生藥學研究所

2018

Melanogenesis inhibitors from the rhizoma of ligusticum sinense in B16-f10 melanoma cells in vitro and zebrafish in vivo

Cheng, M. C., Lee, T. H., Chu, Y. T., Syu, L. L., Hsu, S. J., Cheng, C. H., Wu, J. & Lee, C. K., 12月 1 2018, 於: International Journal of Molecular Sciences. 19, 12, 3994.

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16 引文斯高帕斯（Scopus）

New Hirsutinolide-Type Sesquiterpenoids from Vernonia cinerea Inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells

Kuo, L. M. Y., Tseng, P. Y., Lin, Y. C., Liaw, C. C., Zhang, L. J., Tsai, K. C., Lin, Z. H., Ho, H. O. & Kuo, Y. H., 7月 9 2018, 於: Planta Medica. 84, 18, p. 1348-1354 7 p.

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5 引文斯高帕斯（Scopus）

New terpenoids from Chamaecyparis formosensis (Cupressaceae) leaves with modulatory activity on matrix metalloproteases 2 and 9

Chang, M. L., Mei, H. C., Kuo, I. C., Hsiao, G., Kuo, Y. H. & Lee, C. K., 3月 7 2018, 於: Molecules. 23, 3, 604.

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1 引文斯高帕斯（Scopus）

Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer

Chang, C. E., Hsieh, C. M., Chen, L. C., Su, C. Y., Liu, D. Z., Jhan, H. J., Ho, H. O. & Sheu, M. T., 1月 1 2018, 於: Drug Delivery. 25, 1, p. 632-643 12 p.

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15 引文斯高帕斯（Scopus）

Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer

Lin, L. T., Lai, Y. J., Wu, S. C., Hsu, W. H. & Tai, C. J., 2月 2018, 於: Journal of Food and Drug Analysis. 26, 1, p. 135-144

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21 引文斯高帕斯（Scopus）

Risk-benefit perception of pregnancy among breast cancer survivors

Hsieh, P. L., Huang, S. M., Chien, L. Y., Lee, C. F., Hsiung, Y. & Tai, C. J., 2018, 於: European Journal of Cancer Care.

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12 引文斯高帕斯（Scopus）

Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy

Cheng, W. J., Chen, L. C., Ho, H. O., Lin, H. L. & Sheu, M. T., 1月 1 2018, 於: International Journal of Nanomedicine. 13, p. 7079-7094 16 p.

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29 引文斯高帕斯（Scopus）

Suppression of cell growth, migration and drug resistance by ethanolic extract of antrodia cinnamomea in human lung cancer A549 cells and C57BL/6J allograft tumor model

Wu, C. H., Liu, F. C., Pan, C. H., Lai, M. T., Lan, S. J., Wu, C. H. & Sheu, M. J., 3月 9 2018, 於: International journal of molecular sciences. 19, 3, 791.

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6 引文斯高帕斯（Scopus）

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

Pan, C. H., Li, P. C., Chien, Y. C., Yeh, W. T., Liaw, C. C., Sheu, M. J. & Wu, C. H., 2018, 於: Phytotherapy Research.

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5 引文斯高帕斯（Scopus）

The natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway

Lin, E. Y., Bayarsengee, U., Wang, C. C., Chiang, Y. H. & Cheng, C. W., 1月 1 2018, 於: Environmental Toxicology. 33, 1, p. 72-82 11 p.

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19 引文斯高帕斯（Scopus）

2017

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., 5月 15 2017, 於: International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

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15 引文斯高帕斯（Scopus）

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., 8月 1 2017, 於: Cancer Letters. 400, p. 79-88 10 p.

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18 引文斯高帕斯（Scopus）

Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro

Liu, Y. H., Lu, Y. L., Liu, D. Z. & Hou, W. C., 7月 13 2017, 於: Drug Design, Development and Therapy. 11, p. 2139-2147 9 p.

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4 引文斯高帕斯（Scopus）

Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor a in human ovarian carcinoma cells

Wang, C. W., Hsu, W. H. & Tai, C. J., 2017, 於: Oncotarget. 8, 2, p. 3049-3058 10 p.

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25 引文斯高帕斯（Scopus）

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, 於: Oncotarget. 8, 17, p. 28342-28358 17 p.

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37 引文斯高帕斯（Scopus）

Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts

Tai, C. J., Wang, H., Wang, C. K., Tai, C. J., Huang, M. T., Wu, C. H., Chen, R. J., Kuo, L. J., Wei, P. L., Chang, Y. J., Chang, C. C., Chiou, H. Y. & Wu, C. J., 5月 1 2017, 於: Clinical and Experimental Medicine. 17, 2, p. 141-150 10 p.

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11 引文斯高帕斯（Scopus）

Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes

Chang, J. C., Hsiao, G., Lin, R. K., Kuo, Y. H., Ju, Y. M. & Lee, T. H., 1月 27 2017, 於: Journal of Natural Products. 80, 1, p. 38-44 7 p.

