• No. 250 Wu-Xing Street

    11031 Taipei

研究成果 1985 2020

2019
Sleep
Cohort Studies
Brain Concussion
Brain Diseases
Traumatic Brain Injury

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor

Chiu, C. F., Chin, H. K., Huang, W. J., Bai, L. Y., Huang, H. Y. & Weng, J. R., 十二月 4 2019, 於 : Biomolecules. 9, 12

研究成果: 雜誌貢獻文章

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3 引文 (Scopus)
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antioxidants
lungs
Lipid Peroxidation
Mitochondria
mitochondria
2 引文 (Scopus)

In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer

Lo, Y. W., Sheu, M. T., Chiang, W. H., Chiu, Y. L., Tu, C. M., Wang, W. Y., Wu, M. H., Wang, Y. C., Lu, M. & Ho, H. O., 三月 1 2019, 於 : Acta Biomaterialia. 86, p. 280-290 11 p.

研究成果: 雜誌貢獻文章

Hydrogels
Hydrogel
Breast Neoplasms
Injections
Antibodies
1 引文 (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., 一月 1 2019, 於 : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

研究成果: 雜誌貢獻文章

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Xylaria
Isoptera
termite mounds
Ethers
nitric oxide

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., 十一月 1 2019, 於 : Food and Chemical Toxicology. 133, p. 110808 110808.

研究成果: 雜誌貢獻文章

leptin (116-130)
hepatoma
Leptin
leptin
Hepatocellular Carcinoma
1 引文 (Scopus)
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Phototoxic Dermatitis
Retinal Pigments
luminance
pigments
Cell culture

Meta-Analysis of Genome-Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus

Lu, H-F., Hung, K-S., Chu, H-W., Wong, H. S-C., Kim, J., Choi, B. Y., Kim, M. K., Tai, Y-T., Ikegawa, S., Cho, E-C. & Chang, W-C., 二月 19 2019, 於 : Journal of Bone and Mineral Research. p. e3703 e3703.

研究成果: 雜誌貢獻文章

Calcaneus
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
Taiwan
5 引文 (Scopus)
Metabolome
Mass Spectrometry
Metabolomics
Dysbiosis
Microbiota

Metastatic colorectal cancer rewrites metabolic program through a Glut3-YAP-dependent signaling circuit

Kuo, C. C., Ling, H. H., Chiang, M. C., Chung, C. H., Lee, W. Y., Chu, C. Y., Wu, Y. C., Chen, C. H., Lai, Y. W., Tsai, I. L., Cheng, C. H. & Lin, C. W., 一月 1 2019, 於 : Theranostics. 9, 9, p. 2526-2540 15 p.

研究成果: 雜誌貢獻文章

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Colorectal Neoplasms
Neoplasm Metastasis
Colonic Neoplasms
Neoplasms
Proteins
1 引文 (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., 一月 1 2019, 於 : Frontiers in Oncology. 9, APR, p. 249 249.

研究成果: 雜誌貢獻文章

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Histone Deacetylases
Multiple Myeloma
Neoplasms
Histone Deacetylase Inhibitors
Growth

MWCNT-embedded Li4Ti5O12 microspheres interfacially modified with polyaniline as ternary composites for high-performance lithium ion battery anodes

Cho, E. C., Chang-Jian, C. W., Chou, J. A., Chung, C. L., Ho, P. C., Lee, K. C., Huang, J. H., Huang, J. H. & Hsiao, Y. S., 一月 1 2019, (接受/付印) 於 : Ceramics International.

研究成果: 雜誌貢獻文章

32 引文 (Scopus)

Nitro-Group-Containing Drugs

Nepali, K., Lee, H. Y. & Liou, J. P., 三月 28 2019, 於 : Journal of Medicinal Chemistry. 62, 6, p. 2851-2893 43 p.

研究成果: 雜誌貢獻回顧型文獻

Antitubercular Agents
Antiparasitic Agents
Pharmaceutical Chemistry
Prodrugs
Therapeutic Uses
1 引文 (Scopus)
Coumarins
Cell death
Colonic Neoplasms
Cell Death
Cells
olanzapine
Psychopathology
Schizophrenia
Quality of Life
Pharmacology

Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells

Wong, J. H., Wang, Y. S., Nam, S., Ho, K. H., Chang, C. M., Chen, K. C., Chen, Y. F. & Chang, W. C., 一月 1 2019, 於 : Environmental Toxicology.

