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研究成果 1985 2020

(Journal of Food and Drug Analysis 18, 6, (380))

Cheng, Y. W. & Lou, H. Y., 六月 2011, 於 : Journal of Food and Drug Analysis. 19, 2, p. 243 1 p.

研究成果: 雜誌貢獻文章

Food Analysis
drugs
Pharmaceutical Preparations
16 引文 (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
2 引文 (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., 十一月 10 2017, 於 : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
8 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
13 引文 (Scopus)

1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Lee, H. Y., Yang, C-R., Lai, M-J., Huang, H-L., Hsieh, Y-L., Liu, Y-M., Yeh, T-K., Li, Y-H., Mehndiratta, S., Teng, C-M. & Liou, J. P., 七月 2013, 於 : ChemBioChem. 14, 10, p. 1248-1254 7 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Cytokines
Anti-Inflammatory Agents
Inflammation
13 引文 (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
5 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
12 引文 (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, 於 : Mediators of Inflammation. 2016, 6953459.

研究成果: 雜誌貢獻文章

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
4 引文 (Scopus)

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 十月 21 2016, 於 : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Antineoplastic Agents
Acetylation
Acrylamide
Structure-Activity Relationship
4 Downloads (Pure)

2001藥物實體外觀辨識手冊

Chien, S-C., 2001, 行政院衛生署.

研究成果: 报告类型書籍

檔案

2002藥物實體外觀辨識手冊

Chien, S-C., 二月 2002, 行政院衛生署. 440 p.

研究成果: 报告类型書籍

12 引文 (Scopus)

2-Amino-3,4,5-Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

Chuang, H-Y., Chang, J-Y., Lai, M-J., Kuo, C-C., Lee, H. Y., Hsieh, H-P., Chen, Y-J., Chen, L-T., Pan, W-Y. & Liou, J. P., 三月 7 2011, 於 : ChemMedChem. 6, 3, p. 450-456 7 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Inhibitory Concentration 50
Cells
Lead compounds
Colchicine
42 引文 (Scopus)

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

Chang, J. Y., Yang, M. F., Chang, C. Y., Chen, C. M., Kuo, C. C. & Liou, J. P., 十月 2006, 於 : Journal of Medicinal Chemistry. 49, 21, p. 6412-6415 4 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Antimitotic Agents
Colchicine
Tubulin
Bioactivity
6 引文 (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
37 引文 (Scopus)

2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer

Lin, H. L., Yang, M. H., Wu, C. W., Chen, P. M., Yang, Y. P., Chu, Y. R., Kao, C. L., Ku, H. H., Lo, J. F., Liou, J. P., Chi, C. W. & Chiou, S. H., 十二月 1 2007, 於 : International Journal of Cancer. 121, 11, p. 2547-2555 9 p.

研究成果: 雜誌貢獻文章

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
Stomach Neoplasms
Neoplasm Metastasis
Neoplasms
9 引文 (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
57 引文 (Scopus)

4- And 5-aroylindoles as novel classes of potent antitubulin agents

Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., 九月 6 2007, 於 : Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Colchicine
Tubulin
Inhibitory Concentration 50
Polymerization
8 引文 (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., 七月 7 2017, 於 : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

研究成果: 雜誌貢獻文章

Heterografts
Tumors
Bearings (structural)
Histone Deacetylase Inhibitors
Acrylamide
5 引文 (Scopus)
Morus
mulberries
phenolic compounds
Antioxidants
antioxidants
6 引文 (Scopus)
Colonic Neoplasms
Apoptosis
Cell Line
DNA
Cell Cycle Proteins
63 引文 (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J. Y., 三月 11 2010, 於 : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Inhibitory Concentration 50
Cell Line
Colchicine
Tubulin
42 引文 (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., 十二月 22 2011, 於 : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Sulfones
Sulfides
HT29 Cells
Tubulin
12 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
60 引文 (Scopus)

6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

Lin, C. M., Huang, S. T., Lee, F. W., Kuo, H. S. & Lin, M. H., 七月 1 2006, 於 : Bioorganic and Medicinal Chemistry. 14, 13, p. 4402-4409 8 p.

研究成果: 雜誌貢獻文章

Coumarins
Hydroxyl Radical
Anti-Inflammatory Agents
Phloroglucinol
Derivatives
61 引文 (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., 十一月 16 2006, 於 : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Sulfonamides
Colchicine
Cell growth
Display devices
14 引文 (Scopus)
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Epidermal Growth Factor Receptor
Smooth Muscle Myocytes
Cell Movement
3 引文 (Scopus)

A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

Weng, J. R., Dokla, E. M. E., Bai, L. Y., Chen, C. S., Chiu, S. J. & Shieh, T. M., 一月 1 2018, (接受/付印) 於 : Basic and Clinical Pharmacology and Toxicology.

