生藥學研究所

2021

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Nurrahma, B. A., Tsao, S. P., Wu, C. H., Yeh, T. H., Hsieh, P. S., Panunggal, B. & Huang, H. Y., 5月 7 2021, 於: Frontiers in Aging Neuroscience. 13, 668775.

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16 引文斯高帕斯（Scopus）

Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuli

Li, J., Wang, D., Chang, S. C., Liang, P. H., Srivastava, V., Guu, S. Y., Shie, J. J., Khoo, K. H., Bulone, V. & Hsieh, Y. S. Y., 3月 24 2021, 於: Journal of Agricultural and Food Chemistry. 69, 11, p. 3371-3379

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1 引文斯高帕斯（Scopus）

Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis

Kumar, S., Chang, Y-C., Lai, K-H. & Hwang, T-L., 2021, 於: Current Medicinal Chemistry. p. 3773-3786

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10 引文斯高帕斯（Scopus）

Scalarane-type sesterterpenoids from the marine sponge lendenfeldia sp. Alleviate inflammation in human neutrophils

Peng, B. R., Lai, K. H., Lee, G. H., Yu, S. S. F., Duh, C. Y., Su, J. H., Zheng, L. G., Hwang, T. L. & Sung, P. J., 9月 30 2021, 於: Marine Drugs. 19, 10, 561.

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6 引文斯高帕斯（Scopus）

Suppression of Inflammatory and Fibrotic Signals by Cinnamon (Cinnamomum cassia) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice

Chen, L. L., Lee, M. H., Chang, C. L., Liou, K. T., Liu, S. H., Chern, C. M., Chen, H. I., Shen, Y. C. & Wang, Y. H., 2021, 於: Evidence-based Complementary and Alternative Medicine. 2021, 5205759.

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1 引文斯高帕斯（Scopus）

The Configuration-Dependent Anti-Leukemic Effect of Manoalide Stereoisomers: Reignite Research Interest in these Sponge-Derived Sesterterpenoids

Lai, K. H., Peng, B. R., Hsu, Y. M., El-Shazly, M., Du, Y. C., Lu, M. C., Su, J. H. & Liu, Y. C., 9月 2021, 於: Bioorganic Chemistry. 114, 105150.

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3 引文斯高帕斯（Scopus）

The fruits of paris polyphylla inhibit colorectal cancer cell migration induced by fusobacterium nucleatum-derived extracellular vesicles

Lin, L. T., Shi, Y. C., Choong, C. Y. & Tai, C. J., 7月 1 2021, 於: Molecules. 26, 13, 4081.

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6 引文斯高帕斯（Scopus）

Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity

Vo, T. H., Lin, Y. C., Liaw, C. C., Pan, W. P., Cheng, J. J., Lee, C. K. & Kuo, Y. H., 4月 2021, 於: Phytochemistry. 184, 112666.

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1 引文斯高帕斯（Scopus）

Ursolic acid and its nanoparticles are potentiators of oncolytic measles virotherapy against breast cancer cells

Liu, C. H., Wong, S. H., Tai, C. J., Tai, C. J., Pan, Y. C., Hsu, H. Y., Richardson, C. D. & Lin, L. T., 1月 1 2021, 於: Cancers. 13, 1, p. 1-19 19 p., 136.

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6 引文斯高帕斯（Scopus）

臺灣中藥典第四版中藥材基原及拉丁生藥名之修正

陳昱璋, 李佳蓉, 梁文俐, 劉崇喜, 郭昭麟 & 陳益昇, 12月 1 2021, 於: 中醫藥雜誌. 32, 2, p. 17-40 24 p.

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2020

(+)-Erythro-∆⁸⁰-7S,8R-Dihydroxy-3,3⁰,5⁰-Trimethoxy-8-O-4⁰-Neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt

Lee, C. J., Huang, C. W., Chen, L. G. & Wang, C. C., 10月 2020, 於: Molecules. 25, 19, 4563.

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2 引文斯高帕斯（Scopus）

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., 3月 2020, 於: Food and Function. 11, 3, p. 2328-2338 11 p.

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8 引文斯高帕斯（Scopus）

Anti-acne effects of cembrene diterpenoids from the cultured soft coral sinularia flexibilis

Chen, L. W., Chung, H. L., Wang, C. C., Su, J. H., Chen, Y. J. & Lee, C. J., 10月 2020, 於: Marine Drugs. 18, 10, 487.