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32 引文斯高帕斯（Scopus）

Chemical composition and antioxidant, bactericidal, and matrix metalloproteinase inhibition activity of food-related plant

Chen, C. H., Chang, T. C., Chen, S. Y., Hsu, S. J., Huang, H. W. & Lee, C. K., 9月 1 2017, 於: LWT - Food Science and Technology. 82, p. 411-419 9 p.

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2 引文斯高帕斯（Scopus）

Chinese Medicine Treatment for Afatinib-Induced Paronychia

Yang, P-Y. & Tai, C-J., 2017, 於: Case Reports in Oncological Medicine. 2017, p. 7327359

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Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts

Huang, C. Y., Lin, Y. T., Kuo, H. C., Chiou, W. F. & Lee, M. H., 10月 2017, 於: Journal of Photochemistry and Photobiology B: Biology. 175, p. 244-253 10 p.

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8 引文斯高帕斯（Scopus）

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

Su, Y. C., Burnouf, P. A., Chuang, K. H., Chen, B. M., Cheng, T. L. & Roffler, S. R., 6月 8 2017, 於: Nature Communications. 8, 15507.

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36 引文斯高帕斯（Scopus）

Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: Application to pharmacokinetic studies

Sheu, M. T., Wu, C. Y., Su, C. Y. & Ho, H. O., 12月 1 2017, 於: Scientific Reports. 7, 1, 14609.

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4 引文斯高帕斯（Scopus）

Development and Validation of the Self-Efficacy Regarding Vaginal Birth Scale

Chu, K. H., Chen, A. C., Tai, C. J., Chen, S. F. & Chien, L. Y., 1月 1 2017, 於: JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing. 46, 1, p. e13-e21

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1 引文斯高帕斯（Scopus）

Differences between native and immigrant women in Taiwan in factors associated with caesarean section: A prospective observational study

Weng, S. S., Lin, C. L., Tai, C. J. & Chien, L. Y., 2017, 於: Women and Health. 57, 10, p. 1178-1192 15 p.

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1 引文斯高帕斯（Scopus）

Highly bioavailable silibinin nanoparticles inhibit HCV infection

Liu, C. H., Lin, C. C., Hsu, W. C., Chung, C. Y., Lin, C. C., Jassey, A., Chang, S. P., Tai, C. J., Tai, C. J., Shields, J., Richardson, C. D., Yen, M. H., Tyrrell, D. L. J. & Lin, L. T., 10月 2017, 於: Gut. 66, 10, p. 1853-1861 9 p.

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23 引文斯高帕斯（Scopus）

Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer

Lin, R. K., Hung, W. Y., Huang, Y. F., Chang, Y. J., Lin, C. H., Chen, W. Y., Chiu, S-F., Chang, S. C. & Tsai, S. F., 2017, 於: Oncotarget. 8, 69, p. 113431-113443 13 p.

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7 引文斯高帕斯（Scopus）

Identification of 7-(4′-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells

Wu, T. Y., Cho, T. Y., Lu, C. K., Liou, J. P. & Chen, M. C., 12月 1 2017, 於: Scientific Reports. 7, 1, 12406.

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9 引文斯高帕斯（Scopus）

Intermedin A, a New Labdane Diterpene Isolated from Alpinia intermedia, Prolonged the Survival Time of P-388D₁ Tumor-Bearing CDF₁ Mice

Chen, L. G., Su, P. J., Tsai, P. W., Yang, L. L. & Wang, C. C., 2017, 於: Planta Medica. 83, 1-2, p. 151-157 7 p.

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1 引文斯高帕斯（Scopus）

Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea

Chen, M. C., Cho, T. Y., Kuo, Y. H. & Lee, T. H., 9月 22 2017, 於: Journal of Natural Products. 80, 9, p. 2439-2446 8 p.

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12 引文斯高帕斯（Scopus）

Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma

Li, P. C., Siddiqi, I. N., Mottok, A., Loo, E. Y., Wu, C. H., Cozen, W., Steidl, C. & Shih, J. C., 10月 2017, 於: Journal of Pathology. 243, 2, p. 220-229 10 p.

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22 引文斯高帕斯（Scopus）

Multiple activities of punica granatum linne against acne vulgaris

Lee, C-J., Chen, L. G., Liang, W-L. & Wang, C-C., 1月 12 2017, 於: International Journal of Molecular Sciences. 18, 1, 141.

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30 引文斯高帕斯（Scopus）

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., 12月 1 2017, 於: Scientific Reports. 7, 1, 3228.

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29 引文斯高帕斯（Scopus）

Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography–tandem mass spectrometry

Xu, W., Li, X., Lin, N., Zhang, X., Huang, X., Wu, T., Tai, Y., Chen, S., Wu, C. H., Huang, M. & Wu, S., 11月 30 2017, 於: Journal of Pharmaceutical and Biomedical Analysis. 146, p. 314-323 10 p.

