癌症生物學與藥物研發博士學位學程

  • No. 250 Wu-Xing Street

    11031 Taipei

研究成果 1996 2020

篩選
文章
2017
46 引文 (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., 六月 22 2017, 於 : Nature Communications. 8, 15874.

研究成果: 雜誌貢獻文章

Long Noncoding RNA
Mouth Neoplasms
progressions
hypoxia
cancer
19 引文 (Scopus)

Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer

Chen, W. Y., Tsai, Y. C., Yeh, H. L., Suau, F., Jiang, K. C., Shao, A. N., Huang, J. & Liu, Y. N., 八月 15 2017, 於 : Science Signaling. 10, 492, eaam6826.

研究成果: 雜誌貢獻文章

Epithelial-Mesenchymal Transition
Androgens
Prostatic Neoplasms
Bone
Androgen Receptors

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, 於 : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

研究成果: 雜誌貢獻文章

Osseointegration
Dental Implants
Cell- and Tissue-Based Therapy
Bone and Bones
Atomic Force Microscopy
14 引文 (Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 3228.

研究成果: 雜誌貢獻文章

Histone Deacetylase Inhibitors
Histone Deacetylases
Computer Simulation
Protein Isoforms
Enzymes
8 引文 (Scopus)
Neoadjuvant Therapy
Learning Curve
Robotics
Rectal Neoplasms
Laparoscopy
20 引文 (Scopus)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., 二月 28 2017, 於 : Journal of hematology & oncology. 10, 1, p. 60 1 p.

研究成果: 雜誌貢獻文章

Colon
Carcinogenesis
Colonic Neoplasms
Macrophages
Neoplasms
12 引文 (Scopus)

Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer

Chang, H. Y., Ye, S. P., Pan, S. L., Kuo, T. T., Liu, B. C., Chen, Y. L. & Huang, T. C., 2017, 於 : Theranostics. 7, 16, p. 3889-3900 12 p.

研究成果: 雜誌貢獻文章

AT-Hook Motifs
Colorectal Neoplasms
Neoplasms
Epithelial-Mesenchymal Transition
MicroRNAs
10 引文 (Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., 六月 1 2017, 於 : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

研究成果: 雜誌貢獻文章

Uridine Kinase
Breast Neoplasms
Gene Expression
Genes
Neoplasms
4 引文 (Scopus)

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., 十二月 1 2017, 於 : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

研究成果: 雜誌貢獻文章

Neoplasms
irinotecan
Investigational Drugs
Drug Therapy
Camptothecin
8 引文 (Scopus)

PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells

Chuang, C. Y., Chang, C. P., Lee, Y. J., Lin, W. L., Chang, W. W., Wu, J. S., Cheng, Y. W., Lee, H. & Li, C., 八月 1 2017, 於 : Oncology Reports. 38, 2, p. 1115-1123 9 p.

研究成果: 雜誌貢獻文章

Mouth Neoplasms
Head and Neck Neoplasms
Methylation
Arginine
Down-Regulation
27 引文 (Scopus)

Prostate cancer mortality-to-incidence ratios are associated with cancer care disparities in 35 countries

Chen, S. L., Wang, S. C., Ho, C. J., Kao, Y. L., Hsieh, T. Y., Chen, W. J., Chen, C. J., Wu, P. R., Ko, J. L., Lee, H. & Sung, W. W., 一月 4 2017, 於 : Scientific Reports. 7, 40003.

研究成果: 雜誌貢獻文章

Prostatic Neoplasms
Mortality
Incidence
Neoplasms
Health Expenditures
14 引文 (Scopus)

REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

Chang, Y. T., Lin, T. P., Campbell, M., Pan, C. C., Lee, S. H., Lee, H. C., Yang, M. H., Kung, H. J. & Chang, P. C., 三月 3 2017, 於 : Scientific Reports. 7, 42795.

研究成果: 雜誌貢獻文章

Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Hormones
Phenotype
Castration
6 引文 (Scopus)

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer

Chen, M. C., Tsai, Y. C., Tseng, J. H., Liou, J. J., Horng, S., Wen, H. C., Fan, Y. C., Zhong, W. B. & Hsu, S. P., 十二月 13 2017, 於 : International Journal of Molecular Sciences. 18, 12, 2690.

研究成果: 雜誌貢獻文章

Simvastatin
Cell proliferation
Cell Movement
cancer
Cell Proliferation
10 引文 (Scopus)

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., 八月 1 2017, 於 : Journal of Virology. 91, 15, e00699-17.

研究成果: 雜誌貢獻文章

Papillomavirus Infections
Papillomaviridae
Mus musculus
papilloma
Papilloma
17 引文 (Scopus)

Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., 二月 1 2017, 於 : Nanomedicine. 12, 3, p. 195-205 11 p.