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5 引文斯高帕斯（Scopus）

Antioxidant and anti-inflammation activities of bioactive compounds extracted and isolated from ethanol extract of sesamum indicum L.

Aquino, L. B. B., Hsieh, C. Y., Hsieh, C. L., de Castro-Cruz, K. A., Lee, C. J., Wang, C. C., Shen, C. C., Huang, S. M. & Tsai, P. W., 8月 28 2020, 於: Plant Cell Biotechnology and Molecular Biology. 21, 35-36, p. 115-128 14 p.

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3 引文斯高帕斯（Scopus）

A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab

Chang, T. K., Yin, T. C., Su, W. C., Tsai, H. L., Huang, C. W., Chen, Y. C., Li, C. C., Chen, P. J., Ma, C. J., Chuang, K. H., Cheng, T. L. & Wang, J. Y., 2020, 於: Oncology Research. 28, 7, p. 801-809 9 p.

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3 引文斯高帕斯（Scopus）

Aqueous extract of kan-lu-hsiao-tu-tan ameliorates collagen-induced arthritis in mice by inhibiting oxidative stress and inflammatory responses

Chiang, C. C., Li, Y. R., Lai, K. H., Cheng, W. J., Lin, S. C., Wang, Y. H., Chen, P. J., Yang, S. H., Lin, C. C. & Hwang, T. L., 12月 2020, 於: Life. 10, 12, p. 1-17 17 p., 313.

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4 引文斯高帕斯（Scopus）

BAY 41-2272 attenuates CTGF expression via sGC/cGMP-independent pathway in TGFΒ1-activated hepatic stellate cells

Chen, P. J., Kuo, L. M., Wu, Y. H., Chang, Y. C., Lai, K. H. & Hwang, T. L., 9月 2020, 於: Biomedicines. 8, 9, 330.

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7 引文斯高帕斯（Scopus）

Bioassay-guided isolation and HPLC quantification of antiproliferative metabolites from Stahlianthus thorelii

Nguyen, N. L., Vo, T. H., Lin, Y. C., Liaw, C. C., Lin, Z. H., Chen, M. C. & Kuo, Y. H., 1月 28 2020, 於: Molecules. 25, 3, 551.

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2 引文斯高帕斯（Scopus）

Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia

Chen, L. C., Huang, H. L., Huangfu, W. C., Yen, S. C., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., 10月 23 2020, 於: Journal of Natural Products. 83, 10, p. 2967-2975 9 p.

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11 引文斯高帕斯（Scopus）

Chalcones display anti-nlrp3 inflammasome activity in macrophages through inhibition of both priming and activation steps—structure-activity-relationship and mechanism studies

Leu, W. J., Chu, J. C., Hsu, J. L., Du, C. M., Jiang, Y. H., Hsu, L. C., Huang, W. J. & Guh, J. H., 12月 2020, 於: Molecules. 25, 24, 5960.

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5 引文斯高帕斯（Scopus）

CK1δ as a potential therapeutic target to treat bladder cancer

Lin, Y. C., Chen, M. C., Hsieh, T. H., Liou, J. P. & Chen, C. H., 4月 15 2020, 於: Aging. 12, 7, p. 5764-5780 17 p.

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8 引文斯高帕斯（Scopus）

Compounds isolated from Euonymus spraguei Hayata induce ossification through multiple pathways

Imtiyaz, Z., Lin, Y. T., Cheong, U. H., Jassey, A., Liu, H. K. & Lee, M. H., 9月 2020, 於: Saudi Journal of Biological Sciences. 27, 9, p. 2227-2237 11 p.

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Evaluating the Therapeutic Efficacy of Si-Wu-Tang Decoction and Concentrated Extract in Follicular Maldevelopment-Related Menstrual Disorders Through Pharmacokinetic/Pharmacodynamic Studies

Lee, C. J., Kapelemera, A. M., Tsai, Y. Z., Lee, C. T., Xu, M. Y. & Wang, C. C., 9月 4 2020, 於: Frontiers in Pharmacology. 11, p. 1245 1245.

