癌症轉譯研究中心 - 藥物開發

研究成果 2014 2020

  • 732 引文
  • 15 h-指數
  • 69 文章
  • 3 回顧型文獻
文章
18 引文 (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 二月 8 2018, 於 : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

研究成果: 雜誌貢獻文章

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
4 引文 (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., 十一月 10 2017, 於 : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

研究成果: 雜誌貢獻文章

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
9 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
14 引文 (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
5 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
6 引文 (Scopus)

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., 十月 21 2016, 於 : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Antineoplastic Agents
Acetylation
Acrylamide
Structure-Activity Relationship
6 引文 (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, 於 : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Inhibitory Concentration 50
10 引文 (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., 一月 5 2017, 於 : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
9 引文 (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., 七月 7 2017, 於 : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

研究成果: 雜誌貢獻文章

Heterografts
Tumors
Bearings (structural)
Histone Deacetylase Inhibitors
Acrylamide
13 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
25 引文 (Scopus)
Transforming Growth Factors
Angiotensin II
Androgens
Testosterone
Fibroblasts
3 引文 (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, 於 : Oncotarget. 8, 17, p. 27772-27785 14 p.

研究成果: 雜誌貢獻文章

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
7 引文 (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, 於 : Oncotarget. 5, 20, p. 9838-9850 13 p.

研究成果: 雜誌貢獻文章

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
23 引文 (Scopus)
Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
3 引文 (Scopus)

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huang, H. M., 九月 1 2016, 於 : Apoptosis. 21, 9, p. 1008-1018 11 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
K562 Cells
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Down-Regulation
11 引文 (Scopus)

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

Huang, Y. C., Huang, F. I., Mehndiratta, S., Lai, S. C., Liou, J. P. & Yang, C. R., 2015, 於 : Oncotarget. 6, 21, p. 18590-18601 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Growth
Neoplasms
HCT116 Cells
HSP90 Heat-Shock Proteins
2 引文 (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., 二月 9 2017, 於 : Scientific Reports. 7, 42291.

研究成果: 雜誌貢獻文章

Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy
5 引文 (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., 六月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

研究成果: 雜誌貢獻文章

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
15 引文 (Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C-Y., Lai, M-J., Chuang, H-Y., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 七月 23 2015, 於 : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
KB Cells
Colchicine
Tubulin
Polymerization
7 引文 (Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 四月 22 2014, 於 : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

研究成果: 雜誌貢獻文章

Benzophenones
Antimitotic Agents
KB Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
35 引文 (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 五月 22 2014, 於 : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

研究成果: 雜誌貢獻文章

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
6 引文 (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 九月 1 2014, 於 : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 一月 1 2018, 於 : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

研究成果: 雜誌貢獻文章

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Emotions
10 引文 (Scopus)
Curcumin
Extracellular Matrix
Fibroblasts
Angiotensin II
Transforming Growth Factors
16 引文 (Scopus)

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., 十月 22 2014, 於 : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

研究成果: 雜誌貢獻文章

Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
MicroRNAs
Interleukin-1
Osteoarthritis
10 引文 (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., 三月 1 2018, 於 : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

研究成果: 雜誌貢獻文章

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats
6 引文 (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., 十一月 28 2014, 於 : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Tumors
Substitution reactions
selectivity
substitutes

Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huan, H. M., 八月 18 2017, (接受/付印) 於 : Apoptosis. p. 1 1 p.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Emitter coupled logic circuits
Apoptosis
Industry
Imatinib Mesylate
23 引文 (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 八月 15 2017, 於 : Cancer Research. 77, 16, p. 4305-4316 12 p.

研究成果: 雜誌貢獻文章

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
6 引文 (Scopus)
Autophagy
Colorectal Neoplasms
Cell Death
HCT116 Cells
Cyclin B1
17 引文 (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., 十月 6 2014, 於 : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Cell Survival
Anti-Inflammatory Agents
Cells
3 引文 (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides with potent anti-proliferative and anti-angiogenic activities

Mehndiratta, S., Pan, S. L., Kumar, S. & Liou, J. P., 七月 1 2016, 於 : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 907-913 7 p.