研究成果: 雜誌貢獻文章

Enzyme Activators
AMP-Activated Protein Kinases
Autophagy
Squamous Cell Carcinoma
Protein Tyrosine Phosphatases
26 引文 (Scopus)

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., 二月 10 2014, 於 : PLoS One. 9, 2, e88644.

研究成果: 雜誌貢獻文章

neurotoxicity
Kainic Acid
glutamates
Rats
Glutamic Acid
4 引文 (Scopus)

Accumulation of methylglyoxal and d-lactate in Pb-induced nephrotoxicity in rats

Huang, Y. S., Li, Y. C., Tsai, P. Y., Lin, C. E., Chen, C. M., Chen, S-M. & Lee, J-A., 五月 2017, 於 : Biomedical Chromatography.

研究成果: 雜誌貢獻文章

Pyruvaldehyde
Metformin
Rats
Lactic Acid
Kidney
23 引文 (Scopus)

A Chinese herbal medicine, Jia-Wei-Xiao-Yao-San, prevents dimethylnitrosamine-induced hepatic fibrosis in rats

Chien, S-C., Chang, W. C., Lin, P. H., Chang, W. P., Hsu, S. C., Chang, J. C., Wu, Y. C., Pei, J. K. & Lin, C. H., 2014, 於 : Scientific World Journal. 2014, 217525.

研究成果: 雜誌貢獻文章

Dimethylnitrosamine
Herbal Medicine
Rats
serum
Fibrosis

A combination of pharmacophore and in silico approaches for identification of potential transthyretin amyloidosis inhibitors

Zhou, Z. L., Liu, H. L., Wu, J. W., Tsao, C. W., Chen, W. H., Liu, K. T. & Ho, Y., 一月 2014, 於 : Letters in Drug Design and Discovery. 11, 3, p. 339-348 10 p.

研究成果: 雜誌貢獻文章

Prealbumin
Chemical Databases
Computer Simulation
Familial Amyloid Neuropathies
Molecular Dynamics Simulation
11 引文 (Scopus)

A concise synthesis of denbinobin

Wang, Y. C., Lin, C-H., Chen, C. M. & Liou, J. P., 十一月 21 2005, 於 : Tetrahedron Letters. 46, 47, p. 8103-8104 2 p.

研究成果: 雜誌貢獻文章

Cyclization
Biological Products
Bromides
Free Radicals
Oxidation
3 引文 (Scopus)

Aconitamide, a novel alkaloid from the roots of Aconitum carmichaeli

Li, Z-H., Chen, Y. C., Lee, C. K., Chang, H. S., Kuo, C. C., Chao, C. Y., Lin, J. J., Lo, L. C. & Kuo, Y. H., 2013, 於 : Natural Product Communications. 8, 6, p. 827-828 2 p.

研究成果: 雜誌貢獻文章

Aconitum
telomerase
Far East
Telomerase
Chinese Traditional Medicine

A cost-effectiveness analysis of trastuzumab-containing treatment sequences for HER-2 positive metastatic breast cancer patients in Taiwan

Diaby, V., Alqhtani, H., van Boemmel-Wegmann, S., Wang, C. Y., Ali, A. A., Balkrishnan, R., Ko, Y., Palacio, S. & de Lima Lopes, G., 二月 1 2020, 於 : Breast. 49, p. 141-148 8 p.

研究成果: 雜誌貢獻文章

開啟存取
10 引文 (Scopus)

Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells by polycyclic aromatic hydrocarbons

Li, C. H., Lee, C. C., Cheng, Y. W., Juang, H. A. & Kang, J. J., 七月 15 2004, 於 : Toxicology Letters. 151, 2, p. 367-374 8 p.

研究成果: 雜誌貢獻文章

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Polycyclic Aromatic Hydrocarbons
Endothelial cells
Human Umbilical Vein Endothelial Cells
Polycyclic aromatic hydrocarbons
28 引文 (Scopus)

Acute hypoxia enhances proteins' S-nitrosylation in endothelial cells

Chen, S-C., Huang, B., Liu, Y. C., Shyu, K-G., Lin, P. Y. & Wang, D. L., 十二月 26 2008, 於 : Biochemical and Biophysical Research Communications. 377, 4, p. 1274-1278 5 p.

