神經醫學研究中心-神經影像

研究成果 2002 2019

2019

Behavioral and structural effects of single and repeat closed-head injury

Kao, Y. C. J., Lui, Y. W., Lu, C. F., Chen, H. L., Hsieh, B. Y. & Chen, C. Y., 四月 1 2019, 於 : American Journal of Neuroradiology. 40, 4, p. 601-608 8 p.

研究成果: 雜誌貢獻文章

開啟存取
Closed Head Injuries
Wounds and Injuries
Contusions
Anisotropy
Craniocerebral Trauma
1 引文 (Scopus)
開啟存取
homing
brain damage
stem cells
fibroblasts
Fibroblasts
Brain Diseases
Hypoglycemic Agents
Stroke
Magnetic Resonance Imaging
Axons

Two-vessel occlusion mouse model of cerebral ischemia-reperfusion

Chen, C. Y., Chen, R. J. & Lee, G. A., 三月 1 2019, 於 : Journal of Visualized Experiments. 2019, 145, e59078.

研究成果: 雜誌貢獻文章

Brain Ischemia
Reperfusion
Middle Cerebral Artery Infarction
Middle Cerebral Artery
Blood
2018
9 引文 (Scopus)
NF-kappa B
Magnetic resonance
Reporter Genes
Nanoparticles
Lung Neoplasms

Changes in sensorimotor-related thalamic diffusion properties and cerebrospinal fluid hydrodynamics predict gait responses to tap test in idiopathic normal-pressure hydrocephalus

Tsai, P. H., Chen, Y. C., Chiang, S. W., Huang, T. Y., Chou, M. C., Liu, H. S., Chung, H. W., Peng, G. S., Ma, H. I., Kao, H. W. & Chen, C. Y., 五月 7 2018, (接受/付印) 於 : European Radiology. p. 1-10 10 p.

研究成果: 雜誌貢獻文章

Normal Pressure Hydrocephalus
Hydrodynamics
Gait
Cerebrospinal Fluid
Anisotropy
1 引文 (Scopus)

Diffusion tensor-derived properties of benign oligemia, true “at risk” Penumbra, and infarct core during the first three hours of stroke onset: A rat model

Chiu, F. Y., Kuo, D. P., Chen, Y. C., Kao, Y. C., Chung, H. W. & Chen, C. Y., 十一月 1 2018, 於 : Korean Journal of Radiology. 19, 6, p. 1161-1171 11 p.

研究成果: 雜誌貢獻文章

Anisotropy
Middle Cerebral Artery Infarction
Stroke
Diffusion Tensor Imaging
TP 7
2 引文 (Scopus)
Stents
Meta-Analysis
Stroke
Thrombectomy
Odds Ratio
2 引文 (Scopus)

Histogram analysis of T2*-based pharmacokinetic imaging in cerebral glioma grading

Liu, H. S., Chiang, S. W., Chung, H. W., Tsai, P. H., Hsu, F. T., Cho, N. Y., Wang, C. Y., Chou, M. C. & Chen, C. Y., 三月 1 2018, 於 : Computer Methods and Programs in Biomedicine. 155, p. 19-27 9 p.

研究成果: 雜誌貢獻文章

Pharmacokinetics
Glioma
Tumors
Imaging techniques
Magnetic resonance imaging
3 引文 (Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., 一月 1 2018, 於 : Oncotarget. 9, 15, p. 11922-11937 16 p.

研究成果: 雜誌貢獻文章

Glioblastoma
Brain Neoplasms
Caspase 3
Ataxia Telangiectasia Mutated Proteins
Staining and Labeling
7 引文 (Scopus)

Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury

Lee, G. A., Lin, T. N., Chen, C. Y., Mau, S. Y., Huang, W. Z., Kao, Y. C., Ma, R. Y. & Liao, N. S., 十月 1 2018, 於 : Brain, Behavior, and Immunity. 73, p. 562-570 9 p.

研究成果: 雜誌貢獻文章

Interleukin-15
Reperfusion Injury
Brain Ischemia
Reperfusion
Ischemia
30 引文 (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., 九月 15 2018, 於 : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

研究成果: 雜誌貢獻文章

Glioma
Isocitrate Dehydrogenase
Histology
Phenotype
Glioblastoma
4 引文 (Scopus)
Glioblastoma
Amyloid
Integrins
Serum
Glioma
2017
6 引文 (Scopus)

Amentoflavone enhances sorafenib-induced apoptosis through extrinsic and intrinsic pathways in sorafenib-resistant hepatocellular carcinoma SK-hep1 cells in vitro

Chen, W. L., Hsieh, C. L., Chen, J. H., Huang, C. S., Chen, W. T., Kuo, Y. C., Chen, C. Y. & Hsu, F. T., 2017, 於 : Oncology Letters. 14, 3, p. 3229-3234 6 p.