研究成果: 雜誌貢獻文章

Heterografts
tumor
Nanoparticles
Cisplatin
Tumors
13 引文 (Scopus)

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., 二月 15 2017, 於 : International Journal of Nanomedicine. 12, p. 1305-1315 11 p.

研究成果: 雜誌貢獻文章

Paclitaxel
Heterografts
Nanoparticles
Doxorubicin
Drug delivery
6 引文 (Scopus)

Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., 四月 1 2017, 於 : Tumor Biology. 39, 4

研究成果: 雜誌貢獻文章

Insulin-Like Growth Factor Binding Protein 3
MicroRNAs
Non-Small Cell Lung Carcinoma
Phosphatidylinositol 3-Kinases
Neoplasms
8 引文 (Scopus)
T Cell Transcription Factor 1
Androgen Receptors
MicroRNAs
Androgens
Prostatic Neoplasms

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., 四月 7 2017, 於 : Scientific Reports. 7, 46149.

研究成果: 雜誌貢獻文章

Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
G2 Phase
G1 Phase

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., 九月 1 2017, 於 : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

研究成果: 雜誌貢獻文章

Immunity
Neoplasms
Natural Killer Cells
Cytotoxic T-Lymphocytes
Colonic Neoplasms
9 引文 (Scopus)
Glycyrrhiza
licorice
doxorubicin
autophagy
Autophagy
4 引文 (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., 十二月 1 2017, 於 : PLoS One. 12, 12, e0189461.

研究成果: 雜誌貢獻文章

Neisseria
histones
Histones
DNA
Dimers
6 引文 (Scopus)

The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation

Liu, F. L., Chen, C. L., Lee, C. C., Wu, C. C., Hsu, T. H., Tsai, C. Y., Huang, H. S. & Chang, D. M., 2017, 於 : International Journal of Medical Sciences. 14, 9, p. 840-852 13 p.

研究成果: 雜誌貢獻文章

Niclosamide
Osteoclasts
Osteoblasts
Osteogenesis
Macrophage Colony-Stimulating Factor
15 引文 (Scopus)

The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer

Wu, D. W., Lin, P. L., Wang, L., Huang, C. C. & Lee, H., 2017, 於 : Theranostics. 7, 5, p. 1114-1132 19 p.

研究成果: 雜誌貢獻文章

Colorectal Neoplasms
Neoplasms
Animal Models
Agar
Regression Analysis
20 引文 (Scopus)

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Chen, P. C., Tang, C. H., Lin, L. W., Tsai, C. H., Chu, C. Y., Lin, T. H. & Huang, Y. L., 一月 25 2017, 於 : Journal of Hematology and Oncology. 10, 1, 33.

研究成果: 雜誌貢獻文章

Bone Neoplasms
Matrix Metalloproteinase 2
MicroRNAs
Prostatic Neoplasms
Up-Regulation
5 引文 (Scopus)
Hemorrhoidectomy
Diltiazem
Ointments
Meta-Analysis
Randomized Controlled Trials
1 引文 (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., 十一月 1 2017, 於 : Molecules. 22, 11, 1897.

研究成果: 雜誌貢獻文章

Derivatives
central nervous system
synthesis
liver
flavone
11 引文 (Scopus)

WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis

Lin, C. Y., Tzeng, H. E., Li, T. M., Chen, H. T., Lee, Y., Yang, Y. C., Wang, S. W., Yang, W. H. & Tang, C. H., 一月 1 2017, 於 : Oncotarget. 8, 24, p. 39571-39581 11 p.

研究成果: 雜誌貢獻文章

Chondrosarcoma
Vascular Endothelial Growth Factor A
Osteosarcoma
Endothelial Progenitor Cells
human WISP3 protein
4 引文 (Scopus)
Glioblastoma
Glioma
Cell Cycle
Growth
Survival Rate
2016
12 引文 (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, 於 : Mediators of Inflammation. 2016, 6953459.

研究成果: 雜誌貢獻文章

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
30 引文 (Scopus)

Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

Lin, H. Y., Chin, Y-T., Nana, A. W., Shih, Y-J., Lai, H-Y., Tang, H-Y., Leinung, M., Mousa, S. A. & Davis, P. J., 一月 28 2016, (接受/付印) 於 : Steroids.

研究成果: 雜誌貢獻文章

Thyroxine
Cells
Gene expression
Neoplasms
Proteins
6 引文 (Scopus)

Androgen receptor regulates SRC expression through microRNA-203

Siu, M. K., Chen, W. Y., Tsai, H. Y., Yeh, H. L., Yin, J. J., Liu, S. Y. & Liu, Y-N., 五月 1 2016, 於 : Oncotarget. 7, 18, p. 25726-25741 16 p.

研究成果: 雜誌貢獻文章

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
RNA Stability
3' Untranslated Regions
5 引文 (Scopus)

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., 三月 1 2016, 於 : PLoS One. 11, 3, e0149317.

