癌症轉譯研究中心 - 藥物開發

研究成果 2014 2020

  • 732 引文
  • 15 h-指數
  • 69 文章
  • 3 回顧型文獻
2015
2 引文 (Scopus)
Acrylamide
Colorectal Neoplasms
Histone Deacetylases
Cadherins
Neoplasms
3 引文 (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., 四月 14 2015, 於 : PLoS One. 10, 4, e0123819.

研究成果: 雜誌貢獻文章

ovarian neoplasms
Tubulin
tubulin
Ovarian Neoplasms
apoptosis
7 引文 (Scopus)
Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
16 引文 (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
8 引文 (Scopus)
HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
26 引文 (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., 十二月 12 2015, 於 : Journal of Hematology and Oncology. 8, 1, 176.

研究成果: 雜誌貢獻文章

Vincristine
Leukemia
Microtubules
Tubulin
Cell Survival
2014
25 引文 (Scopus)
Transforming Growth Factors
Angiotensin II
Androgens
Testosterone
Fibroblasts
7 引文 (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於 : Oncotarget. 5, 20, p. 9838-9850 13 p.

研究成果: 雜誌貢獻文章

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
23 引文 (Scopus)
Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms
7 引文 (Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 四月 22 2014, 於 : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

研究成果: 雜誌貢獻文章

Benzophenones
Antimitotic Agents
KB Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
35 引文 (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 五月 22 2014, 於 : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

研究成果: 雜誌貢獻文章

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
6 引文 (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 九月 1 2014, 於 : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase
10 引文 (Scopus)
Curcumin
Extracellular Matrix
Fibroblasts
Angiotensin II
Transforming Growth Factors
16 引文 (Scopus)

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., 十月 22 2014, 於 : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

研究成果: 雜誌貢獻文章

Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
MicroRNAs
Interleukin-1
Osteoarthritis
6 引文 (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., 十一月 28 2014, 於 : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tumors
Substitution reactions
selectivity
substitutes
17 引文 (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., 十月 6 2014, 於 : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Cell Survival
Anti-Inflammatory Agents
Cells
14 引文 (Scopus)

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2

Hou, P., Kuo, C. Y., Cheng, C. T., Liou, J. P., Ann, D. K. & Chen, Q., 十一月 24 2014, 於 : PLoS One. 9, 11, e113865.

研究成果: 雜誌貢獻文章

procollagen-proline dioxygenase
Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Metabolites
metabolites
4 引文 (Scopus)

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells

Tsai, A. C., Pai, H. C., Wang, C. Y., Liou, J. P., Teng, C. M., Wang, J. C. & Pan, S. L., 一月 2014, 於 : British Journal of Pharmacology. 171, 1, p. 122-133 12 p.

研究成果: 雜誌貢獻文章

P-Glycoprotein
Non-Small Cell Lung Carcinoma
lissamine rhodamine B
Neoplasms
Cyclin B1
14 引文 (Scopus)

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Tsai, A. C., Wang, C. Y., Liou, J. P., Pai, H. C., Hsiao, C. J., Chang, J. Y., Wang, J. C., Teng, C. M. & Pan, S. L., 2014, 於 : Cell Death and Disease. 5, 4, e1162.

研究成果: 雜誌貢獻文章

Non-Small Cell Lung Carcinoma
Microtubules
Tubulin
Cyclin B1
Therapeutics
20 引文 (Scopus)

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Hsieh, I-N., Liou, J. P., Lee, H. Y., Lai, M-J., Li, Y-H. & Yang, C-R., 2014, 於 : Cell Death and Disease. 5, 4, e1166.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Arthritis
Pharmacokinetics
Histone Deacetylases
Oral Administration
32 引文 (Scopus)

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, 於 : Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Liver Neoplasms
Heterografts
Cell Survival
Histone Code
49 引文 (Scopus)

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., 一月 2014, 於 : Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Microtubules
Spindle Apparatus
Tubulin
Neoplasms