研究成果: 雜誌貢獻文章

Hepatocellular Carcinoma
Apoptosis
Apoptosis Regulatory Proteins
sorafenib
In Vitro Techniques
3 引文 (Scopus)

Differentiation of the infarct core from ischemic penumbra within the first 4.5 hours, using diffusion tensor imaging-derived metrics: A rat model

Kuo, D. P., Lu, C. F., Liou, M., Chen, Y. C., Chung, H. W. & Chen, C. Y., 三月 1 2017, 於 : Korean Journal of Radiology. 18, 2, p. 269-278 10 p.

研究成果: 雜誌貢獻文章

Diffusion Tensor Imaging
Stroke
Anisotropy
Cerebrovascular Circulation
Animal Care Committees
3 引文 (Scopus)

Early white matter injuries in patients with acute carbon monoxide intoxication

Tsai, P. H., Chou, M. C., Chiang, S. W., Chung, H. W., Liu, H. S., Kao, H. W. & Chen, C. Y., 二月 1 2017, 於 : Medicine (United States). 96, 5, 00032.

研究成果: 雜誌貢獻文章

Carbon Monoxide
Pyramidal Tracts
Wounds and Injuries
Anisotropy
Magnetic Resonance Spectroscopy
6 引文 (Scopus)

Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro

Chen, H. L., Hsu, F. T., Kao, Y. C. J., Liu, H. S., Huang, W. Z., Lu, C. F., Tsai, P. H., Ali, A. A. A., Lee, G. A., Chen, R. J. & Chen, C. Y., 十一月 22 2017, 於 : Journal of Nanobiotechnology. 15, 1, 86.

研究成果: 雜誌貢獻文章

Glioblastoma
Iron oxides
Epidermal Growth Factor Receptor
Nanoparticles
Lipids
16 引文 (Scopus)
Computer aided diagnosis
Glioma
Magnetic resonance imaging
Textures
Magnetic resonance
11 引文 (Scopus)

Radiomic model for predicting mutations in the isocitrate dehydrogenase gene in glioblastomas

Hsieh, K. L. C., Chen, C. Y. & Lo, C. M., 2017, 於 : Oncotarget. 8, 28, p. 45888-45897 10 p.

研究成果: 雜誌貢獻文章

Isocitrate Dehydrogenase
Glioblastoma
Mutation
Magnetic Resonance Imaging
Genes
9 引文 (Scopus)

Role of Genetic Variation in Collateral Circulation in the Evolution of Acute Stroke: A Multimodal Magnetic Resonance Imaging Study

Kao, Y. C. J., Oyarzabal, E. A., Zhang, H., Faber, J. E. & Shih, Y. Y. I., 三月 1 2017, 於 : Stroke. 48, 3, p. 754-761 8 p.

研究成果: 雜誌貢獻文章

Collateral Circulation
Perfusion
Stroke
Magnetic Resonance Imaging
Middle Cerebral Artery Infarction
Putamen
Stroke
Magnetic Resonance Imaging
Substantia Nigra
Lower Extremity
2016

Cerebral microbleeds and iron depletion of dentate nuclei in ataxia-telangiectasia

Liu, H. S., Chen, Y. C. & Chen, C. Y., 九月 6 2016, 於 : Neurology. 87, 10, p. 1062-1063 2 p.

研究成果: 雜誌貢獻評論/辯論

7 引文 (Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 七月 19 2016, 於 : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

研究成果: 雜誌貢獻文章

Salicylanilides
Osteoclasts
Bone Resorption
Osteogenesis
Bone

Early idiopathic normal pressure hydrocephalus patients with neuropsychological impairment are associated with increased fractional anisotropy in the anterior thalamic nucleus

Chen, Y. C., Chiang, S. W., Chi, C. H., Liou, M., Kuo, D. P., Kao, H. W., Chung, H. W., Ma, H. I., Peng, G. S., Wu, Y. T. & Chen, C. Y., 2016, 於 : Medicine (United States). 95, 19, e3636.

研究成果: 雜誌貢獻文章

Anterior Thalamic Nuclei
Normal Pressure Hydrocephalus
Anisotropy
Diffusion Tensor Imaging
Neuropsychological Tests
17 引文 (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., 十一月 11 2016, 於 : Scientific Reports. 6, 36650.

研究成果: 雜誌貢獻文章

Nanoparticles
Neoplasms
Transmission Electron Microscopy
Heterografts
Nude Mice
4 引文 (Scopus)
Occludin
Tight Junctions
Endothelial cells
Ketamine
Bradykinin
9 引文 (Scopus)

Novel anthra[1,2-c][1,2,5]thiadiazole-6,11-diones as promising anticancer lead compounds: Biological evaluation, characterization & molecular targets determination

Ali, A. A. A., Lee, Y. R., Chen, T. C., Chen, C. L., Lee, C. C., Shiau, C. Y., Chiang, C. H. & Huang, H. S., 四月 1 2016, 於 : PLoS One. 11, 4, e0154278.