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7 引文斯高帕斯（Scopus）

Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells

Wu, W. C., Liu, Y. M., Liao, Y. H., Hsu, K. C., Lien, S. T., Chen, I. C., Lai, M. J., Li, Y. H., Pan, S. L., Chen, M. C. & Liou, J. P., 10月 1 2020, 於: European Journal of Medicinal Chemistry. 203, 112540.

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4 引文斯高帕斯（Scopus）

Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice

Mouri, A., Lee, H. J., Mamiya, T., Aoyama, Y., Matsumoto, Y., Kubota, H., Huang, W. J., Chiou, L. C. & Nabeshima, T., 7月 2020, 於: British Journal of Pharmacology. 177, 14, p. 3210-3224 15 p.

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8 引文斯高帕斯（Scopus）

Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

Cheng, Y. A., Wu, T. H., Wang, Y. M., Cheng, T. L., Chen, I. J., Lu, Y. C., Chuang, K. H., Wang, C. K., Chen, C. Y., Lin, R. A., Chen, H. J., Liao, T. Y., Liu, E. S. & Chen, F. M., 8月 27 2020, 於: Journal of Nanobiotechnology. 18, 1, p. 118 118.

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4 引文斯高帕斯（Scopus）

Hypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction

Chang, S. C., Liew, P. L., Ansar, M., Lin, S. Y., Wang, S. C., Hung, C. S., Chen, J. Y., Jain, S. & Lin, R. K., 5月 12 2020, 於: Clinical Epigenetics. 12, 1, p. 67 67.

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9 引文斯高帕斯（Scopus）

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., 1月 2020, 於: Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

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17 引文斯高帕斯（Scopus）

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., 3月 15 2020, 於: European Journal of Medicinal Chemistry. 190, 112086.

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17 引文斯高帕斯（Scopus）

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., 1月 1 2020, 於: European Journal of Medicinal Chemistry. 185, p. 111725 111725.

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31 引文斯高帕斯（Scopus）

Preparation and characterization of a novel swellable and floating gastroretentive drug delivery system (sfGRDDS) for enhanced oral bioavailability of nilotinib

Lin, H. L., Chen, L. C., Cheng, W. T., Cheng, W. J., Ho, H. O. & Sheu, M. T., 2月 2020, 於: Pharmaceutics. 12, 2, 137.

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10 引文斯高帕斯（Scopus）

Preparation and characterization of chemically TEMPO-oxidized and mechanically disintegrated sacchachitin nanofibers (SCNF) for enhanced diabetic wound healing

Chao, F. C., Wu, M. H., Chen, L. C., Lin, H. L., Liu, D. Z., Ho, H. O. & Sheu, M. T., 2月 1 2020, 於: Carbohydrate Polymers. 229, p. 115507 115507.

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18 引文斯高帕斯（Scopus）

Prescription Patterns of Wu Lin San Concentrated Extract Product for Cystitis in Taiwan: A Population-Based Study

Lee, C. J., Huan, S. K. H., Lee, Y. H., Yeh, Y. S., Lin, I. H. & Wang, C. C., 1月 1 2020, 於: Evidence-based Complementary and Alternative Medicine. 2020, p. 2605462 2605462.

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Protective evaluation of compounds extracted from root of rhodiola rosea L. Against methylglyoxal-induced toxicity in a neuronal cell line

Wang, C. H., Safwan, S., Cheng, M. C., Liao, T. Y., Cheng, L. C., Chen, T. A., Kuo, Y. H., Lin, Y. F. & Lee, C. K., 6月 17 2020, 於: Molecules. 25, 12, 2801.

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8 引文斯高帕斯（Scopus）

Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer's disease

Sheu, J. J., Yang, L. Y., Sanotra, M. R., Wang, S. T., Lu, H. T., Kam, R. S. Y., Hsu, I. U., Kao, S. H., Lee, C. K., Shieh, J. C. C. & Lin, Y. F., 2月 1 2020, 於: Clinical Biochemistry. 76, p. 24-30 7 p.

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2 引文斯高帕斯（Scopus）

Reductions of copper ion-mediated low-density lipoprotein (LDL) oxidations of trypsin inhibitors, the sweet potato root major proteins, and LDL binding capacities

Lu, Y. L., Lee, C. J., Lin, S. Y. & Hou, W. C., 12月 1 2020, 於: Botanical Studies. 61, 1, 26.

