癌症生物學與藥物研發博士學位學程

  • No. 250 Wu-Xing Street

    11031 Taipei

研究成果 1996 2019

2019
3 引文 (Scopus)
Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 引文 (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., 一月 1 2019, 於 : Endocrine Research.

研究成果: 雜誌貢獻文章

Integrins
Thyronines
Thyroid Hormone Receptors
Neoplasms
Glioblastoma

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., 一月 1 2019, 於 : Molecular Oncology.

研究成果: 雜誌貢獻文章

開啟存取
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
3 引文 (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., 一月 1 2019, 於 : Cancer Letters. 440-441, p. 35-46 12 p.

研究成果: 雜誌貢獻文章

Prostaglandin-Endoperoxide Synthases
Androgens
Prostatic Neoplasms
Cyclooxygenase Inhibitors
Androgen Receptors
開啟存取
temozolomide
Glioblastoma
Phenotype
Glioma
Stem Cells
2 引文 (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., 六月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

研究成果: 雜誌貢獻文章

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., 一月 31 2019, 於 : ACS Omega. 4, 1, p. 2387-2397 11 p.

研究成果: 雜誌貢獻文章

開啟存取
Receptor, Fibroblast Growth Factor, Type 2
Epitopes
Antibodies, Monoclonal, Humanized
Fibroblast Growth Factor Receptors
Fibroblasts

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., 四月 1 2019, 於 : Journal of Endodontics. 45, 4, p. 435-441 7 p.

研究成果: 雜誌貢獻文章

Dental Pulp
Bone Regeneration
Stem Cell Transplantation
Stem Cells
Osteogenesis

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., 十月 1 2019, 於 : Medicine (United States). 98, 40, e17461.

研究成果: 雜誌貢獻文章

開啟存取
Hypoglycemic Agents
pioglitazone
Neoplasms
Odds Ratio
Confidence Intervals
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc
開啟存取
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., 十月 23 2019, 於 : Journal of Biomedical Science. 26, 1, 1 p.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
Camptothecin
Cyclodextrins
Polymers
Neoplasms
Nanoparticles

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., 八月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

研究成果: 雜誌貢獻文章

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., 十月 22 2019, 於 : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

研究成果: 雜誌貢獻文章

開啟存取
Monocytes
Neutrophils
Breast Neoplasms
Neoplasms
Lung
Pituitary Neoplasms
Oncogenes
Renal Cell Carcinoma
Computer Simulation
Neoplasms
開啟存取
gemcitabine
Computational Biology
Cell Cycle
Adenocarcinoma
Therapeutics

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., 九月 9 2019, 於 : Biomolecules. 9, 9

研究成果: 雜誌貢獻文章

開啟存取
Drug Resistance
Computer Simulation
Colorectal Neoplasms
Etoposide
Topoisomerase Inhibitors
3 引文 (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. 及其他3, Wang, W. C., Chen, H. W. & Kung, H. J., 一月 3 2019, 於 : Oncogene. 38, 1, p. 17-32

研究成果: 雜誌貢獻文章

Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., 十一月 1 2019, 於 : Food and Chemical Toxicology. 133, 110808.

研究成果: 雜誌貢獻文章

leptin (116-130)
hepatoma
Leptin
leptin
Hepatocellular Carcinoma
1 引文 (Scopus)

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., 四月 8 2019, 於 : Clinical cancer research : an official journal of the American Association for Cancer Research.

研究成果: 雜誌貢獻文章

Leukemia Inhibitory Factor
Castration
Prostatic Neoplasms
Androgens
Therapeutics
1 引文 (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., 一月 1 2019, 於 : Oncogene.

研究成果: 雜誌貢獻文章

Lung Neoplasms
Long Noncoding RNA
Breast Neoplasms
Neoplasm Metastasis
Mi-2 Nucleosome Remodeling and Deacetylase Complex
1 引文 (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 9687.

研究成果: 雜誌貢獻文章

開啟存取
Catenins
Colorectal Neoplasms
Neoplasms
Side-Population Cells
Recurrence

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., 一月 1 2019, 於 : Frontiers in Oncology. 9, APR, 249.

研究成果: 雜誌貢獻文章

開啟存取
Histone Deacetylases
Multiple Myeloma
Neoplasms
Histone Deacetylase Inhibitors
Growth
3 引文 (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., 四月 12 2019, 於 : Antioxidants. 8, 4

研究成果: 雜誌貢獻文章

Leiomyoma
Cell growth
Extracellular Matrix
Antioxidants
Growth
1 引文 (Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., 五月 1 2019, 於 : IUBMB Life. 71, 5, p. 539-548 10 p.

研究成果: 雜誌貢獻回顧型文獻

DNA
Charge distribution
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Uracil-DNA Glycosidase
14 引文 (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. 及其他30, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., 二月 1 2019, 於 : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

研究成果: 雜誌貢獻文章

Genetic Loci
Genetic Predisposition to Disease
Colorectal Neoplasms
Genome-Wide Association Study
Confidence Intervals

RAB14 activates MARK signaling to promote bladder tumorigenesis

Chao, H., Deng, L., Xu, F., Fu, B., Zhu, Z., Dong, Z., Liu, Y-N. & Zeng, T., 二月 27 2019, 於 : Carcinogenesis.