研究成果: 雜誌貢獻文章

biochemical compounds
Lead compounds
Cells
bioavailability
rifamycins

Patient safety during radiological examinations: a nationwide survey of residency training hospitals in Taiwan

Lee, Y. H., Chen, C. C. C., Lee, S. K., Chen, C. Y., Wan, Y. L., Guo, W. Y., Cheng, A. & Chan, W. P., 九月 20 2016, 於 : BMJ Open. 6, 9, p. e010756

研究成果: 雜誌貢獻文章

Patient Safety
Internship and Residency
Taiwan
Radiology
Extravasation of Diagnostic and Therapeutic Materials
16 引文 (Scopus)

Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury

Yang, L. Y., Greig, N. H., Huang, Y. N., Hsieh, T. H., Tweedie, D., Yu, Q. S., Hoffer, B. J., Luo, Y., Kao, Y. C. & Wang, J. Y., 十二月 1 2016, 於 : Neurobiology of Disease. 96, p. 216-226 11 p.

研究成果: 雜誌貢獻文章

Oxygen
Apoptosis
Hippocampus
Annexin A5
Dentate Gyrus

Regarding Spontaneous Subdural Hematoma in a Middle-Aged Adult

Liao, P. Y. & Chen, C. Y., 九月 1 2016, 於 : Journal of Emergency Medicine. 51, 3, p. e67-e69

研究成果: 雜誌貢獻快報

Hematoma, Subdural, Acute
Subdural Hematoma
X Ray Computed Tomography
11 引文 (Scopus)

Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier

Chen, J. T., Chen, T. G., Chang, Y. C., Chen, C. Y. & Chen, R. M., 一月 2 2016, 於 : Toxicology. 339, p. 40-50 11 p.

研究成果: 雜誌貢獻文章

Tight Junctions
Endothelial cells
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Occludin
2015
6 引文 (Scopus)

High agatston calcium score of intracranial carotid artery: A significant risk factor for cognitive impairment

Kao, H. W., Liou, M., Chung, H. W., Liu, H. S., Tsai, P. H., Chiang, S. W., Chou, M. C., Peng, G. S., Huang, G. S., Hsu, H. H. & Chen, C. Y., 2015, 於 : Medicine (United States). 94, 39, p. e1546

研究成果: 雜誌貢獻文章

Internal Carotid Artery
Carotid Arteries
Calcium
Cognition
Diabetes Mellitus
4 引文 (Scopus)

Hypertensive brain stem encephalopathy

Liao, P. Y., Lee, C. C. & Chen, C. Y., 一月 1 2015, 於 : American Journal of Emergency Medicine. 33, 1, p. 131.e5-131.e7

研究成果: 雜誌貢獻文章

Brain Diseases
Brain Stem
Hypertensive Encephalopathy
Hypertension
Brain Edema

Middle cerebral artery calcification: Association with ischemic stroke

Kao, H. W., Liou, M., Chung, H. W., Liu, H-S., Tsai, P-H., Chiang, S. W., Chou, M. C., Peng, G. S., Huang, G. S., Hsu, H. H. & Chen, C-Y., 2015, 於 : Medicine (United States). 94, 50, 2311.

研究成果: 雜誌貢獻文章

Middle Cerebral Artery
Stroke
Calcium
Diabetes Mellitus
Smoking
6 引文 (Scopus)

Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Liu, F. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4522-4532 11 p.

研究成果: 雜誌貢獻文章

Oxazines
Osteoclasts
Osteogenesis
Assays
Cathepsin K

Regarding tumefactive demyelinating lesion, its image diagnosis, and discussion

Liao, P. Y. & Chen, C. Y., 二月 1 2015, 於 : American Journal of Emergency Medicine. 33, 2, p. 290-304 15 p., 54574.

研究成果: 雜誌貢獻文章

Multiple Sclerosis
11 引文 (Scopus)

Revisiting neuroimaging of abusive head trauma in infants and young children

Hsieh, K. L. C., Zimmerman, R. A., Kao, H. W. & Chen, C. Y., 五月 1 2015, 於 : American Journal of Roentgenology. 204, 5, p. 944-952 9 p.

研究成果: 雜誌貢獻文章

Craniocerebral Trauma
Neuroimaging
Wounds and Injuries
Brain Injuries
Therapeutics
12 引文 (Scopus)

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c[[1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents

Lee, Y. R., Chen, T. C., Lee, C. C., Chen, C. L., Ahmed Ali, A. A., Tikhomirov, A., Guh, J. H., Yu, D. S. & Huang, H. S., 九月 18 2015, 於 : European Journal of Medicinal Chemistry. 102, p. 661-676 16 p.

