癌症轉譯研究中心 - 藥物開發

研究成果 2014 2019

  • 595 引文
  • 14 h-指數
  • 63 文章
  • 3 回顧型文獻
篩選
文章
2019
3 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
2 引文 (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., 六月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

研究成果: 雜誌貢獻文章

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
Urinary Bladder Neoplasms
Antineoplastic Agents
G1 Phase
Ovarian Neoplasms
Solubility
2018
13 引文 (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
4 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
9 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 一月 1 2018, 於 : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Emotions
6 引文 (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
1 引文 (Scopus)
Hypoxia-Inducible Factor 1
Phosphorylation
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Microtubules

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., 十二月 29 2018, 於 : Clinical Epigenetics. 10, 1, 162.

研究成果: 雜誌貢獻文章

Leukemia
Vincristine
Doxorubicin
Drug Therapy
Neoplasms
11 引文 (Scopus)
Histone Acetyltransferases
Alzheimer Disease
Phosphorylation
Histone Deacetylases
tau Proteins
1 引文 (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., 十月 1 2018, 於 : Redox Biology. 19, p. 74-80 7 p.

研究成果: 雜誌貢獻文章

Acetylation
Oxidative stress
Zinc Fingers
Zinc
Oxidative Stress
2017
2 引文 (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., 十一月 10 2017, 於 : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
9 引文 (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
7 引文 (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., 七月 7 2017, 於 : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

研究成果: 雜誌貢獻文章

Heterografts
Tumors
Bearings (structural)
Histone Deacetylase Inhibitors
Acrylamide
3 引文 (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
2 引文 (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., 二月 9 2017, 於 : Scientific Reports. 7, 42291.

研究成果: 雜誌貢獻文章

Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy

Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huan, H. M., 八月 18 2017, (接受/付印) 於 : Apoptosis. p. 1 1 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Down-Regulation
Apoptosis
Imatinib Mesylate
18 引文 (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 八月 15 2017, 於 : Cancer Research. 77, 16, p. 4305-4316 12 p.

研究成果: 雜誌貢獻文章

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
4 引文 (Scopus)
Autophagy
Colorectal Neoplasms
Cell Death
HCT116 Cells
Cyclin B1
3 引文 (Scopus)
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Microtubules
Down-Regulation
Apoptosis

Pharmacokinetics and protein binding of MPT0B292

Tien, Y. E., Li, C. J., Liou, J. P., Chang, J. Y. & Huang, J. D., 2017, (接受/付印) 於 : Biopharmaceutics and Drug Disposition.

研究成果: 雜誌貢獻文章

Protein Binding
Pharmacokinetics
Albumins
Pharmaceutical Preparations
Nanoparticles
6 引文 (Scopus)
Carbolines
Histone Deacetylases
Cytotoxicity
Hydroxamic Acids
Indoles
5 引文 (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., 十月 1 2017, 於 : Redox Biology. 13, p. 655-664 10 p.

研究成果: 雜誌貢獻文章

temozolomide
Methyltransferases
Glioblastoma
DNA
Proteins
2 引文 (Scopus)
Stilbenes
Rhizome
Glycosides
Metabolites
Oxidation
2016
4 引文 (Scopus)

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 十月 21 2016, 於 : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Antineoplastic Agents
Acetylation
Acrylamide
Structure-Activity Relationship
2 引文 (Scopus)

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huang, H. M., 九月 1 2016, 於 : Apoptosis. 21, 9, p. 1008-1018 11 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
K562 Cells
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Down-Regulation
2 引文 (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides with potent anti-proliferative and anti-angiogenic activities

Mehndiratta, S., Pan, S. L., Kumar, S. & Liou, J. P., 七月 1 2016, 於 : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 907-913 7 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Acrylamide
Acrylamides
Neoplasms
Nude Mice
4 引文 (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., 六月 9 2016, 於 : Scientific Reports. 6, 27794.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Pancreatic Neoplasms
Polyploidy
Microtubules
Growth
10 引文 (Scopus)

MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma

Peng, H. Y., Cheng, Y. C., Hsu, Y. M., Wu, G. H., Kuo, C. C., Liou, J. P., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 七月 1 2016, 於 : PLoS One. 11, 7, e0158440.

研究成果: 雜誌貢獻文章

non-specific protein-tyrosine kinase
Janus Kinase 2
STAT3 Transcription Factor
squamous cell carcinoma
Microtubules
4 引文 (Scopus)
Tubulin Modulators
Myeloid Cells
Paclitaxel
Acute Myeloid Leukemia
Down-Regulation
5 引文 (Scopus)
Antineoplastic Agents
Ovarian Neoplasms
Cisplatin
Apoptosis
Pharmaceutical Preparations
13 引文 (Scopus)
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
7 引文 (Scopus)

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., 十一月 18 2016, 於 : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

研究成果: 雜誌貢獻文章

Glioma
Stem Cells
Glioblastoma
Cells
Histone Deacetylases
7 引文 (Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., 四月 22 2016, 於 : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

研究成果: 雜誌貢獻文章

Stilbenes
Decarboxylation
Cyclization
phenanthrene
denbinobin
6 引文 (Scopus)
Urinary Bladder Neoplasms
Autophagy
G1 Phase Cell Cycle Checkpoints
cdc Genes
Cyclin E
2015
13 引文 (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
6 引文 (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
10 引文 (Scopus)

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

Huang, Y. C., Huang, F. I., Mehndiratta, S., Lai, S. C., Liou, J. P. & Yang, C. R., 2015, 於 : Oncotarget. 6, 21, p. 18590-18601 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Growth
Neoplasms
HCT116 Cells
HSP90 Heat-Shock Proteins
14 引文 (Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
KB Cells
Colchicine
Tubulin
Polymerization
2 引文 (Scopus)
Acrylamide
Colorectal Neoplasms
Histone Deacetylases
Cadherins
Neoplasms
1 引文 (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., 四月 14 2015, 於 : PLoS One. 10, 4, e0123819.

研究成果: 雜誌貢獻文章

ovarian neoplasms
Tubulin
tubulin
Ovarian Neoplasms
apoptosis
6 引文 (Scopus)
Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
15 引文 (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
7 引文 (Scopus)
HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
25 引文 (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., 十二月 12 2015, 於 : Journal of Hematology and Oncology. 8, 1, 176.

研究成果: 雜誌貢獻文章

Vincristine
Leukemia
Microtubules
Tubulin
Cell Survival
2014
22 引文 (Scopus)
Transforming Growth Factors
Angiotensin II
Androgens
Testosterone
Fibroblasts
7 引文 (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於 : Oncotarget. 5, 20, p. 9838-9850 13 p.

研究成果: 雜誌貢獻文章

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
21 引文 (Scopus)
Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms