生藥學研究所

2015

Mycelial mattress from a sporangia formation-delayed mutant of Rhizopus stoloniferas wound healing-enhancing biomaterial

Chien, M. Y., Chen, L. C., Chen, Y. C., Sheu, M. T., Tsai, Y. C., Ho, H. O., Su, C. H. & Liu, D. Z., 8月 14 2015, 於: PLoS ONE. 10, 8, e0134090.

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5 引文斯高帕斯（Scopus）

Neurocytoprotective effects of aliphatic hydroxamates from lovastatin, a secondary metabolite from monascus -fermented red mold rice, in 6-hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cells

Lin, C-M., Lin, Y. T., Lin, R. D., Huang, W-J. & Lee, M-H., 5月 20 2015, 於: ACS Chemical Neuroscience. 6, 5, p. 716-724 9 p.

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31 引文斯高帕斯（Scopus）

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., 12月 2 2015, 於: International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

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15 引文斯高帕斯（Scopus）

N-hydroxycinnamide derivatives of osthole ameliorate hyperglycemia through activation of AMPK and p38 MAPK

Lee, W. H., Wu, H. H., Huang, W. J., Li, Y. N., Lin, R-J., Lin, S. Y. & Liang, Y. C., 3月 1 2015, 於: Molecules. 20, 3, p. 4516-4529 14 p.

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10 引文斯高帕斯（Scopus）

Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors

Jhan, H. J., Liu, J. J., Chen, Y. C., Liu, D. Z., Sheu, M. T. & Ho, H. O., 4月 1 2015, 於: Nanomedicine. 10, 8, p. 1263-1274 12 p.

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26 引文斯高帕斯（Scopus）

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., 8月 27 2015, 於: Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

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24 引文斯高帕斯（Scopus）

Pb²⁺ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells

Chan, C. P., Tsai, Y. T., Chen, Y. L., Hsu, Y. W., Tseng, J. T., Chuang, H. Y., Shiurba, R., Lee, M. H., Wang, J. Y. & Chang, W. C., 2月 1 2015, 於: Environmental Toxicology. 30, 2, p. 129-136 8 p.

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7 引文斯高帕斯（Scopus）

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles

Chen, Y. C., Su, C. Y., Jhan, H. J., Ho, H. O. & Sheu, M. T., 12月 2 2015, 於: International Journal of Nanomedicine. 10, p. 7265-7274 10 p.

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32 引文斯高帕斯（Scopus）

Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells

Wang, C-W., Wang, C. K., Chang, Y. J., Choong, C. Y., Lin, C. S., Tai, C. J. & Tai, C. J., 2015, 於: Evidence-based Complementary and Alternative Medicine. 2015, 570785.

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10 引文斯高帕斯（Scopus）

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., 8月 17 2015, 於: Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

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14 引文斯高帕斯（Scopus）

R173W mutation of hydroxymethylbilane synthetase is associated with acute intermittent porphyria complicated with rhabdomyolysis: The first report

Chen, M. C., Chang, C. J., Lu, Y. H., Niu, D. M., Lou, H. Y. & Chang, C. C., 3月 13 2015, 於: Journal of Clinical Gastroenterology. 49, 3, p. 256-257 2 p.

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6 引文斯高帕斯（Scopus）

Redox reaction mediated direct synthesis of hierarchical flower-like CuO spheres anchored on electrospun poly(vinylidene difluoride) fiber surfaces at low temperatures

Lee, Y. Y., Li, H. Y., Chiu, S. J., Liang, W. L., Yeh, P. L. & Liu, Y. L., 2015, 於: RSC Advances. 5, 121, p. 100228-100234 7 p.

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5 引文斯高帕斯（Scopus）

Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies

Tung, H. Y., Su, Y. C., Chen, B. M., Burnouf, P. A., Huang, W. C., Chuang, K. H., Yan, Y. T., Cheng, T. L. & Roffler, S. R., 6月 1 2015, 於: Molecular Cancer Therapeutics. 14, 6, p. 1317-1326 10 p.

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30 引文斯高帕斯（Scopus）

Swelling/floating capability and drug release characterizations of gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose

Chen, Y. C., Ho, H. O., Liu, D. Z., Siow, W. S. & Sheu, M. T., 1月 24 2015, 於: PLoS One. 10, 1, e0116914.

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37 引文斯高帕斯（Scopus）

The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death

Huang, Y. H., Huang, S. W., Hsu, Y. F., Ou, G., Huang, W. J. & Hsu, M. J., 10月 29 2015, 於: Scientific Reports. 5, 15900.

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7 引文斯高帕斯（Scopus）

The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells

Lin, L. T., Tai, C. J., Su, C-H., Chang, F. M., Choong, C. Y., Wang, C. K. & Tai, C. J., 2015, 於: BioMed Research International. 2015, 415269.

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11 引文斯高帕斯（Scopus）

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., 6月 1 2015, 於: Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

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19 引文斯高帕斯（Scopus）

Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1

Chao, S. W., Su, M. Y., Chiou, L. C., Chen, L. C., Chang, C. I. & Huang, W. J., 8月 28 2015, 於: Journal of Natural Products. 78, 8, p. 1969-1976 8 p.

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20 引文斯高帕斯（Scopus）

Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice

Lin, S. Y., Huang, G. C., Hsieh, Y. Y., Lin, Y. S., Han, C. H., Wen, C. L., Chang, C. I. & Hou, W. C., 10月 28 2015, 於: Journal of Agricultural and Food Chemistry. 63, 42, p. 9286-9294 9 p.

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6 引文斯高帕斯（Scopus）

WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-angiogenic activities via Src-homology-2-domaincontaining protein tyrosine phosphatase 1

Chang, Y. F., Hsu, Y. F., Chiu, P. T., Huang, W. J., Huang, S. W., Ou, G., Sheu, J. R. & Hsu, M. J., 2015, 於: Oncotarget. 6, 1, p. 85-100 16 p.

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11 引文斯高帕斯（Scopus）

WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages

Chen, W. C., Yen, C. S., Huang, W. J., Hsu, Y. F., Ou, G. & Hsu, M. J., 2015, 於: British Journal of Pharmacology. 172, 7, p. 1894-1908 15 p.

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22 引文斯高帕斯（Scopus）

Women who conceived with infertility treatment were more likely to receive planned cesarean deliveries in Taiwan

Chien, L. Y., Lee, Y. H., Lin, Y. H. & Tai, C. J., 6月 1 2015, 於: Human Fertility. 18, 2, p. 141-148 8 p.

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5 引文斯高帕斯（Scopus）

Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice

Shieh, Y. H., Huang, H. M., Wang, C. C., Lee, C. C., Fan, C. K. & Lee, Y. L., 2月 2015, 於: International Immunopharmacology. 24, 2, p. 383-391 9 p.

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45 引文斯高帕斯（Scopus）

不孕症夫妻同治病例分享

YuChuan, C. & Chen-Jei, T., 2015, 於: 中醫婦科醫學雜誌. 19, p. 37-41 5 p.

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卵巢良性腫瘤的中醫治療病例報告

Bo-Feng, W. & Tai, C-J., 2015, 於: 中醫婦科醫學雜誌. 19, p. 52-62 11 p.

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2014

Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats

Lin, T. Y., Huang, W. J., Wu, C. C., Lu, C. W. & Wang, S. J., 2月 10 2014, 於: PLoS One. 9, 2, e88644.

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36 引文斯高帕斯（Scopus）

Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study

Lee, Y-W., Chen, T-L., Shih, Y. R. V., Tsai, C. L., Chang, C-C., Liang, H-H., Tseng, S-H., Chien, S-C. & Wang, C-C., 5月 1 2014, 於: Cancer. 120, 9, p. 1338-1344 7 p.

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89 引文斯高帕斯（Scopus）

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

Huang, W. J., Tang, Y. A., Chen, M. Y., Wang, Y. J., Hu, F. H., Wang, T. W., Chao, S. W., Chiu, H. W., Yeh, Y. L., Chang, H. Y., Juan, H. F., Lin, P. & Wang, Y. C., 4月 28 2014, 於: Cancer Letters. 346, 1, p. 84-93 10 p.

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20 引文斯高帕斯（Scopus）

Aliphatic phenolic ethers from trichobotrys effusa

Chen, J. J., Wang, S. W., Hsiao, H. Y., Lee, M. S., Ju, Y. M., Kuo, Y. H. & Li, Z-H., 5月 23 2014, 於: Journal of Natural Products. 77, 5, p. 1097-1101 5 p.

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4 引文斯高帕斯（Scopus）

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase i

Yu, C. C., Pan, S. L., Chao, S. W., Liu, S. P., Hsu, J. L., Yang, Y. C., Li, T. K., Huang, W. J. & Guh, J. H., 8月 1 2014, 於: Biochemical Pharmacology. 90, 3, p. 320-330 11 p.

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24 引文斯高帕斯（Scopus）

Anoxic androgen degradation by the denitrifying bacterium Sterolibacterium denitrificans via the 2,3-seco pathway

Wang, P. H., Yu, C. P., Li, Z-H., Lin, C. W., Ismail, W., Wey, S. P., Kuo, A. T. & Chiang, Y. R., 2014, 於: Applied and Environmental Microbiology. 80, 11, p. 3442-3452 11 p.

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27 引文斯高帕斯（Scopus）

Anti-inflammatory effects of vitis thunbergii var. taiwaniana on knee damage associated with arthritis

Tsai, C. F., Wang, K. T., Chen, L. G., Lee, C. J., Tseng, S. H. & Wang, C. C., 4月 1 2014, 於: Journal of Medicinal Food. 17, 4, p. 479-486 8 p.

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13 引文斯高帕斯（Scopus）

Antioxidant and antiglycation activities of the synthesised dipeptide, Asn-Trp, derived from computer-aided simulation of yam dioscorin hydrolysis and its analogue, Gln-Trp

Han, C. H., Lin, Y. S., Lin, S. Y. & Hou, W. C., 2014, 於: Food Chemistry. 147, p. 195-202 8 p.

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27 引文斯高帕斯（Scopus）

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, 於: Oncotarget. 5, 24, p. 12891-12907 17 p.

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60 引文斯高帕斯（Scopus）

Antitumor effects and biological mechanism of action of the aqueous extract of the camptotheca acuminata fruit in human endometrial carcinoma cells

Lin, C. S., Chen, P. C., Wang, C. K., Wang, C-W., Chang, Y. J., Tai, C. J. & Tai, C. J., 2014, 於: Evidence-based Complementary and Alternative Medicine. 2014, 564810.

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15 引文斯高帕斯（Scopus）

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential

Wang, S. C., Li, Z-H., Hsu, C. H., Chang, Y. J., Chang, M. S., Wang, Y. C., Ho, Y. S., Wen, W. C. & Lin, R. K., 6月 18 2014, 於: Journal of Agricultural and Food Chemistry. 62, 24, p. 5625-5635 11 p.

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37 引文斯高帕斯（Scopus）

Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice

Han, C. H., Lin, Y. S., Lee, T. L., Liang, H. J. & Hou, W. C., 2014, 於: Food and Function. 5, 9, p. 2228-2236 9 p.

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19 引文斯高帕斯（Scopus）

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 5月 22 2014, 於: Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

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60 引文斯高帕斯（Scopus）

Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system

Hsieh, C. M., Huang, Y. W., Sheu, M. T. & Ho, H. O., 2014, 於: International Journal of Biological Macromolecules. 64, p. 45-52 8 p.