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2 引文斯高帕斯（Scopus）

Sclareol ameliorated ERCC1-mediated cisplatin resistance in A549 human lung adenocarcinoma cells and a murine xenograft tumor model by suppressing AKT-GSK3β-AP1/Snail and JNK-AP1 pathways

Pan, C. H., Chen, S. Y., Wang, J. Y., Tsao, S. P., Huang, H. Y., Wei-Chen Chiu, P. & Wu, C. H., 12月 1 2020, 於: Chemico-Biological Interactions. 332, 109304.

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8 引文斯高帕斯（Scopus）

Solanine Attenuated Hepatocarcinoma Migration and Invasion Induced by Acetylcholine

Lin, L. T., Choong, C. Y. & Tai, C. J., 2020, 於: Integrative Cancer Therapies. 19

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4 引文斯高帕斯（Scopus）

Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Peng, B. R., Lai, K. H., Chang, Y. C., Chen, Y. Y., Su, J. H., Huang, Y. M., Chen, P. J., Yu, S. S. F., Duh, C. Y. & Sung, P. J., 8月 19 2020, 於: Marine Drugs. 18, 9, 434.

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6 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., 2月 1 2020, 於: Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

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3 引文斯高帕斯（Scopus）

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., 4月 15 2020, 於: European Journal of Medicinal Chemistry. 192, p. 112193 112193.

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19 引文斯高帕斯（Scopus）

Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA

Tai, C. J., Jassey, A., Liu, C. H., Tai, C. J., Richardson, C. D., Wong, S. H. & Lin, L. T., 4月 8 2020, 於: Cells. 9, 4

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10 引文斯高帕斯（Scopus）

The potential of Asystasia gangetica (Chinese violet) extracts as an anti-aging agent and as a whitening agent

Barbaza, M. Y. U., Hsieh, C. Y., de Castro-Cruz, K. A., Lee, C. J., Hsieh, C. L. & Tsai, P. W., 9月 16 2020, 於: Plant Cell Biotechnology and Molecular Biology. 21, 40, p. 49-54 6 p.

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1 引文斯高帕斯（Scopus）

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., 1月 15 2019, 於: European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

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27 引文斯高帕斯（Scopus）

A CARE-compliant article: a case report of idiopathic brachial neuritis treated with ultrasound-guided electroacupuncture

Su, P. H. & Tai, C. J., 5月 1 2019, 於: Medicine. 98, 19, p. e15325 e15325.

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Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells

Nepali, K., Lin, M. H., Chao, M. W., Peng, S. J., Hsu, K. C., Eight Lin, T., Chen, M. C., Lai, M. J., Pan, S. L. & Liou, J. P., 10月 1 2019, 於: Bioorganic Chemistry. 91, 103119.

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10 引文斯高帕斯（Scopus）

A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer

Chiu, H. W., Yeh, Y. L., Ho, S. Y., Wu, Y. H., Wang, B. J., Huang, W. J., Ho, Y. S., Wang, Y. J., Chen, L. C. & Tu, S. H., 11月 1 2019, 於: Cancers. 11, 11, 1703.

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13 引文斯高帕斯（Scopus）

Anti-glycation, anti-hemolysis, and ORAC activities of demethylcurcumin and tetrahydroxycurcumin in vitro and reductions of oxidative stress in d-galactose-induced BALB/c mice in vivo

Liu, Y. H., Lee, T. L., Han, C. H., Lee, Y. S. & Hou, W. C., 12月 1 2019, 於: Botanical Studies. 60, 1, 9.

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6 引文斯高帕斯（Scopus）

Characterizing tyrosinase modulators from the roots of angelica keiskei using tyrosinase inhibition assay and UPLC-MS/MS as the combinatorial novel approach

Lee, J. H., Mei, H. C., Kuo, I. C., Lee, T. H., Chen, Y. H. & Lee, C. K., 9月 10 2019, 於: Molecules. 24, 18, 3297.

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5 引文斯高帕斯（Scopus）

Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

Tai, C. J., Liu, C. H., Pan, Y. C., Wong, S. H., Tai, C. J., Richardson, C. D. & Lin, L. T., 12月 1 2019, 於: Scientific Reports. 9, 1, 6767.

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15 引文斯高帕斯（Scopus）

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