研究成果: 雜誌貢獻文章

Urinary Bladder Neoplasms
Carcinogenesis
Urinary Bladder
Mitogen-Activated Protein Kinases
Twist-Related Protein 1

Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

Lin, C. C., Chin, Y. T., Shih, Y. J., Chen, Y. R., Chung, Y. Y., Lin, C. Y., Hsiung, C. N., Whang-Peng, J., Lee, S. Y., Lin, H. Y., Davis, P. J. & Wang, K., 一月 1 2019, 於 : Journal of Dental Sciences.

研究成果: 雜誌貢獻文章

開啟存取
Mouth Neoplasms
Thyroxine
Thyroid Hormones
Genes
Cell Cycle Checkpoints

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Chen, Y. F., Lin, I. H., Guo, Y. R., Chiu, W. J., Wu, M. S., Jia, W. & Yen, Y., 九月 13 2019, 於 : Scientific Reports. 9, 1, 1 p.

研究成果: 雜誌貢獻文章

開啟存取
Kidney
Mitochondria
Kidney Diseases
DNA Replication
Knockout Mice
1 引文 (Scopus)
開啟存取
Vibrio parahaemolyticus
Penaeidae
Chemical activation
Necrosis
Hepatopancreas
開啟存取
Minimally Invasive Surgical Procedures
Robotics
Rectal Neoplasms
Neoplasms
Length of Stay

Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status

Chin, Y-T., He, Z-R., Chen, C-L., Chu, H-C., Ho, Y., Su, P-Y., Yang, Y-C. S. H., Wang, K., Shih, Y-J., Chen, Y-R., Pedersen, J. Z., Incerpi, S., Nana, A. W., Tang, H-Y., Lin, H-Y., Mousa, S. A., Davis, P. J. & Whang-Peng, J., 2019, 於 : Frontiers in Endocrinology. 10, p. 130

研究成果: 雜誌貢獻文章

Integrins
Colorectal Neoplasms
HCT116 Cells
Neoplasms
HT29 Cells
2 引文 (Scopus)

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., 四月 15 2019, 於 : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

研究成果: 雜誌貢獻文章

Long Noncoding RNA
X Chromosome Inactivation
Carcinogenesis
Neoplasms
X Chromosome
virtual reality
Observation
Learning
energy
learning

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., 五月 27 2019, 於 : Journal of Biomedical Science. 26, 1, 42.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
Ubiquitin
Peptide Hydrolases
Ubiquitination
Neoplasms
Proteins
1 引文 (Scopus)

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, H. F., Samman, H., Monzer, A., Hadadeh, O., Cheaito, K., Abdel-Samad, R., Hayar, B., Pisano, C., Msheik, H., Liu, Y-N., Darwiche, N. & Abou-Kheir, W., 七月 2019, 於 : Molecular Carcinogenesis. 58, 7, p. 1208-1220 13 p.

研究成果: 雜誌貢獻文章

Neoplastic Stem Cells
Retinoids
Prostatic Neoplasms
Growth
Apoptosis
開啟存取
biomarkers
Castration
Androgen Receptors
Biomarkers
Prostatic Neoplasms
2018
4 引文 (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., 四月 25 2018, 於 : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

研究成果: 雜誌貢獻文章

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
2 引文 (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., 十月 1 2018, 於 : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

研究成果: 雜誌貢獻文章

Sirtuin 1
Dental Pulp
AMP-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Stem Cells
1 引文 (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. 及其他5, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., 四月 1 2018, 於 : Bioorganic Chemistry. 77, p. 600-607 8 p.

研究成果: 雜誌貢獻文章

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations
10 引文 (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., 一月 29 2018, (接受/付印) 於 : Journal of Medicinal Chemistry.

研究成果: 雜誌貢獻文章

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., 一月 1 2018, 於 : PeerJ. 2018, 10, e5739.

研究成果: 雜誌貢獻文章

chondrocytes
Cartilage
Zebrafish
Chondrocytes
Danio rerio

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., 一月 1 2018, (接受/付印) 於 : European Journal of Medical Genetics.

研究成果: 雜誌貢獻文章

Acidosis
Mutation
Ribonucleotide Reductases
Failure to Thrive
Lactic Acidosis
8 引文 (Scopus)

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Wu, D. W., Wang, Y. C., Wang, L., Chen, C. Y. & Lee, H., 一月 1 2018, 於 : Theranostics. 8, 5, p. 1256-1269 14 p.

研究成果: 雜誌貢獻文章

MicroRNAs
Protein-Tyrosine Kinases
bcl-Associated Death Protein
Neoplasms
Adenocarcinoma of lung
4 引文 (Scopus)

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation

Lee, K. C., Chen, W. T., Liu, Y. C., Lin, S. S. & Hsu, F. T., 九月 1 2018, 於 : In Vivo. 32, 5, p. 1097-1103 7 p.

研究成果: 雜誌貢獻文章

Extracellular Signal-Regulated MAP Kinases
Hepatocellular Carcinoma
Chemical activation
Tumors
Liver
4 引文 (Scopus)
Activating Transcription Factors
CC Chemokines
Epithelial-Mesenchymal Transition
Androgens
Prostatic Neoplasms

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., 六月 28 2018, 於 : Cancer Medicine.

研究成果: 雜誌貢獻文章

Niclosamide
Urologic Neoplasms
Apoptosis
Growth
Control Groups
3 引文 (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., 三月 13 2018, 於 : Frontiers in Pharmacology. 9, MAR, 205.

研究成果: 雜誌貢獻文章

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation