021, 於: Diagnostics. 11, 12, 2220.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo

Liu, Y. M., Tu, H. J., Wu, C. H., Lai, M. J., Yu, S. C., Chao, M. W., Wu, Y. W., Teng, C. M., Pan, S. L. & Liou, J. P., 7月 5 2021, 於: European Journal of Medicinal Chemistry. 219, 113428.

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection

Tsai, T. Y., Huang, M. T., Sung, P. S., Peng, C. Y., Tao, M. H., Yang, H. I., Chang, W. C., Yang, A. S., Yu, C. M., Lin, Y. P., Bau, C. Y., Huang, C. J., Pan, M. H., Wu, C. Y., Hsiao, C. D., Yeh, Y. H., Duan, S., Paulson, J. C. & Hsieh, S. L., 6月 2021, 於: Journal of Clinical Investigation. 131, 11, e141965.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

2 引文斯高帕斯（Scopus）

Single-cell melanoma transcriptomes depicting functional versatility and clinical implications of STIM1 in the tumor microenvironment

Wong, H. S. C. & Chang, W. C., 3月 2021, 於: Theranostics. 11, 11, p. 5092-5106 15 p.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors

Hsu, K-C., Chu, J-C., Tseng, H-J., Liu, C-I., Wang, H-C., Lin, T. E., Lee, H-S., Hsin, L-W., Wang, A. H-J., Lin, C-H. & Huang, W-J., 7月 5 2021, 於: European Journal of Medicinal Chemistry. 219, 113419.

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

The antileukemic effect of xestoquinone, a marine-derived polycyclic quinone-type metabolite, is mediated through ros-induced inhibition of hsp-90

Wang, K. C., Lu, M. C., Hsu, K. C., El-Shazly, M., Shih, S. P., Lien, S. T., Kuo, F. W., Yang, S. C., Chen, C. L. & Yang, Y. C. S. H., 11月 1 2021, 於: Molecules. 26, 22, 7037.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

The HDAC/HSP90 inhibitor G570 attenuated blue light-induced cell migration in RPE cells and neovascularization in mice through decreased VEGF production

Hsu, T. J., Nepali, K., Tsai, C. H., Imtiyaz, Z., Lin, F. L., Hsiao, G., Lai, M. J. & Cheng, Y. W., 7月 2 2021, 於: Molecules. 26, 14, 4359.

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

The role of genetic polymorphisms in STIM1 and ORAI1 for erythropoietin resistance in patients with renal failure

Kao, C. C., Wong, H. S. C., Wang, Y. J., Chou, W. H., Perwitasari, D. A., Wu, M. S. & Chang, W. C., 4月 30 2021, 於: Medicine. 100, 17, p. e25243

研究成果: 雜誌貢獻 › 文章 › 同行評審

開啟存取

臺北醫學大學新藥開發研究中心

研究成果

搜尋結果