研究成果: 雜誌貢獻文章

Protein S
Endothelial cells
Endothelial Cells
Nitric Oxide
Cysteine
86 引文 (Scopus)

Acute nephrotoxicity of aristolochic acids in mice

Sato, N., Takahashi, D., Chen, S. M., Tsuchiya, R., Mukoyama, T., Yamagata, S. I., Ogawa, M., Yoshida, M., Kondo, S., Satoh, N. & Ueda, S., 二月 2004, 於 : Journal of Pharmacy and Pharmacology. 56, 2, p. 221-229 9 p.

研究成果: 雜誌貢獻文章

Aristolochic Acids
Interstitial Nephritis
Inbred C3H Mouse
Aristolochia
Kidney
51 引文 (Scopus)

Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study

Lee, Y-W., Chen, T-L., Shih, Y. R. V., Tsai, C. L., Chang, C-C., Liang, H-H., Tseng, S-H., Chien, S-C. & Wang, C-C., 五月 1 2014, 於 : Cancer. 120, 9, p. 1338-1344 7 p.

研究成果: 雜誌貢獻文章

Chinese Traditional Medicine
Breast Neoplasms
Survival
Population
Therapeutics
1 引文 (Scopus)

A dose-dependent pharmacokinetic study of levodopa by intramuscular administration in rabbits

Wang, L. H., Hsu, K. Y., Hsu, F-L. & Lin, S. J., 十月 2008, 於 : Journal of Food and Drug Analysis. 16, 5, p. 21-27 7 p.

研究成果: 雜誌貢獻文章

L-dopa
Levodopa
intramuscular injection
pharmacokinetics
Pharmacokinetics
11 引文 (Scopus)

A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration

Uang, Y. S. & Hsu, K. Y., 1997, 於 : Biopharmaceutics and Drug Disposition. 18, 8, p. 727-736 10 p.

研究成果: 雜誌貢獻文章

Intravenous Administration
Pharmacokinetics
Rabbits
Half-Life
Urine
3 引文 (Scopus)
Taiwan
Teaching Hospitals
Analgesics
Acetaminophen
Pharmaceutical Preparations
9 引文 (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 五月 15 2017, 於 : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

研究成果: 雜誌貢獻文章

decitabine
Wnt Signaling Pathway
Histone Deacetylase Inhibitors
Histone Deacetylases
Non-Small Cell Lung Carcinoma
16 引文 (Scopus)

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 四月 28 2014, 於 : Cancer Letters. 346, 1, p. 84-93 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Non-Small Cell Lung Carcinoma
Cisplatin
Lung Neoplasms
Neoplasms
11 引文 (Scopus)

Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study

Lin, H. C., Daimon, M., Wang, C. H., Ho, Y., Uang, Y. S., Chiang, S. J. & Wang, L. H., 四月 15 2017, 於 : International Journal of Cardiology. 233, p. 85-90 6 p.

研究成果: 雜誌貢獻文章

Gout
Coronary Disease
Coronary Artery Disease
Benzbromarone
Population
9 引文 (Scopus)
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Vasodilation
Endothelium
Calcium
Human Umbilical Vein Endothelial Cells
10 引文 (Scopus)

Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway

Bai, L. Y., Chiu, C. F., Chiu, S. J., Chen, Y. W., Hu, J. L., Wu, C. Y. & Weng, J. R., 十月 1 2015, 於 : Journal of Functional Foods. 18, p. 368-378 11 p., 1245.

研究成果: 雜誌貢獻文章

Triterpenes
autophagy
Autophagy
squamous cell carcinoma
triterpenoids
1 引文 (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., 一月 1 2019, 於 : Biomaterials. 190-191, p. 1-10 10 p.

研究成果: 雜誌貢獻文章

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress
13 引文 (Scopus)

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., 四月 15 2016, 於 : Life Sciences. 151, p. 7-14 8 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Cell Movement
Breast Neoplasms
Atlases
Assays
4 引文 (Scopus)

Alternative Therapies as a Substitute for Costly Prescription Medications: Results from the 2011 National Health Interview Survey

Wang, C. C., Kennedy, J. & Wu, C. H., 六月 3 2015, 於 : Clinical Therapeutics. 37, 5, p. 1022-1030 9 p.

研究成果: 雜誌貢獻文章

Complementary Therapies
Health Surveys
Prescriptions
Interviews
Logistic Models
6 引文 (Scopus)

A medication assessment tool to evaluate adherence to medication guideline in asthmatic children

Liu, H. P., Chen, H. Y., Johnson, J. & Lin, Y. M., 四月 2013, 於 : International Journal of Clinical Pharmacy. 35, 2, p. 289-295 7 p.

研究成果: 雜誌貢獻文章

Medication Adherence
Guidelines
Asthma
Scotland
Testing