研究成果: 雜誌貢獻文章

Histone Deacetylases
Acrylamide
Acrylamides
Neoplasms
Nude Mice
14 引文 (Scopus)

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2

Hou, P., Kuo, C. Y., Cheng, C. T., Liou, J. P., Ann, D. K. & Chen, Q., 十一月 24 2014, 於 : PLoS One. 9, 11, e113865.

研究成果: 雜誌貢獻文章

procollagen-proline dioxygenase
Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Metabolites
metabolites
4 引文 (Scopus)

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells

Tsai, A. C., Pai, H. C., Wang, C. Y., Liou, J. P., Teng, C. M., Wang, J. C. & Pan, S. L., 一月 2014, 於 : British Journal of Pharmacology. 171, 1, p. 122-133 12 p.

研究成果: 雜誌貢獻文章

P-Glycoprotein
Non-Small Cell Lung Carcinoma
lissamine rhodamine B
Neoplasms
Cyclin B1
5 引文 (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., 六月 9 2016, 於 : Scientific Reports. 6, 27794.

研究成果: 雜誌貢獻文章

Antimitotic Agents
Pancreatic Neoplasms
Polyploidy
Microtubules
Growth
2 引文 (Scopus)
Acrylamide
Colorectal Neoplasms
Histone Deacetylases
Cadherins
Neoplasms
4 引文 (Scopus)
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Microtubules
Down-Regulation
Apoptosis
12 引文 (Scopus)

MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma

Peng, H. Y., Cheng, Y. C., Hsu, Y. M., Wu, G. H., Kuo, C. C., Liou, J. P., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 七月 1 2016, 於 : PLoS One. 11, 7, e0158440.

研究成果: 雜誌貢獻文章

non-specific protein-tyrosine kinase
Janus Kinase 2
STAT3 Transcription Factor
squamous cell carcinoma
Microtubules
5 引文 (Scopus)
Tubulin Modulators
Myeloid Cells
Paclitaxel
Acute Myeloid Leukemia
Down-Regulation
5 引文 (Scopus)
Antineoplastic Agents
Ovarian Neoplasms
Cisplatin
Apoptosis
Pharmaceutical Preparations
1 引文 (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., 一月 1 2019, 於 : Frontiers in Oncology. 9, APR, p. 249 249.

研究成果: 雜誌貢獻文章

開啟存取
Histone Deacetylases
Multiple Myeloma
Neoplasms
Histone Deacetylase Inhibitors
Growth
開啟存取
Colorectal Neoplasms
Apoptosis
Ligands
Autophagy
Cell Death
3 引文 (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., 四月 14 2015, 於 : PLoS One. 10, 4, e0123819.

研究成果: 雜誌貢獻文章

ovarian neoplasms
Tubulin
tubulin
Ovarian Neoplasms
apoptosis
1 引文 (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 一月 1 2020, 於 : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

研究成果: 雜誌貢獻文章

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation
14 引文 (Scopus)
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
4 引文 (Scopus)
Hypoxia-Inducible Factor 1
Phosphorylation
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Microtubules
7 引文 (Scopus)
Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
16 引文 (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 八月 27 2015, 於 : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

研究成果: 雜誌貢獻文章

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
14 引文 (Scopus)

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Tsai, A. C., Wang, C. Y., Liou, J. P., Pai, H. C., Hsiao, C. J., Chang, J. Y., Wang, J. C., Teng, C. M. & Pan, S. L., 2014, 於 : Cell Death and Disease. 5, 4, e1162.

研究成果: 雜誌貢獻文章

Non-Small Cell Lung Carcinoma
Microtubules
Tubulin
Cyclin B1
Therapeutics