新藥研發產業博士學位學程

2023

Degradable Biocompatible Porous Microtube Scaffold for Extended Donor Cell Survival and Activity

Nguyễn, H., Chen, C-C., Czosseck, A., Chen, M. M., George, T. A. & Lundy, D. J., 1月 2023, 於: ACS Biomaterials Science and Engineering.

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2022

2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology

Chen, Y. H., Chen, Y. C., Chin, Y. T., Wang, C. C., Hwang, L. L., Yang, L. Y. & Lu, D. Y., 2022, 於: Aging. 14, 6, p. 2607-2627 21 p.

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1 引文斯高帕斯（Scopus）

2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors

Wang, Y. S., Yeh, T. K., Chang, W. C., Liou, J. P., Liu, Y. M. & Huang, W. C., 12月 5 2022, 於: European Journal of Medicinal Chemistry. 243, 114773.

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Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier

Sharma, R., Chatterjee, E., Mathew, J., Sharma, S., Rao, N. V., Pan, C. H., Lee, S. B., Dhingra, A., Grewal, A. S., Liou, J. P., Guru, S. K. & Nepali, K., 10月 5 2022, 於: European Journal of Medicinal Chemistry. 240, 114602.

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1 引文斯高帕斯（Scopus）

A machine learning-driven approach for prioritizing food contact chemicals of carcinogenic concern based on complementary in silico methods

Wang, C. C., Liang, Y. C., Wang, S. S., Lin, P. & Tung, C. W., 2月 2022, 於: Food and Chemical Toxicology. 160, 112802.

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4 引文斯高帕斯（Scopus）

Amitriptyline improves cognitive and neuronal function in a rat model that mimics dementia with lewy bodies

Lin, C. L., Zheng, T. L., Tsou, S. H., Chang, H. M., Tseng, L. H., Yu, C. H., Hung, C. S. & Ho, Y. J., 10月 28 2022, 於: Behavioural Brain Research. 435, 114035.

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Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

Cheng, W. H., Kao, S. Y., Chen, C-L., Yuliani, F. S., Lin, L. Y., Lin, C. H. & Chen, B-C., 12月 2022, 於: Respiratory Research. 23, 1, 381.

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An investigation of physicians' prescribing behaviors related to antidiabetic agents for Type 2 diabetes mellitus patients and associated factors in Taiwan

Chen, X., Wang, C. Y. & Ko, Y., 2022, (接受/付印) 於: Current Medical Research and Opinion.

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A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation

Lee, H. Y., Tang, D. W., Liu, C. Y. & Cho, E. C., 1月 25 2022, 於: Chemico-Biological Interactions. 352, 109778.

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2 引文斯高帕斯（Scopus）

Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures

Mokgautsi, N., Kuo, Y. C., Tang, S. L., Liu, F. C., Chen, S. J., Wu, A. T. H. & Huang, H. S., 1月 1 2022, 於: Cancers. 14, 1, 262.

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A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis

Lee, Y. H., Tsai, Y. S., Chang, C. C., Ho, C. C., Shih, H. M., Chen, H. M., Lai, H. L., Lee, C. W., Lee, Y. C., Liao, Y. C., Yang, U. C., Cheng, T. H., Chern, Y. & Soong, B. W., 4月 2022, 於: Movement Disorders. 37, 4, p. 767-777 11 p.

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4 引文斯高帕斯（Scopus）

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

Yeh, L-Y., Fang, Y-T., Lee, H-S., Liu, C-H., Chen, Y-Y., Lo, Y-C., Laiman, V., Liou, J-P., Chung, K. F., Chuang, H-C. & Lin, C-H., 5月 2022, 於: Frontiers in Medicine. 9, 794025.

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A Real-World Study on Ge Gen Tang in Combination with Herbal Medicines for Relieving Common Cold-Associated Symptoms

Chou, P. Y., Tai, C. J., Tang, Y. J., Chen, Y. C., Lin, K. Y. & Wang, C. C., 2022, 於: Evidence-based Complementary and Alternative Medicine. 2022, 4790910.

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Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats

Tung, Y. T., Wu, C. H., Chen, W. C., Pan, C. H., Chen, Y. W., Tsao, S. P., Chen, C. J. & Huang, H. Y., 11月 2022, 於: Nutrients. 14, 21, 4665.