研究成果: 雜誌貢獻文章

Plasticizers
phthalate
Cyclooxygenase 2
Stomach
Adenocarcinoma

Prescribing patterns and healthcare costs of gout

Lee, Y. Y., Kuo, L. N., Chen, J. H., Lin, Y. C., Chen, L. F. & Ko, Y., 一月 1 2019, (接受/付印) 於 : Current Medical Research and Opinion.

研究成果: 雜誌貢獻文章

Gout
Health Care Costs
Colchicine
Non-Steroidal Anti-Inflammatory Agents
Delivery of Health Care

Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer's disease

Sheu, J. J., Yang, L. Y., Sanotra, M. R., Wang, S. T., Lu, H. T., Kam, R. S. Y., Hsu, I. U., Kao, S. H., Lee, C. K., Shieh, J. C. C. & Lin, Y. F., 一月 1 2019, (接受/付印) 於 : Clinical Biochemistry.

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

Refluxed Esterification of Fullerene-Conjugated P25 TiO2 Promotes Free Radical Scavenging Capacity and Facilitates Antiaging Potentials in Human Cells

Lee, K. C., Chen, Y. L., Wang, C. C., Huang, J. H. & Cho, E. C., 一月 9 2019, 於 : ACS Applied Materials and Interfaces. 11, 1, p. 311-319 9 p.

研究成果: 雜誌貢獻文章

Fullerenes
Scavenging
Esterification
Free radicals
Nanostructured materials
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1 引文 (Scopus)

Short- and Long-term Risks of Highly Active Antiretroviral Treatment with Incident Opportunistic Infections among People Living with HIV/AIDS

Yen, Y. F., Chen, M., Jen, I. A., Chuang, P. H., Lee, C. Y., Lin, S. I. & Chen, Y. M. A., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 3476.

研究成果: 雜誌貢獻文章

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Opportunistic Infections
Highly Active Antiretroviral Therapy
Acquired Immunodeficiency Syndrome
HIV
Therapeutics

Single-nucleotide polymorphism of rs7944135 (macrophage-expressed gene 1) is associated with hepatitis B surface antigen seroclearance in chronic hepatitis B infection: A cohort study

Irham, L. M., Wong, H. S. C., Perwitasari, D. A., Chou, W. H., Yang, H. I. & Chang, W. C., 十二月 1 2019, 於 : Medicine (United States). 98, 51, e17936.

研究成果: 雜誌貢獻文章

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Spray-dried nanoporous NiO/PANI:PSS composite microspheres for high-performance asymmetric supercapacitors

Cho, E. C., Chang-Jian, C. W., Lee, K. C., Huang, J. H., Ho, B. C., Ding, Y. R. & Hsiao, Y. S., 十月 15 2019, 於 : Composites Part B: Engineering. 175, 107066.

研究成果: 雜誌貢獻文章

Polyaniline
Microspheres
Sodium
Composite materials
Spray drying
6 引文 (Scopus)

Spray-drying synthesis of Li 4 Ti 5 O 12 microspheres in pilot scale using TiO 2 nanosheets as starting materials and their application in high-rate lithium ion battery

Chang-Jian, C. W., Cho, E. C., Huang, J. H., Huang, J. H., Chou, J. A., Ho, B. C., Lee, K. C. & Hsiao, Y. S., 一月 30 2019, 於 : Journal of Alloys and Compounds. 773, p. 376-386 11 p.

研究成果: 雜誌貢獻文章

Spray drying
Nanosheets
Microspheres
Solid state reactions
Energy storage

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

Wang, C. C., Chen, H. F., Wu, J. Y. & Chen, L. G., 一月 21 2019, 於 : Molecules. 24, 2, 365.

研究成果: 雜誌貢獻文章

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Hydrolyzable Tannins
fluids
antioxidants
Fluids
buffers

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Misko, T. A., Liu, Y. T., Harris, M. E., Oleinick, N. L., Pink, J., Lee, H. Y. & Dealwis, C. G., 一月 1 2019, 於 : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 438-450 13 p.