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17 引文斯高帕斯（Scopus）

Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells

Wang, C. H., Hsiao, C. J., Lin, Y. N., Wu, J. W., Kuo, Y. C., Lee, C. K. & Hsiao, G., 11月 1 2014, 於: Pharmaceutical Biology. 52, 11, p. 1451-1459 9 p.

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22 引文斯高帕斯（Scopus）

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption

Hsiao, C. J., Hsiao, G., Chen, W. L., Wang, S. W., Chiang, C. P., Liu, L. Y., Guh, J. H., Li, Z-H. & Chung, C. L., 4月 25 2014, 於: Journal of Natural Products. 77, 4, p. 758-765 8 p.

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44 引文斯高帕斯（Scopus）

Characterizations of plasticized polymeric film coatings for preparing multiple-unit floating drug delivery systems (muFDDSs) with controlled-release characteristics

Hung, S. F., Hsieh, C. M., Chen, Y. C., Wang, Y. C., Ho, H. O. & Sheu, M. T., 6月 26 2014, 於: PLoS One. 9, 6, e100321.

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13 引文斯高帕斯（Scopus）

Comparison of chemical compositions and osteoprotective effects of different sections of velvet antler

Tseng, S. H., Sung, C. H., Chen, L. G., Lai, Y. J., Chang, W. S., Sung, H. C. & Wang, C. C., 1月 10 2014, 於: Journal of Ethnopharmacology. 151, 1, p. 352-360 9 p.

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40 引文斯高帕斯（Scopus）

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., 9月 1 2014, 於: Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

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7 引文斯高帕斯（Scopus）

Cucurbitane-type glycosides from the fruits of Momordica charantia and their hypoglycaemic and cytotoxic activities

Zhang, L. J., Liaw, C. C., Hsiao, P. C., Huang, H. C., Lin, M. J., Lin, Z. H., Hsu, F. L. & Kuo, Y. H., 2014, 於: Journal of Functional Foods. 6, 1, p. 564-574 11 p.

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23 引文斯高帕斯（Scopus）

Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: An in vitro and in vivo study

Li, P. C., Pan, C. H., Sheu, M. J., Wu, C. C., Ma, W. F. & Wu, C. H., 5月 13 2014, 於: PLoS One. 9, 5, e96927.

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22 引文斯高帕斯（Scopus）

Detection of trace ink compounds in erased handwritings using electrospray-assisted laser desorption ionization mass spectrometry

Kao, Y. Y., Cheng, S. C., Cheng, C. N., Shiea, J. & Ho, H. O., 2014, 於: Journal of Mass Spectrometry. 49, 6, p. 445-451 7 p.

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13 引文斯高帕斯（Scopus）

Development of an anti-methoxy poly(ethylene glycol) (α-mPEG) cell-based capture system to measure mPEG and mPEGylated molecules

Chuang, K. H., Kao, C. H., Roffler, S. R., Lu, S. J., Cheng, T. C., Wang, Y. M., Chuang, C. H., Hsieh, Y. C., Wang, Y. T., Wang, J. Y., Weng, K. Y. & Cheng, T. L., 10月 14 2014, 於: Macromolecules. 47, 19, p. 6880-6888 9 p.

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8 引文斯高帕斯（Scopus）

Diterpene glycosides and polyketides from xylotumulus gibbisporus

Chang, Y. C., Lu, C. K., Chiang, Y. R., Wang, G. J., Ju, Y. M., Kuo, Y. H. & Li, Z-H., 4月 25 2014, 於: Journal of Natural Products. 77, 4, p. 751-757 7 p.

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23 引文斯高帕斯（Scopus）

DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer

Yang, Y. C., Tang, Y. A., Shieh, J. M., Lin, R. K., Hsu, H. S. & Wang, Y. C., 2014, 於: Journal of Thoracic Oncology. 9, 9, p. 1305-1315 11 p.

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32 引文斯高帕斯（Scopus）

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