研究成果: 雜誌貢獻文章

Sulfur
Scaffolds
Antineoplastic Agents
Fusion reactions
Apoptosis
1 引文 (Scopus)

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Chen, C. L., Chen, T. C., Lee, C. C., Shih, L. C., Lin, C. Y., Hsieh, Y. Y., Ali, A. A. A. & Huang, H. S., 2015, 於 : Arabian Journal of Chemistry.

研究成果: 雜誌貢獻文章

Cells
Derivatives
thioxanthone
Screening
Molecules

Measuring steady-state cerebral vasomotor reactivity using non-triggered phase-contrast magnetic resonance imaging

Juan, C. J., Liu, Y. J., Huang, T. Y., Chen, C. Y. & Huang, G. S., 2014, 於 : Magnetic Resonance Imaging. 32, 5, p. 487-490 4 p.

研究成果: 雜誌貢獻文章

Magnetic resonance
Magnetic Resonance Imaging
Imaging techniques
Cerebrovascular Disorders
Healthy Volunteers
16 引文 (Scopus)

Modified salicylanilide and 3-phenyl-2 H -benzo[ e ][1,3]oxazine-2,4(3 H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Ahmed Ali, A. A., Sytwu, H. K., Chang, D. M. & Huang, H. S., 十月 9 2014, 於 : Journal of Medicinal Chemistry. 57, 19, p. 8072-8085 14 p.

研究成果: 雜誌貢獻文章

Salicylanilides
Osteoclasts
Bone Resorption
Osteogenesis
Bone Density Conservation Agents
4 引文 (Scopus)

Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

Lee, J. T., Chou, C. H., Cho, N. Y., Sung, Y. F., Yang, F. C., Chen, C. Y., Lai, Y. H., Chiang, C. I., Chu, C. M., Lin, J. C., Hsu, Y. D., Hong, J. S., Peng, G. S. & Chuang, D. M., 2014, 於 : American Journal of Translational Research. 6, 6, p. 820-830 11 p.

研究成果: 雜誌貢獻文章

Middle Cerebral Artery Infarction
Valproic Acid
Recovery
Stroke
Therapeutics
6 引文 (Scopus)

Relations of osteoporosis and follow-up duration to recurrent falls in older men and women

Lin, M. R., Hwang, H. F., Lin, P. S. & Chen, C. Y., 三月 2014, 於 : Osteoporosis International. 25, 3, p. 863-871 9 p.

研究成果: 雜誌貢獻文章

Osteoporosis
Hypnotics and Sedatives
Walking
Accidental Falls
History
13 引文 (Scopus)

Ring fusion strategy for the synthesis of anthra[2,3-d ]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Chang, W. W., Guh, J. H., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 十一月 24 2014, 於 : European Journal of Medicinal Chemistry. 87, p. 30-38 9 p.

研究成果: 雜誌貢獻文章

Topoisomerase Inhibitors
Oxazoles
Thiones
Type I DNA Topoisomerase
Antineoplastic Agents
2013
14 引文 (Scopus)

Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia

Liu, H. S., Chung, H. W., Chou, M. C., Liou, M., Wang, C. Y., Kao, H. W., Chiang, S. W., Juan, C. J., Huang, G. S. & Chen, C. Y., 七月 2013, 於 : Stroke. 44, 7, p. 1872-1877 6 p.

研究成果: 雜誌貢獻文章

Capillary Permeability
Ischemia
Pharmacokinetics
Stroke
Blood-Brain Barrier
2012

Susceptibility-weighted imaging, an additional tool to diagnose brain death: Initial experience

Tsai, F. Y., Lee, K. W., Kao, H. W. & Chen, C. Y., 十月 2012, 於 : Neuroradiology Journal. 25, 5, p. 505-508 4 p.

研究成果: 雜誌貢獻文章

Brain Death
Heart Arrest
Magnetic Resonance Spectroscopy
Arteries
Brain
2011
Brain Infarction
Seminoma
Magnetic Resonance Spectroscopy
Cerebral Infarction
Paresis
22 引文 (Scopus)

Fall mechanisms, bone strength, and hip fractures in elderly men and women in Taiwan

Hwang, H. F., Lee, H. D., Huang, H. H., Chen, C. Y. & Lin, M. R., 八月 2011, 於 : Osteoporosis International. 22, 8, p. 2385-2393 9 p.

研究成果: 雜誌貢獻文章

Bone Fractures
Hip Fractures
Taiwan
Bone and Bones
Hospital Emergency Service