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Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk

Chen, Y. C., Yeh, Y. C., Lin, Y. F., Au, H. K., Hsia, S. M., Chen, Y. H. & Hsieh, R. H., 11月 2022, 於: International journal of molecular sciences. 23, 21, 12740.

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Bioactive pulvinones from a marine algicolous fungus Aspergillus terreus NTU243

Hsiao, G., Chi, W. C., Chang, C. H., Chiang, Y. R., Fu, Y. J. & Lee, T. H., 8月 2022, 於: Phytochemistry. 200, p. 113229 113229.

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1 引文斯高帕斯（Scopus）

Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy

Cheng, W. J., Chuang, K. H., Lo, Y. J., Chen, M., Chen, Y. J., Roffler, S. R., Ho, H. O., Lin, S. Y. & Sheu, M. T., 4月 2022, 於: Journal of Controlled Release. 344, p. 235-248 14 p.

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4 引文斯高帕斯（Scopus）

Bisphosphonate Use Is Not Associated With Tuberculosis Risk Among Patients With Osteoporosis: A Nationwide Cohort Study

Chen, J. H., Lee, C. H., Lee, M. R., Huang, P-Y., Yen, T. H., Lee, M. C., Tsai, C. W., Wang, J. Y. & Lee, J. A., 2022, (接受/付印) 於: Journal of Clinical Pharmacology.

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Chemical constituents and their anti-neuroinflammatory activities from the bark of Taiwan incense cedar, Calocedrus formosana

Wu, H. C., Chen, Y. C., Hsieh, C. L., Hsiao, G., Wang, S. W., Cheng, M. J., Chao, C. Y., Lee, T. H. & Kuo, Y. H., 12月 2022, 於: Phytochemistry. 204, 113347.

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Chemosensitization Effect of Seabuckthorn (Hippophae rhamnoides L.) Pulp Oil via Autophagy and Senescence in NSCLC Cells

Batbold, U. & Liu, J. J., 5月 2022, 於: Foods. 11, 10, 1517.

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1 引文斯高帕斯（Scopus）

Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models

Tseng, S. H., Lee, C. J., Chen, S. H., Chen, C. H., Tsai, P. W., Hsieh, M. S., Chu, J. S. & Wang, C. C., 2022, (接受/付印) 於: Journal of Traditional and Complementary Medicine. 13, 1, p. 51-61 11 p.

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Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan

Wu, K. S., Sung, S-Y., Huang, M. H., Lin, Y. L., Chang, C-C., Fang, C. L., Wong, T. T., Chen, H. H. & Tsai, M-L., 11月 2022, 於: Cancers. 14, 21, p. 5419 5419.

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Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer

Cheng, W. J., Lin, S. Y., Chuang, K. H., Chen, M., Ho, H. O., Chen, L. C., Hsieh, C. M. & Sheu, M. T., 2022, 於: International Journal of Nanomedicine. 17, p. 5353-5374 22 p.

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Combining Mg–Zn–Ca Bulk Metallic Glass with a Mesoporous Silica Nanocomposite for Bone Tissue Engineering

Chu, Y. S., Wong, P. C., Jang, J. S. C., Chen, C. H. & Wu, S. H., 5月 2022, 於: Pharmaceutics. 14, 5, 1078.

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1 引文斯高帕斯（Scopus）

Comparison of 2,3,5,4′-tetrahydroxystilbene-2-O-b-D-glucoside-induced proliferation and differentiation of dental pulp stem cells in 2D and 3D culture systems—gene analysis

Wu, Y., Chung, Y. Y., Chin, Y. T., Lin, C. Y., Kuo, P. J., Chen, T. Y., Lin, T. Y., Chiu, H. C., Huang, H. M., Jeng, J. H. & Lee, S. Y., 1月 2022, 於: Journal of Dental Sciences.

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Cytotoxicity Effect of Constituents of Pinus taiwanensis Hayata Twigs on B16-F10 Melanoma Cells

Chu, M. H., Hsiao, S. W., Kao, Y. C., Yin, H. W., Kuo, Y. H. & Lee, C. K., 5月 2022, 於: Molecules. 27, 9, 2731.

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Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases

Lee, S. B., Chang, T. Y., Lee, N. Z., Yu, Z. Y., Liu, C. Y. & Lee, H. Y., 1月 5 2022, 於: European Journal of Medicinal Chemistry. 227, 113904.