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21 引文斯高帕斯（Scopus）

Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs)

Li, T. P., Wong, W. P., Chen, L. C., Su, C. Y., Chen, L. G., Liu, D. Z., Ho, H. O. & Sheu, M. T., 12月 1 2017, 於: Scientific Reports. 7, 1, 10674.

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11 引文斯高帕斯（Scopus）

Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays

Hao, W. R., Chen, M., Chen, Y. J., Su, C. Y., Cheng, C. M., Hsueh, H. Y., Kao, A. P., Hsieh, Y. C., Chang, J., Tseng, M. Y. & Chuang, K. H., 12月 1 2017, 於: Scientific Reports. 7, 1, 989.

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6 引文斯高帕斯（Scopus）

Pueraria mirifica inhibits 17β-estradiol-induced cell proliferation of human endometrial mesenchymal stem cells

Lin, T. C., Wang, K. H., Kao, A. P., Chuang, K. H. & Kuo, T. C., 12月 2017, 於: Taiwanese Journal of Obstetrics and Gynecology. 56, 6, p. 765-769 5 p.

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4 引文斯高帕斯（Scopus）

Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

Chen, M., Cheng, K. W., Chen, Y. J., Wang, C. H., Cheng, T. C., Chang, K. C., Kao, A. P. & Chuang, K. H., 12月 1 2017, 於: Scientific Reports. 7, 1, 3142.

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17 引文斯高帕斯（Scopus）

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

Chang, C. H., Lee, C. Y., Lu, C. C., Tsai, F. J., Hsu, Y. M., Tsao, J. W., Juan, Y. N., Chiu, H. Y., Yang, J. S. & Wang, C. C., 3月 1 2017, 於: International Journal of Oncology. 50, 3, p. 873-882 10 p.

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112 引文斯高帕斯（Scopus）

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., 2月 15 2017, 於: European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

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15 引文斯高帕斯（Scopus）

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., 4月 7 2017, 於: Scientific Reports. 7, 46149.

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The inhibition of cordycepin on cancer stemness in TGF-beta induced chemo-resistant ovarian cancer cell

Wang, C. W., Lee, B. H. & Tai, C. J., 2017, 於: Oncotarget. 8, 67, p. 111912-111921 10 p.

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10 引文斯高帕斯（Scopus）

The novel HDAC8 inhibitor WK2-16 attenuates lipopolysaccharide-activated matrix metalloproteinase-9 expression in human monocytic cells and improves hypercytokinemia in vivo

Jan, J. S., Chou, Y. C., Cheng, Y. W., Chen, C. K., Huang, W. J. & Hsiao, G., 7月 1 2017, 於: International Journal of Molecular Sciences. 18, 7, 1394.

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10 引文斯高帕斯（Scopus）

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., 11月 1 2017, 於: Molecules. 22, 11, 1897.

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6 引文斯高帕斯（Scopus）

Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells

Liao, H. F., Pan, C. H., Chou, P. Y., Chen, Y. F., Wu, T. S., Sheu, M. J. & Wu, C. H., 9月 2017, 於: PLoS ONE. 12, 9, e0185021.

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5 引文斯高帕斯（Scopus）

WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade

Chuang, Y. F., Huang, S. W., Hsu, Y. F., Yu, M. C., Ou, G., Huang, W. J. & Hsu, M. J., 2017, 於: British Journal of Pharmacology. 174, 17, p. 2941-2961 21 p.

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13 引文斯高帕斯（Scopus）

2016

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, 於: Mediators of Inflammation. 2016, 6953459.

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25 引文斯高帕斯（Scopus）

Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry

Chung, C. Y., Liu, C. H., Burnouf, T., Wang, G. H., Chang, S. P., Jassey, A., Tai, C. J., Tai, C. J., Huang, C. J., Richardson, C. D., Yen, M. H., Lin, C. C. & Lin, L. T., 6月 1 2016, 於: Antiviral Research. 130, p. 58-68 11 p.

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31 引文斯高帕斯（Scopus）

Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer

Hsieh, C. L., Ma, H. P., Su, C-M., Chang, Y. J., Hung, W. Y., Ho, Y. S., Huang, W. J. & Lin, R. K., 4月 15 2016, 於: Life Sciences. 151, p. 7-14 8 p.

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24 引文斯高帕斯（Scopus）

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., 12月 23 2016, 於: Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

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27 引文斯高帕斯（Scopus）

An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract

Tseng, A., Yang, C. H., Chen, C. H., Chen, C. H., Hsu, S. L., Lee, M. H., Lee, H. C. & Su, L. J., 2月 1 2016, 於: Oncology Reports. 35, 2, p. 659-668 10 p.

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21 引文斯高帕斯（Scopus）

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