研究成果: 雜誌貢獻文章

chondrocytes
Nitric Oxide Synthase Type II
Chondrocytes
amides
Amides
4 引文 (Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., 十二月 9 2016, 於 : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

研究成果: 雜誌貢獻文章

Hepatitis delta Antigens
Hepatitis Delta Virus
Cell Nucleus Active Transport
Viruses
Virion
8 引文 (Scopus)
Biliary Tract
Disease-Free Survival
Meta-Analysis
Biliary Tract Neoplasms
Epidermal Growth Factor Receptor
8 引文 (Scopus)
gemcitabine
Pancreatic Neoplasms
Nausea
Vomiting
Fluorouracil
7 引文 (Scopus)
Autoantibodies
Rheumatoid Arthritis
Biomarkers
Concanavalin A
Peptides
1 引文 (Scopus)

Corrigendum to "Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1/ZEB2 up-regulation and EMT processing" [Exp. Eye Res. 146 (2016) 206-211]

Wu, C. W., Peng, M. L., Yeh, K. T., Tsai, Y. Y., Chiang, C. C. & Cheng, Y. W., 2016, (接受/付印) 於 : Experimental Eye Research.

研究成果: 雜誌貢獻文章

Pterygium
Emotions
Up-Regulation
Western Blotting
Cell Line
79 引文 (Scopus)

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., 四月 5 2016, 於 : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

研究成果: 雜誌貢獻文章

Nanoparticles
Camptothecin
Neoplasms
Carbonic Anhydrase I
IT-101
13 引文 (Scopus)

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

Lin, P. L., Chang, J. T., Wu, D. W., Huang, C. C. & Lee, H., 六月 1 2016, 於 : Free Radical Biology and Medicine. 95, p. 121-132 12 p.

研究成果: 雜誌貢獻文章

Tumors
Colorectal Neoplasms
Up-Regulation
Catenins
Neoplasms
23 引文 (Scopus)

DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis

Wu, D. W., Lin, P. L., Cheng, Y. W., Huang, C. C., Wang, L. & Lee, H., 四月 19 2016, 於 : Oncotarget. 7, 16, p. 22687-22699 13 p.

研究成果: 雜誌貢獻文章

Catenins
Colorectal Neoplasms
Neoplasms
Heterografts
Lung
17 引文 (Scopus)

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

He, T. Y., Wu, D. W., Lin, P. L., Wang, L., Huang, C. C., Chou, M. C. & Lee, H., 二月 19 2016, 於 : Scientific Reports. 6, 21483.

研究成果: 雜誌貢獻文章

Catenins
Colorectal Neoplasms
Neoplasms
Survival
Heterografts
3 引文 (Scopus)

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

Chen, T. C., Yu, D-S., Chen, S-J., Chen, C-L., Lee, C-C., Hsieh, Y-Y., Chang, L-C., Guh, J-H., Lin, J-J. & Huang, H-S., 2016, 於 : Arabian Journal of Chemistry.

研究成果: 雜誌貢獻文章

Type I DNA Topoisomerase
Antineoplastic Agents
Cells
Derivatives
Assays
8 引文 (Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., 七月 19 2016, 於 : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

研究成果: 雜誌貢獻文章

Salicylanilides
Osteoclasts
Bone Resorption
Osteogenesis
Bone
15 引文 (Scopus)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., 十一月 10 2016, 於 : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

研究成果: 雜誌貢獻文章

Zanamivir
Triazoles
Neuraminidase
Inhibitory Concentration 50
Orthomyxoviridae
2 引文 (Scopus)

Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis

Lee, C. C., Chen, C. L., Liu, F. L., Chiou, C. Y., Chen, T. C., Wu, C. C., Sun, W. H., Chang, D. M. & Huang, H. S., 五月 1 2016, 於 : Archiv der Pharmazie. 349, 5, p. 342-355 14 p.

研究成果: 雜誌貢獻文章

Osteoclasts
Osteogenesis
Sodium
Bone Resorption
Sodium Compounds
1 引文 (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., 一月 1 2016, 於 : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

研究成果: 雜誌貢獻文章

Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
10 引文 (Scopus)

Down-regulation of let-7a-5p predicts lymph node metastasis and prognosis in colorectal cancer: Implications for chemotherapy

Liu, T. P., Huang, C. C., Yeh, K. T., Ke, T. W., Wei, P. L., Yang, J. R. & Cheng, Y. W., 十二月 1 2016, 於 : Surgical Oncology. 25, 4, p. 429-434

研究成果: 雜誌貢獻文章

Colorectal Neoplasms
Down-Regulation
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
6 引文 (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., 三月 2 2016, 於 : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

研究成果: 雜誌貢獻文章

ferrous sulfate
Anemia
Iron
Hemoglobins
Caco-2 Cells