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1 引文斯高帕斯（Scopus）

Development and Validation of the Chinese Version Non-Nutritive Sweetener Food Frequency Questionnaire with Urinary Biomarker in Children and Adolescents

Chu, Y. Y., Chen, Y. H., Hsieh, R. H., Hsia, S. M., Wu, H. T. & Chen, Y. C., 8月 2022, 於: Public Health Nutrition.

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1 引文斯高帕斯（Scopus）

Development of an enrichment-free one-pot sample preparation and ultra-high performance liquid chromatography-tandem mass spectrometry method to identify Immunoglobulin A1 hinge region O-glycoforms for Immunoglobulin A nephropathy

Chen, H. F., Kao, C. C., Ka, S. M., Wang, S. Y., Chen, M. X., Chen, G. Y., Weng, T. I., Lai, R. Y., Yeh, S. C., Lin, Y. C., Chen, H. H., Chang, W. C., Wu, M. S. & Tsai, I. L., 12月 6 2022, 於: Journal of Chromatography A. 1685, 463589.

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Development of a Novel Hybrid Suture Anchor for Osteoporosis by Integrating Titanium 3D Printing and Traditional Machining

Chen, C. H., Chang, W. J., Chen, Y. S., Chen, K. H., Huang, S. F., Hsueh, H. R., Li, C. B. & Lin, C. L., 2022, 於: International Journal of Bioprinting. 8, 4, p. 161-171 11 p.

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Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay

Yu, M. C., Hung, C. S., Huang, C. K., Wang, C. H., Liang, Y. C. & Lin, J. C., 8月 2022, 於: Microbiology spectrum. 10, 4

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Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment

Lin, T. E., Yang, C. R., Chou, C. H., Hsu, J. Y., Chao, M. W., Sung, T. Y., Hsieh, J. H., Huang, W. J. & Hsu, K. C., 2月 2022, 於: Biomedicine and Pharmacotherapy. 146, 112459.

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Divergent Characteristics of T-Cell Receptor Repertoire Between Essential Hypertension and Aldosterone-Producing Adenoma

Chang, C. M., Peng, K. Y., Chan, C. K., Lin, Y. F., Liao, H. W., Chang, J. G., Wu, M. S., Wu, V. C. & Chang, W. C., 5月 2022, 於: Frontiers in Immunology. 13, 853403.

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Dynamic Changes of Platelet and Factors Related Dengue Haemorrhagic Fever: A Retrospective Study in Indonesian

Faridah, I. N., Dania, H., Chen, Y. H., Supadmi, W., Purwanto, B. D., Heriyanto, M. J., Aufa, M. A., Chang, W. C. & Perwitasari, D. A., 4月 2022, 於: Diagnostics. 12, 4, 950.

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Effects of osteoporosis medications on bone fracture in patients with chronic kidney disease

Kao, C. C., Wu, P. C., Chuang, M. T., Yeh, S. C., Lin, Y. C., Chen, H. H., Fang, T. C., Chang, W. C., Wu, M. S. & Chang, T. H., 2022, (接受/付印) 於: Postgraduate Medical Journal. 140341.

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Fabrication of Low-Molecular-Weight Hyaluronic Acid-Carboxymethyl Cellulose Hybrid to Promote Bone Growth in Guided Bone Regeneration Surgery: An Animal Study

Lin, C-Y., Kuo, P-J., Lin, Y-H., Lin, C-Y., Lin, J. C-Y., Chiu, H-C., Hung, T-F., Lin, H-Y. & Huang, H-M., 8月 2022, 於: Polymers. 14, 15

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Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts

Tsai, Y-T., Li, C-Y., Huang, Y-H., Chang, T-S., Lin, C-Y., Chuang, C-H., Wang, C-Y., Anuraga, G., Chang, T-H., Shih, T-C., Lin, Z-Y., Chen, Y-L., Chung, I., Lee, K-H., Chang, C-C., Sung, S-Y., Yang, K-H., Tsui, W-L., Yap, C-V. & Wu, M-H., 4月 22 2022, (打印前電子出版) 於: Oncogene.