研究成果: 雜誌貢獻文章

Ribonucleotide Reductases
Hydrazones
Neoplasms
Pancreatic Neoplasms
Catalytic Domain
1 引文 (Scopus)

Surface modification of Ni(OH) 2 nanosheets with PEDOT:PSS for supercapacitor and bendable electrochromic applications

Lee, K. C., Chang-Jian, C. W., Cho, E. C., Huang, J. H., Lin, W. T., Ho, B. C., Chou, J. A. & Hsiao, Y. S., 六月 15 2019, 於 : Solar Energy Materials and Solar Cells. 195, p. 1-11 11 p.

研究成果: 雜誌貢獻文章

Nanosheets
Electrochromic devices
Surface treatment
Chemical resistance
Mechanical stability
Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
Protein Kinases
Lipase
2 引文 (Scopus)
Urinary Bladder Neoplasms
Antineoplastic Agents
G1 Phase
Ovarian Neoplasms
Solubility
1 引文 (Scopus)

Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status

Chin, Y-T., He, Z-R., Chen, C-L., Chu, H-C., Ho, Y., Su, P-Y., Yang, Y-C. S. H., Wang, K., Shih, Y-J., Chen, Y-R., Pedersen, J. Z., Incerpi, S., Nana, A. W., Tang, H-Y., Lin, H-Y., Mousa, S. A., Davis, P. J. & Whang-Peng, J., 一月 1 2019, 於 : Frontiers in Endocrinology. 10, APR, p. 130 130.

研究成果: 雜誌貢獻文章

Integrins
Colorectal Neoplasms
HCT116 Cells
Neoplasms
HT29 Cells

The association between the sedative loads and clinical severity indicators in the first-onset major depressive disorder

Wang, Y. C., Lin, H. T., Lu, M. L., Huang, M. C., Chen, C. H., Wu, T. H., Wang, S., Mao, W. C., Kuo, P. H. & Chen, H. C., 一月 1 2019, 於 : Frontiers in Psychiatry. 10, MAR, p. 129 129.

研究成果: 雜誌貢獻文章

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Major Depressive Disorder
Hypnotics and Sedatives
Antidepressive Agents
Lorazepam
Anxiety Disorders

The development and use of a pharmacist-specific Mini-CEX for postgraduate year trainees in Taiwan

Wei, C. J., Lu, T. H., Chien, S. C., Huang, W. T., Liu, Y. P., Chan, C. Y. & Chiu, C. H., 五月 22 2019, 於 : BMC Medical Education. 19, 1, 165.

研究成果: 雜誌貢獻文章

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pharmacist
trainee
Taiwan
evaluation
Teaching
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The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., 三月 15 2019, 於 : Phytomedicine. 56, p. 207-214 8 p.

研究成果: 雜誌貢獻文章

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1
Chemokine CCL2

The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population

Chen, W. C., Chou, W. H., Chu, H. W., Huang, C. C., Liu, X., Chang, W. P., Chou, Y. H. & Chang, W. C., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 17296.

研究成果: 雜誌貢獻文章

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Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth

Chien, C. W., Lo, Y. S., Wu, H. Y., Hsuan, Y., Lin, C. K., Chen, Y. J., Lin, W. & Han, C. L., 一月 1 2019, (接受/付印) 於 : Proteomics - Clinical Applications. 1900024.

研究成果: 雜誌貢獻文章

Ultrasound-assisted synthesis of thermosensitive nanovesicle for direct trap and release of analgesic drugs in biofluid and sewage

Lee, Y. C., Hsieh, C. M., Tsai, T. N., Yang, D. P. & Chen, P. S., 六月 1 2019, 於 : Ultrasonics Sonochemistry. 54, p. 61-67 7 p.

研究成果: 雜誌貢獻文章

sewage
Sonication
urine
Sewage
Acetaminophen
2018
16 引文 (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
8 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
5 引文 (Scopus)
Morus
mulberries
phenolic compounds
Antioxidants
antioxidants
12 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
3 引文 (Scopus)

A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

Weng, J. R., Dokla, E. M. E., Bai, L. Y., Chen, C. S., Chiu, S. J. & Shieh, T. M., 一月 1 2018, (接受/付印) 於 : Basic and Clinical Pharmacology and Toxicology.

研究成果: 雜誌貢獻文章

Enzyme Activators
AMP-Activated Protein Kinases
Autophagy
Squamous Cell Carcinoma
Protein Tyrosine Phosphatases
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
2 引文 (Scopus)

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., 三月 1 2018, 於 : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

研究成果: 雜誌貢獻文章

p38 Mitogen-Activated Protein Kinases
Cell Death
Microtubules
Liver
Phosphorylation