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1 引文斯高帕斯（Scopus）

Genome-Wide Association Study for eGFR in a Taiwanese Population

Chen, Y. C., Wong, H. S. C., Wu, M. Y., Chou, W. H., Kao, C. C., Chao, C. H., Chang, W. C. & Wu, M. S., 11月 2022, 於: Clinical Journal of the American Society of Nephrology. 17, 11, p. 1598-1608 11 p.

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Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells

Unson, S., Chang, T-C., Yang, Y. N., Wang, S. H., Huang, C. H., Crawford, D. R., Huang, H-M., Li, Z. L., Lin, H. Y., Whang-Peng, J., Kuan, W., Davis, P. J. & Li, W. S., 7月 27 2022, 於: Marine Drugs. 20, 8, 482.

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Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes

Chang, C. C., Lee, K. L., Chan, T. S., Chung, C. C. & Liang, Y. C., 3月 1 2022, 於: International journal of molecular sciences. 23, 5, 2604.

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Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics

Hsu, Y. W., Wong, H. S. C., Huang, W. C., Yeh, Y. H., Hsiao, C. D., Chang, W. C. & Hsieh, S. L., 12月 2022, 於: Journal of Biomedical Science. 29, 1, 43.

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Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer

Lin, R. K., Su, C. M., Lin, S. Y., Thi Anh Thu, L., Liew, P. L., Chen, J. Y., Tzeng, H. E., Liu, Y. R., Chang, T. H., Lee, C. Y. & Hung, C. S., 12月 2022, 於: Molecular Medicine. 28, 1, 67.

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4 引文斯高帕斯（Scopus）

Identification and analysis of a selective DYRK1A inhibitor

Lin, T. E., Chao, M. W., HuangFu, W. C., Tu, H. J., Peng, Z. X., Su, C. J., Sung, T. Y., Hsieh, J. H., Lee, C. C., Yang, C. R., Pan, S. L. & Hsu, K. C., 2月 2022, 於: Biomedicine and Pharmacotherapy. 146, 112580.

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Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach

Yen, S. C., Chen, L. C., Huang, H. L., HuangFu, W. C., Chen, Y. Y., Eight Lin, T., Lien, S. T., Tseng, H. J., Sung, T. Y., Hsieh, J. H., Huang, W. J., Pan, S. L. & Hsu, K. C., 4月 2022, 於: Bioorganic Chemistry. 121, p. 105675 105675.

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2 引文斯高帕斯（Scopus）

Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone

Lawal, B., Kuo, Y. C., Rachmawati Sumitra, M., Wu, A. T. H. & Huang, H. S., 9月 2022, 於: Computers in Biology and Medicine. 148, 105814.

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2 引文斯高帕斯（Scopus）

Integrated genomic analysis to identify druggable targets for pancreatic cancer

Mugiyanto, E., Adikusuma, W., Irham, L. M., Huang, W. C., Chang, W. C. & Kuo, C. N., 12月 1 2022, 於: Frontiers in Oncology. 12, 989077.

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In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction

Lu, C. H., Chung, W. M., Tsai, C. H., Cheng, J. C., Hsu, K. C. & Tzeng, H. E., 12月 2022, 於: Scientific Reports. 12, 1, 303.

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2 引文斯高帕斯（Scopus）

Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

Lawal, B., Wu, A. T. H. & Huang, H. S., 5月 2022, 於: Frontiers in Immunology. 13, 872470.

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4 引文斯高帕斯（Scopus）

Luteolin-Rich Extract of Thespesia garckeana F. Hoffm. (Snot Apple) Contains Potential Drug-Like Candidates and Modulates Glycemic and Oxidoinflammatory Aberrations in Experimental Animals

Alozieuwa, U. B., Lawal, B., Sani, S., Onikanni, A. S., Osuji, O., Ibrahim, Y. O., Babalola, S. B., Mostafa-Hedeab, G., Alsayegh, A. A., Albogami, S., Batiha, G. E. S., Wu, A. T. H., Huang, H. S. & Conte-Junior, C. A., 2022, 於: Oxidative Medicine and Cellular Longevity. 2022, 1215097.

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2 引文斯高帕斯（Scopus）

Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer’s Disease

Hsu, T. C., Chew, C. H., Chen, S. M., Huang, W. T., Chen, A. L., Lin, Y. F., Eddarkaoui, S., Buee, L. & Chen, C. C., 6月 1 2022, 於: International journal of molecular sciences. 23, 12, 6855.

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